Each Section Having Inlet(s) And Outlet(s) Patents (Class 210/321.72)
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Patent number: 7303674Abstract: There is disclosed a process and device for Forward Osmosis (FO) Pressurized Device (FOPD) in general and one hydraulically coupled to a reverse osmosis (RO device for a FOPRO (Forward Osmosis Pressurized Reverse Osmosis). Specifically, there is disclosed a passive device (that is, not needed energy input) for using forward osmosis to generate significant hydraulic pressure that can be used to drive a reverse osmosis process, wherein the reverse osmosis process (not needed external energy to run pumps) can separate salt from salt water to generate potable water from water with high salt content (such as sea water, urine, sweat, brackish water and the like).Type: GrantFiled: January 28, 2005Date of Patent: December 4, 2007Assignee: Hydration TechnologiesInventors: Keith Lampi, Edward Beaudry, Jack Herron
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Patent number: 7303666Abstract: A water filtration system includes a filter for receiving water to be filtered and having an output. A water storage vessel is connected to receive water from the filter output; and water is removed from the storage vessel and supplied back to the input of the filter, whereupon filtered water to be utilized is obtained solely from the output of the filter.Type: GrantFiled: September 22, 2004Date of Patent: December 4, 2007Inventor: Charles W. Mitsis
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Patent number: 7285106Abstract: A hemodiafiltration/hemofiltration cartridge is preferably formed of a single cartridge providing multi-stage hemofiltration and hemodiafiltration defined by a first hemodiafiltration stage having first filtering elements and a second hemofiltration stage having second filtering elements. Both stages are contained in a single cartridge. The cartridge can be used in a mid-dilution scheme, a pre-dilution scheme or a post-dilution scheme.Type: GrantFiled: December 11, 2001Date of Patent: October 23, 2007Assignee: Nephros, Inc.Inventors: Gregory R. Collins, James Summerton, Edward Spence
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Patent number: 7255788Abstract: A catchment header allowing a plurality of membrane modules to be connected thereto, having a tubular catchment part with a Young's modulus of 4.0 GPa or less for collecting and taking out filtrated liquid from the membrane modules, wherein at least a part of the tubular catchment part is covered with a reinforcement member with a Young's modulus of 4.0 to 250 GPa, the tubular catchment part of the catchment header is preferably formed of a synthetic resin, and the cross sectional area thereof perpendicular to the longitudinal direction of the tubular catchment part is preferably 4 to 36 cm2.Type: GrantFiled: February 6, 2003Date of Patent: August 14, 2007Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Hiroyuki Okazaki, Masumi Kobayashi, Kenji Honjou, Katsuyuki Yanone, Manabu Yanou
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Publication number: 20070151925Abstract: A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.Type: ApplicationFiled: December 22, 2006Publication date: July 5, 2007Applicant: SPF INNOVATIONS, LLCInventors: Gaston de los Reyes, Leon Mir
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Patent number: 7214301Abstract: Filter or filter-element designated for Modified Electro-Dialysis (MED) purposes characterized in that the filter or filter-element comprises a porous, ceramic, mainly uniform material with functional, preferably ion selective groups grafted onto the inner, porous surface of the ceramic body. The outer surface of the filter or filter-element may be completely or partly covered by layers of porous, ceramic membranes with a pore size of less than 1 ?m and thickness less than 1 mm, and/or anion, cation or bipolar groups or membranes. The thickness of the filter-element is larger than 1 mm and has pores of size larger than 1 ?m. The invention also relates to a method for the manufacture of such a filter either continuously by tape-casting, extruding, rolling or calendaring or single-bodied by casting, pressing or forging, of a paste containing a non-conductive, ceramic material.Type: GrantFiled: July 3, 2001Date of Patent: May 8, 2007Inventor: Bernt Thorstensen
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Patent number: 7182858Abstract: A filter apparatus is provided which includes a first filter membrane element (40a), and a second bacterial filter membrane element. The first viral filter element (40a) is capable of treating water at a first second flow rate and is adapted to remove contaminants which are larger than a first size, while the second bacterial filter element (40b) is capable of treating water at a second higher flow rate and is adapted to remove contaminants which are larger than a second contaminant size. The first and second filter elements (40a), (40b) may be commonly housed within a sealed housing. An accumulating vessel (60) is placed in fluid communication with an outlet of the first filter element (40a) and an outlet of the second filter element (40b). The filter apparatus includes a duck bill type check valve (75) made of an antimicrobial material intermediate the second filter element (40b) and a dispensing faucet (70).Type: GrantFiled: March 4, 2003Date of Patent: February 27, 2007Assignee: Kinetico IncorporatedInventors: Keith E. Brown, Paul Peterson, Stuart Park, Ron Kindel, Eric Sklar, John Miller, Ken Weight
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Patent number: 7156996Abstract: The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.Type: GrantFiled: September 2, 2003Date of Patent: January 2, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Manfred Watzele, Bernd Buchberger, Hans Schels, Horst Menzler, Ulrike Fischer
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Patent number: 7128836Abstract: A dialysis apparatus for treating a patient with liver and/or kidney disease. In one embodiment a liver dialysis apparatus comprises an artificial liver. The artificial liver comprises a blood compartment, a vegetable protein compartment, and a clear dialysis compartment. In another embodiment the liver dialysis apparatus comprises cartridge made up of at least one layer of vegetable protein. In a further embodiment of the invention a dialysate regeneration device is provided which comprises at least one layer of vegetable protein. The vegetable protein is preferably a soy protein. The soy protein may be unmodified soy protein with urease enzyme activity, modified soy protein with or without urease activity, alone or in combination.Type: GrantFiled: March 8, 2004Date of Patent: October 31, 2006Inventors: Potito De Paolis, Saleh Slehmoghaddam
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Patent number: 7125393Abstract: A device for carrying fluids for a medical treatment device with two balancing chambers, each having two partial chambers. The filling times of the partial chambers are initially determined using a monitoring device, and then the filling times of the first partial chambers of the first and second balancing chambers, are compared to the filling times of the second partial chambers of the first and second balancing chambers, respectively, to detect leakage or an incomplete filling or discharging of the respective partial chambers.Type: GrantFiled: August 21, 2003Date of Patent: October 24, 2006Assignee: Fresenius Medical Care Deutschland GmbHInventors: Helge Brauer, Walter Ehrenberger, Helmuth Ender, Joachim Noack
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Patent number: 7077953Abstract: An acid recovery system used in a hydrolysis operation includes a chromatographic unit to provide initial separation of sugar and acid. The sugar product provided by the chromatographic unit is processed to produce higher value products, such as ethanol. The remaining acid is contaminated by sugar. A nanofiltration unit containing a nanofilter membrane processes the sugar contaminated acid. The acid is allowed to permeate across the nanofilter membrane while sugar is rejected. The permeate is provided to a conventional acid recovery system and recycled for use in the hydrolysis process.Type: GrantFiled: September 11, 2003Date of Patent: July 18, 2006Assignee: Harris Group, Inc.Inventor: Jeffrey T. Ranney
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Patent number: 7074332Abstract: In a blood dialysis system including a source of substitution fluid (10) and a blood dialysis machine, a hemodiafiltration system having a first dialyzer (1) including a first blood compartment (4) having a first blood inlet which receives blood to be cleaned and a first blood outlet which discharges partially diafiltered blood and a first dialysate compartment (5) having a first dialysate inlet and a first dialysate outlet, means (8) for mixing the partially diafiltered blood with substitution fluid from the source to obtain a blood/substitution fluid mixture, and a second hemofilter (2) including a second blood compartment (11) having a second blood inlet which receives the blood/substitution fluid mixture and a second blood outlet which discharges filtered blood and a second permeate compartment (12) having a second permeate outlet.Type: GrantFiled: December 20, 2001Date of Patent: July 11, 2006Assignee: Nephros, Inc.Inventors: James Summerton, Gregory R. Collins, Edward Spence
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Patent number: 7067060Abstract: A dual-stage system and methods for using the same include first and second filtration cartridges is provided and is particularly suited for hemodiafiltration and/or hemodialysis. As fluid enters the first filtration cartridge, the hydroxyl ion concentration and hence pH is increased by exposing it to either a strong base or a salt of a weak acid across a filter membrane. This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at higher pH. As the filtered fluid enters the second filtration cartridge, the pH of the fluid is restored to normal levels prior to infusion to a patient.Type: GrantFiled: September 24, 2004Date of Patent: June 27, 2006Assignee: Nephros, Inc.Inventors: Gregory R. Collins, James Summerton, Edward Spence
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Patent number: 7063216Abstract: The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.Type: GrantFiled: September 4, 2003Date of Patent: June 20, 2006Assignee: Millipore CorporationInventors: Joseph P. Lane, Louis L. Bonhomme, Douglas A. Boucher, Richard T. Burnham, Kenneth G. Desilets, Luc Lirot, Stéphane Jean Marie Olivier, Steven D. Sheridan
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Patent number: 7048856Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.Type: GrantFiled: September 11, 2003Date of Patent: May 23, 2006Assignees: Regents of the University of Michigan, Cleveland Clinic FoundationInventors: William H. Fissell, IV, H. David Humes, Shuvo Roy, Aaron Fleischman
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Patent number: 6955655Abstract: A hemofiltration system and method is provided that allows for high flow rate, accurate determination of net fluid withdrawal from or addition to a patient, and simple and reliable home operation. A removable, disposable assembly includes a filter housing and pump member including one or more fluid conduits mounted against the pump member. When the disposable filter/pump member assembly is attached to the treatment system, a pump roller mechanism associated with the system actuates the conduits mounted against the pump member. A disposable waste receptacle and fluid replacement (infusate) reservoir can be provided as an integral part of the disposable filter/pump member assembly.Type: GrantFiled: June 27, 2001Date of Patent: October 18, 2005Assignee: NxStage Medical, Inc.Inventors: Jeffrey H. Burbank, Charles D. Finch, Jr., James M. Brugger
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Patent number: 6918886Abstract: A membrane module for hemodiafiltration having a cylinder-shaped housing and a bundle of hollow-fiber membranes capable of supporting fluid flow and arranged in the direction of the longitudinal extent of the housing. The ends of the hollow-fiber membranes are embedded in a fluid-tight manner in first and second sealing compounds joined to the housing inner wall in a fluid-tight manner. The exterior space formed around the hollow-fiber membranes and delimited by the first and second sealing compounds and the housing inner wall is divided along the longitudinal extent of the housing into a dialyzate space and a substituate space by a dividing wall that is made from a substantially dimensionally stable material. The dividing wall encloses each hollow-fiber membrane and is arranged substantially transversely to the hollow-fiber membranes. The dialyzate space and substituate space each have at least one opening for introducing or draining a fluid.Type: GrantFiled: September 20, 2000Date of Patent: July 19, 2005Assignee: Membrana GmbHInventor: Ulrich Baurmeister
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Patent number: 6916424Abstract: This invention provides a method and apparatus for a hemodiafiltration delivery module that is used in conjunction with a UF controlled dialysis machine to enable hemodiafiltration therapy to be performed. The advantage is that one can fully utilize a current functioning dialysis machine to perform a hemodiafiltration therapy as opposed to purchasing a completely new machine that offers this capability.Type: GrantFiled: February 7, 2002Date of Patent: July 12, 2005Assignee: Nephros, Inc.Inventors: Gregory R Collins, James Summerton, Edward Spence
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Patent number: 6872315Abstract: The present invention concerns a method of producing flow rates of a transport liquid of about 1 to 1000 nl/min. The method provides a pump having a housing defining a space and including a channel and a wettable membrane positioned in the housing, the membrane including a first side facing toward the channel and a second side facing the space. The method further includes at least partially filling the channel with the transport liquid, contacting the wettable membrane with the transport liquid to generate an underpressure in the channel,evaporating the transport liquid at the wettable membrane to remove the transport liquid from the channel and to create an underpressure in the channel, and maintaining a generally constant vapor pressure of the transport liquid in the space.Type: GrantFiled: August 5, 2004Date of Patent: March 29, 2005Assignee: Roche Diagnostics CorporationInventors: Carlo Effenhauser, Herbert Harttig, Peter Kraemer
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Patent number: 6860993Abstract: The present invention concerns a pump for flow rates from about 1 to 1000 nl/min in which liquid transport takes place by evaporation of a transport liquid through a wettable membrane. The pumps according to the invention are particularly suitable for applications in the field of medical diagnostics such as microdialysis or ultrafiltration.Type: GrantFiled: June 19, 2001Date of Patent: March 1, 2005Assignee: Roche Diagnostics CorporationInventors: Carlo Effenhauser, Herbert Harttig, Peter Kraemer
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Patent number: 6858146Abstract: Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes (23) which are either unattached or attached to inert carriers and suspended in a cell culture medium which circulates in the devices with the hepatocytes (23). Blood or plasma passes on one side (7?) of semi-permeable membranes, on the other side (7) of which is the cell culture medium and across which is a concentration and/or pressure gradient. Solutes diffusing across the membrane into the cell culture medium are metabolized by the hepatocytes (23) and/or captured by additional removal means (4). Those undesirable substances which do not diffuse out of the blood or plasma into the hepatocyte containing culture medium are captured by additional removal means (50).Type: GrantFiled: September 27, 1994Date of Patent: February 22, 2005Assignee: XenogenicsInventors: Edward F. Myers, Albert P. Li, Achilles A. Demetriou
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Patent number: 6849184Abstract: There is disclosed a process and device for Forward Osmosis (FO) Pressurized Device (FOPD) in general and one hydraulically coupled to a reverse osmosis (RO device for a FOPRO (Forward Osmosis Pressurized Reverse Osmosis). Specifically, there is disclosed a passive device (that is, not needed energy input) for using forward osmosis to generate significant hydraulic pressure that can be used to drive a reverse osmosis process, wherein the reverse osmosis process (not needed external energy to run pumps) can separate salt from salt water to generate potable water from water with high salt content (such as sea water, urine, sweat, brackish water and the like).Type: GrantFiled: December 11, 2002Date of Patent: February 1, 2005Assignee: Hydration Technologies Inc.Inventors: Keith Lampi, Edward Beaudry, Jack Herron
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Patent number: 6843779Abstract: An apparatus and method for use in blood dialysis. The apparatus includes: two dialyzers each containing a semipermeable membrane that divides the dialyzer into a blood compartment and a dialysate compartment; a blood compartment connecting line connecting the blood compartments of the dialyzers together in series; blood connecting lines for connecting the blood compartments to the vascular system of a patient; a dialysate compartment connecting unit connecting the dialysate compartments of the dialyzers together in series; and dialysate connecting lines for connecting the dialysate compartments to a dialysis machine. The dialysate compartment connecting unit includes an adjustable flow varying device for controllably setting the rate of the flow of dialysate through the connecting unit.Type: GrantFiled: September 17, 2001Date of Patent: January 18, 2005Assignee: MiriMedical, LLCInventors: Philip Andrysiak, Gary Mishkin
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Publication number: 20040256307Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: May 28, 2004Publication date: December 23, 2004Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 6821431Abstract: A dual-stage system and methods for using the same include first and second filtration cartridges is provided and is particularly suited for hemodiafiltration and/or hemodialysis. As fluid enters the first diafiltration cartridge, the hydrogenion concentration (pH) is reduced by exposing it to an acidic solution such as citric acid across a filter membrane. This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at lower pH. As the filtered fluid enters the second filtration cartridge, the pH of the fluid is restored to normal levels prior to infusion to a patient.Type: GrantFiled: July 9, 2002Date of Patent: November 23, 2004Assignee: Nephros, Inc.Inventors: Gregory R. Collins, James Summerton, Edward Spence
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Publication number: 20040222156Abstract: The invention discloses an apparatus for filtration of water from hydrocarbons comprised of a fresh-feed inlet, a first dead end filter, that is hydrophobic, a second sweeping-flow filter, that is hydrophobic, a common housing containing both the first and second filters, a system for the recirculation of the retentate, a chamber for water settling, and an outlet for clean fuel permeate. This invention takes advantage of the properties of the functional groups of a surfactant, by using the surfactant to allow a hydrophobic medium to attract water, attach the water molecules to the hydrophobic medium, and then allow for agglomeration of the water molecules, which finally become large enough to detach and be swept away by the sweeping-flow. This invention can thus be used to remove high concentrations of water, up to 5%, in hydrocarbons, while allowing a high flow rate by preventing blockage of the final filter by water.Type: ApplicationFiled: June 9, 2004Publication date: November 11, 2004Inventors: Guanghua Yu, Chang-Wei Jen, Thierry Montfort
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Patent number: 6802821Abstract: A dialyzer design that includes a potting material encasing a microfiber bundle in each end of a cylindrical body. The potting material is set by spinning the dialyzer in a centrifuge to force the potting material to the ends of the dialyzer interior chamber, where it sets with a non-planar surface. Dialysate fluid distribution rings define a space between the dialyzer interior chamber and dialyzer inlet and outlet ports, and laterally support the microfiber bundle against the dialysate fluid flow pressure. The dialysate fluid distribution ring circumferential edge substantially conforms to the non-planar potting material surface, to ensure that the lateral support to the microfiber bundle is constant, thereby lessening distortion, rupturing and obstruction of the microfibers.Type: GrantFiled: October 1, 2001Date of Patent: October 12, 2004Assignee: Fresenius USA, Inc.Inventors: Veronica Lee Jacobsen, Stephen Kuykendall, Olli Touminen, Troy McGhee
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Publication number: 20040195163Abstract: The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.Type: ApplicationFiled: September 2, 2003Publication date: October 7, 2004Inventors: Manfred Watzele, Bernd Buchberger, Hans Schels, Horst Menzler, Ulrike Fischer
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Patent number: 6797173Abstract: An apparatus and method suitable for use in a reverse osmosis system has a process chamber having a feed inlet, a low pressure outlet and a high pressure outlet. A feed pump is used to increase the feed pressure to process the process chamber. A common shaft having rotatably coupled thereto a booster pump fluidically coupled between the feed pump and the feed inlet and an energy recovery turbine fluidically coupled to the high pressure concentrate outlet. The energy recovery turbine drives the booster pump.Type: GrantFiled: October 31, 2000Date of Patent: September 28, 2004Inventor: Eli Oklejas, Jr.
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Publication number: 20040182771Abstract: A method of potting a plurality of hollow fiber membranes into a mass of solidified potting liquid is described. Open ends of a plurality of hollow fiber membranes are enclosed in a first material held in a container which may be a part of a permeate collection means, for example, a permeate pan or header enclosure. A potting liquid is flowed into the container over the first material. The potting liquid surrounds each hollow fiber membrane and then becomes a solid mass that provides a fluid-tight seal to the outside of the hollow fiber membranes. The first material prevents the potting liquid or solid mass from closing the ends of the membranes. The first material is later removed from the ends of the hollow fiber membranes.Type: ApplicationFiled: January 30, 2004Publication date: September 23, 2004Inventors: Mailvaganam Mahendran, Steven Kristian Pedersen
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Patent number: 6766259Abstract: A system and a method are provided for detecting fiber damage in a dialyzer. The system may have a device which may transmit a gas into an interior of a fiber within a dialyzer. The temperature of the gas may be different than a temperature of the dialyzer. A thermal imaging camera may detect a temperature difference at a surface of the fiber where the gas may be escaping. The thermal imaging camera may be connected to a monitor which enables a user to view a location of the difference in temperature. As a result, the user may locate the damaged area of the fiber. The user may then repair the damaged area.Type: GrantFiled: July 29, 2002Date of Patent: July 20, 2004Assignee: Baxter International Inc.Inventors: William Brandon Padgett, Ralph Steven Kesler, Michael E. Cameron, Roger D. Horton
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Patent number: 6758971Abstract: A medical filter (11) is constructed as a container with an interior volume in open fluid communication with a patient connection element (31) and a transport connection element (39). Filter support structure (13) mounted within the interior is structured as a thin, perforated member (14) carrying hydrophilic filter medium (17). A first flow path directs spent dialysate from the patient across the surface of the filter medium (17) to the transport connection (39). A second flow path directs fresh dialyalysate from the transport connection (39) through the filter medium (17) and the perforated support structure (13) to the patient connection (31).Type: GrantFiled: February 26, 2001Date of Patent: July 6, 2004Assignee: Sorenson Development, Inc.Inventor: LeVoy G. Haight
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Publication number: 20040104153Abstract: A portable water purifier having a housing, a handle, an input tube, an output valve, a power supply line, and a water purification system. This water purification system includes a preliminary filter, a pump, two reverse osmosis units and a discharge tube. The preliminary filter can be placed in a river or a lake. The power supply line can connect to an electric energy source, such as electric generator, solar electric generator, and so on. So, it is very convenient to use it indoors or outdoors.Type: ApplicationFiled: November 29, 2002Publication date: June 3, 2004Inventor: Chung-Hsiang Yang
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Patent number: 6742659Abstract: The present invention provides for a multiple well filter plate and method of producing same, the multiple well filter plate comprising a molded plate and a filter sealed via an adhesive, the method particularly adapted for producing multiple well filter plate having substantial well densities and small volume sample wells.Type: GrantFiled: April 27, 2001Date of Patent: June 1, 2004Assignee: Millipore CorporationInventors: Phillip Clark, Kurt Lautenschlager
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Patent number: 6719907Abstract: A dual-stage filtration cartridge is provided. The cartridge can be embodied as a mid-dilution hemodiafiltration cartridge or a redundant sterilization filtration cartridge. The cartridge includes a housing having a first end and an opposing second end. The housing has a primary fluid inlet and outlet at the first end of the cartridge. The housing also defines first and second filtration stages with the first filtration stage including first filtering elements disposed between the first and second ends of the housing. Each stage has a separate inter-lumen fiber space, but shares a common extra-lumen space. The primary fluid inlet communicates with the first filtering elements at the first end so that fluid flows through the first filtering elements toward the second end. The second filtration stage includes second filtering elements disposed between the first and second ends of the housing with the fluid outlet communicating with the second filtering elements at the first end.Type: GrantFiled: October 30, 2001Date of Patent: April 13, 2004Assignee: Nephros, Inc.Inventors: Gregory R Collins, James Summerton, Edward Spence
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Patent number: 6716356Abstract: The present invention provides a hemodialysis or hemodiafiltration system and method using two dialyzer stages (122, 138), wherein the temperature of a dialysate fluid stream of the first cartridge (122) is increased such that the blood in the first cartridge (122) is dialyzed or diafiltered at an elevated temperature, while blood in the second cartridge (138) is dialyzed or diafiltered against a dialysate stream at normal blood temperature. This results in an increased solute diffusivity and a corresponding increase in removal of blood substances by diffusion. When diafiltration is performed, an additional removal of substances occurs by convection as a larger portion of plasma water from a blood compartment (142) can be filtered across a semi-permeable membrance (140) at the same transmembrane pressure due to the reduced viscosity of the heated blood and plasma water.Type: GrantFiled: December 6, 2001Date of Patent: April 6, 2004Assignee: Nephros, Inc.Inventors: Gregory R. Collins, James Summerton, Edward Spence
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Publication number: 20040004037Abstract: There is disclosed a hydration bag for providing potable or even sterile water from contaminated water sources. Specifically, there is disclosed two embodiments of a passive membrane osmotic device. The first embodiment has an interior space sealed with one or two membrane walls, having an osmotic agent formulation within the interior space, and having direct osmotic concentration properties. The second embodiment has a sealable nutrient/osmotic agent chamber with a spiral wound membrane wrapped around the nutrient/osmotic agent chamber to form the membrane element, wherein the membrane element is located within a sealable dirty water compartment or within a dirty water source and wherein the membrane element communicates with a clean water compartment. More specifically, the osmotic agent or nutrient can be a partially dehydrated food source, a sugar, a medicine, or combinations thereof.Type: ApplicationFiled: December 11, 2002Publication date: January 8, 2004Inventor: Jack Herron
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Publication number: 20030220599Abstract: A method, system and apparatus for performing peritoneal dialysis are provided. To this end, in part, a device for organizing a number of tubes extending from a unit of a medical fluid system is provided. The organizing device includes a body having a number of openings that each can removably receive an end of one of the number of tubes.Type: ApplicationFiled: May 24, 2002Publication date: November 27, 2003Inventors: Loren M. Lundtveit, Jose Alvaro, Joseph H. Bowman, Dan O'Sullivan, Stan Thompson
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Publication number: 20030213740Abstract: This invention relates to equilibrium dialysis systems in multi-well formats for simultaneously preparing multiple samples. The equilibrium dialysis systems described herein may be made in 8-well, 12-well, 96-well, 384-well, 1536-well or other multi-well formats. The equilibrium dialysis systems can be used for protein binding assays, molecule-molecule interaction studies, tissue cultures and many other biological and chemical applications.Type: ApplicationFiled: December 4, 2002Publication date: November 20, 2003Inventor: Andrew Creasey
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Patent number: 6649047Abstract: A protection system arranged to prevent a large trans-membrane pressure difference over a pressure sensitive membrane (4) fitted in a pressure resistant chamber (3), wherein the membrane forms a physical barrier between a liquid and a gas mixture carried through the chamber (3), the protection system includes two shut-off valves (9, 10) provided in the liquid inlet and outlet lines respectively, a buffer tank (3) provided in the line between one of the shut-off valves (9, 10) and the pressure resistant chamber (3), a pressure equalizing valve (12) provided between the gas inlet line (8) and the buffer tank (2) and a pressure sensing valve (14) for measuring the pressure difference over the membrane (4) and which activates the shut-off valves (9, 10) once this pressure difference exceeds a predetermined value.Type: GrantFiled: May 2, 2002Date of Patent: November 18, 2003Assignee: K.V. Aerner Process Systems ASInventor: Nils T. Ottestad
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Patent number: 6635026Abstract: A haemofiltration machine designed to work with a haemofilter comprises two compartments separated by a semipermeable membrane, one compartment having an inlet connected to a withdrawing tube for taking blood from the patient and an outlet connected to a blood return tube, the other having an outlet connected to a tube for removing used liquid.Type: GrantFiled: November 6, 2000Date of Patent: October 21, 2003Assignee: Hospal IndustrieInventor: Bernard Béné
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Patent number: 6623638Abstract: A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inlet and includes a plurality of flutes that extend into a portion of the fiber bundles, the flutes define an opening for allowing dialysate to flow from the inlet fluid channel into the interior of the casing. Methods of providing dialysis are also provided.Type: GrantFiled: June 1, 2001Date of Patent: September 23, 2003Assignee: Baxter International Inc.Inventors: Randolph H. Watkins, James S. Slepicka, Michael R. Prisco
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Publication number: 20030173285Abstract: An improved wide passage cross-flow filtration cassette is disclosed that incorporates an open mesh matrix retentate spacer that is dimensioned and oriented so as to improve flux and cause turbulence in the flow of fluids through the cassette.Type: ApplicationFiled: October 28, 2002Publication date: September 18, 2003Inventors: Hans-Weddo Schmidt, Ulrich Grummert, Ina Pahl, Claudia Hartmann
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Patent number: 6620314Abstract: A unit 1 for producing pyrogen controlled water on a small to medium factory scale comprises a number of charged ultrafiltration units 10 arranged in parallel. Orifice plates 15 are used to restrict and control the flow of deionized water to each filter 10. The filter units 10 are mounted on a frame 2 with a wheeled chassis 3 which may be pushed or moved by a forklift truck to a site where pyrogen controlled water is required. The unit 1 has an inlet line 4 for connection to a supply of deionized water and an outlet line 6 for connection to a user of pyrogen controlled water. The unit 1 may be purged with nitrogen from a supply 18. Sampling ports 17 in a common supply inlet 4 and a common outlet 6 ensure that the filtration efficiency can be closely monitored. The flow of water is monitored by a flowmeter 19 and pressure sensors 16 upstream of each filter facilitate a high level of control.Type: GrantFiled: June 14, 2002Date of Patent: September 16, 2003Assignee: Warner-Lambert CompanyInventors: William Tully, Evelyn Madigan
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Publication number: 20030111402Abstract: An apparatus for the separation of fluid mixtures into a permeate and a retentate comprises separation modules each having fluid containment chambers stacked therein. Each fluid containment chamber is defined by a pair of selectively permeable membranes having their active surfaces facing inwardly toward one another, with a gasket sandwiched therebetween in sealing engagement with each membrane. A channelled support plate is positioned adjacent to the outside surface of each membrane. The channels in the support plates fluidly communicate with a housing, thereby allowing negative pressure from the housing to be brought into direct contact with the outside surface of each selectively permeable membrane. The fluid mixture is pumped into each fluid containment chamber at one end and moves across the active surfaces of the membranes toward a retentate receiver positioned at the opposite end. In doing so, permeate is drawn out through both membranes into the channels and the housing.Type: ApplicationFiled: December 19, 2001Publication date: June 19, 2003Applicant: Petro Sep International Ltd.Inventors: Fakhir U. Baig, Abdul M. Kazi, Aiser Al-Hassani
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Publication number: 20030111414Abstract: Membrane module for substance-specific treatment of fluids, in which are arranged first and second membrane elements (1, 2) with one end pointing toward a distribution space (8) and the other toward a collection space (9), each having a cavity (10,11) formed by the membrane wall. The first membrane elements (1) have their ends embedded in sealing compounds (4, 5) such that their cavities are open and open into the distribution space (8) and collection space (9). The second membrane elements (2) are also embedded in the sealing compound (5) at the end pointing toward the collection space (9), their cavities opening into the collection space, but are closed at the end pointing toward the distribution space (8).Type: ApplicationFiled: November 12, 2002Publication date: June 19, 2003Inventors: Ulrich Baurmeister, Rudolf Wollbeck
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Patent number: 6579451Abstract: The water desalting installation comprises at least an auxiliary pump (1) and another high pressure pump (2) in parallel with an internal circulation pump (3), and at least one pair of feed chamber (5 and 5′) which are pressurized alternatively, each of them forming a closed circuit, preferably toroidal, so that the water circulates always in the same direction and continuously, taking advantage of its kinetic energy in the valve actuation; it may have separation means to separate the water masses of different salinity, said separation means being comprised of pistons (7 and 7′) having a spherical shape and of which the apparent density is similar to that of the water, said pistons being retained briefly during the cycle change by baskets (6 and 6′) or equivalent devices, while the water circulates to the expense of its kinetic energy, the cycle changes being controlled by approximation (29 and 29′) and housing (28 and 28′) sensors, or by flowmeters (31, 31′ and 32) or by sType: GrantFiled: December 28, 2000Date of Patent: June 17, 2003Inventor: Manuel Barreto Avero
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Patent number: 6521127Abstract: A filtration system includes production modules (305) which are mechanically coupled in series, and which contain filters that are fluidly coupled in parallel. Among the many different possibilities contemplated, each production module may advantageously contain not only a filter (314), but also flowpaths for feed fluid (334a), waste fluid (334b), and product fluid (334c) so that a series of coupled modules can be installed, accessed, and removed as single unit. It is further contemplated that coupled modules may be deployed in space efficient manner, such as by insertion into a deep or shall well, a tower, along the ground, into the side of a hill or mountain, or even under a road or parking lot. It is still further contemplated that adjacent production modules may be designed to mate with one another using a slip fit joint, and that the production modules may be maintained in mating relationship through connections to supporting cables or rods.Type: GrantFiled: October 29, 1999Date of Patent: February 18, 2003Assignee: Nate InternationalInventor: Dennis Chancellor
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Patent number: 6511599Abstract: A filter filters fluid flowing along an axial flow direction and includes a plurality of concentric cylindrical pleated filter elements having a common axis. A plurality of annular radial gaps between filter elements provide additional flow axially through the filter, providing equalized flow and reducing restriction. In further embodiments, a central filter element is concentrically surrounded by a cylindrical pleated outer filter element and provides additional flow axially therethrough.Type: GrantFiled: December 18, 2000Date of Patent: January 28, 2003Assignee: Nelson Industries, Inc.Inventors: Tadeusz Jaroszczyk, Kent J. Kallsen, Jason E. Dorgan, Z. Gerald Liu, Stephen L. Fallon, James A. Debilzen, Larry T. Gunderson, Brad Henke, Jeffrey S. Morgan
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Patent number: H2168Abstract: Elongated processing elements are anchored at opposite ends thereof between holding discs retained within rigid seal rings enclosing a chamber within a cylindrical module housing, through which a flow of contaminate-laden bilgewater is conducted. Such discs are formed within the seal rings with the elongated elements positioned therein by deposit and curing of epoxy resin. Such elements are then assembled within the module housing to seal the chamber thereby established therein. Spacing between the bundled elements is maintained by spacers to accommodate filtration of the bilgewater during flow thereof through the chamber and lateral outflow of a cleansed filtered portion from the elements through a drain outlet.Type: GrantFiled: June 13, 2001Date of Patent: September 5, 2006Assignee: The United States of America as represented by the Secretary of the NavyInventors: William M. Appleman, Lawrence P. Murphy