Abstract: Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer. The devices may also include a mixing chamber fluidly connected to the fluid channel, and a control channel overlapping with a deflectable membrane that defines a portion of the flow channel, where the control channel may be operable to change a rate at which the liquid reagent flows through the fluid channel. The devices may further include a rigid plastic layer on the elastomeric layer.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: The invention describes methods that use nanostructures and quantum confinement to detect and manipulate chemical and biochemical molecules. To increase selectivity and sensitivity nanostructures are built to have the density of states similar to that in analyte that will be detected and operated. Using device that incorporates such nanostructures, measuring electrical and optical properties of nanostructures and analyte or charge and energy transfer between the nanostructures and analyte a rapid and sensitive continuous detection in fluids can be achieved. Detection can be further enhanced by controlling external environmental parameters and applying external fields. In addition to be detected analyte can be positioned, moved, separated, extracted, and controlled.

Abstract: Disclosed herein is a microparticle sorting apparatus, including: a discharge direction confirming section configured to confirm a discharge direction of a discharged liquid discharged from a discharge outlet of a flow path; opposite electrodes disposed downstream with respect to the discharge outlet; an opposite electrode position controlling section configured to control positions of the opposite electrodes in accordance with the discharge direction confirmed by the discharge direction confirming section; a droplet generating section configured to generate a droplet from the discharge outlet; and a charging section configured to electrically charge the droplet with electric charges.

Abstract: The present disclosure provides in vitro analyte meters that include a meter portion that is moveable relative to at least one other meter portion. Embodiments include moveable meters that are integrated with in vivo analyte systems. Also provided are methods, systems and kits.

Abstract: The present invention relates to droplet-based washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.

Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

Abstract: Provided are a centrifugal force-based microfluidic device, in which biochemical treatments of samples are executed, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device is mountable on a rotatable device and includes: a disk-shaped portion; and an inlet hole defined within, configured to receive fluid from outside the centrifugal force-based microfluidic device having a first opening with a first inner diameter, and a second opening disposed on the first opening having a second inner diameter greater than the first inner diameter, and a depth of the second opening greater than a height of a fluid droplet formable in the second opening.

Abstract: A method of actuating a valve, comprises operatively coupling the valve with an electroosmotic pump; flowing a fluid through the electroosmotic pump; and generating a fluidic pressure of at least 0.75 PSI to actuate the valve, wherein the electroosmotic pump comprises one or more thin, porous, positive electroosmotic membranes and one or more thin porous, negative electroosmotic membranes; a plurality of electrodes comprising cathodes and anodes, and a power source; wherein each of the positive and negative electroosmotic membranes are disposed alternatively and wherein at least one of the cathodes is disposed on one side of one of the membranes and at least one of the anodes is disposed on the other side of the membrane and wherein at least one of the cathodes or anodes is disposed between a positive and a negative electroosmotic membrane.

Abstract: Particular embodiments of the inventive technology relate to ‘off-axis detector’ technology that employs a third detector 23 exhibiting a flow orthogonal axis 43 as defined by its EMR collection angle, where such axis is from 30 degrees to 60 degrees from an intended, flow orthogonal, cell cross section long axis alignment line 13, in addition to employing a fourth detector 24 exhibiting a flow orthogonal axis 44 as defined by its collection angle, where such axis is orthogonal to the flow orthogonal, third detector axis 43. Particular embodiments of the inventive technology relate to ‘axially spaced illumination’ technology featuring more than one cell illumination site, where, other than the most upflow illumination site (e.g., 121), all illumination site(s) are downflow of at least one other illumination site. Particular embodiments of the inventive technology may feature aspects of both technologies.

Abstract: A micro-cassette 1 stores a sample, a reagent, and an additive, and comprises a sensor measures the component of measurement item. Analysis device 2 comprises liquid control unit controls each liquid in micro-cassette 1. Mixing controller 33 mixes the sample and the additive sent to sample processing unit 13, and generates the first sample includes a formed element. Isolation unit 14 generates the second sample from the first sample sent from sample processing unit 13. Sensor 18 measures the compound liquid of the second sample and reagent, and generates the analysis signal.

Abstract: An automatically operating apparatus designed as a table-top apparatus for the reproducible production of cell or tissue samples to be examined and arranged on specimen slides comprises, located its center, a rotatably supported, advance device having arranged on its periphery a plurality of modular processing stations at a distance from the advance device. Receiving devices provided in the peripheral region of the advance device are disposed to receive specimen slides on which automatically segmented cell and tissue segments can be positioned in a reproducible and correctly aligned manner. The cell and tissue segments are durably fixed in position on the specimen slides with the use of a curable adhesive, and the specimen slides, after being delivered, are subjected to further treatment processes in a further treatment device.

Abstract: A fluid flow characteristic regulator (58) which provides a variable volume flow path in which a fluid flow can be continuously adjusted by a control fluid (57) to regulate at least one fluid flow characteristic of the fluid flow (11) within the variable volume flow path.

Abstract: An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.

Abstract: A molecularly imprinted polymer denuder sensor that includes a trapping solution; a delivery device transporting the trapping solution; a denuder operatively connected to the trapping solution and contacting ambient air, wherein the denuder infuses the sample into the trapping solution; a molecularly imprinted polymer sensor operatively connected to the denuder, wherein the MIP sensor captures and detects the threat material; an excitation source operatively connected to the MIP sensor and having an excitation band, wherein the excitation band excites europium (or other signal transducing lanthanide or metal ion) in the MIP when it is bound to the threat material providing unique emission band(s); and an analytical device operatively connected to the MIP sensor, wherein the analytical device senses the presence of the threat material in the sample.

Abstract: An apparatus (10, 60, 70, 100, 110, 120) for handling specimen slides (21) encompasses a coverslipping module (14) for coverslipping thin sections arranged on the specimen slides (21), the coverslipping module (14) applying first a mounting medium and then a coverslipping means onto the specimen slides (21). The apparatus (10, 60, 70, 100, 110, 120) further has an output unit (18) for outputting the specimen slides (21), which unit encompasses a drying unit (32) for at least partial extraction of at least one solvent from the applied mounting medium of the specimen slides (21) arranged in the output unit (18).

Abstract: The invention relates to a tissue sample handling apparatus, in particular for grasping histological samples after infiltration of an embedding medium such as, for example, paraffin, which is characterized in that a sample is immobilizable on the handling apparatus, in particular in a sample holding position, by means of negative pressure.

Abstract: A sensor module (38, 40, 42) for a tissue processor (20) has a thermal sensor (66) for measuring a temperature of a container (30, 32, 34) of the tissue processor (20), and further has a position sensor for detecting a working position of the container (30, 32, 34).

Abstract: A mobile intra-operative microscopic diagnosis laboratory capable of analyzing fresh tissue specimens and providing intra-operative consultation within 20 minutes is described. The mobile laboratory is preferably a van and contains a cryostat for freezing the fresh tissue specimens and a means for cutting the specimens. In addition, it also contains the means for reading the slides to make microscopic diagnosis and a means for handling for fresh tissue and a means for indicating various locations in the specimen, preferably by inking them. It preferably contains a stainer for staining the samples and an intercom for communicating the microscopic diagnosis back to the operating room.

Abstract: A sensor device includes an optical limiting structure including a metal layer with at least one metal particle having a size no greater than about 1500 nanometers, and a phase-change material layer disposed adjacent at least a portion of the metal layer, the phase-change material layer including a phase-change material, and a dendritic-metal layer disposed over at least a portion of the phase-change material layer of the optical limiting structure, the dendritic-metal layer including an organic compound including branching chain amino acid groups attached to a metal structure. The optical limiting structure is configured to transition from a first optical state to a second optical state when the phase-change material is heated above a critical temperature, with transmittance of light at a predetermined wavelength through the optical limiting structure being lower at the second optical state of the optical limiting structure in relation to the first optical state of the optical limiting structure.

Abstract: In an analysis device and a method for testing the catalytic activity of surfaces, a reaction cell is provided that has a recess for a sample that is provided with the catalytic surface. In the analysis device, an optical test of the reaction occurring in the reaction cell may occur. The reaction cell has a closed channel that is part of a fluid circuit. The reaction cell may be advantageously designed in a very space-saving manner in its scale, such that a portable use of the analysis cell is possible as well. Here, a simple measurement process of the absorption capacity of the sample fluid located in the reaction cell is conducted. To this end, a laser diode is provided, the measurement stream of which is directed into the reaction cell and reflected multiple times. The light intensity is measured by means of a photodetector.

Abstract: Trays comprising a base have a plurality of axial slots adapted to receive buffer or other medical solution containers within the slots. A spring or other compression element at the bottom of the slot is configured to engage a plunger at the bottom of the solution container when present in the slot so that pressure is applied to the contents of the container in order to stabilize the contents while the containers are sterilized at an elevated temperature.

Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.

Abstract: Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.

Abstract: A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.

Abstract: This invention relates to a nucleic acid analyzer comprising: reaction containers capable of containing nucleic-acid-containing samples and reagents; an incubation mechanism capable of controlling temperatures of reaction containers set at different levels; an analysis mechanism for analyzing the samples contained in the reaction containers; and a transport mechanism for transporting a reaction container. In accordance with the assay technique to be performed on a nucleic-acid-containing sample, the transport mechanism transports a reaction container to a given incubation mechanism in a given order. The reaction container subjected to the process of sample preparation is transported to the analysis mechanism at a given time and the sample is analyzed.

Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.

Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

Abstract: The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3).

Abstract: A separator (1a) under the invention for the taking of blood serum or blood plasma contained in a blood sample from a separating strip comprises a top part (3), a bottom part (4) and a joint (5). Said top part (3) and bottom part (4) are linked by the joint (5) in a pivoting way. Bottom part (4) is designed to support the separating strip. At least one nose (7a, 7b) is provided at the bottom part (4) and/or underside of top part (3) which can exert local pressure on the separating strip once top part (3) and bottom part (4) are folded together thus pressing blood serum or blood plasma out of the rear end of the separating strip.

Abstract: A laboratory device unit (1) for processing or analyzing substances, mixtures or media, is provided having functional elements provided in or on a laboratory device (3) for carrying out said processing and/or analyzing. At least two remote controls (2, 6) are provided, wherein a range of functions of the functional elements can be used to a lesser extent with the one remote control (6) than with the other remote control (2).

Abstract: A sensor holder comprises a sensor mounting part having a first face on which a blood sensor is placed, a second face provided on the opposite side from the first face, and a through-hole that goes from the first face to the second face and is large enough to allow a laser beam to pass through; a finger holding part that is provided on the second face and surrounds the through-hole, and a grip that sticks out from the blood testing device when the sensor holder is mounted to the blood testing device.

Abstract: A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.

Abstract: The present invention is directed to a fiber optic device consisting of a fiber bundle having multiple legs of silica fibers, using a plurality of microspheres construct to attach target cells, for the assay of cytotoxic compounds. Each leg of silica fibers consists of twenty-five or more silica fibers treated with biotin and streptavidin treated microspheres which chemically bind the microspheres to the silica fibers. Further, the present invention is directed to the unique microspheres. The microspheres have a core, preferably alginate, with an outer surface of chitosan. The present invention is further directed to the use of the described fiber optic device to isolate, research and develop biological medicaments and diagnostic cytotoxic compounds. The fiber optic device utilizes thousands of fibers and the unique microspheres to provide a high-throughput screening device.

Abstract: An object of the present invention is to provide a method and an apparatus by which PCBs in insulating oil can be analyzed with high accuracy in a convenient, inexpensive, and rapid manner. The method for analyzing polychlorobiphenyls by measuring the concentration of polychlorobiphenyls in insulating oil comprises a step of, as pretreatment, bringing particles of a copolymer that contains divinylbenzene and a methacrylate organic monomer as monomer components into contact with insulating oil containing polychlorobiphenyls, so as to separate polychlorobiphenyls in insulating oil from oil content that is an impurity. The methacrylate organic monomer preferably has a diol type hydroxyl group.

Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Abstract: The present invention relates to a method for measuring a blood sample comprising the steps of: communicating the inside of a sealed container with atmosphere by piercing a cap for sealing the sealed container; supplying a diluted solution from the base end side of the aspiration pipe to fill the aspiration pipe with the diluted solution; aspirating the blood sample in the sealed container; discharging the aspirated blood sample into a measurement sample preparing container; and measuring a measurement sample prepared in the measurement sample preparing container.

Abstract: Devices and methods for measuring the acidity of airborne matter are provided. A filter can be impregnated with an indicator dye which changes color in response to changes in acidity. After the sample passes through the filter, the filter can be analyzed using UV-visible spectrometry.

Abstract: A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first and second containers carrier materials of differing degrees of purity are kept ready for use, respectively, for performing various infiltration steps on tissue samples. By means of the described method and apparatus the tissue processor can be operated with as little interruptions as possible and an ease in operation is achieved.

Abstract: A self-contained, mobile assay facility built in a modified armored truck is completely equipped to melt and assay precious metals, particularly gold and silver. An induction furnace melts the metal that is then poured into an ingot. The ingot is weighed and analyzed using an XRF alloy analyzer and the percentage of gold and/or other metals recorded. The value of the gold at current market prices is calculated and the assay and the value of the ingot is printed and given to the seller. The seller may opt to receive the ingot and pay the assayer an assay fee. Alternately, the seller may ask to be paid cash, by bullion, wire transfer, or by an open hedge. Either a transfer or hedge is initiated and confirmed from the assay facility. The ingots may be safely stored or shipped directly from the mobile facility to a wholesaler for further processing.

Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include a first sensor member coupled to a base, wherein the first sensor member includes a semiconductor material, a second sensor member coupled to the base; and an active region in contact with at least the first sensor member. In some aspects, the first sensor member may be a fiber, and may have a conductive core and a semiconducting cladding surrounding the core. Manufacturing methods and apparatus utilizing the sensors are provided, as are numerous other aspects.

Abstract: The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules.

Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.

Abstract: This passive one-way valve is used in a connection portion between first and second flow channels, and includes: an inlet portion into which a fluid from the first flow channel flows; an elastic portion for blocking the inlet portion; a rigid portion for supporting the elastic portion from a side opposite to the inlet portion across the elastic portion; a gap portion formed around the rigid portion; and an outlet portion which is in communication with the gap portion for letting the fluid flow out into the second flow channel. Furthermore, the inlet portion is hermetically sealed by the elastic portion being pressed against the inlet portion side by the rigid portion. According to this passive one-way valve, it is possible to provide a simple and inexpensive passive one-way valve without requiring special equipment such as a vacuum pump and pressurized air, and to provide a microfluidic device using the same.

Abstract: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge of said cartridge or from said pipette.

Abstract: An apparatus for safely and conveniently placing and retrieving biological indicators and/or computerized data tracers from deep within loads of Regulated Medical/Infectious Waste comprises a rod with a cavity for holding the biological indicators and/or computerized data tracers. Preferably, the rod is tapered to a point on one end, has a handle on the opposite end, and has a cover to enclose the cavity. Additionally, it is preferred that the rod is fitted with a movable sealing ring of soft material for sealing the area where the rod penetrates the waste load.

Abstract: Disclosed herein is a microparticle sorting apparatus, including: a discharge direction confirming section configured to confirm a discharge direction of a discharged liquid discharged from a discharge outlet of a flow path; opposite electrodes disposed downstream with respect to the discharge outlet; an opposite electrode position controlling section configured to control positions of the opposite electrodes in accordance with the discharge direction confirmed by the discharge direction confirming section; a droplet generating section configured to generate a droplet from the discharge outlet; and a charging section configured to electrically charge the droplet with electric charges.

Abstract: The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.

Abstract: A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device.