Patents by Inventor Nigel Clarke

Nigel Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220299524
    Abstract: Methods are provided for detecting insulin-like growth factor-I (IGF-I) variant(s) in a sample. Methods provided herein are further directed to using the detected ion or ions to determine the presence of IGF1 variant(s) in the sample.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 22, 2022
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Ievgen Motorykin, Nigel Clarke, Michael J. McPhaul, Zengru Wu
  • Publication number: 20220291228
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Inventors: Nigel CLARKE, Zhaohui CHEN
  • Patent number: 11428682
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: August 30, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Nigel Clarke
  • Patent number: 11415793
    Abstract: An apparatus includes a backlight, a color filter disposed in front of the backlight along a viewing direction, wherein the color filter includes a plurality of pixels repeating at a first spacing along a first axis. The apparatus further includes a lenticular layer disposed in front of the backlight, the lenticular layer including a section of material having a first index of refraction, a first, substantially flat side, and a second side defining a lenticularly patterned cross section along the first axis, the lenticularly patterned cross section including lens elements repeating at a second spacing and directing light originating from the backlight in two or more directions.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 16, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Nigel A. Clarke, Sergio Perdices-Gonzalez
  • Publication number: 20220214366
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Brett HOLMQUIST, Nigel CLARKE
  • Patent number: 11360098
    Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: June 14, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Diana Tran, Darren Weber, Nigel Clarke
  • Patent number: 11361953
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 14, 2022
    Assignee: Quest Diagnostics Investments Incoporated
    Inventors: Darren Weber, Nigel Clarke
  • Patent number: 11346845
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: May 31, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Publication number: 20220163494
    Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 26, 2022
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Patent number: 11280799
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: March 22, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20220026734
    Abstract: In one embodiment, an apparatus includes a multi-view display that includes several pixels. The apparatus includes a parallax barrier that overlays the several pixels of the multi-view display. The parallax barrier includes several barrier rows that are arrayed in a first dimension, where each barrier row includes several barriers arrayed in a second dimension. Each of the barriers are separated from adjacent barriers in the barrier row by an aperture. Each barrier row is offset from adjacent barrier rows by a macro offset distance in the second dimension. A portion of each barrier is offset by a micro offset distance in the second dimension, where the micro offset distance is smaller than the macro offset distance.
    Type: Application
    Filed: December 17, 2020
    Publication date: January 27, 2022
    Inventor: Nigel A. Clarke
  • Patent number: 11231401
    Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: January 25, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Publication number: 20210382076
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Zhaohui CHEN, Nigel CLARKE
  • Publication number: 20210349109
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Application
    Filed: March 22, 2021
    Publication date: November 11, 2021
    Inventors: Brett HOLMQUIST, Nigel CLARKE
  • Patent number: 11099198
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: August 24, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Zhaohui Chen, Nigel Clarke
  • Publication number: 20210239717
    Abstract: The present disclosure relates to methods of detecting various analytes, including glycated hemoglobin (HbA1c) and total hemoglobin (THb), in a biological sample obtained with a microsampling device.
    Type: Application
    Filed: August 21, 2019
    Publication date: August 5, 2021
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Nigel Clarke, Mildred Goldman, Jueun Kim, Jane Yang
  • Patent number: 11040717
    Abstract: The present invention includes a system for use in a vehicle for determining the terrain type in proximity to a vehicle. The system comprises a processor configured to receive primary output data from at least one vehicle-mounted sensor, and secondary output data from a secondary data source; and a data memory configured to store pre-determined primary data relating primary output data for the at least one vehicle-mounted sensor to a particular terrain type, and store at least one data set relating to one or more terrain types. The processor is configured to compare the primary output data with the pre-determined data to determine an indication of the particular terrain type corresponding to the primary output data, and compare the secondary output data with a data set corresponding to the indication of the particular terrain type.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: June 22, 2021
    Assignee: Jaguar Land Rover Limited
    Inventors: Mikhail Cherniakov, Alex Bystrov, Edward Hoare, Marina Gashinov, Thuy-Yung Tran, Nigel Clarke
  • Patent number: 11042249
    Abstract: In one embodiment, a method includes generating, at a multi-view display, a first content to be viewed at a first angle and a second content to be viewed at a second angle. The first content and the second content are displayed simultaneously. The method also includes receiving, at a touch-screen panel coupled to the multi-view display, a first plurality of capacitive signals. The method then generates, by the touch-screen panel, a first touch-screen panel heatmap based on the received first plurality of capacitive signals. The method afterwards determines, based on the first touch-screen panel heatmap, whether a first user input is received with respect to the first content or the second content. The method then assigns, based on determining the first user input corresponds to either the first content or the second content, the first user input to the first content or the second content.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: June 22, 2021
    Assignee: SAMSUNG ELECTRONICS COMPANY, LTD.
    Inventors: Sergio Perdices-Gonzalez, Nigel Clarke
  • Patent number: 10955424
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 23, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20210055277
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Application
    Filed: November 9, 2020
    Publication date: February 25, 2021
    Inventor: Nigel CLARKE