Abstract: Systems and techniques are described for optimizing an integrated circuit (IC) design. Some embodiments can select a wide-bus in the IC design. Next, the embodiments can divide the wide-bus into one or more subsets of bus-wires, wherein each subset of bus-wires corresponds to a unit of information. The embodiments can then optimize clock gating for each subset of bus-wires.

Abstract: Systems and techniques are described for optimizing an integrated circuit (IC) design. Some embodiments can select a wide-bus in the IC design. Next, the embodiments can divide the wide-bus into one or more subsets of bus-wires, wherein each subset of bus-wires corresponds to a unit of information. The embodiments can then optimize clock gating for each subset of bus-wires.

Abstract: An example method includes displaying, by a display (104) of a wearable device (100), a content card (114B); receiving, by the wearable device, motion data generated by a motion sensor (102) of the wearable device that represents motion of a forearm of a user of the wearable device; responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is less than an acceleration of the supination, displaying, by the display, a next content card (114C); and responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is greater than an acceleration of the supination, displaying, by the display, a previous content card (114A).

Abstract: In one example, a wearable device includes one or more processors, a plurality of communication components, one or more motion sensors configured to detect motion of the wearable device and generate, based on the detected motion, motion data, and a storage device configured to store at least one module. The at least one module may be operable by the one or more processors to: responsive to determining that the wearable device is not connected to the computing device using the first communication technology, determine, based on the motion data, whether the wearable device is currently being worn, and responsive to determining that the wearable device is currently being worn, establish the wireless connection to the computing device using the second communication component.

Abstract: In one example, a wearable device includes one or more processors, a plurality of communication components, one or more motion sensors configured to detect motion of the wearable device and generate, based on the detected motion, motion data, and a storage device configured to store at least one module. The at least one module may be operable by the one or more processors to: responsive to determining that the wearable device is not connected to the computing device using the first communication technology, determine, based on the motion data, whether the wearable device is currently being worn, and responsive to determining that the wearable device is currently being worn, establish the wireless connection to the computing device using the second communication component.

Abstract: An example method includes displaying, by a display (104) of a wearable device (100), a content card (114B); receiving, by the wearable device, motion data generated by a motion sensor (102) of the wearable device that represents motion of a forearm of a user of the wearable device; responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is less than an acceleration of the supination, displaying, by the display, a next content card (114C); and responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is greater than an acceleration of the supination, displaying, by the display, a previous content card (114A).

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: In one example, a wearable device includes one or more processors, a plurality of communication components, one or more motion sensors configured to detect motion of the wearable device and generate, based on the detected motion, motion data, and a storage device configured to store at least one module. The at least one module may be operable by the one or more processors to: responsive to determining that the wearable device is not connected to the computing device using the first communication technology, determine, based on the motion data, whether the wearable device is currently being worn, and responsive to determining that the wearable device is currently being worn, establish the wireless connection to the computing device using the second communication component.

Abstract: A computing device is described that executes a centralized service and a plurality of applications. The centralized service detects a change from a first power mode of the computing device to a second power mode of the computing device and responsive to detecting the change, determines a first application from the plurality of applications executing at the computing device, to notify of the change from the first power mode to a second power mode. The centralized service outputs to the first application an indication of the change from the first power mode to the second power mode, and responsive to receiving an indication response from the first application, suspends an application processor of the computing device.

Abstract: The present invention relates to a bending assembly for bending a workpiece. The assembly includes a bending apparatus configured to bend the workpiece and form a curved portion of the workpiece. The curved portion of the workpiece has a longitudinal periphery and a curvature. The assembly includes a camera configured to produce an image of the longitudinal periphery of the curved portion of the workpiece. The assembly includes a processor configured to receive the image of the longitudinal periphery of the curved portion of the workpiece. The processor is configured to identify a plurality of measuring points spaced-apart along the longitudinal periphery of the curved portion of the workpiece. The processor is configured to determine the curvature of the curved portion of the workpiece based on the measuring points.

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: An example method includes displaying, by a display (104) of a wearable device (100), a content card (114B); receiving, by the wearable device, motion data generated by a motion sensor (102) of the wearable device that represents motion of a forearm of a user of the wearable device; responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is less than an acceleration of the supination, displaying, by the display, a next content card (114C); and responsive to determining, based on the motion data, that the user has performed a movement that includes a supination of the forearm followed by a pronation of the forearm at an acceleration that is greater than an acceleration of the supination, displaying, by the display, a previous content card (114A).

Abstract: This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R6, n and m are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: The present invention relates to a plastics-material strapping band (4) for wrapping around one or more articles. The plastics-material strapping band has the following constituent parts: a) up to approximately 90% by weight polyester, b) approximately 1% by weight to 5% by weight polyolefin and c) approximately 5% by weight to 10% by weight fiber material. The invention also relates to a method for producing a plastics-material strapping band.

Abstract: A method, device, system, or article of manufacture is provided for improved delivery of contextual data to a computing device while preserving data privacy.

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R6, n and m are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.