Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.

Abstract: Provided herein are sulfo n-hydroxysuccimidyl ester (sulfo-SE) linked peptides, methods of synthesis thereof, and methods of using such peptides for labeling of biomolecules. In particular, peptides comprising non-alkyl group such as serine, threonine, cysteine, tyrosine, glutamic acid, and aspartic acid are stably modified (e.g., without autoreactivity) with a sulfo-SE group and used to label or otherwise modify biomolecules.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds, and methods of using the thienopyrrole compounds.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: A quick action nut and a threaded fastener assembly including the quick action nut are proposed in the present invention. The quick action nut includes a nut housing, a control operating member, and at least two moving blocks movably connected inside the nut housing. A first through hole having a first hole axis is provided on the nut housing for a screw to pass through. Radial slide ways are provided on the nut housing for the moving blocks to move in a direction perpendicular to the first hole axis. The radial slide ways and the moving blocks have the same quantity, are matched in a one-to-one correspondence, and are distributed around the first hole axis. Threads are provided on the moving block to form or not form a threaded hole structure that is matched with the screw.

Abstract: Conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. The quinone-containing linker may be reduced intracellularly to trigger release of the drug or probe. These conjugates may selectively deliver a drug or probe to a site of action of interest for local release of the active drug or probe.

Abstract: Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds, and methods of using the thienopyrrole compounds.

Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.

Abstract: A blood pressure detection device, includes a detection airbag, a pressure sensor provided on the detection airbag, an air pump configured for inflating detection airbag and a solenoid valve or a proportional valve or an exhaust valve for deflating detection airbag. The blood pressure detection device further includes an airbag clamp configured outside the detection airbag for clamping the inflated detection airbag on the finger, wrist, or arm of the human body. The present invention eliminates the operation of wrapping the airbag on the arm or the wrist in the traditional blood pressure detection, so that the blood pressure detection is more convenient. In addition, the present invention incorporates an airbag into the device of the present invention, so as to avoid separation of the airbag from the detection device body, thereby facilitating the combination of the present invention with household or sanitary products.

Abstract: A toilet capable of measuring body temperature, includes a toilet base and a machine body connected to the toilet base, wherein the machine body is connected to a toilet seat. The toilet seat is rotatable relative to the machine body and covers the toilet base. A body temperature detection device is provided on the machine body. In the present invention, the combination of human body temperature measurement and the toilet can enable people to measure body temperature while using the toilet. The temperature measurement has the advantages of quick operation, convenience, and being close to life.

Abstract: A smart toilet having a function of human blood oxygen detection is provided. The smart toilet includes a toilet base and a machine body connected to the toilet base. The machine body is provided with a controller and the following modules which are electrically connected to controller respectively, i.e., human blood oxygen detection module, display or voice prompt module, and power supply module which is used to supply power. After processing, the controller obtains the human blood oxygen saturation value based on the electrical signal transferred from the human blood oxygen detection module. Also, the controller controls the display or voice prompt module to output the human blood oxygen saturation value. The present invention combines the toilet with the human blood oxygen detection, such that it is easy for the user to know about his/her blood oxygen condition in real time.

Abstract: A smart toilet with a function of human blood pressure detection, the smart toilet includes a toilet base. The smart toilet further includes a body connected to the toilet base. The body is provided with a controller and a human blood pressure detection module, a display or voice prompt module, a key input module for sending back operation information of the user to the controller, and a power supply module for supplying power, which are electrically connected to the controller respectively. The controller processes the electrical signal transmitted by the human blood pressure detection module to obtain the blood pressure value of the human body, and controls the display or voice prompt module to output the blood pressure value. The human blood pressure can be conveniently and rapidly detected while the users use the toilet every day, so that abnormal blood pressure can be discovered early.

Abstract: A smart toilet with a function of electrocardiographic lead monitoring, includes a toilet base, and further includes a body connected to the toilet base. The body is provided with a controller, and an electrocardiographic lead monitoring module, a display or voice prompt module, a power supply module for supplying power, which are electrically connected to the controller respectively. The human body ECG signal obtained by the electrocardiographic lead monitoring module is processed by the controller, to obtain human body electrocardiographic lead data, and the display or voice prompt module is controlled to output the data. The invention combines the electrocardiographic monitoring function with the toilet, which enables people to know electrocardiographic data quickly and conveniently while using the toilet, so as to understand their own heart health, thereby detecting and dealing with possible diseases as soon as possible.

Abstract: Described are coelenterazine analogs, methods for making the analogs, kits comprising the analogs, and methods of using the compounds for the detection of luminescence in luciferase-based assays with low backgrounds and enhanced signal-to-background ratios.

Abstract: Described are substituted imidazo[1,2-a]pyrazine compounds of formula (I), which are coelenterazine analogs, methods for making the compounds, kits comprising the compounds, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.