Abstract: A system for separating solids from fluid including a solid-laden fluid including a base fluid, a first separator configured to receive the solid-laden fluid and separate the fluid into a solids portion and an effluent, and a membrane separator configured to receive the effluent and separate the effluent into a permeate and a concentrate is disclosed. A method for separating solids from fluid including obtaining a solid-laden fluid, wherein the solid-laden fluid comprises a base fluid, feeding the solid-laden fluid through a centrifuge, removing at least a portion of high gravity solids from the solid-laden fluids, flowing the solid-laden fluid through a membrane separator, removing at least a portion of low gravity solids from the solid-laden fluid, and collecting a permeate from the membrane separator is also disclosed.

Abstract: Reverse-osmosis modules, each containing a module tube with a module bottom and a module lid, and a reverse osmosis membrane arranged in the module tube and comprising a permeate collection tube, are characterized in that the reverse osmosis membrane has a fixed predetermined diameter and a length selected from predetermined length values.

Abstract: The water provisioning system mainly contains a selection switch, a water volume switch, a human-machine interface (HMI), a RO waste water recycling device, an electromagnetic valve, a RO water purification device, an antichlor device, an aeration pipe assembly, a first ozone module, and a second ozone module. The selection switch selects a type of water to use. The RO water purification device filters water from a low-temperature water source, stores purified water in a storage barrel, and provides high-quality drinking water. The 70% water from the RO water purification process that fails the drinking water standard is recycled through the RO waste water recycling device. The low-temperature water source is connected to an antichlor device and the water is therefore dechlorinated. The first and second ozone modules are used to produce ozonated water and to release ozone through the aeration pipe assembly into the kitchen cabinet for deodorization and sterilization.

Abstract: Embodiments of the invention provide venting and filtration systems with a membrane that is permeable to gas and substantially impermeable liquid. The systems can remove a gas from a liquid entrained with gas. The systems can include a reservoir in fluid communication with the membrane and a liquid outlet. The membrane can help prevent the gas from reaching the liquid outlet.

Abstract: A hemofiltration system or method removes unwanted molecules from a flow of blood using cascaded first and second hemofilters. Filtration of the blood in first hemofilter raises hemoconcentration of unwanted protein-bound molecules. Combination of a substitution fluid with outflow from the first hemofilter creates a concentration differential between bound and unbound molecules that frees unwanted molecules from protein bonds. Filtration of the combined fluids in a second hemofilter removes the unwanted free molecules. A second substitution fluid may be added to the twice filtered blood fluid for return to a patient. Removal of inflammatory mediators, apoptotic mediators, and certain electrolytes may be effected, and the removal may be optimized by controlling fluid flows and transmembrane pressures.

Abstract: A split thin-flow separations device can include a fluid channel having an inlet zone, an outlet zone, and a transport region between the inlet zone and outlet zone. The inlet zone includes a sample inlet and a carrier fluid inlet which are fluidly separated by an inlet splitter to minimize mixing of fluids from respective inlets in the inlet zone. The transport region can be a substantially open channel. Similar to the inlet zone, the outlet zone can include a sample outlet and a carrier outlet which are fluidly separated by an outlet splitter to segregate portions of a fluid into each of the two outlets as the fluid enters the outlet zone. A plurality of cross-flow inducers can also be oriented along a wall of the fluid channel in the transport region. The cross-flow inducers are oriented to form a cross-flow field across the transport region.

Abstract: Hemofiltration systems and methods to treat an Inflammatory Mediator Related Disease in a patients, including chronic and acute diseases, may include a hemofilter and an adsorptive device. The systems and methods may further include one or more therapeutic agents administered to the patient. The hemofilter removes ultrafiltrate from a blood stream extracted from the patient to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal. Other systems and methods are disclosed.

Abstract: The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

Abstract: A filter device and a method for the filtration of beer, where, for an improved and simplified filtration, the filter includes a nonfiltrate chamber having a nonfiltrate inlet and a nonfiltrate outlet, wherein the nonfiltrate flows into the nonfiltrate chamber substantially tangentially to the walls thereof, and the bottom of the nonfiltrate chamber is constructed at least partially as a filter. The filter also includes a filtrate chamber underneath the bottom, and a filtrate outlet.

Abstract: A submodule is used to know exactly fouling of a membrane surface in a separation membrane module. The membrane separation apparatus of the present invention includes: a separation membrane module (1) configured to produce at least a permeate fluid from a feed fluid; and at least one submodule (2) having a separation membrane (23) made of the same material as a separation membrane in the separation membrane module (1). A deposition member (22) is provided on a surface of the separation membrane (23) in the submodule (2), and the feed fluid is supplied onto the surface.

Abstract: A system is described in which a cooling tower is operated with a solution of a non-volatile organic molecule osmolyte and water. Makeup water for the tower is provided by forward osmosis using the fluid as the draw solution for the extraction of water from feeds which require dewatering or from low value available water.

Abstract: A blood purification instrument for extracorporeally circulating a patient's blood and a concentration detector detects a concentration of liquid during blood purification wherein the concentration detector has a light emitter irradiating light onto the liquid, a light receiver receives the light as transmitted through the liquid, a reference light receiver receives reference light branched from the light emitter without transmission through the liquid, and a detector detecting the light intensity respectively of the transmitted light and the reference light received by the light receiver and the reference light receiver, respectively.

Abstract: A forward osmosis fluid purification system includes a cross-flow membrane module with a membrane, a channel on each side of the membrane which allows a feed solution and a draw solution to flow through separately, a feed side, a draw side including a draw solute, where the draw solute includes an aryl sulfonate salt. The system can be used in a process to extract water from impure water, such as wastewater or seawater. The purified water can be applied to arid land.

Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.

Abstract: A water electrolysis apparatus is provided that can stably produce water with high purity while preventing soiling and breakage, allows easy handling, detachment, and replacement, and allows inexpensive manufacture and maintenance.

Abstract: A renal therapy blood cleansing system is provided. The renal therapy blood cleansing system includes a blood filtering device in fluid communication with a blood circuit, a balance chamber configured to exchange like volumes of fresh and used therapy fluid with the blood filtering device, a first pump configured to pump fresh fluid to the balance chamber, a second pump positioned and arranged to receive used fluid from the blood filtering device, and a control scheme. The control scheme is programmed to isolate the blood filtering device from the second pump and deliver a volume of fresh fluid to the blood filtering device via the balance chamber while the second pump is isolated from the blood filtering device, so as to increase fluid volume within the blood circuit.

Abstract: A method and a device for supply of a dialyser in a dialysis unit with dialysis fluid is disclosed. At least one dialysis fluid concentrate is mixed with water to produce the dialysis fluid. The dialysis fluid concentrate is prepared in a reservoir unit in a given amount. A control and arithmetic unit calculates the dialysis fluid rate (Qd) such that, after a given treatment time (TB) has passed, a given residual amount of dialysis fluid concentrate or no residual amount remains in the reservoir unit. It is preferable to empty the reservoir unit by the end of treatment.

Abstract: The present invention is directed toward spiral wound modules including membrane sheets with regions (70,72) having different permeabilities. Said regions are arranged either axially or radially or both.

Abstract: A hemodialysis apparatus includes a dialysis device, a detecting device, an evaluation device and a memory device. The dialysis device dialyzes and ultrafiltrates blood of a patient according to an ultrafiltration volume based on an estimated dry weight while performing hemodialysis treatment on the blood circulating extracorporeally. The detecting device obtains time series data by measuring a parameter related to concentration of the blood circulating extracorporeally at a plurality of points in time series in a process of the hemodialysis treatment by the dialysis device. The evaluation device evaluates appropriateness of the hemodialysis treatment by evaluating whether the estimated dry weight approximates to a dry weight after the hemodialysis treatment by the dialysis device. The memory device stores a plurality of time series data when the hemodialysis treatment is evaluated to be appropriate by the evaluation device.

Abstract: One embodiment of a method to system for enhancing TOC removal while maintaining membrane filter performance is the implementation of a dual pH control system. This embodiment will enhance the ability to maximize TOC removal while maintaining optimum membrane filter performance. By adjusting pH, dosing a chemical coagulant and incorporating liquid-solids separation, a considerably higher degree of TOC removal is possible. By adjusting pH again after liquid-solids separation this embodiment can drastically increase the efficiency of the membrane microfiltration/ultrafiltration system. Thus pH control for soluble organic removal is critical. This pH level however may not be the ideal set point for minimizing membrane fouling which is the basis for this embodiment. An example: the pH set point for optimum soluble organic removal is designated to be 5.5. However, the optimum pH set point for optimum membrane performance is 7.0.

Abstract: A gasifier waste stream from a gasification process is directed to a solids separator. A portion of the suspended solids in the waste stream is removed in the solids separator, producing slag and fly ash and a grey water effluent. The grey water effluent is directed to one or more ceramic membranes which remove at least portions of the remaining suspended solids in the grey water. Permeate from the ceramic membrane is directed to an evaporator located downstream from the ceramic membrane for further concentration. Placing the ceramic membrane upstream from the evaporator reduces fouling and plugging in the evaporator that would otherwise occur due to the suspended solids in the grey water.

Abstract: Housings for reverse osmosis filter cartridges and methods of making the same. The housings include: (1) a hollow cylindrical liner formed of a thermoplastic polymer that is adapted to surround a reverse osmosis filter cartridge; (2) a hollow head assembly that includes a transition collar portion formed of a thermoplastic polymer that is joined to said liner and a barrel portion formed of a chopped glass fiber-filled polymer that is overmolded onto said transition collar portion; (3) an end plug that is adapted to be received within an opening in the barrel portion; and (4) an overwrap layer comprising wound glass filaments and a polymeric resin that covers the outer surfaces of the liner and head assembly.

Abstract: A magnetic sifter is adapted for manipulation of biological cells by providing a greater pore density at the edge of the sifter than at the center. Application of an external magnetic field to the sifter causes high magnetic fields and field gradients at the sifter pores. These conditions are suitable for capturing magnetically tagged or labeled cells at the sifter pores. Altering the external magnetic field can provide controlled capture and/or release of magnetically labeled cells from the sifter pores. The purpose of having a greater pore density at the periphery of the sifter than at the center is to provide improved flow rate uniformity through the sifter. Such flow rate uniformity is advantageous for cell quantification.

Abstract: A gas separation unit 102, 200, 300 for permeating a gas out from a pressurized feed mixture includes an input manifold 104, 204, an exhaust manifold, 106, 206 and a permeate assembly 108, 208, 303. The permeate assembly supports one or more permselective foils 130, 132, 218, 232, 318 over a hollow cavity 134, 272, 306 supported by a microscreen element 142, 144, 228, 230, 326. The microscreen element includes non-porous perimeter walls 190, 192, 278 supported on a frame surface and a porous central area 194, 280 supported over the hollow cavity. A porous spacer 138, 140, 174, 234 disposed inside the hollow cavity structurally supports the entire microscreen surface spanning the hollow cavity while also providing a void volume for receiving fluid passing through the porous central area and for conveying the fluid through the hollow cavity.

Abstract: To present a membrane element in an immersion type membrane separation apparatus capable of filtering efficiently by holding a uniform filtering capacity on the whole of the membrane surface if clogging occurs in a part of the membrane surface. The membrane element A is composed of a filtration chamber forming part C arrayed by dividing filtration chambers into a plurality in a vertical direction, water collecting transverse groove forming parts B forming transverse grooves (4) for collecting filtered water from each filtration chamber in a lateral direction by connecting with the filtration chamber forming part C, and a water collecting route (10) by connecting with the water collecting transverse groove forming parts B for collecting the water flaker in the lateral direction from each transverse groove (4) and discharging to outside.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: Selective retaining a relatively hydrophilic molecule from a mixture of a relatively hydrophobic molecule and the relatively hydrophilic molecule can be achieved using a hydrophobic, microporous hybrid membrane based on silica, wherein at least 25% of the silicon atoms is bound to a bridging C1-C12-hyrdocarbylene group. The average number of carbon atoms of the bridging groups and any additional monovalent organic groups, taken together, is at least 3.5. The membrane can be part of a production facility for separating alcohol/water mixtures.

Abstract: Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be definedwithin one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to, urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices actuated using a control fluid, optionally delivered using to detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.

Abstract: A dialysis fluid cassette that includes a base and a flexible membrane attached to the base. The flexible membrane and the base cooperate to at least partially define a venting chamber and a fluid channel fluidly connected to the venting chamber.

Abstract: The present invention provides a method for preparing poly(allylamine) hydrochloride, sevelamer hydrochloride, sevelamer carbonate and colesevelam hydrochloride. The present invention also relates to a process for preparing oly(allylamine) hydrochloride, sevelamer hydrochloride, sevelamer carbonate and colesevelam hydrochloride with low allylamine content and high specific gravity.

Abstract: Devices and methods for separating plasma from biological fluids such as blood and blood products are disclosed.

Abstract: An arterial line blood filter for use in extracorporeal blood circuits during heart bypass surgery has, among other components, a housing with a cap portion, a base portion, and a generally cylindrical wall portion. The blood filter has a filter element disposed within the housing. An inlet is positioned at an upward angle with respect to the housing and includes an opening in the generally cylindrical wall portion in fluid communication with the inlet chamber. In some embodiments the position of the inlet limits the pressure drop and prime volume of the filter. According to one embodiment, the cap portion has an upwardly sloping inner surface and there is a vent in the cap portion. The inner surface of the cap portion can have a projection proximate the vent configured to limit immobilization of gaseous microemboli within the inlet chamber.

Abstract: A microsieve includes a patterned forest of vertically grown and aligned carbon nanotubes with a patterned matrix of vertically aligned pores. A conformal coating of substantially uniform thickness coats the nanotubes defining coated nanotubes. An interstitial material infiltrates the carbon nanotube forest and substantially fills interstices between individual coated nanotubes. The interstitial material can be a metal material infiltrated by electroplating.

Abstract: Filtration membrane comprising polymeric nanofibers and/or microfibers attaching dendrimer component presenting reactive sites selective for chemicals to be filtered, and related nanofibers and microfibers, composite materials, compositions, methods and system.

Abstract: The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.

Abstract: Provided is a filtering apparatus having a fixed-type chaos-flow inducer that saves energy as well as sufficiently washes a separation membrane in an environment of high concentration by efficiently generating chaos flow by using a structure of a fixed type.

Abstract: A desalination device that uses the natural and constant static pressure of the ocean depths to cause seawater to push against a reverse osmosis membrane with sufficient force to separate the molecules of water and salt. The resulting water, the permeate, is pumped to the surface using normal subsurface pumps.

Abstract: The present invention relates to a method for priming a line for adding a medical solution, the line branching off a return line of an extracorporeal blood circuit, in particular a calcium line, a control device for controlling or regulating the method according to the present invention and a blood or plasma treatment apparatus with at least the control device according to the present invention. It further relates to a digital storage medium, a computer program product as well as a computer program.

Abstract: A device that allows for serial (time) use of clean blood filters during the use of a heart lung machine. The device is comprised of a series of filters and a switching mechanism that allows the new filter to be placed in the blood flow pathway while at the same time removing the old (previous) filter. A clean filter is always available, and filters for specific components of blood or those able to bind and remove specific biochemicals can be used.

Abstract: This disclosure relates to dialysis venting devices and related methods. In some aspects, a dialysis system includes a fluid inlet line, a venting device in fluid communication with the fluid inlet line, and a fluid outlet line in fluid communication with the venting device. The venting device can include a housing defining a fluid chamber, a valve member disposed above the fluid chamber between a lower seat and an upper seat, and a pump that is operable to draw fluid into the fluid chamber from the fluid inlet line and to force fluid out of the fluid chamber into the fluid outlet line.

Abstract: A connecting device comprises a buffer chamber (2), a first connecting line (3) between a liquid source (4) and an inlet (5) of the buffer chamber, a second connecting line (9) between an outlet (10) of the buffer chamber and the medical treatment apparatus (11), two valves (7, 8) arranged in series on the first connecting line, a pump (12) on the second connecting line, two liquid level sensors (15, 16) operating in the buffer chamber, a vent valve (18) connected to the buffer chamber. The liquid source is a centralized distribution plant of dialysate, while the medical treatment apparatus is a dialysis apparatus. The invention prevents back-contamination of the centralized plant with disinfectant sourced from the dialysis apparatus.

Abstract: The disclosure describes end cap assemblies adapted for interconnecting filtration elements in end-to-end relationship and including means for selectively preventing relative rotation between adjacent end caps once engaged.

Abstract: Systems and methods for the washing and processsing of biological fluid/biological cells are disclosed. The systems and methods prevent inadvertent target cell loss by monitoring pressure and providing for the dilution of the cell feed.

Abstract: A fluid trap apparatus includes an inlet configured to receive a flow of composite fluid into the apparatus. The composite fluid contains at least a first fluid and a second fluid. An outer wall defines an interior chamber. A flow diffuser is interposed within the interior chamber. The flow diffuser directs the flow of the composite fluid to circulate through the interior chamber. The first fluid and the second fluid separate as the composite fluid circulates through the interior chamber. A method of separating a first fluid from a second fluid includes introducing a flow of composite fluid into a separate chamber. A pressure gradient is created within the separation chamber. A flow diffuser is interposed in a flow path between an inlet and an outlet. The flow diffuser directs the flow of the composite fluid within the separation chamber. The first fluid and the second fluid are separated.

Abstract: A spherical dialysis chamber with a heavier cap (the density of cap material is higher than that of the dialyzer) or the distribution of weight is such that it is higher weight distribution is towards the cap, so that it tilts always towards the bottom of the container containing the dialysis buffer.

Abstract: The present invention is directed to degassing devices for dialysate circuits. One embodiment has a first housing and a second housing positioned within the first housing in an annular relationship. A second embodiment comprises a dialysate regeneration system with urease, a dialyzer, and a housing with an external wall, where the external wall is exposed to atmosphere and comprises a material that passes gas but does not pass liquid and where the housing is positioned between the urease and dialyzer.

Abstract: A non-blocking filtration system wherein the suspension filtered continuously scrubs the filter, keeping it free of deposits of solid deposits while the filtrate is removed in a variety of biological and chemical applications, substantially reducing the cost of unit operations.

Abstract: To provide a humidifying membrane module that is reduced in weight, size and cost by making a case in a single layer structure, the humidifying membrane module has a hollow fiber membrane bundle constructed from plural hollow fiber membranes, a case accommodating the hollow fiber membrane bundle, a first flow passage extending through hollows of the hollow fiber membranes, and a second flow passage extending through the outer surface sides of the hollow fiber membranes, the membrane bundle and the case are simultaneously integrated at both ends of the membrane bundle by using potting members sealing gaps between the membrane bundle and the case, an inlet and an outlet constructing the first flow passage are formed at the both ends of the case respectively, and an entrance and an exit constructing the second flow passage are formed in side surfaces near the both ends of the case respectively.