Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Partially absorbable fiber-reinforced composites for controlled drug delivery
    Patent number: 8399013
    Abstract: This invention describes a partially absorbable, fiber-reinforced composite in the form of a ring, or a suture-like thread, with modified terminals for use as a controlled delivery system of at least one bioactive agent, wherein said composite comprising an absorbable fiber construct capable of providing time-dependent mechanical properties of a biostable elastomeric matrix containing an absorbable microparticulate ion-exchanger to modulate the release of the bioactive agent(s) for a desired period(s) of time at a specific biological site; this can be a vaginal canal, peritoneal cavity, scrotum, prostate gland, an ear loop or subcutaneous tissue. Such drug delivery systems can be used for the local administration of at least one bioactive agent, including those used as contraceptive, antimicrobial, anti-inflammatory and/or antiviral agents as well as for cancer treatment.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: March 19, 2013
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions
    Patent number: 8383140
    Abstract: Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: February 26, 2013
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth David Gray, Georgios T Hilas
  • Compliant, long-lasting absorbable monofilament sutures
    Patent number: 8298260
    Abstract: Monofilament sutures are disclosed, which are formed of complaint, segmented, polyaxial, absorbable copolyesters. The sutures are capable of retaining at least 50 percent of their initial breaking strength after 6 weeks following placement in animal or human tissues.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: October 30, 2012
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, James M Lindsey, III
  • Acetone-soluble, absorbable, crystalline polyaxial copolymers and applications thereof
    Patent number: 8299205
    Abstract: High-purity, acetone-soluble, absorbable components of medical devices are designed for optimum interfacing with human blood or the cell lining of a body cavity, and are formed of a crystalline, segmented l-lactide polyaxial copolymer structurally tailored to have certain molecular dimensions, thermal and physicomechanical properties, and solubility characteristics to allow their uses, optimally, as parts of vascular, urological, and post-surgical adhesion prevention devices.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: October 30, 2012
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M Lindsey, Christof Merckle, Helmut Goldmann
  • Fiber-reinforced composite absorbable endoureteral stent
    Patent number: 8252064
    Abstract: Absorbable/disintegratable endourological stents, specifically endoureteral stents, and applicators for their introduction into the biological site, are formed from fiber-reinforced elastomeric films configured to prevent their migration from the application site.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: August 28, 2012
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Kenneth W. Clinkscales
  • HYDROSWELLABLE, SEGMENTED, ALIPHATIC POLYURETHANES AND POLYURETHANE UREAS
    Publication number: 20120208789
    Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
    Type: Application
    Filed: March 8, 2012
    Publication date: August 16, 2012
    Applicant: POLY-MED, INC.
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, David R. Ingam, Michael A. Vaughn, James E. Shalaby
  • High strength nitrogenous caprolactone copolymers and biomedical constructs therefrom
    Patent number: 8226683
    Abstract: This invention is directed to an absorbable, nitrogenous copolyester composition based on more than 50 percent of ?-caprolactone-derived repeat units, having a number average molecular weight of more than ?30 kDa and its use as (1) an absorbable coating for stents which may also contain a bioactive compound at ?10 percent loading; (2) an absorbable suture or mesh and similar devices; and (3) plugs for blocking the end of seed needles used in radiation therapy.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: July 24, 2012
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • RADIATION AND RADIOCHEMICALLY STERILIZED FIBER-REINFORCED, COMPOSITE URINOGENITAL STENTS
    Publication number: 20120083897
    Abstract: A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
    Type: Application
    Filed: November 22, 2011
    Publication date: April 5, 2012
    Applicant: POLY-MED, INC.
    Inventors: Shalaby W. Shalaby, Kenneth W. Clinkscales, Kenneth David Gray
  • Controlled release systems of pluribioactive antifungal drugs and applications thereof
    Publication number: 20120077823
    Abstract: Controlled release systems release at least one pluribioactive antifungal drug exhibiting at least one additional bioactivity from the group consisting of spermiostatic, antineoplastic, antibacterial, antirestenotic and antiviral activities. The drug release system is designed for use as a spermiostatic contraceptive, intravaginal ringed-mesh which may also exhibit antiviral activity, an in situ-forming implant for treating different forms of cancer and topical film for treating or preventing bacterial and fungal infections.
    Type: Application
    Filed: January 29, 2011
    Publication date: March 29, 2012
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas, Sheila Nagatomi
  • In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers
    Publication number: 20120077822
    Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
    Type: Application
    Filed: January 29, 2011
    Publication date: March 29, 2012
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich
  • Absorbable adhesive paste
    Publication number: 20120064027
    Abstract: An absorbable adhesive paste contains absorbable solid carboxy-bearing microparticles dispersed in a continuous phase of an alkoxyalkyl cyanoacrylate. The paste may contain a soluble absorbable polymeric viscosity modifier and at least one bioactive agent to maximize the effective application as a cover for compromised tissues and wounds or as sealants, blocking agents, or hemostatic agents.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 15, 2012
    Inventor: Shalaby W. Shalaby
  • MULTICOMPONENT BIOACTIVE INTRAVAGINAL RING
    Publication number: 20120024472
    Abstract: Intravaginal ring devices have multicomponent drug releasing substrates loaded with at least one bioactive agent and designed to effect contraception and/or provide means to treat and/or prevent diseases caused by infectious bacteria, fungi, virus, and retroviruses, without compromising the primary function of normally occurring, useful vaginal microflora in female patients.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 2, 2012
    Applicant: POLY-MED, INC.
    Inventors: SHALABY W. SHALABY, GEORGIOS T. HILAS
  • Absorbable endo-urological devices and applications therefor
    Patent number: 8083805
    Abstract: This invention deals with an absorbable/disintegratable endo-urological stent and applicators for introduction into biological conduits, including such as urethras and ureters, with said stent comprising a fiber-reinforced, multicomponent tube made of polyesters having a range of physicochemical properties.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: December 27, 2011
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents
    Patent number: 8083806
    Abstract: A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: December 27, 2011
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth W Clinkscales, Kenneth David Gray
  • Self-setting polymeric cyanoacrylate composites
    Patent number: 8076388
    Abstract: Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 13, 2011
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Michael Aaron Vaughn, Shawn J Peniston, Sheila Nagatomi
  • Textile vascular prosthesis with a coating
    Patent number: 8075612
    Abstract: Textile vascular prostheses having a coating include an absorbable polymer in the form of a three-armed polyester having terminal hydroxyl groups from hydroxy acids polymerized onto a central trifunctional hydroxy compound, the three arms being tetrapolymers of lactide, ?-caprolactone, trimethylene carbonate and glycolide. The polymer is composed of about 30 to about 45 mol % of lactide, about 20 to about 40 mol % of ?-caprolactone, about 10 to about 28 mol % of trimethylene carbonate and about 10 to about 25 mol % of glycolide.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: December 13, 2011
    Assignees: Aesculap AG, Poly-Med, Inc.
    Inventors: Helmut Goldmann, Christof Merckle, Shalaby W. Shalaby
  • Multicomponent bioactive intravaginal ring
    Patent number: 8062658
    Abstract: Intravaginal ring devices have multicomponent drug releasing substrates loaded with at least one bioactive agent and designed to effect contraception and/or provide means to treat and/or prevent diseases caused by infectious bacteria, fungi, virus, and retroviruses, without compromising the primary function of normally occurring, useful vaginal microflora in female patients.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: November 22, 2011
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Georgios T Hilas
  • Intravaginal ringed mesh device and applicator therefor
    Patent number: 8057817
    Abstract: This invention generally covers a ringed-mesh intravaginal device and applicator therefore wherein the ringed-mesh comprises a composite ring comprising a flexible matrix containing one or more bioactive agent or agents and needed excipients or modulators, and the said matrix is reinforced with a fibrous construct to provided needed initial and in-use biomechanical stability. Of special application of the medicated, ringed-mesh is its use for securing contraception relying on biomechanical, pharmacological, and biochemical means.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: November 15, 2011
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • PARTIALLY MICROCELLULAR, SELECTIVELY HYDROPHILIC COMPOSITE CONSTRUCT FOR OCULAR DRUG DELIVERY
    Publication number: 20110268783
    Abstract: A partially microcellular, selectively hydrophilic composite as a self-standing construct or a component of a device for ocular delivery of at least one bioactive agent, the composite comprising a highly hydrophilic microcellular foam adjoined with a flexible hydrophobic barrier polymeric film.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 3, 2011
    Applicant: POLY-MED, INC.
    Inventors: SHALABY W. SHALABY, JOEL T. CORBETT, JASON M. OLBRICH
  • Self-setting absorbable composites and applications thereof
    Patent number: 8034850
    Abstract: Self-setting, bioactive, absorbable composites are derived from inorganic phosphate microparticles and a cyanoacrylate matrix of a methoxypropyl cyanoacrylate at a weight to volume ratio of at least 20/80 of microparticles/matrix. The self-setting composites are capable of the controlled release of bone mineralizing ions, antimicrobials, and bone growth promoters. Such composites are useful as bone cements, fillers, and/or substitutes.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: October 11, 2011
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Michael Aaron Vaughn