Abstract: An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation induced cancer.

Abstract: The present disclosure relates to the field of solid-state data storage, and particularly to improving the speed performance of solid-state data storage devices by reducing multi-stream data write collision. A method according to embodiments includes: writing a plurality of data chunks in a skewed sequence from a plurality of different data write buffers in the storage device into a plurality of different super-pages across all channels of the storage device.

Abstract: A startup stage protection device used in Electric Multiple Unit (EMU) train coupler experiment is provided between two test cars. The startup stage protection device is arranged between and tightly abuts two test cars at the starting stage of the experiment to receive a compressing force in place of the coupler. The startup stage protection device separates from the two test cars after the end of the starting stage.

Abstract: Disclosed are a tumor biomarker and application thereof, and a tumor detection kit. Patients suffering from non-small cell lung cancer, containing an EML4-ALK or SLC34A2-ROS1 fusion gene, have a specific circular RNA in blood. The base sequences of the circular RNA are represented by SEQ ID NOS. 1-6. The circular RNA is associated with non-small cell lung cancer, stably and constantly exists in plasma samples, and has high specificity and effectiveness, and thus can be used as a biomarker for tumor detection. Reagents such as primers and probes for detecting the circular RNA can be used for preparing the tumor detection kit.

Abstract: A high density manufacturing cell or carousel for optimizing floor space usage to reduce equipment footprint and material travel path is disclosed. The carousel allows processing and transferring of products to be concurrently performed, minimising non-productive time. The manufacturing cell or carousel comprises: (a) a plurality of rotary platforms, (b) a plurality of vertical moving platforms, (c) a vertical walking beam, and (d) a load gripper and a unload gripper mounted to independent robots.

Abstract: Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition containing the compound can be used to treat IDH1 mutation-induced cancers.

Abstract: A method for manufacturing an array substrate includes: forming a strip-shaped barrier wall(s) on a base substrate, wherein the width of each barrier wall is less than or equal to a distance between a first metal trace to be formed and a second metal trace to be formed; and forming a first metal trace at one side of each barrier wall located in a direction perpendicular to an extending direction of the barrier wall, and forming a second metal trace at an opposite side of the barrier wall located in the direction perpendicular to the extending direction of the barrier wall.

Abstract: The present invention describes an air-burst projectile (100) and a system (200) for deploying the airburst projectile to counter an unmanned aerial vehicle (UAV) 10. Each airburst projectile includes one or more spinners (140, 140a-140d); each spinner has a sleeve or a tube (146), a number of radial partition plates (148, 148a-148d) extending from the sleeve/tube and an annular rear plate (144) connected to the sleeve. Adjacent partition plates thus form a compartment (150). Disposed in each compartment is a streamer or streamers (170,170a,170b), which are formed in a coiled-up state. When the airburst projectile is deployed into a flight path of a target UAV, the spinners (140, 140a-140d) are ejected and the streamers (170,170a,170b) are dispersed in the flight path to create a streamer cloud, so that a streamer may entangle with propellers of the UAV and bring down the UAV, or as a warning or fence marking shot.

Abstract: Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals.

Abstract: A system and method of implementing distributed metadata checkpointing in a storage device. A storage device is disclosed that includes storage device that employs distributed metadata checkpointing, including: flash memory; and a controller that collects metadata checkpoints and includes: a checkpoint partitioner that partitions a metadata checkpoint into a set of segments; and a segment loader that stores each segment of the set of segments into a spare region of a corresponding different flash memory pages during a write operation of data to flash memory.

Abstract: Disclosed are compounds having formulae I and II or pharmaceutically acceptable salts or hydrates thereof, a preparation method thereof and pharmaceutical compositions thereof. The compounds having formulae I and II possesses an isocitrate dehydrogenase 2 (IDH2) inhibitory activity and are capable of treating IDH2 mutation-induced cancers.

Abstract: Embodiments of the present disclosure disclose a display substrate, a display panel, a display apparatus, and a method for driving a display apparatus. The display substrate includes: a plurality of first wiring groups each comprising a plurality of first wirings extending in a first direction; a plurality of second wiring groups each comprising a plurality of second wirings and at least one transmission signal line extending in a second direction crossing the first direction; a plurality of first switching circuits each connecting a plurality of first wirings in a corresponding one of the first wiring groups to a control signal line; and a plurality of second switching circuits each connecting a plurality of second wirings in a corresponding one of the second wiring groups to the control signal line.

Abstract: A data storage device that includes a data storage medium and a controller communicatively coupled to the data storage medium. The controller is configured to receive commands from a host and to detect a hung state in the data storage device. The controller is also configured to determine an execution status of a command, of the commands from the host, associated with the hung state. The controller is further configured to dynamically carry out a self-recovery operation in the data storage device to clear the hung state. The self-recovery operation includes steps that depend upon the execution status of the command associated with the hung state.

Abstract: A data storage device includes a main storage memory and a non-volatile cache memory system. The non-volatile cache memory system comprises a master device, a first slave device communicatively coupled to the master device, the first slave device comprising a first non-volatile memory, and a second slave device communicatively coupled to the master device, the second slave device comprising a second non-volatile memory of a different type than the first non-volatile memory. The data storage device also includes a controller communicatively coupled to the main storage memory and to the non-volatile cache memory system, the controller is configured to, upon a power loss to the data storage device, store volatile data into the non-volatile cache memory system.

Abstract: Disclosed are compounds having formulae I and II or pharmaceutically acceptable salts or hydrates thereof, a preparation method thereof and pharmaceutical compositions thereof. The compounds having formulae I and II possesses an isocitrate dehydrogenase 2 (IDH2) inhibitory activity and are capable of treating IDH2 mutation-induced cancers.

Abstract: A data storage device includes a first memory section with a reserved area having stored therein an event trigger log that includes a history of past logged events. The data storage device also includes a second memory section separate from the first memory section. The data storage further includes a controller that, upon power up of the data storage device and before the data storage device is ready to receive host commands, allocates a buffer in the second memory section for capturing new events. The controller postpones linking of any captured new events with the past logged events until at least after the data storage device is ready to receive the host commands.

Abstract: A file system permission setting method and apparatus, where an access control list (ACL) permission for a parent node is set such that all child nodes of the parent node inherit the ACL permission for the parent node when a semantic type identifier of an access permission for the parent node is a permission root type.

Abstract: A data storage device includes a data storage medium and a controller. The controller performs a boot-up sequence that includes operations that transition the data storage device from a lower operational state to a higher operational state in which the data storage device is ready to service host commands. The controller also carries out metadata updating operations independently of the boot-up sequence operations. Carrying out the metadata updating operations independently of the boot up sequence operations prevents the metadata updating operations from substantially contributing to a boot-up time.

Abstract: The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrrolopyrimidine CDK inhibitor, in particular to a compound as shown in formula I or a pharmaceutically acceptable salt or solvate thereof, as well as a preparation method thereof and a pharmaceutical composition thereof. The present invention also relates to the use of the compound and the pharmaceutical composition thereof in the preparation of a drug for treating diseases associated with CDK inhibition. The compound according to the present invention has a marked inhibitory effect on CDK, excellent drug absorption and significantly superior oral absorption effect.

Abstract: The present application relates to the field of pharmaceutical chemistry, and in particular, to a pyrrolopyrimidine compound represented by general formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for preparing the pyrrolopyrimidine compound represented by general formula (I), pharmaceutical compositions and an application of the pyrrolopyrimidine compound in treating diseases mediated by Janus Kinase.