Abstract: Provided is a method of detecting free mannose and glucose in serum using high performance liquid chromatography. Compared to existing technology, the pretreatment process of samples is simpler, the detection time is shortened, and the detection efficiency is greater. When detection of serum samples is carried out, mannose, rhamnose and glucose may be completely separated, and mannose and glucose will not affect each other during quantification, thereby ensuring the accuracy of detection results.

Abstract: Disclosed is a ?-cyclodextrin-based star-shaped polymer and a preparation method therefor, and an integrated unimolecular micelle system for diagnosis and treatment based on the star-shaped polymer and the use thereof. The polymer has a structure represented by the following formula (I): wherein x=4-15, y=3-20, and z=10-30.

Abstract: Embodiments provide a packaging arrangement that includes a high density interconnect bridge for interconnecting dies within the packaging arrangement. The packaging arrangement comprises one or more redistribution layers and an interconnect bridge embedded within the one or more redistribution layers. A first die is coupled to (i) a first portion of the one or more redistribution layers and (ii) a first portion of the interconnect bridge. A second die coupled to a (ii) a second portion of the one or more redistribution layers and (ii) a second portion of the interconnect bridge to electrically couple the first die and the second die via at least the first interconnect bridge.

Abstract: The present disclosure discloses a method for forming a rim of a cast-spun aluminum alloy hub, that is, a special spinning composite machining method for forming a structure that the spokes and the inner wheel flange of the hub are cast and the middle of the rim is spun. The method can prevent the performance, strength and as-cast structure of the inner wheel flange from being destroyed, effectively improve the impact resistance of the cast-spun hub at the inner wheel flange, prevent the inner wheel flange of the cast-spun hub from cracking during radial impact and improve the performance of the spun structure of the rim, is beneficial to thinning the rim and realizes light weight of the rim.

Abstract: Disclosed in the present disclosure is a process for manufacturing an aluminum alloy wheel. The process flow comprises: casting, de-flashing, soaking, spinning, thermal treatment, de-gating, X-ray and machining. The process reduces the cost by about 18 yuan/piece and reduces the weight of the finished product by 0.7-1.1 Kg by improving the casting production efficiency and the product quality, saving original cooling compressed air, canceling pre-machining, preheating and spinning the thermal blank, thermally treating the thermal blank and the like, has the cost equivalent to the comprehensive manufacturing cost of an ordinary cast wheel, and improves the market competitiveness of the cast-spun wheel. The process realizes short flow, light weight and low cost for manufacturing a cast-spun wheel, achieves intelligence of machining, and is suitable for automatic production of large-batch cast-spun wheels.

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract: The present disclosure describes a coaxial-interconnect structure that is integrated into a semiconductor component and methods of forming the coaxial-interconnect structure. The coaxial interconnect-structure, which electrically couples circuitry of an integrated-circuit (IC) die to traces of a packaging substrate, comprises a signal core elongated about an axis, a ground shield elongated about the axis, and an insulator disposed between the signal core and the ground shield.

Abstract: A CMP (chemical mechanical polishing) composite groove polishing pad includes a polishing pad substrate and has a rotation center located in a middle of the polishing pad substrate, a first groove, a second groove and a third groove; the first groove and the second groove are communicated with each other end to end to form a petal-shaped composite groove. The first groove includes at least two positive spiral logarithmic sub grooves each of which is a semicircular curve radially distributed along the polishing pad substrate, starts from the rotation center and ends with an edge of the polishing pad substrate. The second groove includes at least two negative spiral logarithmic sub grooves each of which is a reverse semicircular curve radially distributed along the polishing pad substrate, starts from the rotation center and ends with the edge of the polishing pad substrate.

Abstract: A surface treatment process of a CMP (chemical mechanical polishing) polishing pad includes steps of rough-machining, fine-machining and finish-machining a substrate in sequence with an abrasive belt with a particle size of 120-mesh, an abrasive belt with a particle size of 240-mesh and an abrasive belt with a particle size of 400-mesh, respectively till a target thickness of the substrate is obtained. In each processing stage, the surface of the substrate is sanded through effectively adjusting the height of the corresponding abrasive belt so as to effectively control a surface roughness of the substrate. Moreover, through the surface treatment process provided by the present invention, the initial surface roughness is consistent with the surface roughness in the usage process of the substrate, so as to solve the problem that the initial grinding rate is unstable, thereby significantly improving the stability of the substrate in the CMP process.

Abstract: A process for spraying back-adhesive of a CMP pad, includes steps of: horizontally placing an underlayment on middle portions of an upper conveying roller and a lower conveying roller of a hot melt machine for feeding; providing an upper layer glue-coated paper closely attached with an upper surface of the underlayment on the upper conveying roller, providing a lower layer glue-coated paper closely attached with a lower surface of the underlayment on the lower conveying roller; spraying hot melt adhesive on an upper surface of the lower layer glue-coated paper via an ejector nozzle of the hot melt machine; wherein the upper layer glue-coated paper, the underlayment and the lower layer glue-coated paper are transmitted and adhered with each other on the upper conveying roller and the lower conveying roller.

Abstract: Disclosed are a use of FATS gene, by knocking out or inhibiting the FATS gene, in promoting macrophage polarization into M1 type and/or inhibiting macrophage polarization into M2 type, or activating and proliferating killer T cells; and a use of FATS gene or an expression product thereof in any one of i) developing and screening a functional product for tumors and ii) preparing a functional product for treatment or prevention of tumors. The present application demonstrates that FATS gene or an expression product thereof is closely related to tumors, and thus can be used as a drug target to develop tumor-related drugs. Cellular and molecular mechanisms of the FATS gene or its expression product in tumors are further demonstrated, providing an effective targeting means or a major basis for the development of tumor-related drugs.

Abstract: Tetrapeptides consisting of (I or V)-X1-K-X2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERM™ skin substitutes.

Abstract: The present application provides an apparatus and a method for measuring apparent permeability of a tight rock core, the apparatus comprises: a rock core holder, a first high-pressure injection pump, a second high-pressure injection pump, a micro-differential pressure meter, a micro-flow meter, a first pressure control unit, a second pressure control unit, a first valve, a second valve, a third valve, and a fourth valve; the first pressure control unit comprises: a first pressure-resistant piston container and a second pressure-resistant piston container, both of which are divided into an upper cavity and a lower cavity by a piston, the upper cavities of the first pressure-resistant piston container and the second pressure-resistant piston container are filled with gases and communicate with each other, and the lower cavity of the first pressure-resistant piston container is filled with pump pressure-transmission liquids, and the lower cavity of the second pressure-resistant piston container is filled with ex

Abstract: An EM testing method includes forcing electrical current through EM monitor wiring arranged in close proximity to the perimeter of the TSV and measuring an electrical resistance drop across the EM monitor wiring. The method may further include determining if an electrical short exists between the EM monitor wiring and the TSV from the measured electrical resistance. The method may further include determining if an early electrical open or resistance increase exists within the EM monitoring wiring due to TSV induced proximity effect.

Abstract: A structure, such as a wafer, semiconductor chip, integrated circuit, or the like, includes a through silicon via (TSV) and an electromigration (EM) monitor. The TSV) incldues at least one perimeter sidewall.

Abstract: A structure, such as a wafer, chip, IC, design structure, etc., includes a through silicon via (TSV) and an electromigration (EM) monitor. The TSV extends completely through a semiconductor chip and the EM monitor includes a plurality of EM wires proximately arranged about the TSV perimeter. An EM testing method includes forcing electrical current through EM monitor wiring arranged in close proximity to the perimeter of the TSV, measuring an electrical resistance drop across the EM monitor wiring, determining if an electrical short exists between the EM monitor wiring and the TSV from the measured electrical resistance, and/or determining if an early electrical open or resistance increase exists within the EM monitoring wiring due to TSV induced proximity effect.

Abstract: A through-silicon-via (TSV) structure is formed within a trench located within a semiconductor structure. The TSV structure may include a first electrically conductive liner layer located on an outer surface of the trench and a first electrically conductive structure located on the first electrically conductive liner layer, whereby the first electrically conductive structure partially fills the trench. A second electrically conductive liner layer is located on the first electrically conductive structure, a dielectric layer is located on the second electrically conductive liner layer, while a third electrically conductive liner layer is located on the dielectric layer. A second electrically conductive structure is located on the third electrically conductive liner layer, whereby the second electrically conductive structure fills a remaining opening of the trench.

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract: Embodiments provide a packaging arrangement that includes a high density interconnect bridge for interconnecting dies within the packaging arrangement. The packaging arrangement comprises one or more redistribution layers and an interconnect bridge embedded within the one or more redistribution layers. A first die is coupled to (i) a first portion of the one or more redistribution layers and (ii) a first portion of the interconnect bridge. A second die coupled to a (ii) a second portion of the one or more redistribution layers and (ii) a second portion of the interconnect bridge to electrically couple the first die and the second die via at least the first interconnect bridge.

Abstract: Tetrapeptides consisting of (I or V)—X1-K—X2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERM™ skin substitutes.