Abstract: A strap adjustment system has a base body having a bottom wall, two side walls and a strap retaining bar extending between the two side walls, the bottom wall having an aperture therethrough with screw threads extending around an inside surface, and a screw disc having a central protrusion and screw threads extending around the central protrusion. The central protrusion fits through the aperture in the base body by rotating the screw disc so that the threads in the screw disc mate with the threads in the aperture, such that a height of the protrusion above the bottom wall of the base body is adjustable by turning the screw disc. In situations where a high degree of friction is required, the protrusion can be positioned at a maximum height through the aperture, and in situations where a low degree of friction is desired, the protrusion can be positioned lower.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: A method for editing and updating content of a collaborative document within a preview user interface is provided. The method includes a content management platform receives a request for a file stored which is stored in a third-party application format. The system causes a rendered graphical image of the file to be presented within a preview user interface. The rendered graphical image of the file represents a view of the file as if opened within a third-party application. The system receives from the preview user interface, content associated with a portion of the file. The system generates a new version of the file that includes the content associated with the portion of the file.

Abstract: A attachment system is formed by a primary device and a secondary device connected to the primary device in a pivoting manner. The primary device has a main body, two lateral sides and a bar for attaching the primary device to another object. Each of the lateral sides has a protrusion extending laterally outward from the lateral sides. The secondary device has two lateral sides, each equipped with an aperture that corresponds to one of the protrusions on the primary device, so that fitting the protrusions into the apertures pivotally connects the primary device to the secondary device, with the lateral sides of the secondary device being disposed outside of the lateral sides of the primary device. The secondary device can be pivoted between a folded position where the secondary device lies against the primary device, and an open position where the secondary device is raised up.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: An attachment system is formed by a primary device and a secondary device connected to the primary device in a pivoting manner. The primary device has a main body, two lateral sides and a bar for attaching the primary device to another object. Each of the lateral sides has a protrusion extending laterally outward from the lateral sides. The secondary device has two lateral sides, each equipped with an aperture that corresponds to one of the protrusions on the primary device, so that fitting the protrusions into the apertures pivotally connects the primary device to the secondary device, with the lateral sides of the secondary device being disposed outside of the lateral sides of the primary device. The secondary device can be pivoted between a folded position where the secondary device lies against the primary device, and an open position where the secondary device is raised up.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: An attachment system is formed by a primary device and a secondary device connected to the primary device in a pivoting manner. The primary device has a main body, two lateral sides and a bar for attaching the primary device to another object. Each of the lateral sides has a protrusion extending laterally outward from the lateral sides. The secondary device has two lateral sides, each equipped with an aperture that corresponds to one of the protrusions on the primary device, so that fitting the protrusions into the apertures pivotally connects the primary device to the secondary device, with the lateral sides of the secondary device being disposed outside of the lateral sides of the primary device. The secondary device can be pivoted between a folded position where the secondary device lies against the primary device, and an open position where the secondary device is raised up.

Abstract: Systems and methods disclosed herein provide access to a data file stored at a remote data storage system. A user device can send a file access request, via a user interface provided by the remote storage server, to the application server to access a data file stored at the remote storage server. The application server can then optionally identify a relevant application for accessing the data file, and send, to the remote server, a metadata-and-content request relating to the data file. The metadata-and-content request includes version information of a previously cached version of the data file cached at the application server. When the cached version is not the latest version, the application server receives the latest version of the data file from the remote storage server. The latest version of the data file is then presented, via the relevant application on the application server, to the user device.

Abstract: The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration.

Abstract: Clip-on sunglasses for plastic eyeglass frames are shaped more like a bracket, with a nearly 90° bend to accommodate the thickness of plastic eyeglass frames. The ends of the bracket also angle for 45° towards each other to avoid hitting the nose piece of the plastic eyeglass frame. In the clip-on sunglasses, a latch controls two arms to rotate the arms up to a 45° angle with respect to a pair of plastic eyeglass frames. The arms are formed in three bent portions so as to extend away from an interconnecting rod portion. The three bent portions of the arms allows the latch to fit the shape of the plastic eyeglass frame along the bridge portion of the eyeglass frame as effectively as possible and minimizes movement of the clip-on sunglasses relative to the eyeglass frame.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: A method, computer-readable medium and system for manipulating image data are disclosed. A method of manipulating image data includes accessing first image data configured for display using a first display device. Information associated with a manipulation of the first image data is accessed. Second image data is generated from the first image data using the information, wherein the second image data is configured for display using a second display device.

Abstract: A pair of eyeglasses is accessorized with a different appearance by the purchase of only a single pair of eyeglasses. This is accomplished by having removable and interchangeable sleeves for fitting over the temples of a pair of eyeglasses. Opposite sides of each of the sleeves are of different color, ornamentation or other decoration.

Abstract: A housing to locate sunglasses or clip-on sunglasses directly in front of a driver by securing the sunglasses or clip-on sunglasses in a container clipped to the sun visor of an automobile. In addition, the sunglasses or clip-on sunglasses are held firmly in place in a compartment of different configurations such that the sunglasses or clip-on sunglasses are readily available in a position immediately in front of a driver. The container is secured to the visor by a wire clip or other appropriate connection to the sun visor. A portion of the compartment folds away from the portion of the container which is clipped or fixed to the visor. The movable portion of the container is held firmly in place in a closed position as well as in an open condition by a magnet or other secure connection device.

Abstract: The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration.