Abstract: The present invention provides an allergen inhibitor which effectively prevents allergens from reacting with specific antibodies, mitigates the allergic symptoms or prevents appearance thereof, and is less likely to cause unpredictable discoloration and discoloration under usual conditions. The allergen inhibitor of the present invention comprises an allergen-inhibiting compound including a linear polymer having at least one of substituents represented by the formulas (1) to (3) at a side chain. Thus, the allergen inhibitor of the present invention shows excellent allergen-inhibiting effects.

Abstract: A system includes a UV light source and an optical medium coupled to receive UV light from the UV light source. The optical medium is configured to emit UV light proximate to a surface to be protected from biofouling. A method corresponds to the system.

Abstract: A mobile device for transporting, tracking and processing medical instruments. The device comprises a cart including at least one receptacle for receiving an instrument container having instruments stored therein. The cart also includes plumbing for circulating processing fluids through the instrument container and a communications system for communicating tracking data associated with the instrument container and the cart.

Abstract: A surgical instrument support tray and method of sterilization comprising, in general, a first surface configured with a pattern of apertures, each aperture configured to support the surgical instrument, a second surface configured with a pattern of finger and positioned in parallel proximity to the first surface, wherein the second surface is configured to slide relative to the first surface and releasably lock the surgical instrument therebetween and, thus such apparatus, functions to removeably secure surgical instrument in group for identification, cleaning, sterilization and storage prior to surgery.

Abstract: The present invention relates to a sterilization and disinfection apparatus. In particular, the present invention relates to a sterilization and disinfection apparatus for surgical equipment. Thus preferred embodiments may have a number of advantages over the prior art which can include: reduced risk of spillage of the sterilization fluid outside the sterilization apparatus; reduced risk of contamination of the equipment after sterilization through inadvertent contact with the equipment by the user; economy of use of the sterilization fluid; improved convenience of transport and storage of sterilized equipment in the sterilization apparatus; automatic override procedure to reduce the risk of overexposure of the equipment to the sterilization fluid if the correct sterilization cycle is not followed; automatic control of contact time of the equipment with the sterilization fluid to avoid over processing and resultant damage; and data logging to provide traceability of the previous sterilization cycles used.

Abstract: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.

Abstract: A mobile deactivation apparatus for deactivating contaminants within a defined region that includes a source of a vaporous deactivating agent, a gas handling system, a support member, a drive means, a control system, and a power system is disclosed. The gas handling system dispenses the vaporous deactivating agent to the defined region. The support member is movable in the defined region and supports the source of the vaporous deactivating agent and the gas handling system. The support member can be propelled by the drive means. The control system is programmed to control the operation of the gas handling system and the drive means. A power system is provided to supply power to the mobile deactivation apparatus.

Abstract: A method provides for sterilizing with radiation objects which have a low bioburden and which are sensitive to radiation. A dosage of radiation sufficient to ensure sterilization without damaging the object is determined by determining the bioburden upon one or more samples of the objects, determining an estimate of the dose that results in a preselected probability (e.g., 0.1, 0.01, 0.001, 0.0003162 . . . etc. (i.e., SAL=10?1, 10?2, 10?3, 10?3.5 . . . etc.

Abstract: A grommet device and method of using a grommet device is provided. A top structure has a top surface. An aperture having a central axis is positioned interior of the top structure. A sidewall is formed around the aperture and connected to the top structure. The sidewall is positioned substantially perpendicular from the top surface of the top structure. At least two upper protruding structures are connected to the top structure at different locations along the top structure, wherein each of the upper protruding structures extends into the aperture. At least two lower protruding structures extend from the sidewall at different locations along the sidewall, wherein each of the lower protruding structures have a flexing portion extending into the aperture, wherein each of the upper protruding structures are substantially radially aligned with the flexing portion of each of the lower protruding structures, respectively.

Abstract: The present invention provides for a process for preserving biological material. The process comprises subjecting the biological material to a fixation process and then packaging the biological material in a container under a controlled atmosphere of noble gas. In the process, the controlled atmosphere of noble gas utilized comprises one or more noble gases selected from argon, xenon, helium, neon, krypton and radon. The process optionally also utilizes one or more additional gases selected from nitric oxide, hydrogen, hydrogen sulfide, carbon monoxide, carbon dioxide, nitrogen and oxygen. This process allows for the long term storage of the biological material.

Abstract: An assembly and method for treating or otherwise improving an atmosphere contained within an enclosed space. The enclosed space can be a container such as a bag or other housing for equipment, food and/or suitable material. Ozone is generated within an atmosphere that is exposed to the material. The generated ozone is mixed with the atmosphere. At least a portion of the generated ozone is then removed from the mixed atmosphere. The assembly and method can be used to treat contaminated sports equipment and the like, as well as to treat food storage atmospheres, such as those exposed to fresh fruits and vegetables.

Abstract: The present invention relates to a bio-silica chip comprising a silica-binding protein and a fabrication method thereof, and more particularly to a bio-silica chip in which a fusion protein of a silica-binding protein and a probe protein is immobilized on a chip comprising a silica layer, a fabrication method thereof and a method of using the bio-silica chip to detect interactions with biomaterials. The bio-silica chip will be very useful in biosensors, etc., because the bio-silica chip is advantageous in that it does not cause non-specific protein binding in the detection of protein-DNA, protein-ligand, protein-antibody, protein-peptide, protein-carbohydrate, protein-protein and cell-biomaterial interactions. Also, in the method for fabricating the bio-silica chip, a probe chip can be selectively immobilized on a silica device chip, which is widely used in biosensors, without a chemical surface treatment process.

Abstract: A laryngoscope disinfector characterized by a drawer that provides positioning for laryngoscopes in the drawer so that all surfaces of the laryngoscopes are exposed to ultraviolet radiation. The drawer provides for the laryngoscope blades to be positioned generally horizontally and generally vertically for disinfection of the blades. The drawer also provides, in some embodiments, positioning for the laryngoscope handles.

Abstract: The invention relates to methods and apparatus for preventing the contraction of the causative agents of infectious diseases, such as, for example, bacteria and viruses by way of the most common public activities, via the interaction of commerce and the exchange of monetary goods. More specifically, the invention generally relates to methods and apparatus for sterilizing commerce media using the germicidal properties of ultraviolet light and/or ozone.

Abstract: The sterilizing toybox apparatus addresses illness risk, especially with children, by providing UV light sterilization within. UV lighting is offered both above and beyond toys within the apparatus. A time-release latch ensures exposure for a time determined to be optimal for UV exposure of contents. The apparatus provides UV lighting both in the bottom of the chest and in the lid. The clear shelf above the lower UV bulbs is in communication with the vibrator that jostles any toys so that full UV exposure is ensured. Reflective material distributed fully within the chest further guarantees full exposure of contents to sterilization. Additionally, the optional mesh basket is selectively suspended within the chest.

Abstract: The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.

Abstract: The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.

Abstract: The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.

Abstract: The apparatus and method for sterilising caps/stoppers for pharmaceutical purposes comprises a vessel, pump, heater, circulation line. The sterilising liquid (hot water, steam) is heated and pumped to the vessel where a fluidised bed of caps etc. is generated. After leaving the vessel the liquid is circulated/heated. Optionally an additive (siliconisation in case rubber parts) or cooling liquid is added. Further, the vessel is disconnectably attached to the supply lines for transportation to a production facility.

Abstract: A sterilization system includes a plurality of vaporizers that are controlled by a network of interconnected controllers. The network includes a plurality of control units with each control unit controlling an associated vaporizer to adjust independently the rate at which the associated vaporizer injects vaporized sterilant into the different regions of an enclosure. The network also includes a master control unit configured to control each control unit over the network to coordinate the aggregate injection of sterilant vapor.

Abstract: Provided are viscous and adherent food-safe antimicrobial compositions, and methods for using same in the immediate and residual decontamination of microbial-contaminated substrate surfaces, in reducing or precluding cutting implement-mediated transfer of surface contamination during cutting operations in the food industry, and for reducing or preventing transfer of contamination from contaminated surfaces in the food and pharmaceutical industries. Adherent antimicrobial protective layers are formed on substrate surfaces (e.g., processing equipment and utensils), providing a barrier (e.g., chemical and/or physical) to the passage or transport of microbial contamination between and among surfaces.

Abstract: A method of sterilizing a closed environment is provided in which a disinfection apparatus is placed into the closed environment; it then generates ozone to a predetermined ozone concentration, following which the humidity of the closed environment is rapidly increased. A catalytic converter then reduces the ozone concentration to safe levels. When the ozone concentration is reduced to a predetermined safe level, the disinfection apparatus signals.

Abstract: The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.9° C.; microwaving the vitrification solution for a first period of time; allowing the vitrification solution to rest for a second period of time; repeating steps b and c until the vitrification solution enters into a glassy state.

Abstract: Shock waves are applied to clean and sterilize fluids in containers and conveyances. Shock waves destroy pathogens and pollutants in blood, water, food liquids and other fluids.

Abstract: According to the invention a method (and corresponding system) of enhancing application of high intensity acoustic waves is provided, wherein acoustic waves, e.g. ultrasound, and a gaseous medium, e.g. steam, coincide at a treatment zone. This is achieved by a combination of one or more high intensity acoustic generators and/or reflectors. In this way, enhanced efficiency in an area of the gaseous medium (or where the gaseous medium is to affect something) is obtained since a second generator or a reflector is located so that the acoustic waves directly influence the gaseous medium.

Abstract: A systematic decontamination and containment method for decontaminating personnel is disclosed. This method includes providing a plurality of components positionable on a selected location for establishment of a multi-station decontamination and containment facility to decontaminate personnel and to contain contaminants collected during the decontamination process. The components can include a plurality of collapsible frame and roof assemblies, wall and roof covers, a weapons clearing assembly, a weapons storage locker, a hanging bar, a signage assembly, collapsible containment hamper assemblies, a covered dispensing assembly, a shuffle box, a multi-wipe dispensing assembly, and a transportable containment enclosure. The enclosure is shaped and sized to removably retain the system's components for transportation or the like.

Abstract: A protocol for pasteurising microbial cells is disclosed. The protocol has three stages, a first heating stage, a second plateau stage at which the cells are held at a (maximum and) constant temperature, and a third cooling stage. The heating and cooling stages are rapid, with the temperature of the cells passing through 40 to 80° C. in no more than 30 minutes in the heating stage. The heating rate is at least 0.5° C./minute and during cooling is at least ?0.5° C./minute. The plateau maximum temperature is from 70 to 85° C. By plotting the pasteurisation protocol on a time (t, minutes) versus temperature (T, ° C.) graph, a trapezium is obtained having an area less than 13,000° C. minute. This results in a smaller energy input and a better quality oil results having a peroxide value (POV) of less than 1.5 and an anisidine value (AnV) of less than 1.0.

Abstract: The present invention relates to preservation of cosmetic formulations. More specifically, the present invention relates to a preservative composition for cosmetic formulations comprising thymol, monolaurin and magnolol obtained from supercritical fluid extracts of Magnolia officinalis.

Abstract: A vacuum packaged product and method for reducing tensile strength loss associated with sterilization of polyolefin-based products by gamma radiation, and reducing odors commonly produced by such sterilization.

Abstract: A method and device for sterilizing a flange connection including a sealing seat used for establishing a connection between product-bearing pipelines, and where the sealing seat of the flange connection is treated by thermal energy input from the not product-bearing side.

Abstract: Poly(?-peptoid)s selected from the group consisting of poly(N-methyl-?-alanine)s (PMeA) and poly(N-ethyl-?-alanine)s (PEtA) and polyl(methyl-?-alanine-co-ethyl-?-alanine) copolymers (P(MeA-co-EtA) are found to be good anti-fouling materials in that they resist protein adsorption. A process for protecting a surface of an object from protein adsorption comprises the steps of binding such poly(?-peptoid)s to the surface. A medical implant is coated with such poly(?-peptoid)s. A medical drug delivery device is coated with such poly(?-peptoid)s. A filtration device has pores coated with such poly(?-peptoid)s, and an object placed in freshwater or saltwater and having a surface in contact with the freshwater or saltwater has that surface coated with such poly(?-peptoid)s.

Abstract: An isostatic press is disclosed in which tunnel-like passages are formed between the envelope surface of a force absorbing body and a prestressing device. A method and a press are further disclosed, wherein a cylindrical element is prestressed simultaneously with obtaining a tunnel-like passage on the cylindrical element.

Abstract: A processes of sterilizing a contact lens, that is immersed in an aqueous liquid and hermetically in a container, using at least 284 mJ/cm2 of UV radiation in the range of 240-280 nm is disclosed herein.

Abstract: Disclosed are a germicidal system and method for deactivating pathogens on the surface of a bodily extremity protected by a prophylactic covering substantially opaque to UV-C radiation. The device includes an enclosure having one or more openings through which the extremity can be inserted. The enclosure contains a radiation source configured to produce germicidal radiation having a wavelength of about 253.7 nm. The openings are configured relative to the radiation source such that the inserted extremity is in close proximity to the radiation source. The prophylactic covered extremity is preferably a gloved hand thereby sanitizing the surface of the glove. The extremity inserted is preferably exposed for a predetermined period of time to ensure a desired level of sanitization. Optionally, the device can include detectors to determine the position of the hand, the spread of the fingers, and whether the hand is covered by a glove.

Abstract: A method of radiation sterilizing a plurality of stent-catheter assemblies includes positioning a plurality of stent-catheter assemblies on a fixture, each of the stent catheter assemblies being arranged in a planar configuration and disposed in corresponding planar packages supported on the fixture, wherein the packages are stacked horizontally on the fixture, and wherein the stents of the assemblies are positioned at a position in each package such that the stents are exposed to the same or substantially the same radiation; and exposing the packages to an incoming radiation beam, the radiation beam being at an acute angle to the planes of the planar configuration of the assemblies, wherein the packages are arranged such that a front end of the stack faces the radiation beam and a back end of the stack faces away from the radiation beam.

Abstract: An electron beam emitter including a vacuum chamber having a width. An electron generator can be positioned within the vacuum chamber for generating electrons. An elongate nozzle can extend from the vacuum chamber along a longitudinal axis and have an exit window at a distal end of the nozzle. The nozzle can have a width that is less than the width of the vacuum chamber. The electron generator can be shaped and dimensioned, and positioned with the vacuum chamber to form and direct a narrow electron beam that enters and travels through the nozzle, and exits out the exit window.

Abstract: Sterilization of medical devices can be performed by stacking packages containing the medical devices. The packages are arranged in a partially-overlapping orientation which is at an oblique angle to the direction of irradiation. The partially-overlapping orientation and oblique angle are predetermined for high sterilization throughput and tight control of irradiation. Instead arranging the packages directly on a sterilization platform at a sterilization facility, the packages can be stacked in the partially-overlapping orientation into a transport container at a location remote from the sterilization facility. The transport container maintains the orientation of the packages. Thereafter, the transport container is placed on the sterilization platform, which results in greater uniformity in radiation exposure while maintaining a high level of sterilization throughput.

Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.

Abstract: The invention provides glycated peptides and glycated fragments and glycated variants thereof, antibodies and aptamers which bind thereto, compositions and kits comprising the same, related conjugates, and a database comprising data indicating the concentration of glycated peptides present in diabetic and non-diabetic persons. The invention also provides a method of monitoring glycemic control, a method of treating or preventing diabetes, a method of preventing a complication of diabetes, a method of monitoring the status of diabetes, a method of determining the efficacy of a diabetes treatment, as well as methods of detecting diabetes or a predisposition thereto.

Abstract: A pasteurisation protocol for pasteurising microbial cells is disclosed. The protocol has a heating stage, a plateau stage at which the cells are held at a (maximum and) constant temperature, and a cooling stage. The heating and cooling stages are rapid, the temperature of the cells passing through 40 to 80° C. in no more than 30 minutes in the heating stage. The heating rate is at least 0.5° C./minute and during cooling is at least ?0.5° C./minute. The plateau maximum temperature is from 70 to 85° C. By plotting the pasteurisation protocol on a time (t, minutes) versus temperature (T, ° C.) graph, one obtains a trapezium having an area less than 13,000° C. minute. This results in a smaller energy input (so a reduction in costs) and a better quality (and less oxidised) oil having a peroxide value (POV) of less than 1.5 and an anisidine value (AnV) of less than 1.0.

Abstract: Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus.

Abstract: A method for sterilizing a plastic bottle in an aseptic filling system according to which at least an inner surface or an outer surface of a bottle is sterilized by injecting a heated sterilizing fluid at 65° C.-90° C. while maintaining internal pressure of the bottle at 1 kPa-20 kPa.

Abstract: A surgical instrument includes an elongated transmission waveguide defining a longitudinal axis. The transmission waveguide has a distal end and a proximal end. The at least one strike surface is formed on the proximal end and is configured to receive vibratory energy.

Abstract: The present scent distributor is a cartridge for attaching to a permeable substrate such as an air filter or humidifier pad. The cartridge housing is configured to hold the scenting media, said housing including a body and a cover; a plurality of openings in said housing to allow air to flow through at least a portion of said housing for interaction with the scenting media; a restrictor that slidingly engages with said housing to selectively restrict the flow of air through said housing; and an attachment device on said housing to attach said housing to a porous substrate.

Abstract: The present invention provides with a method of purifying air with significant content of ethylene gas. Bacteria, pathogens, molds, fungus and ethylene gas are removed by using ozone and air filtration technology. This process is useful for storages and production facilities where ethylene might be harmful for perishable products.

Abstract: A method of dispensing a volatile material includes the steps of providing power to a volatile material diffuser having a diffusion element and operating the diffusion element for a first period of time, wherein the diffusion element is continuously activated and deactivated during the period of time at a first duty cycle having a first on time and a first off time. Still further, the method includes the step of operating the diffusion element for a final period of time, wherein the diffusion element is continuously activated and deactivated during the final period of time at a final duty cycle having a final on time and a final off time. The first duty cycle is less than about 100% such that the first off time is greater than about 0 seconds and the final duty cycle is about 100% such that the final off time is about 0 seconds and wherein the final period of time begins after the first period of time has finished.

Abstract: A mobile device for transporting, tracking and processing medical instruments. The device comprises a cart including at least one receptacle for receiving an instrument container having instruments stored therein. The cart also includes plumbing for circulating processing fluids through the instrument container and a communications system for communicating tracking data associated with the instrument container and the cart.

Abstract: A fluid purification device includes an inner tube composed of a non-conductive material and an outer tube which is spaced apart from the inner tube by predetermined space S and composed of a non-conductive material, and the tubes are concentrically arranged. A conductive member is attached to apart or entire periphery of the inside of the outer tube to provide an electrode so as to form a device main body. When a voltage is applied to the electrode of the device main body, discharge in the space S is created by using a fluid to be treated W composed of liquid such as water which flows within the inner tube as an earth electrode. This causes a gas such as oxygen or air flowing in the space S to be reacted to generate ozone and mixes the ozone with the fluid to be treated W so as to purify the fluid.

Abstract: A dual-mode autoclave for sterilizing a battery is disclosed including a controller and an environmental system in operative communication with the controller and configured sterilize a battery contained within the dual-mode autoclave in response to a command from the controller. The environmental system configured to reduce a temperature of the battery to a first, pre-cooled temperature during a first operational phase and configured to increase the temperature of the battery to a second, autoclaving temperature during a second operational phase.

Abstract: A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source.