Abstract: A device and method for monitoring the connection of a blood treatment unit to a fluid system of an extracorporeal blood treatment apparatus are described, in which the blood treatment unit includes an inlet and an outlet for connection to the fluid system and the fluid system includes a line system with a first line segment connected to the inlet and a second line segment connected to the outlet. An extracorporeal blood treatment apparatus includes a device for monitoring the connection of the blood treatment unit to the fluid system. The device and method for monitoring the connection of the blood treatment unit to the fluid system is based on measurement of pressure in the fluid system of the blood treatment apparatus. Solely on the basis of the pressure measurement, it is ascertained whether the connection of the blood treatment unit to the fluid system is correct or incorrect.

Abstract: Described herein is a method for altering the characteristics of a membrane comprising a dielectric material. The method comprises heating the membrane and applying an electric field in a direction out of the plane of the membrane to at least a portion of the dielectric material. At least a portion of the dielectric material becomes aligned with the applied electric field. In some embodiments, the membrane is piezoelectric and application of an electric signal to the membrane causes out of plane movement of the membrane. Also disclosed are membranes and systems and apparatuses comprising such membranes.

Abstract: A self-regulating FO system is disclosed comprising a container containing a source water supply, a forward osmosis membrane element located within the container comprising an area of osmotic membranes, an osmotic agent inlet and a drink outlet, an osmotic pump element also located within the container comprising an area of osmotic membranes, an osmotic agent inlet and a drink outlet, and an osmotic agent tank located above the container. The osmotic agent tank comprises a feed tube connected to an outlet located on the bottom of the osmotic agent tank. The feed tube communicates with the osmotic agent inlet of the forward osmosis membrane unit and the osmotic agent inlet of the osmotic pump element. A return tube communicates with the drink outlet of the osmotic pump element and a port near the top of the osmotic agent tank.

Abstract: An apparatus, system, and method for desalinating water is presented. The invention relates to recovery of water from impaired water sources by using FO and seawater as draw solution (DS). The seawater becomes diluted over time and can be easily desalinated at very low pressures. Thus, a device consumes less energy when recovering water. The apparatus, system and method comprise an immersed forward osmosis cell.

Abstract: According to the present invention, a dialyzing fluid pump comprises; a housing having an accommodating space formed therein; a dialyzing fluid supply tube and a dialyzing fluid recovery tube, at least a portion of each of which is accommodated in the accommodating space; a cam rotatably installed in the accommodation space; and a motor for rotating the cam. The dialyzing fluid supply tube is made of a flexible material which can be contracted or relaxed, and one end thereof is connected to a hemodialysis filter and the other end thereof is connected to a dialyzing fluid supply tank. The dialyzing fluid recovery tube is made of a flexible material which can be contracted or relaxed, and one end thereof is connected to the hemodialysis filter and the other end thereof is connected to a dialyzing fluid recovery tank.

Abstract: The present invention involves the use of a multi-stage membrane system for gas, vapor, and liquid separations. In this multi-stage membrane system, high selectivity and high permeance or at least high selectivity polybenzoxazole membranes or cross-linked polybenzoxazole membranes are applied for a pre-membrane or both the pre-membrane and the secondary membrane. A primary membrane can be from conventional glassy polymers. This multi-stage membrane system can reduce inter-stage compression cost, increase product recovery and product purity for gas, vapor, and liquid separations. It can also save the cost compared to the system using all the high cost polybenzoxazole membranes or cross-linked polybenzoxazole membranes.

Abstract: The present invention generally relates to a filtration system having one or more apparatuses for filtering gases, liquids, or fluids (e.g., water) to remove particulate matter, and methods of making and using the apparatus. More particularly, embodiments relate to apparatuses and methods for applying centrifugal force(s) to push a fluid or gas to be filtered through a porous membrane or filter within the apparatus to separate particulate matter therefrom. The present invention takes advantage of the Coriolis effect within a cylindrical filter radiating out from a rotating central body. The filtration apparatus provides an energy efficient system for microfiltration (or other filtration process) to remove contaminants from gases and fluids, such as waste water.

Abstract: A fluid treatment arrangement may include a fluid treatment unit having a multilayer structure. The multilayer structure may include at least one feed layer, at least one permeate layer, and at least one layer of a permeable fluid treatment medium between the feed layer and the permeate layer. The fluid treatment unit may further include a thermoset which holds the layers together and forms at least a portion of a first end surface of the fluid treatment unit. The fluid treatment arrangement may also include a thermoplastic sheet which overlies the first end surface of the fluid treatment unit. The thermoset directly bonds to the thermoplastic sheet.

Abstract: Provided is a method of purifying oil by which nano particles are effectively removed from the oil.

Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

Abstract: According to one embodiment, a method for separating a solvent from an object solution includes the solvent and a solute is provided. The method includes preparing a forward osmosis membrane having a first surface and a second surface, and contacting the first surface of the membrane with the object solution and contacting the second surface with a liquid for collection. A substance having solidity is configured to exert a force for transferring the solvent in the object solution to the membrane, and disposed on the second surface of the membrane and/or dispersed in the liquid for collection to transfer the solvent in the object solution from the first surface to the liquid for collection.

Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

Abstract: The permeate collectors of a set of membrane filter elements are connected in line to form a vertical permeate collection pipe serving the set of elements. The connectors between adjacent elements are configured to allow a disconnected element to move perpendicular to the permeate collectors. When an element is disconnected, it may slide horizontally out of the frame. A connector has a spigot that spans between two sockets when connected. In a membrane assembly, each socket is associated with a permeate collector of a membrane filter element. To disconnect the sockets, the spigot is retracted further into one of the sockets until it is spaced apart from the other socket. With the spigot retracted, one membrane element may move relative to the other in a direction perpendicular to the direction of movement of the spigot.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: A separation module utilizing a feed spacer and a method for forming such a separation module are provided. A gasket comprising a flexible waterproof material is disposed on at least part of one or more edges of the feed spacer. A membrane layer is disposed on a first surface of the feed spacer. A permeate carrier is disposed on a surface of the membrane element opposite the feed spacer.

Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

Abstract: A reverse osmosis system and method for operating the same includes a fluid reservoir, a valve and a brine feed tank in fluid communication with the fluid reservoir through an input. The brine feed tank has brine feed fluid therein. The system also includes a high pressure pump and a pressure vessel in fluid communication with the fluid reservoir through the high pressure pump. The pressure vessel comprises a permeate outlet. The brine feed tank is in fluid communication with the pressure vessel. During a permeate production cycle, the high pressure pump pumps additional fluid under high pressure from the fluid reservoir into the pressure vessel using a high pressure pump. The pressure vessel communicates brine fluid into the brine feed tank. The high pressure pump raises a pressure in the pressure vessel until an amount of permeate is produced from a permeate output of the pressure vessel.

Abstract: The present invention relates to a functionalized membrane contactor extraction/reaction system and method for extracting target species from multi-phase solutions utilizing ionic liquids. One preferred embodiment of the invented method and system relates to an extraction/reaction system wherein the ionic liquid extraction solutions act as both extraction solutions and reaction mediums, and allow simultaneous separation/reactions not possible with prior art technology.

Abstract: The present invention is directed to novel systems for conducting the filtration of blood using manifolds. The manifolds integrate various sensors and have fluid pathways formed therein to direct fluids from various sources through the requisite blood filtration or ultrafiltration system steps.

Abstract: To provide a method for manufacturing a module having a selectively permeable membrane wherein the surface of the selectively permeable membrane thereof can be washed with good efficiency and further contaminants having been exfoliated from the surface of the membrane by a washing operation can be discharged from the inside of a housing with good efficiency; and the above module having a selectively permeable membrane. A module wherein a selectively permeable membrane is held in a housing and both ends of the above selectively permeable membrane are fixed, the both ends of the above selectively permeable membrane are fixed to an upper holder and an under holder connected by at least one washing tube, and then, the membrane is held in the housing; and a module having a selectively permeable membrane manufactured by the above manufacturing method.

Abstract: The invention relates to an apparatus and method for simultaneous extrarenal blood purification therapy and respiration support therapy. The apparatus includes a CO2 removing means having a first inlet for receiving a flow of blood for CO2 removal and a first outlet for expelling blood deprived of CO2. The apparatus also includes filtering means having a first inlet for receiving the flow of blood, a first outlet for expelling purified blood, and at least one drain channel. The drain channel directs a diluting liquid obtained from the blood expelled during purification of the blood. The drain channel is directly connected to the first inlet of the CO2 removing means to supply the diluting liquid to the CO2 removing means without submitting the diluting liquid to any filtering treatment during passage along the drain channel.

Abstract: The invention provides a sealing gasket for mounting in a passage (5) of a support plate (4) to surround the end of a tubular-shaped filter element (3) provided with at least one fluid flow channel (31), the channel lying within a flow section Sc, the gasket being constituted in the form of a sleeve: possessing a height h not less than the height hps of the passage (5) in the support plate (4); and presenting an overlap bore (15) for the filter element (3) defined between one end (16) of the sleeve and a shoulder (17) which co-operates with the other end of the sleeve to define a channel bore (19) for the fluid, the shoulder (17) possessing a surface for acting as an abutment for the terminal portion of the filter element and presenting dimensions that are adapted to extend outside the flow section Sc so as to avoid impeding fluid circulation, the overlap bore (15) being provided with a groove (28) adjacent to the shoulder (17) in order to allow the gasket to creep.

Abstract: An SWRO module for use in a desalination plant receives refresh water to increase production and product quality and reduce scaling problems. The SWRO module includes a pressure vessel having a front-end feed port, a rear-end brine port and a rear-end permeate port. A plurality of RO membrane elements are located in series within the pressure vessel. At least one refresh port leading to an interconnector mixing zone within the pressure vessel is located between two of the plurality of RO membrane elements. The port is configured such that refresh water added to the SWRO module through the refresh port mixes with the feed water supplied through the front-end feed port in the interconnector mixing zone.

Abstract: An apparatus for the transfer of mass and heat including a membrane having a hydrophilic surface and an opposing hydrophobic surface. The construction prevents transmission or leakage of fluids from one side of the membrane to the other regardless of pressure gradients within the membrane bubble point or water intrusion pressure range, but allows the transfer of vaporized fluid from one side of the membrane to the other.

Abstract: The scope of the invention is to apply an electric current or to use a kind of iontophoresis system with the hemodialysis cartridge and system (the proposed method is also applicable to peritoneal dialysis or other similar methods) to remove unwanted molecules from blood, plasma or serum or other body fluids and to increase the effectiveness of the process. This cartridge can be used for patients with uremia and cartridge fixed to the conventional hemodialysis machine and additionally the electric current applied to the electrodes placed in to the cartridge or electrode connectors placed to the conventional cartridge. When the system activated, the molecules in the blood or other body fluid migrates to the hemodialysis solution. Charged ions or uncharged molecules move together with electroosmotic flow. The sterilized electrodes preferably made by Ag/AgCl to prevent pH changing effect. Other apparatus can also be used for providing an electropotential gradient.

Abstract: A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.

Abstract: The present invention generally relates to a filtration system having one or more apparatuses for filtering gases, liquids, or fluids (e.g., water) to remove particulate matter, and methods of making and using the apparatus. More particularly, embodiments relate to apparatuses and methods for applying centrifugal force(s) to push a fluid or gas to be filtered through a porous membrane or filter within the apparatus to separate particulate matter therefrom. The present invention takes advantage of the Coriolis effect within a cylindrical filter radiating out from a rotating central body. The filtration apparatus provides an energy efficient system for microfiltration (or other filtration process) to remove contaminants from gases and fluids, such as waste water.

Abstract: The invention provides a method for the filtration of a bioreactor liquid (10) from a bioreactor (1) with a cross-flow membrane module (20) comprising one or more membranes (40). The method comprises feeding part of the bioreactor liquid (10) to a liquid inlet (21) of the cross-flow membrane module (20), transporting the bioreactor liquid (10) through the cross-flow membrane module (20) in a cross-flow mode, and removing a retentate (12) from a liquid outlet (22) of the cross-flow membrane module (20). The cross-flow membrane module (20) is arranged to allow a liquid downward flow of the bioreactor liquid (10) through the cross-flow membrane module (20). The method further comprises providing the liquid downward flow and a downward gas flow of a gas (30) through the cross-flow membrane module (20). Fouling of the membranes is relatively good prevented or reduced in time. Further, the liquid flow may be reduced relative to conventional configurations.

Abstract: An external pressure type hollow fiber membrane module, comprising a hollow fiber membrane bundle formed of a plurality of hollow fiber membranes, a housing, and an inlet/outlet nozzle for fluid, wherein hollow fiber membranes are fixedly adhered to each other and the hollow fiber membranes are fixedly adhered to the inner wall of the housing at both ends of the hollow fiber membrane bundle. The hollow part at one or both side adhesively-fixed ends is opened, and the inlet/outlet nozzle for fluid is installed at the side face of the housing at least at one adhesively-fixed end in which the hollow part is opened. Where the membrane occupied rates of the nozzle in a neighboring area (A) and a non-neighboring area (B) among membrane chargeable areas on the inside of the adhesively-fixed part at at least one adhesively-fixed end positioned near the nozzle and where the hollow part is opened are PA and PB, the ratio of the membrane occupied rates PB/PA is 0.50 to 0.95.

Abstract: In some embodiments, systems and methods are provided for purifying a liquid, such as an impaired water. In some examples, seawater or brackish water is purified, such as to a potable level. Some configurations provide a system which includes a membrane-distillation unit, such as a vacuum-enhanced direct contact membrane distillation unit. The system also includes a forward-osmosis system, which may include one or more forward-osmosis units. A concentrated draw stream from the membrane-distillation unit, such as a concentrated brine solution, serves as a draw solution for a forward-osmosis unit, which may extract water from a source water, such as an impaired water. In some implementations, the forward-osmosis system includes a second forward-osmosis unit which uses the diluted draw solution from the first forward-osmosis unit as a draw solution to extract water from a source water. The system may include additional components, such as a heater or a buffer tank.

Abstract: A novel separator assembly for a spiral flow reverse osmosis apparatus is provided. In one embodiment, the separator assembly comprises a central core element comprising at least two permeate exhaust conduits and not comprising a concentrate exhaust conduit. Each permeate exhaust conduit defines an exhaust channel and one or more openings allowing fluid communication between an exterior surface of the permeate exhaust conduit and the exhaust channel, said permeate exhaust conduits independently defining a cavity between said conduits. The cavity is configured to accommodate a first portion of a membrane stack assembly comprising at least one feed carrier layer, at least two permeate carrier layers, and at least two membrane layers. A first portion of the membrane stack assembly is disposed within the cavity, and a second portion of the membrane stack assembly is wound around the central core element and forms a multilayer membrane assembly disposed around the central core element.

Abstract: A Liquid-Liquid Extraction apparatus for extracting at least one species from a donor liquid solution (6) into at least one recipient liquid (8) is disclosed The apparatus comprises one or more cells comprising a cartridge (3) with an open macro-porous solid matrix made o a micro-porous material having affinity to an extractant material, so that a thin layer of liquid extractant may attach to the matrix.

Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

Abstract: The invention relates to a forward osmosis (FO) device (10) with a semipermeable membrane (5, 5a) capable of performing forward osmosis between a first (F1) and a second fluid (F2). In a first fluid confinement (4a), a first swirl generator (7a) is positioned and in a second fluid confinement (4b) positioned on the other second side of the membrane, a second swirl generator (7b) is positioned. The swirl generators are arranged to create a circular flow pattern (S2, S3) for the first and the second fluid, respectively, wherein the first (7a) and second (7b) swirl generator, upon engagement, are arranged to create a circular flow pattern for the first and the second fluid, respectively, by rotating motion (RA1, RA2). The invention is advantageous by obtaining FO device that is capable of reducing the concentration polarisation (CP) near the membrane by creating a cross flow velocity over the membrane and facilitate control of the cross flow velocity independent of the through flow of the membrane.

Abstract: The invention relates to a device for the equilibrium dialysis of fluids having small volumes. The object of the invention of creating a device for equilibrium dialysis , the device being designed as a simple as possible, being universally usable and reliable in the use thereof, with which a large ratio of the membrane surface to the sample volume is created and which facilitates very short diffusion paths inside the sample as well as low sample losses, even with small sample volumes, is achieved in that a device is proposed, which comprises corresponding capillaries (1, 1?), which are connected through a membrane (2) and each are open at the ends on both sides, said capillaries for dialysis purposes each comprising a preferably substantially U-shaped arched capillary portion, and the at least one opening (4, 4?) thereof being provided each with a sealing element for introducing and/or removing the liquid.

Abstract: The invention provides microfluidic devices and methods of using such devices for filtering solutions, such as blood.

Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.

Abstract: The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

Abstract: The present invention relates to a composite hollow fibre capillary membrane in particular for exploiting the value of dialysate and a method for the production thereof as well as its use in particular in haemo and peritoneal dialysis.

Abstract: The invention relates to a filter unit for purification of impure water, which could be seawater intended for ballast water, pool water, waste water or the like. The purification is performed by means of filter modules comprising filter means with dead end filter elements of a sintered material, and the filter unit facilitates alternating backwashing of the filter means at the same time as the filter unit may perform filtration of the impure water. The invention likewise relates to use of a dead end filter element in a de-gassing version, the filter element comprising a top end, a bottom end and a plurality of substantially parallel arranged channels with blockings in different ends.

Abstract: A system that is suitable for extracting plasma from blood received from a blood supply is provided. The system comprises a housing, an inlet opening for receiving the blood, a filtration chamber comprising a membrane, and a plasma compartment. The membrane forms a barrier between the blood and the plasma extracted from the blood, and the plasma compartment collects the plasma extracted from the blood. In some embodiments, the system comprises a plasma flow path compression chamber for pulling plasma across the membrane. In some embodiments, the system comprises a blood flow path compression chamber for facilitating blood flow. Some embodiments of the system further comprise means for measuring plasma and blood analytes using spectroscopic and biosensor techniques.

Abstract: This invention relates to filtration manifolds, filtration assemblies, methods of channeling permeate, and filtration units. Filtration assemblies may include filtration units and filtration manifolds having isolated permeate collection passages. Permeate may be channeled through the isolated permeate collection passages of the filtration manifold during filtration and then output from the manifold.

Abstract: The invention relates to a dialysis apparatus, comprising: a body with two planar sides, wells contained in the body, the wells being accessible from one planar side, a plurality of membranes for separating the wells into compartments, wherein each of said membranes is isolated one from another.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.

Abstract: A filter column module is disclosed, which has an upper column having a top opening, and a protruding bottom shell. The bottom shell has a plurality of apertures, and a diameter smaller than that of the upper column. A lower column has a support at the bottom and an opening that accommodates the protruding bottom shell of the upper column. The support partially contacts the protruding bottom shell of the upper column, and liquid or air can pass through the support. A filter is placed between the protruding bottom shell of the upper column and the support of the lower column.

Abstract: A dialysis system includes an extracorporeal circuit including a dialyzer; a dialysis fluid circuit including a first balance chamber, a second balance chamber, a fresh dialysis fluid pump in fluid communication with first and second fresh compartments of the first and second balance chambers, respectively, the first and second fresh compartments in fluid communication with a fresh dialysate fluid inlet of the dialyzer, and a spent dialysis fluid pump in fluid communication with first and second spent compartments of the first and second balance chambers, respectively, the spent dialysis fluid pump also in fluid communication with a spent dialysis fluid outlet of the dialyzer; and wherein the system is configured to run a priming sequence that uses (i) at least one of the fresh and spent dialysis fluid pumps and the first and second balance chambers to pump dialysis fluid through the dialysis fluid circuit and (ii) at least one of the fresh and spent dialysis fluid pumps to pump dialysis fluid through the dia

Abstract: An extracorporeal blood circuit defines a blood course comprising a first conduit (27) having an upturned U shape forming a curve with a convex external side facing upwards. The circuit has an infusion fluid course with a terminal tract (28) opening into the extracorporeal blood course at said convex external side. The first conduit and the terminal tract are integrated in a single rigid body (20). The circuit enables an optimal mixture between the blood flow and the infusion fluid flow in a relatively-small mixing space.

Abstract: The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.