Preparing Nitrogen-containing Organic Compound Patents (Class 435/128)
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Publication number: 20110300591Abstract: The invention relates to a method for converting nitrates to nitrites and to specific compositions of bacteria belonging to the Staphylococcus vitulinus species optionally in association with lactic acid bacteria such as Lactococcus genus or Pediococcus genus and their use for developing the red color of a food product containing myoglobin.Type: ApplicationFiled: December 11, 2008Publication date: December 8, 2011Applicant: DANISCO A/SInventors: Lionel Gilet, Caroline de Lamarliere, Martine Perrin, Pascal Fourcassie
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Patent number: 8071340Abstract: A process for the production of ortho-aminophenolic analogs of chloramphenicol using a biocatalyst consisting of pure enzymes, partially purified enzymes, cell lysate, intact cells, or a metal reaction linked with a subsequent enzymatic reaction. The biocatalyst is an enzyme system that makes use of a nitroreductase enzyme that initially reduces the nitroarene to the hydroxylaminoarene and a mutase enzyme that converts the hydroxylaminoarene to an ortho-aminophenol. The biocatalyst can also consist of a coupled, two-step metal and enzyme reaction in which the metal, such as zinc, catalyzes the transformation of the nitroarene to the hydroxylaminoarene and the mutase then catalyzes the transformation of hydroxylaminoarene to the corresponding ortho-aminophenol.Type: GrantFiled: November 2, 2006Date of Patent: December 6, 2011Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Lloyd J. Nadeau, Heather R. Luckarift, Jim C. Spain
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Patent number: 8063008Abstract: A process is provided to produce a concentrated aqueous peracid solution in situ using at least one enzyme having perhydrolase activity in the presence of hydrogen peroxide (at a concentration of at least 500 mM) under neutral to acidic reaction conditions from suitable carboxylic acid esters (including glycerides) and/or amides substrates. The concentrated peracid solution produced is sufficient for use in a variety of disinfection and/or bleaching applications.Type: GrantFiled: May 22, 2009Date of Patent: November 22, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Robert DiCosimo, Mark Scott Payne, Eugenia Costa Hann, Vincent Brian Croud, John Edward Gavagan, Lorraine Winona Wagner
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Patent number: 8052992Abstract: Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease. The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.Type: GrantFiled: April 28, 2006Date of Patent: November 8, 2011Assignee: Enzymotec Ltd.Inventors: Gai Ben Dror, Dorit Plat, Orly Farkash, Rassan Zuabi, Zohar Bar-On, Avidor Shulman, Dori Pelled
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Publication number: 20110269180Abstract: The present invention relates to the use of nucleic acid molecules coding for a bacterial xylose isomerase (XI), preferably coming from Clostridium phytofermentans, for reaction/metabolization, particularly fermentation, of recombinant microorganisms of biomaterial containing xylose, and particularly for the production of bioalcohols, particularly bioethanol, by means of xylose fermenting yeasts. The present invention further relates to cells, particularly eukaryotic cells, which are transformed utilizing a nucleic acid expression construct which codes for a xylose isomerase, wherein the expression of the nucleic acid expression construct imparts to the cells the capability to directly isomerize xylose into xylulose. Said cells are preferably utilized for reaction/metabolization, particularly fermentation, of biomaterial containing xylose, and particularly for the production of bioalcohols, particularly bioethanol.Type: ApplicationFiled: July 1, 2009Publication date: November 3, 2011Inventors: Dawid Brat, Eckhard Boles, Marco Keller, Beate Wiedemann
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Patent number: 8044166Abstract: The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof.Type: GrantFiled: July 25, 2007Date of Patent: October 25, 2011Assignee: BASF AktiengesellschaftInventors: Martin Fiene, Eckhard Stroefer, Wolfgang Siegel, Stephan Freyer, Oskar Zelder, Gerhard Schulz
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Patent number: 8039236Abstract: The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.Type: GrantFiled: March 18, 2009Date of Patent: October 18, 2011Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata, Aya Kubota, Hajime Ikeda
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Publication number: 20110250657Abstract: The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.Type: ApplicationFiled: March 22, 2011Publication date: October 13, 2011Applicant: VERENIUM CORPORATIONInventors: MARK J. BURK, GRACE DESANTIS, BRIAN MORGAN, Zoulin ZHU
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Publication number: 20110244531Abstract: The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.Type: ApplicationFiled: July 23, 2009Publication date: October 6, 2011Inventors: Andreas Hendrikus Maria De Vries, Gerardus Karel Maria Verzijl, Petrus Johannes Hermsen, Anna Maria Cornelia Francisca Castelijns
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Publication number: 20110244525Abstract: The present invention relates to a transformed microorganism capable of (a) a higher xylose isomerase activity than the equivalent microorganism prior to transformation; and/or (b) a higher growth rate in or on a growth medium comprising xylose than the equivalent microorganism prior to transformation; and/or (c) a faster metabolism of xylose than the equivalent microorganism prior to transformation; and/or (d) a higher production of ethanol when grown anaerobically on xylose as the carbon source than the equivalent microorganism prior to transformation.Type: ApplicationFiled: December 10, 2009Publication date: October 6, 2011Applicant: TERRANOL A/SInventors: Birgitte Rönnow, Thomas Hvid Andersen, Ole Sibbesen
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Publication number: 20110230343Abstract: A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M.Type: ApplicationFiled: October 14, 2009Publication date: September 22, 2011Applicant: BASF SEInventors: Michael Schroers, Rainer Dyllick-Brenzinger, Michael Merk, Heiko Barg
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Publication number: 20110229942Abstract: Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, iso-propanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol.Type: ApplicationFiled: December 15, 2008Publication date: September 22, 2011Applicant: Glycos Biotechnologies, IncorporatedInventors: Paul Campbell, Ramon Gonzalez
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Publication number: 20110223284Abstract: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.Type: ApplicationFiled: October 14, 2010Publication date: September 15, 2011Applicant: Ambrozea, Inc.Inventor: Peter R. David
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Patent number: 8008461Abstract: The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the polypeptide and a transformant of producing the polypeptide. Another feature of the present invention is a process for producing an optically active alcohol such as (R)-3-hydroxy-3-phenylpropanenitrile by reducing a carbonyl compound such as 3-oxo-3-phenylpropanenitrile by use of the polypeptide or the transformant.Type: GrantFiled: October 20, 2005Date of Patent: August 30, 2011Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Makoto Ueda, Daisuke Moriyama, Naoaki Taoka, Yoshihiko Yasohara
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Publication number: 20110207183Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.Type: ApplicationFiled: April 28, 2009Publication date: August 25, 2011Applicant: BASF SEInventors: Andrea Herold, Hartwig Schröder, Weol Kyu Jeong, Corinna Klopprogge, Oskar Zelder, Stefan Haefner, Ulrike Richter, Judith Becker, Christoph Wittmann
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Publication number: 20110203019Abstract: The present invention describes an alternative approach to increase GABA production in prokaryotes or eukaryotes, namely by the insertion of the putrescine catabolic pathway in organisms where the pathway does not exist or has not clearly been identified. The invention describes methods for the use of polynucleotides that encode functional putrescine aminotransferase (PAT) and gamma-aminobutyricaldehyde dehydrogenase (GABAlde DeHase) polypeptides in plants to increase GABA production. The preferred embodiment of the invention is in plants but other organisms may be used. Changes in GABA availability will improve growth and increase tolerance to biotic and abiotic stress.Type: ApplicationFiled: April 27, 2011Publication date: August 18, 2011Applicant: PLANT SENSORY SYSTEMS, LLCInventors: Frank Turano, Kathleen Turano
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Publication number: 20110178292Abstract: The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a ?-, ?- or ?-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.Type: ApplicationFiled: July 16, 2009Publication date: July 21, 2011Inventors: George Lentzen, Thorsten Neuhaus
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Publication number: 20110171699Abstract: The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.Type: ApplicationFiled: March 11, 2009Publication date: July 14, 2011Inventors: Petronella Catharina Raemakers-Franken, Martin Schurmann, Axel Christoph Trefzer, Stefaan Marie Andre De Wildeman
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Publication number: 20110171700Abstract: The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.Type: ApplicationFiled: September 15, 2009Publication date: July 14, 2011Applicant: BASF SEInventors: Michael Breuer, Andreas Pletsch, Bernhard Hauer, Wolfgang Siegel
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Publication number: 20110171696Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.Type: ApplicationFiled: March 18, 2011Publication date: July 14, 2011Applicant: Celexion, LLCInventors: Brian M. Baynes, John Michael Geremia
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Publication number: 20110165636Abstract: The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.Type: ApplicationFiled: May 19, 2009Publication date: July 7, 2011Applicant: SANDOZ AGInventors: Martin Albert, Ferdinand Zepeck, Andreas Berger, Waander Riethorst, Helmut Schwab, Daniel Luschnig, Peter Remler, Joerg Salchenegger, Doris Osl, Dominic DeSouza
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Publication number: 20110165634Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.Type: ApplicationFiled: December 29, 2010Publication date: July 7, 2011Applicant: Solazyme, Inc.Inventors: Scott Franklin, Aravind Somanchi, Karen Espina, George Rudenko, Penelope Chua
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Patent number: 7968328Abstract: The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R).Type: GrantFiled: June 19, 2006Date of Patent: June 28, 2011Assignee: BASF SEInventor: Klaus Ditrich
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Publication number: 20110151523Abstract: A nitrogen compound production method includes the step of establishing at least one aquatic plant in a cell containing water and alternating a step of inhibiting photosynthesis inducing light from reaching the at least one aquatic plant and a step of allowing photosynthesis inducing light to reach the at least one aquatic plant. The step of inhibiting photosynthesis inducing light defines a dark phase. A concentration of oxygen is reduced in the water to define an anoxic condition. During the anoxic condition, the at least one plant releases nitrogen compounds into the water and these nitrogen compounds are collected from the water contained in the cell.Type: ApplicationFiled: March 3, 2011Publication date: June 23, 2011Inventor: Tony A. Hagen
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Publication number: 20110136958Abstract: A polymer is characterized by a repeat unit represented by Structural Formula (I), or a copolymer thereof. A crosslinked polymer characterized by a repeat unit represented by Structural Formula (II), (III), (IV) or (V), or a copolymer thereof, wherein at least one such repeat unit of a first polymer strand is crosslinked with at least one repeat unit of a second polymer strand by at least one bridging unit, the first and second polymer strands and the repeat unit being components of the crosslinked polymer.Type: ApplicationFiled: September 10, 2008Publication date: June 9, 2011Inventors: Arthur C. Watterson, Ravi Mosurkal, Jayant Kumar, Virinder S. Parmar, Lynne A. Samuelson, Rajesh Kumar, Vincent Tucci
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Publication number: 20110136177Abstract: A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene involved in the biosynthesis pathway leading to a low molecular weight organic aglycon compound and a glycosyltransferase gene capable of glycosylating the produced aglycon.Type: ApplicationFiled: October 21, 2010Publication date: June 9, 2011Applicant: BLMAPSInventors: Joergen Hansen, Thomas Hvid Andersen, Finn Thyge Okkels
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Publication number: 20110137007Abstract: Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.Type: ApplicationFiled: January 3, 2011Publication date: June 9, 2011Inventors: Mototaka Suzuki, Keiichi Yokoyama, Yoshimi Kikuchi
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Publication number: 20110111458Abstract: An object of the present invention is to provide an E. coli mutant strain having a chromosomal DNA not less than 1040 kbp shorter than that of a wild-type Escherichia coli, and a production method of a useful substance using the variant.Type: ApplicationFiled: March 18, 2009Publication date: May 12, 2011Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Kimie Masuda, Noriko Nakamura, Hiroshi Mizoguchi, Hideo Mori
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Publication number: 20110111469Abstract: The document describes a process for the preparation of N-Acyl-Phosphatidyl-Ethanolamine of formula (I) on an industrial scale, In which R1, R2 and R3 are, independently from each other, saturated, monounsaturated or polyunsaturated acyls C10-C30, pure or mixed together, and X=OH or OM, where M=alkaline metal or alkaline earth, ammonium or alkylammonium. The process in question allows the conversion of lecithin of synthetic or natural origin into N-Acyl-Phosphatidyl-Ethanolamine of formula (I) of high purity, using a limited molar excess of the reagent N-acyl-ethanolamine, where the acyl is as defined above for the formula (I) through reaction of transphosphatidylation in the presence of the enzyme phospholipase D and in conditions suitable for production on an industrial scale.Type: ApplicationFiled: July 8, 2008Publication date: May 12, 2011Applicant: CHEMI S.P.A.Inventors: Lorenzo De Ferra, Mauro Anibaldi, Ettore Ammirati
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Patent number: 7939302Abstract: The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at least one of said one or more kinds of amino acids, allowing the dipeptide to form and accumulate in the medium, and recovering the dipeptide from the medium.Type: GrantFiled: March 10, 2009Date of Patent: May 10, 2011Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata
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Publication number: 20110104764Abstract: The invention relates to a method for synthesizing ?-amino-alkanoic acids or the esters thereof from mono-unsaturated natural fatty acids comprising at least one step of forming the unsaturated diacid corresponding to the original fatty acid.Type: ApplicationFiled: July 9, 2009Publication date: May 5, 2011Applicant: Arkema FranceInventor: Jean-Luc Dubois
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Publication number: 20110104736Abstract: The present invention relates to a method for selecting a strain of an organism capable of improved consumption of a mixed substrate comprising two or more carbon sources as compared to a reference strain of the organism, which method comprises: growing a population of the reference strain of the organism in the presence of the two or more carbon sources, wherein the number of generations of growth of the said population on each of the said carbon sources is at least about 50% of the number of generations of growth on the carbon source most preferred by the organism; and selecting the resulting strain of the organism, thereby to select a strain of the organism capable of improved consumption of a mixed substrate comprising the two or more carbon sources as compared to the reference strain of the organism. The invention also relates to strains of organisms selected using such a method.Type: ApplicationFiled: March 10, 2009Publication date: May 5, 2011Inventors: Jacobus Thomas Pronk, Antonius Antonius Maris Van, Hendrik Wouter Wisselink
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Publication number: 20110097767Abstract: A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. A method for producing aniline, includes culturing these non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce aniline.Type: ApplicationFiled: October 22, 2010Publication date: April 28, 2011Inventor: Priti Pharkya
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Patent number: 7932064Abstract: The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.Type: GrantFiled: June 13, 2003Date of Patent: April 26, 2011Assignee: Verenium CorporationInventors: Mark J. Burk, Grace Desantis, Brian Morgan, Zoulin Zhu
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Publication number: 20110091944Abstract: The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.Type: ApplicationFiled: March 11, 2009Publication date: April 21, 2011Applicant: DSM IP ASSETS B.V.Inventors: Liang Wu, Stefaan Marie Andre De Wildeman, Marco Alexander Van Den Berg, Axel Christoph Trefzer
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Patent number: 7923236Abstract: This invention relates to enzymes and methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing of clothing, detergent processes, deinking and biobleaching of paper and pulp, and treatment of waste streams.Type: GrantFiled: August 2, 2007Date of Patent: April 12, 2011Assignee: Dyadic International (USA), Inc.Inventors: Alexander Vasilievich Gusakov, Peter J. Punt, Jan Cornelis Verdoes, Jacoba Van der Meij, legal representative, Arkady Panteleimonovich Sinitsyn, Elena Vlasenko, Sandra Wihelmina Agnes Hinz, Mark Gosink, Zhijie Jiang
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Patent number: 7915019Abstract: A process for preparing an optically active (S or R)-?-amino acid represented by formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-?-amino acid ester represented by formula (III): wherein R has the same meaning as defined above, R1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II), which comprises selectively hydrolyzing water and one of enantiomers of a ?-amino acid ester represented by formula (I): wherein R and R1 have the same meanings as defined above, which is a racemic mixture, in the presence of a hydrolase in an organic solvent.Type: GrantFiled: October 11, 2005Date of Patent: March 29, 2011Assignee: UBE Industries, Ltd.Inventors: Tadayoshi Konegawa, Hiroyuki Miyata, Yasuhito Yamamoto
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Publication number: 20110065154Abstract: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.Type: ApplicationFiled: November 16, 2010Publication date: March 17, 2011Inventors: MARINA VICTOROVNA ALEXEEVA, ALEXIS ENRIGHT, MAHMOUD MAHMOUDIAN, NICHOLAS TURNER
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Patent number: 7906596Abstract: Processes for enzymatic synthesis comprising: (a) providing an aliphatic poly(oxyalkylene)amine; and (b) reacting the aliphatic poly(oxyalkylene)amine with a reactant selected from the group consisting of acrylic acid compounds and alkyl esters thereof, in the presence of a hydrolase in bulk or in a liquid reaction medium comprising an organic solvent to for a poly(oxyalkylene)acrylamide.Type: GrantFiled: April 20, 2006Date of Patent: March 15, 2011Assignee: BASF SEInventors: Dietmar Häring, Bernhard Hauer, Stefan Becker
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Publication number: 20110045553Abstract: A process for converting tryptophan into kynurenine. The conversion of tryptophan into kynurenine is carried out by irradiating a substance comprising tryptophan with electromagnetic radiation comprising waves with wavelength in the range of 10 nanometer to 750 nanometer.Type: ApplicationFiled: May 5, 2009Publication date: February 24, 2011Applicant: HUNTSMAN INTERNATIONAL LLCInventors: Johan Sanders, Francisc Peter, Elinor Scott, Mohamed Hamdy Saad, Robert Henry Carr
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Publication number: 20110045550Abstract: The present invention refers to a recombinant fission yeast strain useful for the improved production of human cytochrome P450s. The improvement in the cytochrome P450 rate is achieved by a coexpression of a functional human electron transfer chain e.g. CPR (cytochrome P450 reductase). The invention further relates to uses of the recombinant fission yeast and particularly the use of the recombinant fission yeast in methods to generate cytochrome P450 dependent metabolites.Type: ApplicationFiled: June 12, 2008Publication date: February 24, 2011Applicant: POMBIOTECH GMBHInventor: Calin-Aurel Dragan
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Patent number: 7892784Abstract: An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.Type: GrantFiled: February 26, 2007Date of Patent: February 22, 2011Assignee: Fukui Prefectural UniversityInventors: Hiroshi Takagi, Yoshimitsu Hamano
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Publication number: 20110039313Abstract: The invention relates to recombinant microorganisms in which polynucleotides which code for lysine decarboxylase are enhanced and, using which, cadaverine (1,5-diaminopentane) is produced fermentatively, with the carbon source used preferably being renewable raw materials such as, for example, glucose, sucrose, molasses and the like.Type: ApplicationFiled: January 10, 2008Publication date: February 17, 2011Inventors: Stefan Verseck, Harald Haeger, Andreas Karau, Lothar Eggeling, Hermann Sahm
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Publication number: 20110033896Abstract: The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention.Type: ApplicationFiled: April 9, 2009Publication date: February 10, 2011Applicant: BASF SEInventors: Matthias Boy, Stephan Freyer, Julia Brodersen
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Publication number: 20110034528Abstract: The present invention describes Elansolids, a new class of novel anti-bacterial compounds of formula (I).Type: ApplicationFiled: February 19, 2009Publication date: February 10, 2011Inventors: Klaus Gerth, Heinrich Steinmetz, Gerhard Höfle
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Publication number: 20110008852Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).Type: ApplicationFiled: December 19, 2008Publication date: January 13, 2011Inventors: Ben De Lange, Anna Maria Cornelia Francisca Castelijns, Johannes Gerardus De Vries, Andreas Hendrikus Maria De Vries, Jeroen Antonius Boogers, Quirinus Bernardus Broxterman
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Patent number: 7867736Abstract: The invention relates to a method for preparing a complex of an organic amine and lactic acid in a reactor, characterized in that a water-miscible organic amine is brought into contact with magnesium lactate in an aqueous medium in the reactor to form the complex and precipitated magnesium hydroxide, after which the magnesium hydroxide is separated from the complex.Type: GrantFiled: March 2, 2007Date of Patent: January 11, 2011Assignee: Purac Biochem B.V.Inventor: Jan Van Krieken
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Publication number: 20100324258Abstract: The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant micro-organism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.Type: ApplicationFiled: February 20, 2009Publication date: December 23, 2010Applicant: BASF SEInventors: Oskar Zelder, Weol Kyu Jeong, Corinna Klopprogge, Andrea Herold, Hartwig Schröder
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Publication number: 20100324257Abstract: The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ?-aminocarboxylic acids, more ?-aminocarboxylic acid esters or more lactams derived from ?-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ?-aminocarboxylic acids, of ?-aminocarboxylic acid esters or of lactams derived from ?-aminocarboxylic acids, the ?-aminocarboxylic acids, ?-aminocarboxylic acid esters or lactams derived from ?-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ?-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.Type: ApplicationFiled: December 12, 2008Publication date: December 23, 2010Applicant: EVONIK DEGUSSA GmbhInventors: Andreas Karau, Volker Sieber, Thomas Haas, Harald Haeger, Katrin Grammann, Bruno Buehler, Lars Blank, Andreas Schmid, Guido Jach, Bernd Lalla, Andreas Mueller, Katrin Schullehner, Peter Welters, Thorsten Eggert, Andrea Weckbecker
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Publication number: 20100317518Abstract: Particular aspects provide methods for converting glucosinolate in a glucosinolate-containing plant material to glucosinolate breakdown products (GBPs), comprising: providing an amount of processed glucosinolate-containing plant material, the processed material being depleted of oil and glucosinolate converting enzyme activity by virtue of said processing; providing an amount of glucosinolate converting enzyme activity; mixing the processed material with the amount enzyme activity; hydrating the mixture; and incubating the hydrated mixture, wherein the glucosinolates are enzymatically converted to GBPs. Preferably, the processed plant material comprises a oilseed-derived seedmeal material (e.g., meadowfoam seedmeal) from which the oil has been removed by the processing (e.g., solvent extraction and/or heat treatment). In particular embodiments, the glucosinolate converting enzyme activity comprises at least one of a myrosinase activity and a nitrile-forming activity.Type: ApplicationFiled: July 21, 2008Publication date: December 16, 2010Inventors: Jan F. Stevens, Stephen Machado, Ralph Reed, Michael S. Martinez