Patents by Inventor Nigel Clarke

Nigel Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240153092
    Abstract: In one embodiment, a method includes accessing, by a computing device, a thermal image of a space within a cooking apparatus, wherein the space contains a food item. The method further includes segmenting, by a computing device and based on the thermal image, the food item in the space from the food item's environment.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 9, 2024
    Inventors: Pedro Martinez Lopez, Brian Patton, Nigel Clarke, William Augustus Workman, Megan Rowe
  • Publication number: 20240131563
    Abstract: In one embodiment, a system includes a sensor and an airflow generator coupled to an airflow guide configured to direct airflow from the airflow generator toward and past the sensor. The system includes one or more processors and a non-transitory computer readable storage media embodying instructions coupled to the one or more processors, the one or more processors operable to execute the instructions to acquire data about an operational state of the system, wherein the operational state is related to at least one air contaminant generated by the system; and to control the airflow from the airflow generator based on the data about the operational state of the system.
    Type: Application
    Filed: November 22, 2022
    Publication date: April 25, 2024
    Inventors: Yufeng Wu, Nigel Clarke, Brian Patton, Pedro Martinez Lopez, Forrest Gia-Bao Tran
  • Patent number: 11953507
    Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
    Type: Grant
    Filed: September 21, 2022
    Date of Patent: April 9, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard Reitz
  • Publication number: 20240110899
    Abstract: A method for determining the amount of chromogranin A (CgA) in a sample includes: (a) purifying CgA in the sample; (b) adding an internal standard; (c) ionizing CgA and the internal standard to produce one or more CgA ion(s) and one or more internal standard ion(s) detectable by mass spectrometry; (d) determining the amount of the ion(s) from step (c) by mass spectrometry; and (e) correlating the amount of CgA in the sample to the amount of ion(s) measured in step (d).
    Type: Application
    Filed: December 12, 2023
    Publication date: April 4, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Patent number: 11929243
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: March 12, 2024
    Assignee: QUEST DIAGNOSTICS INVESTMENTS LLC
    Inventors: Darren Weber, Nigel Clarke
  • Publication number: 20240077503
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Application
    Filed: November 7, 2023
    Publication date: March 7, 2024
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20240060950
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
    Type: Application
    Filed: October 25, 2023
    Publication date: February 22, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventor: Nigel Clarke
  • Patent number: 11892659
    Abstract: An apparatus includes a display device having a lenticular layer. The lenticular layer includes (i) a first side, (ii) a second side opposite the first side, and (iii) particles in a fluid medium between the first and second sides of the lenticular layer. The second side of the lenticular layer includes lens elements forming a lenticular array. The particles of the lenticular layer are configured to move within the fluid medium such that (i) the lens elements are filled with the particles in a first mode or (ii) the lens elements are filled with the fluid medium in a second mode. The display device is configured to operate as a directional display in one of the first and second modes and as a single display in another of the first and second modes.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: February 6, 2024
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Nigel A Clarke, Sergio Perdices-Gonzalez
  • Patent number: 11885780
    Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: January 30, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Publication number: 20240007730
    Abstract: In one embodiment, an apparatus includes a head unit that includes one or more image sensors and one or more illumination sources. Both an intensity level of the one or more illumination sources and a position or an orientation of the head unit are adjustable. The apparatus also includes one or more processors and one or more memory elements that can execute instructions to capture, by the one or more image sensors, an image of a user's physical workspace, and provide the captured image for display to one or more users.
    Type: Application
    Filed: June 29, 2022
    Publication date: January 4, 2024
    Inventors: Nigel Clarke, Fulya Yilmaz, Curtis Aumiller, Mohammad Abu Saude
  • Publication number: 20230417760
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: September 12, 2023
    Publication date: December 28, 2023
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11852636
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: December 26, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 11835505
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: December 5, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventor: Nigel Clarke
  • Publication number: 20230375575
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Application
    Filed: August 2, 2023
    Publication date: November 23, 2023
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 11808773
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: November 7, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 11789289
    Abstract: A method for controlling content rendering by a multi-view, directionally dependent display includes defining a first display as a first pixel of a pixelated array of the multi-view display, the first display associated with a first viewing angle relative to a first axis; and defining a second display as a second pixel of the pixelated array, the second display. The method includes controlling chromatic properties of the first pixel by applying a filter based on a rendering of first content to be displayed. The method also includes controlling chromatic properties of the second pixel by applying a filter based on a rendering of second content to be displayed; and controlling points of incidence of light from the first and second pixel relative to an optical multiplexer thereby changing the directionality of the multi-view, directionally dependent display.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: October 17, 2023
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Nigel A. Clarke, Sergio Perdices-Gonzalez
  • Patent number: 11789026
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: October 17, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Publication number: 20230324414
    Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution / high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution / high accuracy mass spectrometry.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 12, 2023
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard Reitz
  • Patent number: 11761968
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: September 19, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20230273226
    Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
    Type: Application
    Filed: May 4, 2023
    Publication date: August 31, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Mildred M. Goldman, Scott Goldman, Julia Colletti, Nigel Clarke