Casing Divided By Membrane Into Sections Having Inlet(s) And/or Outlet(s) Patents (Class 210/321.6)
  • Publication number: 20130082001
    Abstract: An object of the present invention is to provide a fresh water generating apparatus that is capable of efficiently producing fresh water according to an intended use, while utilizing wastewater. Provided is a fresh water generating apparatus equipped with a seawater-treating reverse osmosis membrane device that produces fresh water from seawater by a reverse osmosis membrane, which includes: a mixing section that mixes wastewater as dilution water with a portion of seawater to be subjected to membrane treatment to produce mixed water; a first seawater-treating reverse osmosis membrane device that acts as the seawater-treating reverse osmosis membrane device to filter the mixed water; and a second seawater-treating reverse osmosis membrane device that acts as the seawater-treating reverse osmosis membrane device to filter the remaining portion of the seawater to be subjected to membrane treatment, in an unmixed state with the dilution water.
    Type: Application
    Filed: May 12, 2011
    Publication date: April 4, 2013
    Applicant: KOBELCO ECO-SOLUTIONS CO., LTD.
    Inventors: Kazutaka Takata, Hiromi Sato, Yutaka Ito, Mitsushige Shimada, Tomoyuki Tachimi, Masanobu Noshita
  • Publication number: 20130075314
    Abstract: The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement.
    Type: Application
    Filed: March 15, 2011
    Publication date: March 28, 2013
    Inventors: Dejan Nikolic, Alexander Heide
  • Patent number: 8404116
    Abstract: A transducer protector for use in an extra-corporeal circuit includes a first half-shell, a second half-shell, and a hydrophobic semi-permeable membrane enclosed between the half-shells. The first half-shell includes a first tubular connector with a seat having a substantially cylindrical shape and defining an axis X. The second half-shell includes a second tubular connection configured for connection to a transducer. The seat receives an end of a branch pipe from the circuit. The end defines a front surface substantially in the form of an annulus that is insertable inside the seat, which has one or more abutments that form a support for the front surface of the end to define a stop for the end. The abutment defines at least one radially outer cavity and provides a partial support for the front surface of the end. The cavity provides at least one radially outer zone of the annulus without support.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: March 26, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Reinhold Reiter, Paolo Stabilini
  • Patent number: 8403152
    Abstract: In one embodiment, the present disclosure provides fail-safe mechanisms for final filters. The fail-safe mechanisms of the present disclosure include a prefilter that is essentially transparent or translucent to TOC contaminants and a microporous filter downstream from the prefilter that filters contaminants by means of size-exclusion, mechanical interception, coagulation, or a combination thereof, the filter being adapted to significantly reduce fluid flow and undergo blockage under a challenge by TOC contaminants.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: March 26, 2013
    Assignees: Pur Water Purification Products, Inc., 3M Innovative Properties Company
    Inventors: Hemang Patel, Keith Wesner, Thomas J. Hamlin, Robert A. Governal, Guillermo M. Vidal, Dimitris I. Collias, Jeannine R. Bahm
  • Patent number: 8404119
    Abstract: A method of membrane separation and membrane separation apparatus, with which not only a supply liquid can be evaluated but also the problems, such as scale, occurring on reverse osmosis membrane can be monitored in a highly straightforward fashion. There is provided a membrane separation apparatus equipped with reverse osmosis membrane module (3) so as to be adapted for feeding of a supply liquid and obtaining of a permeated liquid and a concentrated liquid, characterized by comprising a feeding-side membrane separation means (10) which includes a separation membrane (11) of which the membrane face (11a) can be monitored and guides the supply liquid so as to separate the membrane, and a concentrating-side membrane separation means (20) which includes a separation membrane (21) of which the membrane face (21a) can be monitored and guides the concentrated liquid so as to separate the membrane separation thereof.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: March 26, 2013
    Assignee: Nitto Denko Corporation
    Inventors: Masashi Echizen, Takuji Shintani, Naoki Kurata, Kouji Maruyama
  • Publication number: 20130071350
    Abstract: The present invention refers to a system for inducing an immune response against transformed, infected, or diseased tissue comprising a device for removing only components present in blood or plasma having a molecular weight of 120,000 daltons or less, having an inlet and outlet for connection to a pump and tubing to recirculate the blood or plasma of a patient through the device. Further, the present invention refers to methods of inducing an immune response against transformed, infected, or diseased tissue comprising administering to a patient blood, plasma, or a blood fraction from which only components having a molecular weight of 120,000 daltons or less have been removed, whereby administration of said blood, plasma, or blood fraction induces an immune response against transformed, infected, or diseased tissue in the patient until the transformed, infected, or diseased tissue is reduced in amount.
    Type: Application
    Filed: August 9, 2012
    Publication date: March 21, 2013
    Applicant: Biopheresis Technologies, Inc.
    Inventor: M. Rigdon Lentz
  • Patent number: 8398859
    Abstract: Device for haemodiafiltration, which comprises a first circuit for a dialysis solution and a second circuit for blood, so that the toxic substances from the blood flow pass into the dialysis liquid within a haemofilter (11), a liquid pump (20) located upstream of the haemofilter (11) in the first dialysis liquid circuit, is adapted for injecting replacement liquid into the dialysis solution flow after a blood pump (15) finishes pumping blood to the interior of the haemofilter (11).
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: March 19, 2013
    Assignee: Fundacion Para la Investigacion Biomedica del Hospital Gregorio Maranon
    Inventor: Juan Francisco Del Cañizo López
  • Patent number: 8394046
    Abstract: A method provides for checking the correct coupling of an adding device to a therapeutic appliance that includes an extracorporeal circuit with which the adding device is connected such that a drug can be introduced into the extracorporeal circuit by the adding device during operation of the therapeutic appliance. The adding device is coupled to the extracorporeal circuit on the suction side of a pump disposed in the extracorporeal circuit, with a portion in the region of negative pressure of the extracorporeal circuit being in connection with a portion of the adding device that is closed with respect to the other parts of the extracorporeal circuit, and with the pressure in the closed portion being varied and measured.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: March 12, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Thomas Nuernberger, Marco Blasek, Peter Kloeffel
  • Patent number: 8382981
    Abstract: A module arrangement (5) according to an embodiment of the invention consists of a plurality of membrane modules (6) arranged in a two dimensional array (7) and extending between upper and lower block-type manifolds (8) and (9), respectively. The array of modules is further divided into sub-groups of modules (10) separated from each other by space (11) extending transversely across the membrane array (7). An integrated support frame (12) is positioned in the space (11) between the sub-groups (10) and is fixed to the upper and lower manifold blocks (8) and (9) to form an integrated support structure within the module array (7).
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: February 26, 2013
    Assignee: Siemens Industry, Inc.
    Inventors: Peter Rogers, Stephen Bowmer, Bruce Gregory Biltoft, James W. Polson, Robert James McMahon, Huw Alexander Lazaredes, Michael Collignon
  • Patent number: 8382885
    Abstract: A filter for filtering a fluid in a substrate processing apparatus comprises first and second stages that are connected to one another. A delivery system provides a vaporized liquid to the filter. The first stage of the filter comprises a basic compound, and the second stage of the filter comprises a desiccant. A second filter comprises a permeation filter with permeable membrane to filter the fluid. Methods of filtering the fluid to reduce formation of undesirable process residues using the filter(s) are also described.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: February 26, 2013
    Assignee: Applied Materials, Inc.
    Inventors: Dustin W. Ho, Juan Carlos Rocha-Alvarez, Hichem M'Saad
  • Patent number: 8377298
    Abstract: Housings for reverse osmosis filter cartridges and methods of making the same. The housings include: (1) a hollow cylindrical liner formed of a thermoplastic polymer that is adapted to surround a reverse osmosis filter cartridge; (2) a hollow head assembly that includes a transition collar portion formed of a thermoplastic polymer that is joined to said liner and a barrel portion formed of a chopped glass fiber-filled polymer that is overmolded onto said transition collar portion; (3) an end plug that is adapted to be received within an opening in the barrel portion; and (4) an overwrap layer comprising wound glass filaments and a polymeric resin that covers the outer surfaces of the liner and head assembly.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: February 19, 2013
    Assignee: Enpress, LLC
    Inventors: Douglas S. Stolarik, Douglas M. Horner, Michael P. Mormino, Robert John Pristas
  • Patent number: 8377302
    Abstract: A reverse osmosis system and method for operating the same includes a pressure tank having a first end and a second end, the pressure tank has a first volume adjacent to the first end and a second volume adjacent to the second end and a third volume between the first volume and the second volume and a fluid passage fluidically coupling the second volume to the first volume. The reverse osmosis system also includes a plurality of membranes disposed within the third volume generating permeate and a permeate manifold receiving permeate from the membranes and fluidically communicating permeate out of the pressure tank. A feed line couples feed fluid into the pressure tank. A first pump pressurizes the feed line. A second pump is disposed within the tank and circulates brine fluid from the second volume through the fluid passage.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 19, 2013
    Assignee: Fluid Equipment Development Company, LLC
    Inventor: Eli Oklejas, Jr.
  • Publication number: 20130037467
    Abstract: In a first membrane filtration module comprises a membrane module comprising a plurality of permeable hollow membranes; a fluid distribution device adapted to removably surround at least a portion of the membranes of the membrane module, the fluid distribution device comprising a plurality of through-hole openings for distributing a fluid, and the fluid distribution device adapted to distribute a flow of fluid along a surface of the permeable hollow membranes. In a second membrane filtration device comprises a membrane module comprising a plurality of permeable hollow membranes, each of the permeable hollow membranes having a surface; and a gas distribution device: adapted to distribute gas bubbles to the surface of the permeable hollow membrane, adapted to removably surround at least a portion of the plurality of permeable hollow membranes, and defining a plurality of through openings for distributing the gas bubbles to the membranes.
    Type: Application
    Filed: March 28, 2011
    Publication date: February 14, 2013
    Inventors: Bruce Gregory Biltoft, Zhiyi Cao, Jen Thai Law, Huw Alexander Lazaredes
  • Publication number: 20130032525
    Abstract: The filtering and pumping apparatus (1; 100; 200) for medical use comprises: feed lines (13, 15, 18, 20, 22, 24, 26) for feeding in and out a liquid to be pumped and filtered; a pumping unit (10, 11, 12) for pumping the fluid in said lines (13, 15, 18, 20, 22, 24, 26); a filter unit (4) for filtering said liquid; said lines V, said pumping unit (10, 11, 12), said filter unit (4) being associated together into a single compact body (2).
    Type: Application
    Filed: April 20, 2011
    Publication date: February 7, 2013
    Applicant: RAND S.R.L.
    Inventors: Daniele Galavotti, Claudio Ronco
  • Publication number: 20130032536
    Abstract: Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments.
    Type: Application
    Filed: August 8, 2012
    Publication date: February 7, 2013
    Applicant: DEKA Products Limited Partnership
    Inventors: Michael J. Wilt, Jason A. Demers, Kevin L. Grant, Brian Tracey, James D. Dale
  • Publication number: 20130032540
    Abstract: A modular water purification system has a high pressure pump interchangeably received into one of two or more alternative power modules that can rely on different energy sources, such as an combustion engine module or an electric motor module. The pump applies water pressure to a reverse osmosis filter element. The system is reconfigurable for a given deployment, such as with a higher pressure pump operation for a high dissolved solute concentration, such as sea water desalination, or at a lower pressure for fresh water. Modules for deploying parallel paths each having a high pressure pump and reverse osmosis filter can be supplied as an addendum, or included in the supplied unit. The supplied unit is dimensioned so that the modules are stackable atop one another and in abutment to fill out a rectilinear volume on a pallet.
    Type: Application
    Filed: October 5, 2012
    Publication date: February 7, 2013
    Applicant: TerraGroup Corporation
    Inventors: Primo L. Acernese, James Novak, JR.
  • Publication number: 20130030388
    Abstract: For the examiner's convenience, a clean text version of the replacement abstract (114 words) is presented below: A blood treatment machine has a housing and a blood treatment module to hold components of an extracorporeal blood circulation. The machine simplifies access to a securing means for securing objects, in particular containers such as bags containing medicinal fluids, that is attached to a rod-shaped means attached to the blood treatment machine. Vertical and horizontal directions are defined by the orientation of the housing during the use of the blood treatment machine. The rod-shaped means has at least one first section and a second section, whereby the axial extent in the second section runs in a different direction than in the first section. In another embodiment, the rod-shaped means has a cropped course.
    Type: Application
    Filed: July 31, 2012
    Publication date: January 31, 2013
    Inventor: WINFRIED BREHM
  • Publication number: 20130026085
    Abstract: The present invention provides a filtration assembly in the form of a disposable cartridge. A key feature of the invention is a filtration chamber having a porous membrane also referred to as a filter, a sample inlet to the filtration chamber, and an outlet for outflow of the fraction of sample that does not penetrate the membrane. The membrane can be used in any configuration, for example a hollow fiber. The fraction of sample that penetrates the membrane is referred to as the filtrate, and the fraction that does not penetrate the membrane is referred to as the retentate or concentrate. Some uses of the cartridge are to prepare plasma from blood, and to prepare a plasma ultra-filtrate from plasma, without the need for centrifugation. Many therapeutic drugs are highly protein bound, and a plasma ultra-filtrate is sometimes required to measure the unbound biologically active drugs.
    Type: Application
    Filed: July 14, 2012
    Publication date: January 31, 2013
    Inventor: James Samsoondar
  • Patent number: 8361317
    Abstract: A filter device for a motor vehicle has a filter element with a porous ceramic support body provided with one or more passages for receiving a liquid to be filtered and filter membranes formed on inner walls of the passages. The liquid to be filtered passes through the filter membranes into the support body and exits from the support body through a circumferential surface of the support body. At least one compensation element is arranged at an end face of the support body. The compensation element is elastically deformable for providing an additional liquid volume that is generated when the liquid expands due to freezing.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: January 29, 2013
    Assignee: Mann + Hummel GmbH
    Inventors: Michael Micke, Guenter Jokschas, Martin Weindorf, Dieter Schreckenberger, Elke Duerr
  • Patent number: 8357298
    Abstract: Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: January 22, 2013
    Assignee: DEKA Products Limited Partnership
    Inventors: Jason A. Demers, Michael J. Wilt, Todd A. Ballantyne, Kevin L. Grant, James D. Dale
  • Publication number: 20130015119
    Abstract: The present invention relates to portable filtration units including filter components mated with retentate and permeate flow channels wherein particle containing solutions are introduced into the portable filtration units and contacted with the filter components for filtration thereby producing a retentate outflow and a permeate outflow for capture of desired end product.
    Type: Application
    Filed: November 29, 2010
    Publication date: January 17, 2013
    Applicant: SMARTFLOW TECHNOLOGIES, INC.
    Inventors: Marc Pugh, Todd Benson, Richard Hibbitts, Jim Kacmar, Gary Cooke, Derrick Marconi, Kim Davis, Diane Seamans, Greg Holzer, Michael Eggers
  • Patent number: 8354026
    Abstract: A center tube is disclosed which allows a draw solution to flow through all membrane elements in a membrane system in parallel. The center tube may include a cylindrical wall with two open ends and a barrier element there between separating an upstream chamber and a downstream chamber within the cylindrical wall. At least one non-perforated bypass tube may be located substantially within the cylindrical wall, which extends a length of the downstream chamber and/or the upstream chamber so that the upstream chamber is configured to communicate with a second upstream chamber of a second center tube and/or the downstream chamber is configured to communicate with a second downstream chamber of the second center tube.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: January 15, 2013
    Assignee: Hydration Systems, LLC
    Inventor: John R. Herron
  • Patent number: 8354029
    Abstract: A control device for a filtration unit for filtering a fluid, the control device comprising an integrity test unit for performing an integrity test for checking the functional integrity of the filtration unit, and a reaction unit for determining a reaction based on a result of the integrity test.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: January 15, 2013
    Assignee: Seccua GmbH
    Inventor: Michael Hank
  • Publication number: 20130008854
    Abstract: The invention covers a cartridge for use in a hemodialysis machine, the cartridge comprising a dialysate flow path including a dialyzer, the dialysate flow path for delivering a flow of dialysate through the dialyzer; a mixing pump defining a chamber having volume variable between a maximum volume and a minimum volume for receiving a predetermined volume of a first dialysate solution base, second dialysate solution base, and a volume of water; a first dialysate solution base supply conduit having a first positive displacement pump having a first inlet valve and a first outlet valve associated therewith; a second dialysate solution base supply conduit having a second positive displacement pump having a second inlet valve and a second outlet valve associated therewith; a first and second fluid conduit associated joining respective first and second positive displacement pumps with the mixing pump; and a third fluid conduit for connecting the mixing pump outlet to a dialyzer filter inlet.
    Type: Application
    Filed: June 15, 2010
    Publication date: January 10, 2013
    Applicant: Quanta Fluid Solutions Ltd
    Inventors: Mark Wallace, Ben Higgit, Keith Heyes
  • Patent number: 8349174
    Abstract: A fuel-cell powered medical fluid processing machine or dialysis machine is disclosed. The machine is intended for remote or rural areas where standard household or utility power is not available or is subject to interruption. The fuel cell is powered by hydrogen or other source of protons, or may instead be powered by methanol or ethanol, such as a direct methanol fuel cell. The fuel cell may be operated directly, as in powering a portable, wearable dialysis device, or may be operated indirectly, to generate and store power in an electric power storage device of the medical fluid or dialysis device. The medical fluid processing machine or dialysis machine may include circuitry allowing for use by household or utility power while also including a fuel cell for use when other power is not available. A catalytic heater may be used to warm the dialysis fluid.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: January 8, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: John A. Bedingfield, Richard E. Kienman, Brian C. Lauman
  • Patent number: 8343338
    Abstract: A valve assembly having a first valve defining an inlet connected to the inlet supply and an outlet connected to the concentrate chamber, a second valve defining an inlet connected to the permeate chamber and an outlet connected to the faucet, and a third valve defining an outlet connected to drain, a port connected to the concentrate chamber, and an inlet connected to the inlet supply. The port is selectively in fluid communication with the third valve outlet and inlet. When the faucet opens, the first valve opens, the second valve has permeate flowing, and the third valve opens a flowpath between the third valve port and the inlet due to pressure dropping in the second valve. When the faucet closes, the first valve closes and the third valve opens another flowpath between the third valve port and outlet due to pressure created in the second valve.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 1, 2013
    Assignee: Watts Water Technologies, Inc.
    Inventor: Craig A. Schmitt
  • Patent number: 8343359
    Abstract: A system and method for treating an aqueous effluent having organic material. The system comprises a single cell reactor having an injector for injecting an oxidizing gas into the reactor. Disposed downstream from the injector is an immersed membrane filtration device for filtering the effluent contained or passing through the reactor. Disposed between the membrane filtration device and the injector for directing an oxidizing gas into the reactor, is a bed of catalyst material. Preferably the oxidizing gas injector injects an oxidizing gas in a direction co-currently the direction of the effluent being treated. The bed of catalyst material is capable of catalyzing the oxidation of the organic material in the effluent or absorbing the organic material.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: January 1, 2013
    Assignee: Veolia Water Solutions & Technologies Support
    Inventors: Catherine Daines, Jean-Christophe Schrotter, Herve Paillard
  • Patent number: 8343346
    Abstract: A cassette is described for holding circuit components used with a hemodialysis machine.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: January 1, 2013
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Martin Joseph Crnkovich, Lynn E. Jensen, Melvin D. Jensen, DeLoy Lindley, Mohsen Reihanifam, Colin Weaver
  • Patent number: 8337700
    Abstract: A biological fluid filtration device, system, and method, for filtering a biological fluid, the device comprising a housing having an inlet, a first outlet and a second outlet, with a first fluid flow path defined between the inlet and the first outlet, with a second fluid flow path defined between the inlet and the second outlet, with a first biological fluid filtration media interposed between the inlet and the first outlet and across the first fluid flow path, with a second biological fluid filtration media interposed between the inlet and the second outlet and across the second fluid flow path, the housing essentially lacking a solid partition wall between the first biological fluid filtration media and the second biological fluid filtration media, a first flow restriction may be added downstream of the first biological fluid filtration media, and a second flow restriction may be added downstream of the second biological fluid filtration media, in another embodiment, the device comprises a housing having
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: December 25, 2012
    Assignee: Hemerus Medical, LLC
    Inventor: Peter Zuk, Jr.
  • Patent number: 8337698
    Abstract: The present invention relates to a spiral wound reverse osmosis membrane element comprising at least one set of the water purification membrane module comprising a laminated mesh-like treated water flow guiding member, a reverse osmosis membrane and a mesh-like feed water flow guiding member wound around a central treated water pipe; the reverse osmosis membrane is folded at a folded side to form a feed water flow channel therein along its inner surface and closed and sealed at areas remote from the central treated water tube at two sides adjacent to the folded side; a treated water flow channel is formed between outer surfaces of adjacent reverse osmosis membranes and opened only at a treated water outlet which opens towards the central treated water tube and is closed and sealed at remaining three sides; the mesh-like treated water flow guiding member is disposed inside the feed water flow channel.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: December 25, 2012
    Assignee: A. O. Smith (Shanghai) Water Treatment Products Co., Ltd.
    Inventor: Yizhi Hou
  • Publication number: 20120318726
    Abstract: Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 20, 2012
    Inventors: Joseph L. Charest, Else Frohlich, Jeffrey T. Borenstein
  • Patent number: 8329030
    Abstract: A hemodialysis system includes (i) blood tubing; (ii) a peristaltic blood pump contacting the blood tubing to pump blood through the blood tubing; (iii) a dialyzer in fluid communication with the blood tubing; (iv) first and second peristaltic dialysate pumps; (v) a dialysate heater; (vi) a plurality of pinch valves; and (vii) a cassette including a rigid structure, a heating portion, first and second dialysate pumping tubes, and a plurality of incoming tubes, the rigid structure when the cassette is mounted for operation orienting (a) the heating portion adjacent to the dialysate heater so that dialysate can be heated by the dialysate heater, (b) the first and second dialysate pumping tubes adjacent to the first and second peristaltic dialysate pumps, and (c) the plurality of incoming tubes adjacent to the plurality of pinch valves to enable the tubes to be individually closed by the pinch valves.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: December 11, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8328749
    Abstract: A blood purification apparatus includes a blood circuit having arterial and venous blood circuits, a blood pump, a blood purifying device, an indicator applying device that applies a predetermined indicator to the blood flowing extracorporeally through the blood circuit, a detecting device that detects the indicator applied by the indicator applying device, an arithmetic device that calculates, based on the indicator detected by the detecting device, a recirculation rate, and a calculating device that calculates an ideal extracorporeally circulating blood flow that results in the recirculation rate being no more than a predetermined value when the recirculation rate calculated by the arithmetic device is greater than the predetermined value. The recirculation rate is a proportion of a recirculated blood flow, which is reintroduced to the patient from the venous blood circuit and directed again to the arterial blood circuit, relative to an extracorporeally circulating blood flow.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: December 11, 2012
    Assignee: Nikkiso Co., Ltd.
    Inventors: Tomoya Murakami, Masahiro Toyoda, Yoshihiro Mori
  • Publication number: 20120310136
    Abstract: A system and method provide improved ultrafiltration of charged/uncharged solutes in a fluid, especially a body fluid. The improvement is achieved through imposed electric field and/or surface charge patterning to a permeable membrane. In many of the embodiments, at least one selected material is used as an additive on a permeate side of the permeable membrane to reduce the sieving coefficient of the membrane with regard to a solute present in the fluid.
    Type: Application
    Filed: August 1, 2011
    Publication date: December 6, 2012
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Albert Terrence Conlisk, JR., Subhra Datta, William H. Fissell, Shuvo Roy
  • Publication number: 20120305484
    Abstract: Synthesis and use of a new class of polymeric materials with favorable separation characteristics for the dehydration of ethanol and other organic solvents is described herein. The thermally rearranged (TR) polybenzoxazole (PBO), polybenzimidazole (PBI) and polybenzothiazole (PBT) membranes of the present invention can be used for the dehydration of ethanol during processing to fuel grade biodiesel by either pervaporation or vapor permeation. The unique microstructure of the membranes provides excellent separation characteristics, and this, coupled with their inherent thermal and chemical stability, enables their usage in other separations, such as the dehydration of other organic solvents.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 6, 2012
    Applicant: Board of Regents, The University of Texas System
    Inventors: Benny D. Freeman, Donald R. Paul, Katrina Czenkusch, Claudio P. Ribeiro, JR., Chaoyi Ba
  • Patent number: 8323482
    Abstract: An extracorporeal blood therapy control unit housing has a first and second manually mounted panels and spring loaded components configured for releasably engaging and tensioning the said panels against a side of said housing. The first and second panels have arch-shaped tubing segments mounted on the interior side of said respective panels. Each of the tubing segments are held in operational engagement with a different peristaltic pump rotor by the panel engaging and tensioning components.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: December 4, 2012
    Assignee: B. Braun Avitum AG
    Inventors: Harold Peters, Adam Heintzelman, Jacob Kearns, Tommy Cooper
  • Patent number: 8323490
    Abstract: A piston pressurized water filter activated by the user or external source. The water filter assembly includes a hollow cylindrical water reservoir, a hollow cylindrical piston threaded into the top of the water reservoir, and a water filter threaded into the bottom of the water reservoir. The interior of the water reservoir is sealed by the piston and water filter. When the water reservoir is filled with unfiltered water, the piston can be threaded down into the water reservoir to create sufficient pressure on the unfiltered water and force the water into the water filter. The water filter can include any combination of carbon, ceramic or other filtering material in a block or disk form. Water is forced into the water filter, through the carbon or ceramic filter mass, and into a container that may or may not be coupled to the water filter.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: December 4, 2012
    Assignee: Instapure Brands, Inc.
    Inventors: William Scott Wright, Bradley J. Florin
  • Patent number: 8323492
    Abstract: A hemodialysis system including (i) an instrument; (ii) first and second peristaltic dialysate pumps operated by the instrument; (iii) a cassette including a rigid structure and first and second dialysate pumping tubes carried by the rigid structure; and (iv) a mechanism configured to initially allow the cassette to be accepted by the dialysis instrument after which the mechanism engages the first and second dialysate pumping tubes for operation with the first and second peristaltic dialysate pumps.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: December 4, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8323503
    Abstract: This patent application relates generally to processing devices in the medical device area.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: December 4, 2012
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Roland Levin, Martin Joseph Crnkovich, Fei Wang, Michael Emmanuel Kotsos, Gregg Eric Fuhriman
  • Publication number: 20120298578
    Abstract: Filtration systems (40) utilize a pre-treatment method to cause scale formation to occur on particles (94) in the fluid stream (96) rather than on the filter surface and may also destroy microorganisms in the fluid stream. More specifically, but not limited to, a filtration device can be a filtration membrane, such as spiral wound filtration membrane (60), that utilizes an open feed spacer (80), such for example an embossed or printed pattern on the membrane, to create a thin feed spacer channel which replaces a conventional feed spacer mesh material. System (40) further utilizes a treatment device (54) to enable a pulsed power, magnetic, electro-magnetic, electro-static, or hydrodynamic fluid treatment scheme to condition particles in the fluid stream (96) such that scale forming elements precipitate (94) on to the particles in the fluid stream rather than on the filtration surfaces.
    Type: Application
    Filed: January 25, 2011
    Publication date: November 29, 2012
    Inventors: Rodney Herrington, John E. Dresty, Mark K. Winter
  • Publication number: 20120298580
    Abstract: A method is provided for rinsing and/or filling a blood treatment device, in particular for priming such a device. The blood treatment device includes at least one membrane filter, in particular a hollow fiber membrane filter, at least one first partial circuit, and at least one second partial circuit, with the first and second partial circuit being separated by the membrane filter in a semipermeable manner. The first partial circuit is first filled with a fluid with a uniform and/or a pulsatile first volumetric flow rate that does not exceed a specified threshold value. At this value the fluid has not yet completely wetted and/or soaked the membrane, and/or the second partial circuit is at least temporarily open towards the atmosphere, and air is displaced from the first into the second partial circuit via the membrane filter, and/or during filling no negative pressure is applied to the first partial circuit.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 29, 2012
    Applicant: Fresenius Medical Care Deutschland GmbH
    Inventors: Soeren GRONAU, Joachim Noack, Juergen Haecker, Ralf Mueller
  • Publication number: 20120292237
    Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dislysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.
    Type: Application
    Filed: June 5, 2012
    Publication date: November 22, 2012
    Inventors: Keith James Heyes, Hugh Christopher Bramley, Mark Reeves, Mark Jervis
  • Publication number: 20120292246
    Abstract: The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 22, 2012
    Inventors: Goran Jovanovic, Sundar V. Atre, Brian Kevin Paul, John Simonsen, Vincent Thomas Remcho, Chih-Hung Chang
  • Patent number: 8313642
    Abstract: A peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine including a logic implementer and a wireless interface receiver. The system also includes at least one of a scale or a blood pressure monitor including a wireless interface transmitter. The scale or blood pressure monitor is operable to send at least one of patient blood pressure data and patient weight data wirelessly, respectively, to the wireless interface receiver. The logic implementer is configured to store the patient blood pressure data or patient weight data. A server computer is configured to communicate with the logic implementer to receive the stored at least one patient blood pressure data and patient weight data.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: November 20, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Anping Yu, James Grayson, Robert W. Childers
  • Patent number: 8313651
    Abstract: The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: November 20, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Elena N. Komkova, Donna Lisa Crossley, Alicja M. Mika
  • Patent number: 8303809
    Abstract: A peritoneal dialysis machine includes an enclosure; dialysate pump located within the enclosure; a graphical user interface allowing a patient to program a treatment including at least one patient fill performed by the dialysate pump, at least one dwell, and at least one drain performed by the dialysate pump; and the GUI further programmed to provide an alert when it is time to begin the treatment so as to complete the at least one patient fill, dwell and drain by a prescribed time.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: November 6, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: John A. Biewer, Andrey Kopychev, Merrick F. Kossack, Philip J. D'Almada Remedios
  • Patent number: 8303814
    Abstract: A cross-flow filtration system includes a first filter element having a first conduit for receiving a flow of a first aqueous feed stream, a second conduit operable to discharge a flow of first permeate water and a third conduit operable to discharge a flow of first retentate water. The cross-flow filtration system includes a coil assembly disposed about the first conduit. The first coil assembly is operable to subject the first aqueous feed stream to electromagnetic pulses. A second filter element is in fluid communication with the first filter element via the third conduit. The second filter element is operable to receive the first retentate water via the third conduit. A second coil assembly is disposed about the third conduit and is operable to subject the first retentate water to electromagnet pulses.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: November 6, 2012
    Assignee: Clearwater Systems Corporation
    Inventor: David Wayne Alley
  • Patent number: 8298427
    Abstract: A method for controlling an apparatus for treating blood outside the human body, with a view to improving the operation of the apparatus, the apparatus including a semi-permeable membrane carrying out an exchange of solutes, referred to as dialysis, and of liquid, referred to as ultrafiltration, with the blood, the method including at least one iteration of the following steps: determination of a so-called instantaneous value, of an ultrafiltration coefficient corresponding to the ratio of an ultrafiltration flow rate to a difference in pressure, the so-called transmembrane pressure, on either side of the semi-permeable membrane, comparison of the instantaneous value with at least one previously determined characteristic value; and control of the treatment apparatus to reach a maximum value of the ultrafiltration coefficient, the control including a variation of the ultrafiltration flow rate up to a value corresponding to the maximum value of the ultrafiltration coefficient.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: October 30, 2012
    Assignee: RD Nephrologie
    Inventors: Alain Ficheux, Angel Argiles Ciscart
  • Patent number: 8298420
    Abstract: A drainless reverse osmosis (RO) water purification system provides relatively pure water for on-demand dispensing, while recycling brine to a domestic hot water system. The drainless purification system includes a pre-filter catalyst cartridge for removing chlorine-based contaminants from a tap water supply upstream from an RO membrane. The catalyst is regularly refreshed by a high through-flow of water to a conventional cold water dispense faucet, thereby significantly prolonging the service life of the RO membrane. The RO membrane is incorporated into a multi-cartridge unit adapted for facilitated slide-out removal and replacement as needed. A control valve recycles brine from the RO membrane to the hot water system during pure water production, and recirculates tap water through the RO membrane when a pure water reservoir is substantially filled. The multi-cartridge unit may further include an air filtration system for providing a flow of filtered air.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: October 30, 2012
    Inventor: Bruce D. Burrows
  • Publication number: 20120267307
    Abstract: Separation processes using osmotically driven membrane systems are disclosed generally involving the extraction of solvent from a first solution to concentrate solute by using a second concentrated solution to draw the solvent from the first solution across a semi-permeable membrane. Enhanced efficiency may result from using low grade waste heat from industrial or commercial sources. Pre-treatment and post-treatment may also enhance the osmotically driven membrane processes.
    Type: Application
    Filed: April 24, 2012
    Publication date: October 25, 2012
    Inventor: Robert L. McGinnis