Patents by Inventor Peiming Zhang

Peiming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein and peptide sensors using electrical detection methods
    Patent number: 6824669
    Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: November 30, 2004
    Assignee: Motorola, Inc.
    Inventors: Changming Li, Jaymie Robin Sawyer, Vi-En Choong, George Maracas, Peiming Zhang
  • Compositions and methods for rolling circle amplification
    Publication number: 20040014078
    Abstract: This invention is directed to novel methods of amplifying and detecting DNA. More specifically, the invention applies variations of Rolling Circle Amplification to several detection platforms.
    Type: Application
    Filed: February 6, 2003
    Publication date: January 22, 2004
    Inventors: James Xia, Charles K. Brush, Vineet Gupta, Heshu Huang, Changming Li, George Maracas, Robert Marrero, Melissa L. Ray, Lei Sun, Peiming Zhang
  • Protein and peptide sensors using electrical detection methods
    Publication number: 20030138845
    Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.peptide.
    Type: Application
    Filed: August 23, 2002
    Publication date: July 24, 2003
    Inventors: Changming Li, Jaymie Sawyer, Vi-En Choong, George Maracas, Peiming Zhang
  • Schiff base reductant co-dispense process
    Patent number: 6500921
    Abstract: This invention provides efficient methods for producing a covalent linkage having improved chemical stability between an amine-containing biomolecule and a solid support or hydrogel surface containing an aldehyde moiety.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: December 31, 2002
    Assignee: Amersham Biosciences AB
    Inventors: Norman Gery Fuller, W. Travis Johnson, Michael Gaskin, Peiming Zhang
  • Oligonucleotides having universal nucleoside spacers
    Patent number: 5681947
    Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: October 28, 1997
    Assignees: Purdue Research Foundation, The Regents of the University of Michigan
    Inventors: Donald Eugene Bergstrom, Philip Charles Andrews, Ruthann Nichols, Peiming Zhang
  • 3-nitropyrrole nucleoside
    Patent number: 5438131
    Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: August 1, 1995
    Inventors: Donald E. Bergstrom, Philip C. Andrews, Ruthann Nichols, Peiming Zhang