Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract: Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides and polypeptides having at least one ALK inhibitor resistance mutation are provided and find use in methods and compositions useful in the diagnosis, prognosis, and/or treatment of diseases associated with aberrant ALK activity, more particularly, those that are resistant to at least one ALK kinase inhibitors. Methods and compositions are also provided for the identification of agents that can inhibit the kinase activity and/or reduce the expression level of the ALK resistance mutants.

Abstract: This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract: Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides and polypeptides having at least one ALK inhibitor resistance mutation are provided and find use in methods and compositions useful in the diagnosis, prognosis, and/or treatment of diseases associated with aberrant ALK activity, more particularly, those that are resistant to at least one ALK kinase inhibitors. Methods and compositions are also provided for the identification of agents that can inhibit the kinase activity and/or reduce the expression level of the ALK resistance mutants.

Abstract: A system, method, and apparatus for radar pulse detection using a digital radar receiver are disclosed herein. In electronic warfare (EW), radars operate in an environment with highly dense electronic waveforms. As a result, the radars may receive thousands or millions of radar pulses every second. To detect and sort out radar pulses emitted from different radars is a challenging problem in electronic warfare. The present disclosure teaches a radar pulse detection system that utilizes digital channelization and joint-channel detection techniques to detect and separate radar pulses that are sent from different radar emitters. The main features of the present disclosure are: 1.) a digital channelization technique to separate radar pulses from their mixtures; 2.) a multi-channel detection technique to detect radar pulses; and 3.) an innovative technique to separate overlapped radar pulses.

Abstract: A computer-implemented method of sonar processing includes identifying, with a processor, a detection having a detection probability value, the detection in a selected beam, wherein the detection is associated with a detection range cell having detection range cell data. The method also includes comparing, with the processor, the detection range cell data with range cell data from a corresponding range cell from at least one overlapping beam overlapping the selected beam. The method also includes updating, with the processor, the detection probability value based upon the comparing. A sonar system uses the above-described method. A computer readable storage medium has instructions thereon to achieve the above-described method.

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract: An active sonar system and associated method combine signals from a plurality of receive beams in order to reduce a noise in a reference one of the signals from the plurality of receive beams.

Abstract: A system and a corresponding method used with a sensor array selects candidate weak target signals from within one or more received signals and enhances those candidate weak target signals relative to a noise background.

Abstract: Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides and polypeptides having at least one ALK inhibitor resistance mutation are provided and find use in methods and compositions useful in the diagnosis, prognosis, and/or treatment of diseases associated with aberrant ALK activity, more particularly, those that are resistant to at least one ALK kinase inhibitors. Methods and compositions are also provided for the identification of agents that can inhibit the kinase activity and/or reduce the expression level of the ALK resistance mutants.

Abstract: The present invention relates to a valuation-based learning system. The system is configured to receive a plurality of inputs, each input being input evidence corresponding to a variable in a Dempster-Shafer Reasoning System. The Dempster-Shafer Reasoning System is a network of interconnected nodes, with each node representing a variable that is representative of a characteristic of a problem domain. A discount weight is then optimized for assigning to each of the inputs. A basic probability assignment (bpa) is generated using the Dempster-Shafer Reasoning System, and where the bpa is an output for use in determining a solution of the problem domain. Finally, a solution to the problem domain is determined using the bpa.

Abstract: An active sonar system and associated method combine signals from a plurality of receive beams in order to reduce a noise in a reference one of the signals from the plurality of receive beams.

Abstract: A computer-implemented method of sonar processing includes identifying, with a processor, a detection having a detection probability value, the detection in a selected beam, wherein the detection is associated with a detection range cell having detection range cell data. The method also includes comparing, with the processor, the detection range cell data with range cell data from a corresponding range cell from at least one overlapping beam overlapping the selected beam. The method also includes updating, with the processor, the detection probability value based upon the comparing. A sonar system uses the above-described method. A computer readable storage medium has instructions thereon to achieve the above-described method.

Abstract: An electro-magnetic interference device attached to a surface of an object by soldering is disclosed. The device comprises a base comprising a surface defining at least one recessed portion. The at least one recessed portion comprises a side wall. An angle between the side wall and the surface of the base is equal to or greater than 90 degrees.

Abstract: Described is a system for temporal prediction. The system includes an extraction module, a mapping module, and a prediction module. The extraction module is configured to receive X(1), . . . X(n) historical samples of a time series and utilize a genetic algorithm to extract deterministic features in the time series. The mapping module is configured to receive the deterministic features and utilize a learning algorithm to map the deterministic features to a predicted {circumflex over (x)}(n+1) sample of the time series. Finally, the prediction module is configured to utilize a cascaded computing structure having k levels of prediction to generate a predicted {circumflex over (x)}(n+k) sample. The predicted {circumflex over (x)}(n+k) sample is a final temporal prediction for k future samples.

Abstract: Anomaly prediction of battery parasitic load includes processing input data related to a state of charge for a battery and a durational factor utilizing a machine learning algorithm and generating a predicted start-up state of charge. Warnings are issued if the predicted start-up state of charge drops below a threshold level within an operational time.

Abstract: A method for enhancing weak target signals for a sensor array, the method including: a) determining the locations of weak candidate target signals using one or more adaptive thresholding processes, b) extracting a wave profile of a center beam signal of a weak candidate target signal and adjacent beam signals of the weak candidate target signal using a local signal profile window, c) determining cross-beam correlations between an extracted wave profile of the center beam signal and extracted wave profiles of the adjacent beam signals and between extracted wave profiles of adjacent beam signal profiles based on the similarity of the wave profiles to determine the occurrence of a weak candidate target signal and compute a set of weighting factors, d) enhancing the center beam signal of the weak candidate target signal based on the said correlations and said set of weighting factors, and e) repeating steps b) through d) for each of the weak candidate target signals to provide enhanced weak candidate target signa

Abstract: A system and method for finding edge orientation and magnitude, and extracting a road path from an image. An image is segmented into at least a first window and a second window. A first road segment having plural parameters within the first window is specified. Plural road segments are identified, each having plural parameters, in the second window. The orientation of plural line segments in the second window are determined, and paired, based on their orientation. The line segment orientations are determined by receiving a plurality of edge orientation estimates, transforming a portion of them, and aggregating the transformed portion into an edge orientation estimate. A stochastic process is performed on the plural parameters of the plural road segments to identify a second road segment having the maximum correlation with the plural parameters of the first road segment.