Abstract: Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.

Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.

Abstract: Multifunctional, single, bilayer, and trilayer coated tablets for combination therapy are formed wherein the bioactive agents responsible for the therapeutic multifunctionality are present as a combination of a gastric acid-reducing agent, such as omeprazole and ranitidine, and at least one analgesic/anti-inflammatory agent, such as acetaminophen, naproxen sodium, ibuprofen, tolmetin, and aspirin.

Abstract: Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are formed in situ onto polymeric surfaces that are chemically activated to bond, ionically, the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, tube, or a medical device for tissue repair regeneration and/or replacement, although other forms of thermoplastic and thermoset polymers can be used as the substrates for pretreatment using, most preferably, C-succinylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. The resultant conductive surface imparts unique properties to the substrates and allows their use in antistatic clothing, surface conducting films for electronic components and the like, and electromagnetic interference shielding for civilian and military installations as well as implantable medical devices.

Abstract: A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications.

Abstract: This invention deals with a composite vascular construct, which is formed of a first, blood contacting component and a second, tissue contacting component. Preferably, the present vascular constructs are in the form of a vascular patch or vascular graft with surface-activated, non-absorbable fabric with immobilized biomolecules on the blood contacting surface, and an absorbable, compliant film or microporous sheath on the other surface of the non-absorbable component of the composite graft or patch.

Abstract: Silk/absorbable polyester hybrid medical devices for tissue repair and regeneration are formed of degummed, naturally produced, multifilament silk yarn in combination with at least one absorbable polyester in the form of a surface coating, with or without an antimicrobial agent, for producing value-added braided silk sutures and multifilament yarn, as well as silk/absorbable polyester fiber composites, for producing tailored hybrid sutures, meshes, and scaffolds for tissue regeneration.

Abstract: Suture-specific coatings having a number average molecular weight not exceeding 20 kDa, a melting temperature above 37° C., and heat of fusion exceeding 20 J/g, are formed of copolyesters of polycaprolactone or of ?-caprolactone and at least one cyclic monomer forming a segmented polyester chain initiated by a polyaxial crystalline organic compound or an amorphous polyaxial polymeric initiator and include from about 0.01 to about 10 weight percent of at least one molecularly dispersed bioactive agent.

Abstract: A first, solid oral pharmaceutical composition includes an extended release acetaminophen, a non-steroidal anti-inflammatory drug, such as naproxen or ibuprofen, and a third drug capable of reducing gastric acid secretion, such as ranitidine or omeprazole. A second, solid oral pharmaceutical composition includes a non-steroidal anti-inflammatory drug and an agent for reducing gastric acid secretion.

Abstract: This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.

Abstract: Disclosed are absorbable sealants or coatings for biomedical devices which are formulated from a segmented copolyester having a molecular weight of more than 5 kDa, a glass transition temperature of less than 35° C., and low degree of crystallinity evidenced by a heat of fusion of less than 25 J/g.

Abstract: One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one conjugated drug. Each conjugated drug includes a control agent and a bioactive agent, where the control agent controls the elution rate of the bioactive agent.

Abstract: The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate polyelectrolytes encased in a sealed, flexible, absorbable copolyester fabric construct and is capable of undergoing solidification to a solid, integral mass having a modulus of more than about 0.5 GPa upon contact with an aqueous medium. In an alternative embodiment the absorbable copolyester fabric construct is filled with a mixture of a microparticulate zincophosphate glass or glass-ceramic and at least one material carrying both acidic and basic groups on the same molecule.

Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yams of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

Abstract: Absorbable heterochain polymers carrying acid or basic groups, capable of ionic conjugation with basic or acidic bioactive agents, respectively, are produced by free-radical addition of unsaturated functional monomers onto absorbable liquid polymers and subsequent generation of reactive functionality or by direct copolymerization of a carboxylic initiator with cyclic monomers to produce liquid carboxyl-bearing copolyesters or polyester carbonates.

Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

Abstract: The present invention is directed to adhesive/hemostatic formulations of 2-alkoxyalkyl cyanoacrylate, an absorbable liquid or solid polymeric modifier, and a general stabilizer against premature anionic polymerization of cyanoacrylates. The present adhesive formulations are useful as tissue adhesives/sealants, hemostatic agents, or as a means of patching and anastomotic coupling of damaged organs.

Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

Abstract: The present invention provides a system for treating a vascular condition, including a catheter, a stent coupled to the catheter, a polymeric coating on the stent including a segmented homochain copolyester, and a bioactive drug dispersed within the polymeric coating.