Abstract: Disclosed is an optometry apparatus capable of measuring para-central defocus, comprising a diopter measurement module. The diopter measurement module comprises a first light source (1) emitting a first light beam. The optometry apparatus also comprises a scanning module for adjusting the position of a light spot formed on the retina by the first light beam. The scanning module comprises a first reflecting mirror (3) and a second reflecting mirror (5) rotatably positioned in sequence in the emergent optical path of the first light source (1). The rotation axis of the first reflecting mirror (3) and the rotation axis of the second reflecting mirror (5) form therebetween an angle greater than 0 degree and less than 180 degrees.

Abstract: A method and apparatus for maintaining an aircraft. Real-time event information indicating faults in systems on the aircraft and aircraft condition monitoring system data indicating conditions of the systems on the aircraft are stored during a plurality of legs of flights of the aircraft. A feature table comprising the real-time event information and the aircraft condition monitoring system data is built. Feature vectors are extracted from the feature table. A machine learning algorithm is applied to the extracted feature vectors to generate a predicted maintenance event message that identifies a predicted maintenance event. The predicted maintenance event message is used to perform a maintenance operation on the aircraft.

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract: Described is a system for object detection in images or videos using spiking neural networks. An intensity saliency map is generated from an intensity of an input image having color components using a spiking neural network. Additionally, a color saliency map is generated from a plurality of colors in the input image using a spiking neural network. An object detection model is generated by combining the intensity saliency map and multiple color saliency maps. The object detection model is used to detect multiple objects of interest in the input image.

Abstract: Described herein is a method for enhancing image data that includes dividing an image into multiple regions. The method includes measuring variations in pixel intensity distribution of the image to determine high pixel intensity variations for identifying an intensity-changing region. The method includes calculating a histogram of intensity distribution of pixel intensity values for the intensity-changing region without calculating a histogram of intensity distribution of pixel intensity values for each region of the multiple regions. The method also includes determining a transformation function based on the intensity distribution for the intensity-changing region. The method includes applying the transformation function to modify an intensity for each pixel in the image to produce an enhanced image in real time. The method also includes detecting in the enhanced image a horizon for providing to an operator of a vehicle an indication of the horizon in the image on a display in the vehicle.

Abstract: Described herein is a method of enhancing an image includes determining a level of environmental artifacts at a plurality of positions on an image frame of image data. The method also includes adjusting local area processing of the image frame, to generate an adjusted image frame of image data, based on the level of environmental artifacts at each position of the plurality of positions. The method includes displaying the adjusted image frame.

Abstract: Described herein is a method of displaying an object that includes detecting a first location of the object on a first image frame of image data. The method also includes determining a second location of the object on a second image frame of the image data on which the object is not detectable due to an obstruction. The method includes displaying a representation of the object on the second image frame.

Abstract: The present invention discloses a hand-held autonomous visual acuity measurement apparatus and a visual acuity measuring method. The invention comprises a corneal curvature measurement module comprising a first light source for emitting a first light beam and a first image collector for collecting an image formed from the first light beam after it has been reflected by cornea, the first image collector being movably provided in the corneal curvature measurement optical path of the corneal curvature measurement module, and the corneal curvature measurement module further comprises a first motor for driving the first image collector to move along the corneal curvature measurement optical path so that the first image collector moves to the imaging position.

Abstract: Disclosed is an optometry apparatus capable of measuring para-central defocus, comprising a diopter measurement module. The diopter measurement module comprises a first light source (1) emitting a first light beam. The optometry apparatus also comprises a scanning module for adjusting the position of a light spot formed on the retina by the first light beam. The scanning module comprises a first reflecting mirror (3) and a second reflecting mirror (5) rotatably positioned in sequence in the emergent optical path of the first light source (1). The rotation axis of the first reflecting mirror (3) and the rotation axis of the second reflecting mirror (5) form therebetween an angle greater than 0 degree and less than 180 degrees.

Abstract: Some variations provide a method for real-time estimation of state of charge and state of power of a battery, comprising: (a) cycling a battery with a driving profile; (b) utilizing a recursive algorithm that relates battery terminal voltage to battery current, wherein the algorithm includes open-circuit voltage and a finite-impulse-response filter to dynamically model kinetic voltage; measuring the battery terminal voltage and the battery current at least at a first time and a second time during cycling; calculating battery open-circuit voltage and finite-impulse-response filter parameters; calculating battery state of charge based on the open-circuit voltage; and calculating battery state of power based on the open-circuit voltage and the finite-impulse-response filter parameters. An extended Kalman filtering technique is incorporated for real-time updating of FIR model parameters.

Abstract: Described herein is a method for enhancing image data that includes dividing an image into multiple regions. The method includes measuring variations in pixel intensity distribution of the image to determine high pixel intensity variations for identifying an intensity-changing region. The method includes calculating a histogram of intensity distribution of pixel intensity values for the intensity-changing region without calculating a histogram of intensity distribution of pixel intensity values for each region of the multiple regions. The method also includes determining a transformation function based on the intensity distribution for the intensity-changing region. The method includes applying the transformation function to modify an intensity for each pixel in the image to produce an enhanced image in real time. The method also includes detecting in the enhanced image a horizon for providing to an operator of a vehicle an indication of the horizon in the image on a display in the vehicle.

Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Abstract: The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.

Abstract: A method, system, and computer program product for predicting abnormal operation of at least one component of a machine is provided. Real time monitoring data from an operating machine is received and monitoring features that are informative of likely abnormal operation are extracted and/or calculated. The monitoring features are applied to a prediction matrix that outputs probabilities of abnormal operation within one or more prediction time horizons. If the output probabilities exceed a threshold probability, then an alert can be output. Maintenance can be automatically scheduled in response to the alert.

Abstract: Described is a system for object detection in images or videos using spiking neural networks. An intensity saliency map is generated from an intensity of an input image having color components using a spiking neural network. Additionally, a color saliency map is generated from a plurality of colors in the input image using a spiking neural network. An object detection model is generated by combining the intensity saliency map and multiple color saliency maps. The object detection model is used to detect multiple objects of interest in the input image.

Abstract: The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.

Abstract: Described herein is a method for enhancing image data that includes transforming image data from an intensity domain to a wavelet domain to produce wavelet coefficients. A first set of wavelet coefficients of the wavelet coefficients includes low-frequency wavelet coefficients. The method also includes modifying the first set of wavelet coefficients using a coefficient distribution based filter to produce a modified first set of wavelet coefficients. The method includes transforming the modified first set of wavelet coefficients from the wavelet domain to the intensity domain to produce enhanced image data.

Abstract: The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.

Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.