Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

Abstract: In one embodiment, a method includes, by an electromagnetic device, generating an initial map of a temperature profile of a load disposed inside a cavity, emitting electromagnetic radiation into the cavity based on initial control parameter configurations, where a change in temperature of the load during the emission is measured by one or more sensors, generating updated maps of electromagnetic energy absorbed by the load based on the measured change in temperature of the load, where the updated maps comprise an indication of a spatial heating rate within the load, determining a sufficient number of the updated maps of electromagnetic energy absorbed by the load disposed inside the cavity have been measured, and, in response to determining that a sufficient number of the one or more updated maps of electromagnetic energy have been measured, storing the updated maps of electromagnetic energy absorbed by the load.

Abstract: In one embodiment, a method includes accessing real-time content captured by a first user's client device, where the real-time content is captured at a first high quality and is one of a plurality of content frames in a real-time stream of content. The method includes downgrading the quality of the real-time content to a second lower quality for transmission to a second user and transmitting the downgraded content to the second user. The method includes determining, based on a request made by the second user, an area of interest of a subsequent real-time image, where the subsequent real-time image is at the first high quality, modifying the subsequent real-time image to focus on the area of interest, where the modified subsequent real-time image is at the first high quality, and downgrading and transmitting the modified subsequent real-time image for to the second user.

Abstract: A control system for a vehicle, can include one or more controllers, and is configured to: determine a region of interest within a field-of-view of a scanning system of the vehicle; and operate the scanning system to scan portions of the field-of-view outside the region of interest at or below a nominal scanning resolution, and to scan the region of interest at an increased scanning resolution relative to the nominal scanning resolution.

Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.

Abstract: Embodiments of the present invention provide a system for determining a location of a tow hitch (280) mounted to a vehicle (250), comprising imaging means (260) disposed in relation to the vehicle to output image data corresponding to an image (105), and processing means (200, 210) arranged to receive the image data (270), wherein the processing means is arranged to select image data corresponding to a region (310) of the image and to search within the selected data for image data corresponding to the tow hitch (280) to determine the location of the tow hitch within the image.

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Abstract: A method by an electromagnetic device includes determining a pattern of electromagnetic energy absorbed by a load disposed inside a cavity into which electromagnetic radiation is directed and generating one or more maps of the pattern of electromagnetic energy absorbed by the load. The one or more maps comprises an indication of a distribution of heating within the load. The method further includes determining, based on the one or more maps, a plurality of sequences of operating parameter combinations configured so as to heat the load via absorption of the electromagnetic radiation in accordance with a target temperature profile with respect to the load. The method thus includes emitting electromagnetic radiation into the cavity based on the plurality of sequences of operating parameter combinations to achieve the target temperature profile with respect to the load.

Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Abstract: An apparatus includes a display device having a lenticular layer. The lenticular layer includes (i) a first side, (ii) a second side opposite the first side, and (iii) particles in a fluid medium between the first and second sides of the lenticular layer. The second side of the lenticular layer includes lens elements forming a lenticular array. The particles of the lenticular layer are configured to move within the fluid medium such that (i) the lens elements are filled with the particles in a first mode or (ii) the lens elements are filled with the fluid medium in a second mode. The display device is configured to operate as a directional display in one of the first and second modes and as a single display in another of the first and second modes.

Abstract: In one embodiment, an apparatus includes a multi-view display that includes several pixels. The apparatus includes a parallax barrier that overlays the several pixels of the multi-view display. The parallax barrier includes several barrier rows that are arrayed in a first dimension, where each barrier row includes several barriers arrayed in a second dimension. Each of the barriers are separated from adjacent barriers in the barrier row by an aperture. Each barrier row is offset from adjacent barrier rows by a macro offset distance in the second dimension. A portion of each barrier is offset by a micro offset distance in the second dimension, where the micro offset distance is smaller than the macro offset distance.

Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.