Abstract: A system and method of implementing distributed metadata checkpointing in a storage device. A storage device is disclosed that includes storage device that employs distributed metadata checkpointing, including: flash memory; and a controller that collects metadata checkpoints and includes: a checkpoint partitioner that partitions a metadata checkpoint into a set of segments; and a segment loader that stores each segment of the set of segments into a spare region of a corresponding different flash memory pages during a write operation of data to flash memory.

Abstract: A system, method and program product for implementing an LSM tree data store in a storage infrastructure. A system is disclosed having: a system for handling read requests and write requests using a key-value pair index to store and retrieve data in an LSM data store; and a compaction manager that reorganizes data in the LSM data store using: a partition system that (a) partitions a first level file into a set of subfiles when a partition threshold is exceeded, and (b) stores the subfiles from the first level file in an intermediate level between the first level and a second level, wherein the subfiles are partitioned by range to correspond with files in the second level; and a merge system that merges a group of files comprising a second level file with one or more corresponding subfiles when a merge threshold is exceeded.

Abstract: Provided are a compound represented by formula (III) or pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, esters, tautomers or prodrugs thereof, pharmaceutical compositions containing the compound represented by formula (III), and the application of the pharmaceutical compositions as selective inreversible inhibitor of Bruton's tyrosine kinase for the prevention and treatment of inflammation, autoimmune diseases (such as rheumatoid arthritis) associated with aberrant B cell proliferation and cancers.

Abstract: Systems and methods for saving critical data upon power loss are described. In one embodiment, the systems and methods include performing a write operation to a first track of a storage drive, monitoring a voltage level of a storage drive to detect power loss on the storage drive while performing the write operation, identifying a track ID of a second track adjacent to the first track upon detecting power loss on the storage drive, and storing the identified track ID in a non-volatile memory on the storage drive.

Abstract: An implementation of a system disclosed herein provides an apparatus, comprising a system on chip, wherein the system on chip is configured to receive a sleep command from a host and in response to the sleep command, calculate a primary checksum of a block of data from a low latency memory such as a tightly coupled memory (TCM), copy the primary checksum and the block of data into a volatile storage media, preserve interface variables of the system on chip in the volatile storage media, operate the volatile storage media in a self-refresh mode, and shut down power to other components on the system on chip.

Abstract: The present application relates to compounds represented by general formula (I), general formula (II) or general formula (III), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (I), general formula (II) or general formula (III) have inhibitory activities against isocitrate dehydrogenase 2 (IDH2), thereby being capable of treating IDH2 mutation-induced cancers.

Abstract: The present disclosure relates to aniline pyrimidine derivatives or pharmaceutically acceptable salts thereof as EGFR inhibitors, specifically relates to compounds represented by formula (I) or pharmaceutically acceptable salts, pharmaceutical compositions, the method and uses thereof for treating EGFR mediated diseases.

Abstract: A protective cover for a portable electronic device, which is configured for supporting the device and for storing an earphone and cable, includes a casing body, a winding portion, a limiting plate, and a support plate. The device is received in a receiving portion in the casing body and the winding portion protrudes out of one side of the casing body spaced apart from the receiving portion, the winding portion being able to accept the cable of the earphone wound onto it. The limiting plate covers one side of the winding portion spaced apart from the casing body and defining an opening. The support plate covers the opening of the limiting plate and is rotatably coupled to the limiting plate. A ring-shaped accommodating space is defined between the limiting plate and the casing body for receiving the cable of the earphone wound onto the winding portion.

Abstract: Systems and methods for saving critical data upon power loss are described. In one embodiment, the systems and methods include performing a write operation to a first track of a storage drive, monitoring a voltage level of a storage drive to detect power loss on the storage drive while performing the write operation, identifying a track ID of a second track adjacent to the first track upon detecting power loss on the storage drive, and storing the identified track ID in a non-volatile memory on the storage drive.

Abstract: A storage module and method for configuring the storage module with memory operation parameters are provided. In one embodiment, a storage module is provided comprising a memory and a controller. The controller is configured to receive a selection of one of a plurality of sets of memory operation parameters stored in the storage module and perform at least one of a read operation and a write operation on the memory in accordance with the selected set of memory operation parameters.

Abstract: The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a method for preparing the same, a pharmaceutical composition comprising the same, and a use of the same in treating and/or preventing diseases and disorders benefitting from DPP-IV inhibition.

Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.

Abstract: A positioning system having a flat base comprising (i) a X-axis assembly having a X-axis linear actuator means arranged orthogonal to the Y-axis; (ii) a Y-axis assembly having a pair of Y-axis linear actuator means mounted onto the flat base forming a H-configuration; (iii) a Z-axis assembly having an aerostatic bearing mechanism that floats on thin film of externally pressurized air on top of the flat base; and a ?-axis actuator anchored from the X-axis to drive the Z-axis assembly which carries a workpiece, wherein the Z-axis assembly is rotated with the rotary axis for the ?-axis perpendicular to the flat base.

Abstract: A method or system comprises reading content of a plurality of system files from storage media of a storage device, generating a master storage device system file, and storing the master storage device system file on the storage media at a master system file location. The location of the master system file is provided to boot firmware or hardware. As a result, when the system boots up, the master system file is read into a temporary cache.

Abstract: Systems and methods for saving critical data upon power loss are described. In one embodiment, the systems and methods include performing a write operation to a first track of a storage drive, monitoring a voltage level of a storage drive to detect power loss on the storage drive while performing the write operation, identifying a track ID of a second track adjacent to the first track upon detecting power loss on the storage drive, and storing the identified track ID in a non-volatile memory on the storage drive.

Abstract: The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.

Abstract: The present invention discloses substituted 2-aminopyridine derivatives as protein kinase inhibitors; specifically, the invention relates to 2-aminopyridine derivatives having protein kinase inhibitory properties, their manufacture, pharmaceutical compositions containing them, and use of the compounds and the pharmaceutical compositions thereof for the treatment of diseases associated with protein kinase.

Abstract: A method or system comprises reading content of a plurality of system files from storage media of a storage device, generating a master storage device system file, and storing the master storage device system file on the storage media at a master system file location. The location of the master system file is provided to boot firmware or hardware. As a result, when the system boots up, the master system file is read into a temporary cache.

Abstract: Provided are a compound represented by formula (III) or pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, esters, tautomers or prodrugs thereof, pharmaceutical compositions containing the compound represented by formula (III), and the application of the pharmaceutical compositions as selective inreversible inhibitor of Bruton's tyrosine kinase for the prevention and treatment of inflammation, autoimmune diseases (such as rheumatoid arthritis) associated with aberrant B cell proliferation and cancers.

Abstract: A protective cover for a portable electronic device, which is configured for supporting the device and for storing an earphone and cable, includes a casing body, a winding portion, a limiting plate, and a support plate. The device is received in a receiving portion in the casing body and the winding portion protrudes out of one side of the casing body spaced apart from the receiving portion, the winding portion being able to accept the cable of the earphone wound onto it. The limiting plate covers one side of the winding portion spaced apart from the casing body and defining an opening. The support plate covers the opening of the limiting plate and is rotatably coupled to the limiting plate. A ring-shaped accommodating space is defined between the limiting plate and the casing body for receiving the cable of the earphone wound onto the winding portion.