Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    Patent number: 7026437
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: April 11, 2006
    Assignee: Poly-Med, INC
    Inventors: Shalaby W. Shalaby, Dan Åkerfeldt, Fredrik Preiniz, Per Egnelöv, Torbjörn Mathisen
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Patent number: 7005420
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: February 28, 2006
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventors: Shalaby W. Shalaby, Ruth M. Russell, Jacques-Pierre Moreau, Steven A. Jackson, Francis X. Ignatious
  • Interlinked solid polyethylene glycols and copolymers thereof
    Patent number: 6861503
    Abstract: The present invention is directed primarily to an interlinked crystalline solid polyethylene glycol composition (I-PEG) having a molecular weight of at least 20 kDa and a melting temperature of at least 40° C. and its use as an absorbable device having hydrolabile ester or carbonate interlinks that allow in vivo dissociation of the interlinked chain into excretable, low molecular weight PEG segments.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: March 1, 2005
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Composite absorbable/biodegradable rings for controlled drug delivery
    Publication number: 20040265355
    Abstract: A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.
    Type: Application
    Filed: June 3, 2004
    Publication date: December 30, 2004
    Inventor: Shalaby W. Shalaby
  • Absorbable / biodegradable tubular stent and methods of making the same
    Publication number: 20040260386
    Abstract: The present invention is directed toward a medicated or unmedicated, absorbable/biodegradable, polymeric tubular stent for temporary placement in body lumens to maintain patency and provide dimensional stability at the biological site. The stent design is based on a radially fluted, tubular form having grooves or flutes along its entire length for expansion to a predetermined diameter after deployment, using a balloon catheter, into a tubular body lumen through outward deformation of the fluted wall.
    Type: Application
    Filed: January 31, 2004
    Publication date: December 23, 2004
    Inventor: Shalaby W. Shalaby
  • Polyester/cyanoacrylate tissue adhesive compositions
    Publication number: 20040199207
    Abstract: This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.
    Type: Application
    Filed: March 3, 2004
    Publication date: October 7, 2004
    Inventors: Shalaby W. Shalaby, M. Aaron Vaughn
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Patent number: 6794364
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: September 21, 2004
    Assignee: Kinerton Limited
    Inventors: Shalaby W. Shalaby, Steven A. Jackson, Francis X. Ignatious, Jacques-Pierre Moreau, Ruth M. Russell
  • Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    Patent number: 6794485
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: September 21, 2004
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Antimicrobial, synthetic, fibrous, and tubular medical divices
    Publication number: 20040171323
    Abstract: The present invention is directed toward antimicrobial absorbable and non-absorbable fibrous and tubular medical devices comprising synthetic polymers and one or more antimicrobial agent molecularly dispersed within the surface to allow the continuous release of said agent or agents under simulated physiologic conditions for at least one week.
    Type: Application
    Filed: January 15, 2004
    Publication date: September 2, 2004
    Inventor: Shalaby W. Shalaby
  • Composite vascular constructs with selectively controlled properties
    Publication number: 20040171978
    Abstract: This invention deals with a composite vascular construct, which is formed of a first, blood contacting component and a second, tissue contacting component. Preferably, the present vascular constructs are in the form of a vascular patch or vascular graft with surface-activated, non-absorbable fabric with immobilized biomolecules on the blood contacting surface, and an absorbable, compliant film or microporous sheath on the other surface of the non-absorbable component of the composite graft or patch.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 2, 2004
    Inventor: Shalaby W. Shalaby
  • Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
    Publication number: 20040166088
    Abstract: The present invention is directed toward an injectable, single- or multiple-component polymeric liquid precursor of an in situ-forming, non-absorbable, flexible, and resilient hydrogel or semi-solid that can be used in non-surgical, minimally invasive treatment of herniated disc.
    Type: Application
    Filed: January 15, 2004
    Publication date: August 26, 2004
    Inventor: Shalaby W. Shalaby
  • Antimicrobial fabrics
    Patent number: 6780799
    Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: August 24, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Absorbable nitrogenous epsilon-caprolactone copolymers and applications thereof
    Publication number: 20040161465
    Abstract: This invention deals with monocentric, triaxial, nitrogenous &egr;-caprolactone copolyester for coating/sizing absorbable, fibrous vascular devices wherein the said copolyesters have a molecular weight of more than 20 kDa. The invention also relates to medical devices such a absorbable micro-threads as in small diameter suture braids or twisted multifilament yarn coated with absorbable, nitrogenous &egr;-caprolactone copolyester wherein the copolyester chain bears one or more carboxyl groups to which a basic polyamino acid, such as polylysine or polyarginine, is linked ionically and/or covalently.
    Type: Application
    Filed: February 13, 2004
    Publication date: August 19, 2004
    Inventor: Shalaby W. Shalaby
  • Photo-crosslinkable, crystalline, polyaxial, absorbable polyester for rapid prototyping
    Publication number: 20040152800
    Abstract: Crystalline, absorbable, polyaxial copolymers prepared using, for example, &egr;-caprolactone and glycolide, were tipped with methacrylate groups and photopolymerized into crystalline, absorbable solid constructs under typical conditions for stereolithography.
    Type: Application
    Filed: October 9, 2003
    Publication date: August 5, 2004
    Inventors: Shalaby W. Shalaby, R. Larry Dooley, Joseph A. Pilgrim
  • Liquid conjugates of solid pharmaceuticals
    Publication number: 20040147532
    Abstract: A liquid phase conjugate formed of a bioactive agent such as a drug compound, e.g. ziprasidone, and a liquid polymer of requisite functionality is disclosed.
    Type: Application
    Filed: October 24, 2003
    Publication date: July 29, 2004
    Applicant: Pfizer Inc
    Inventors: Shalaby W. Shalaby, Jaymin C. Shah
  • Solid and semi-solid polymeric ionic conjugates
    Publication number: 20040142039
    Abstract: Aqueous solubility of drugs including insoluble or poorly soluble drugs such as ziprasidone is improved using a functional polymer to form an ionic conjugate with said drug.
    Type: Application
    Filed: October 24, 2003
    Publication date: July 22, 2004
    Applicant: Pfizer Inc
    Inventors: Shalaby W. Shalaby, Jaymin C. Shah, Joel T. Corbett
  • Functionalized, absorbable, segmented copolyesters and related copolymers
    Publication number: 20040132923
    Abstract: Absorbable heterochain polymers carrying acid or basic groups, capable of ionic conjugation with basic or acidic bioactive agents, respectively, are produced by free-radical addition of unsaturated functional monomers onto absorbable liquid polymers and subsequent generation of reactive functionality or by direct copolymerization of a carboxylic initiator with cyclic monomers to produce liquid carboxyl-bearing copolyesters or polyester carbonates.
    Type: Application
    Filed: October 24, 2003
    Publication date: July 8, 2004
    Inventor: Shalaby W. Shalaby
  • Radiation and radiochemically sterilized absorbable devices with dose-controlled functional strength retention
    Publication number: 20040133237
    Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
    Type: Application
    Filed: October 9, 2003
    Publication date: July 8, 2004
    Inventor: Shalaby W. Shalaby
  • Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
    Publication number: 20040127995
    Abstract: The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate polyelectrolytes encased in a sealed, flexible, absorbable copolyester fabric construct and is capable of undergoing solidification to a solid, integral mass having a modulus of more than about 0.5 GPa upon contact with an aqueous medium. In an alternative embodiment the absorbable copolyester fabric construct is filled with a mixture of a microparticulate zincophosphate glass or glass-ceramic and at least one material carrying both acidic and basic groups on the same molecule.
    Type: Application
    Filed: July 24, 2003
    Publication date: July 1, 2004
    Inventor: Shalaby W. Shalaby
  • Endosteal dental implant
    Patent number: D503803
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: April 5, 2005
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Bruce L. Anneaux, M. Scott Taylor