Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract: The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.

Abstract: In an example implementation according to aspects of the present disclosure, a method may include receiving by a controller a BIOS image, extracting a current manufacturing programming mode state corresponding to a computer system. A BIOS personality of the BIOS image is evaluated, wherein the BIOS personality is based on a differentiation of hardware and software functionality. Based on the current manufacturing programming state and the BIOS personality, a compatibility with the computer system is determined. Based on the compatibility, the BIOS image is written to non-volatile memory.

Abstract: Examples associated with heartbeat signal verification are disclosed. One example includes verifying a provisioning key using a trusted key. The provisioning key is received from a remote device via an intermediary process. An intermediate key provided by the intermediary process is verified using the provisioning key. A session identifier encrypted using the intermediate key and provided to the intermediary process. A first heartbeat signal is received from intermediary process. The heartbeat signal is generated based on the session identifier.

Abstract: Examples associated with password updates are described. One example method includes receiving a request to modify an administrator password in a basic input/output system (BIOS). The administrator password may be updated. A first password tied to the administrator password may be identified. A first updated password is generated by concatenating a character string to the administrator password. The character string may be generated based on a password policy for the first password. The first password may then be updated to the first updated password.

Abstract: A drug-loaded composite nanofiber membrane system, the system including a first nanofiber layer, a second nanofiber layer, and a third nanofiber layer. The first nanofiber layer includes a poly(lactic-co-glycolic acid) copolymer, poly(p-dioxanone) and a drug. The second nanofiber layer includes the poly(lactic-co-glycolic acid) copolymer, polyglycolic acid and the drug. The third nanofiber layer includes the poly(lactic-co-glycolic acid) copolymer, polyethylene glycol and the drug.

Abstract: A storage may store machine-readable instructions for execution by a processor. Execution of the machine-readable instructions may cause the processor to receive an update capsule via a firmware update interface. The update capsule may include a device identifier and a payload. The payload may include data that is different from a firmware update. Execution of the machine-readable instructions may cause the processor to execute a virtual device handler, based on the device identifier, to process the payload.

Abstract: In an example implementation according to aspects of the present disclosure, a method may include receiving by a controller a BIOS image, extracting a current manufacturing programming mode state corresponding to a computer system. A BIOS personality of the BIOS image is evaluated, wherein the BIOS personality is based on a differentiation of hardware and software functionality. Based on the current manufacturing programming state and the BIOS personality, a compatibility with the computer system is determined. Based on the compatibility, the BIOS image is written to non-volatile memory.

Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.

Abstract: T cell receptors that specifically recognize hAFP158 and methods of their use are provided.

Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.

Abstract: The update progress of a basic input/output system (BIOS) is displayed on a display screen. A first chipset lock is applied to a first region of a shared serial peripheral interface (SPI) chip of the BIOS of a computer system containing a first program of instructions. A system management memory mode lock is applied to a second and a third region of the shared SPI chip containing a second and third programs of instructions respectively. The second program of instructions is updated, and control of the BIOS is transferred to the updated second program of instructions. The updated second program of instructions updates the first program of instructions. The BIOS update progress visual is displayed on the display screen of the computer system while updating the first program of instructions.

Abstract: The present invention discloses a detection and analysis method for urine-modified nucleoside based on a surface-enhanced resonance Raman spectroscopy technology. In the method, a tumor marker modified nucleoside in the urine of a normal person and a cancer patient is extracted through the specificity of borophenylic acid gel; Au colloid is taken as an enhancing substrate to detect SERRS signals; and statistical analysis is conducted by using PLS-DA algorithms to establish a diagnosis and identification model for the SERRS of the urine-modified nucleoside. The model is used to discriminate that the to-be-detected urine-modified nucleoside belongs to the normal person or the cancer patient. After PLS-DA, the surface-enhanced resonance Raman spectroscopy data of the urine-modified nucleoside of the present invention has specificity of 96.9%, sensitivity of 98.2% and accuracy of 97.6%.

Abstract: A method for evaluating a multi-modal emotion cognition capability of a patient with an autism spectrum disorder, mainly includes the following steps: (1) setting a multi-modal evaluation environment, where the multi-modal evaluation environment is used to stimulate a tested object; and the multi-modal evaluation environment includes: a visual scene, a verbal communication scene, and an emotional communication scene; (2) collecting multi-modal evaluation information, where the evaluation information includes: intelligence information, behavioral data, and eye movement data of the tested object; and (3) performing statistical analysis, to obtain an emotion cognition capability of the tested object, where the performing statistical analysis includes: performing statistical analysis on the behavioral data, performing statistical analysis on the eye movement data, and performing statistical analysis on a combination of the behavioral data and the eye movement data.

Abstract: Poly(aryl piperidinium) polymers with pendant cationic groups are provided which have an alkaline-stable cation, piperidinium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells comprising the poly(aryl piperidinium) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

Abstract: The present invention discloses a detection and analysis method for urine-modified nucleoside based on a surface-enhanced resonance Raman spectroscopy technology. In the method, a tumor marker modified nucleoside in the urine of a normal person and a cancer patient is extracted through the specificity of borophenylic acid gel; Au colloid is taken as an enhancing substrate to detect SERRS signals; and statistical analysis is conducted by using PLS-DA algorithms to establish a diagnosis and identification model for the SERRS of the urine-modified nucleoside. The model is used to discriminate that the to-be-detected urine-modified nucleoside belongs to the normal person or the cancer patient. After PLS-DA, the surface-enhanced resonance Raman spectroscopy data of the urine-modified nucleoside of the present invention has specificity of 96.9%, sensitivity of 98.2% and accuracy of 97.6%.

Abstract: An example device comprises a plurality of components and a BIOS includes a non-volatile memory having instructions stored thereon that are executable by a processor of the device to cause the BIOS to determine a component identification (ID) of a component of the plurality of components, and fetch a plurality of recall component IDs. The instructions also are to cause the BIOS to compare the determined component ID with the plurality of recall component IDs. In response to a correspondence between the determined component ID and one recall component ID of the plurality of component IDs, the BIOS is to transmit signals representing a prompt to place the component of the plurality of components in a safety mode. The instructions also cause the BIOS to receive signals in response to the prompt and, responsive to the received signals, disable the component of the plurality of components.

Abstract: Poly(aryl alkylene) polymers or poly(aryl-crown ether-alkylene) polymers with pendant cationic groups are provided which have an alkaline-stable cation, such as imidazolium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the poly(aryl alkylene) polymers or poly(aryl-crown ether-alkylene) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

Abstract: A machine intelligent communication and control system is able to dynamically predict and adapt information presented to various users. The system provides a personalized experience with its ability to identify users, become contextually aware of the user's location and environment, identify objects and actions, and present customized information tailored for the user and the current environment. The system is further able to control connected items within the environment based upon various user preference considerations.

Abstract: A system design apparatus has a metamodel definition unit that generates a second metamodel based on a first metamodel described using a modeling language, the second metamodel including the first metamodel, a metamodel of a condition class which describes a condition, and a metamodel which describes an association between the condition class and a trace in order to distinguish presence or absence of the condition with respect to the trace, a model construction unit that constructs a model according to the second metamodel, and a script file generation unit that generates a script file corresponding to the model.