Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Absorbable / biodegradable tubular stent and methods of making the same
    Publication number: 20090299465
    Abstract: Medicated or unmedicated, absorbable/biodegradable, polymeric tubular stents for temporary placement in body lumens maintain patency and provide dimensional stability at the biological site. The stent design is based on a radially fluted, tubular form having grooves or flutes along its entire length for expansion to a predetermined diameter after deployment, using a balloon catheter, into a tubular body lumen through outward deformation of the fluted wall.
    Type: Application
    Filed: July 1, 2009
    Publication date: December 3, 2009
    Inventor: Shalaby W. Shalaby
  • Bioactive polymeric liquid formulations of absorbable, segmented aliphatic polyurethane compositions
    Publication number: 20090291925
    Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
    Type: Application
    Filed: May 22, 2009
    Publication date: November 26, 2009
    Inventor: Shalaby W. Shalaby
  • Palatable, solid oral formulations for male chemical sterilization
    Publication number: 20090285865
    Abstract: Palatable, solid oral formulations or compositions include at least one bioactive agent capable of chemical sterilization of human and animal males. Depending on the targeted species, the bioactive formulations comprise suitable additives, excipients, water-swellable compositions, and/or processing aids and can be made into uncoated or coated forms to modulate the release profile of the bioactive agents. Among the bioactive agents are zinc compounds and complexes and organic drugs with established pharmacological activities, which are traditionally unrelated to any form of contraception.
    Type: Application
    Filed: May 14, 2009
    Publication date: November 19, 2009
    Inventor: Shalaby W. Shalaby
  • Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof
    Publication number: 20090287228
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Application
    Filed: June 23, 2009
    Publication date: November 19, 2009
    Inventors: Shalaby W Shalaby, Kimberly A Carpenter, Kenneth W Clinkscales
  • Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers
    Publication number: 20090264555
    Abstract: Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
    Type: Application
    Filed: April 18, 2009
    Publication date: October 22, 2009
    Inventors: Shalaby W. Shalaby, Michael Aaron Vaughn, James M. Lindsey, III
  • Solid and Semi-Solid Polymeric Ionic Conjugates
    Publication number: 20090257975
    Abstract: Aqueous solubility of drugs including insoluble or poorly soluble drugs such as ziprasidone is improved using a functional polymer to form an ionic conjugate with said drug.
    Type: Application
    Filed: June 17, 2009
    Publication date: October 15, 2009
    Inventors: Shalaby W. Shalaby, Jaymin C. Shah, Joel T. Corbett
  • TEXTILE VASCULAR PROSTHESIS WITH A COATING
    Publication number: 20090234442
    Abstract: Textile vascular prostheses having a coating include an absorbable polymer in the form of a three-armed polyester having terminal hydroxyl groups from hydroxy acids polymerized onto a central trifunctional hydroxy compound, the three arms being tetrapolymers of lactide, ?-caprolactone, trimethylene carbonate and glycolide. The polymer is composed of about 30 to about 45 mol % of lactide, about 20 to about 40 mol % of ?-caprolactone, about 10 to about 28 mol % of trimethylene carbonate and about 10 to about 25 mol % of glycolide.
    Type: Application
    Filed: November 7, 2007
    Publication date: September 17, 2009
    Inventors: Helmut Goldmann, Christof Merckle, Shalaby W. Shalaby
  • Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas
    Publication number: 20090233887
    Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
    Type: Application
    Filed: February 26, 2009
    Publication date: September 17, 2009
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, David R. Ingam, Michael Aaron Vaughn
  • Multiphasic absorbable compositions of segmented /-lactide copolymers
    Publication number: 20090204116
    Abstract: Absorbable, multiphasic, crystalline, solid blend compositions having at least two first order thermal transitions, are formed of a segmented l-lactide copolymer as the principal or major component and at least one additional crystalline thermoplastic absorbable polyester having glycolide-based sequences, a fraction of which participated in ester-ester interchange reactions with lactide-based sequences to produce crystalline materials with modulated properties for use in producing orthopedic and tissue-repair devices.
    Type: Application
    Filed: February 7, 2009
    Publication date: August 13, 2009
    Inventors: Shalaby W. Shalaby, Michael Scott Taylor, Shawn J. Peniston
  • Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents
    Publication number: 20090177286
    Abstract: A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
    Type: Application
    Filed: February 12, 2009
    Publication date: July 9, 2009
    Inventors: Shalaby W. Shalaby, Kenneth W. Clinkscales, Kenneth David Gray
  • Absorbable / biodegradable composite yarn constructs and applicatons thereof
    Publication number: 20090024162
    Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
    Type: Application
    Filed: July 17, 2007
    Publication date: January 22, 2009
    Inventors: Shalaby W. Shalaby, Shawn Peniston, M. Scott Taylor, Douglas D. Greene
  • Absorbable/Biodegradable Composite Yarns and Property-Modulated Surgical Implants Therefrom
    Publication number: 20090024151
    Abstract: The present invention is directed to absorbable/biodegradable composite yarns, each comprising at least two types of fibrous components having distinctly different absorption and strength retention profiles and the use of these composite yarns to construct surgical implants, such as sutures and meshes with integrated physicochemical and biological properties, modulated through varying the individual yarn content and controlling the geometry of these constructs.
    Type: Application
    Filed: April 20, 2006
    Publication date: January 22, 2009
    Inventors: Shalaby W Shalaby, Shawn J. Peniston
  • Bioswellable sutures
    Publication number: 20090017083
    Abstract: Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
    Type: Application
    Filed: August 20, 2008
    Publication date: January 15, 2009
    Inventor: Shalaby W. Shalaby
  • Inorganic-organic melt-extruded hybrid filaments and medical applications thereof
    Publication number: 20090004470
    Abstract: Inorganic-organic hybrid, melt-extruded filaments having variable cross-sectional geometry with a cross-sectional area ranging between 100?2 and 4 mm2 include an inorganic component that comprises at least 10 weight percent of the total system and is present as dispersed micro-/nanoparticles in an organic absorbable or non-absorbable matrix representing no more than 90 weight percent. Hybrid filaments are particularly useful for the production of absorbable/disintegratable coil components of an absorbable/disintegratable endoureteral stent and radiopaque surgical markers or sutures.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 1, 2009
    Inventor: Shalaby W. Shalaby
  • Inorganic-organic melted-extruded hybrid filaments and medical applications thereof
    Patent number: 7465489
    Abstract: This invention deals with a family of inorganic-organic hybrid, melt-extruded filaments having variable cross-sectional geometry with a cross-sectional area ranging between 100 ?2 and 4 mm2, wherein the inorganic component comprises at least 10 weight percent of the total system and is present as dispersed micro-/nanoparticles in an organic absorbable or non-absorbable matrix representing no more than 90 weight percent. Hybrid filaments are particularly useful for the production of absorbable/disintegratable coil components of an absorbable/disintegratable endoureteral stent and radiopaque surgical markers or sutures.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 16, 2008
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth W Clinkscales, Kimberly A. Carpenter
  • Package components for radiochemical sterilization
    Publication number: 20080286144
    Abstract: Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.
    Type: Application
    Filed: June 11, 2008
    Publication date: November 20, 2008
    Inventor: Shalaby W. Shalaby
  • Thermo-Chemically Activated Implantable Apparatus and Method
    Publication number: 20080269749
    Abstract: The present invention provides an implantable device, a portion of which is formed of a material which is a combination of copolymers PCLM-12 and SMC-7, and nucleating agent A-6. The implantable device may be an intramedullary bone fixation device. The implantable device may have a body with a composite portion including a thermo-chemically activated matrix formed from the copolymer material, and a support structure formed from a second material. The body may be deformable at a first thermo-chemical state and hardened at a second thermo-chemical state. The implantable device may be heated to reach the deformable first thermo-chemical state, deformed, inserted into the intramedullary canal of a fractured bone, and cooled to reach the hardened second thermo-chemical state, providing rigid support during healing of the fractures.
    Type: Application
    Filed: February 7, 2008
    Publication date: October 30, 2008
    Applicant: OSTEOLIGN
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Daniel F. Justin
  • Crystalline high-compliance glycolide copolymers and applications thereof
    Patent number: 7435789
    Abstract: The present invention is directed toward an absorbable crystalline segmented copolymer comprising a polyalkylene succinate segment end-grafted in a single-step with a mixture of monomers comprising caprolactone, l-lactide, and/or glycolide. The present invention is also directed toward an absorbable crystalline segmented copolymer arising from a trihydroxy compound that is reacted in a single-step with a mixture of monomer comprising ?-caprolactone, l-lactide, and/or glycolide to produce monocentric polyaxial polymers.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: October 14, 2008
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Micromantled drug-eluting stent
    Publication number: 20080241352
    Abstract: Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
    Type: Application
    Filed: May 14, 2008
    Publication date: October 2, 2008
    Inventor: Shalaby W. Shalaby
  • Self-setting polymeric cyanoacrylate composites
    Publication number: 20080220045
    Abstract: Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
    Type: Application
    Filed: April 4, 2008
    Publication date: September 11, 2008
    Inventors: Shalaby W. Shalaby, Michael Aaron Vaughn, Shawn J. Peniston, Sheila Nagatomi