Abstract: A training simulator for intraoperative neuromonitoring (IONM) systems includes channels where at least one of the channels is identified as an active stimulation channel and a subset of the rest of the channels is identified as reference or pick up sites. Channels of the subset having signal data that exceed a predefined threshold are retained for further processing, while channels with signal data that do not exceed the threshold are eliminated from further reporting. Response data for the remaining channels are generated in advance of a future time when the response would occur. The generated data is time stamped and stored for display at a time window when requested by the system.

Abstract: A medication delivery patch that is applied to the skin and activated to deliver a medication or other fluid into or through the skin. The patch may be completely mechanically driven, with no electronic components, for low cost, safety, and reliability. Pressing an activation button may set in motion a sequence of mechanical events that result in a needle exiting the patch into the skin of the user, and flow of fluid from an internal pouch in the patch into the user. When delivery is complete, another sequence of mechanical events may occur to retract the needle from the skin and stop the flow of fluid, and to show a visible indicator that delivery is complete. The patch may contain a fluid channel, such as a microfluidic channel, that controls the rate and time of delivery; this channel can be configured or selected for different medications or use cases.

Abstract: Disclosed herein is a method of enabling supervision of a laboratory environment utilizing diagnostic equipment. The method includes utilization of a device for capturing an optical image of at least a portion of the laboratory environment. The method further requires selectively capturing the optical image using the image capture device and selectively transmitting the captured image over a communications medium. The method further requires receiving the transmitted optical image by an image receiver in communication with the image transmission device via the communications medium. The method then requires selectively generating, by an image processor in communication with the image receiver, a display of at least a portion of the captured optical image on an image display device and receiving status information from the diagnostic equipment at a laboratory manager that is in communication with multitude of diagnostic equipment.

Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.

Abstract: Analyte sensing and response methods include using a non-invasive analyte sensor to detect at least one analyte in a medium. The sensor uses decoupled transmit and receive elements or antennas to transmit a signal, and to receive a response to the signal transmitted into the medium. An action is determined based on the detection of the analyte, which can affect a property of the analyte or the medium, and the action is automatically carried out. The action can be increasing or decreasing flow from a source of the analyte, increasing or decreasing flow of a chemical compound interacting with the analyte, or modifying a temperature of the medium. An example of the action is controlling an insulin pump, where the analyte is glucose.

Abstract: Classification of individuals based on their glycemic pattern and applications thereof are described. Generally, systems utilize continuous glucose monitoring data to determine glycemic pattern variability, which can be used as a basis to classify and treat individuals.

Abstract: A system and method can provide for a remote electronic device to be used to remotely initiate delivery of a medicament bolus with a medical device, such as an insulin pump, with the medical device providing audible or tactile confirmation of the programmed bolus. The bolus amount can be calculated by or programmed or otherwise entered into the smartphone, etc., and then transmitted to the medical device. When the pump receives the transmitted bolus amount, it issues one or more indications such as audible sounds and/or vibrations in any number of desired combinations. For instance, each individual sound or vibration may correspond to an increment of the medicament. The user can therefore determine the size of the medicament bolus by the number of sounds or vibrations and can confirm or cancel delivery of the bolus.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

Abstract: A method for detecting deviations between an event log and a process model includes converting the process model into a probability process model, the probability process model comprising multiple nodes in multiple hierarchies and probability distribution associated with the multiple nodes, a leaf node among the multiple nodes corresponding to an activity in the process model; detecting differences between at least one event sequence contained in the event log and the probability process model according to a correspondence relationship; and identifying the differences as the deviations in response to the differences exceeding a predefined threshold; wherein the correspondence relationship describes a correspondence relationship between an event in one event sequence of the at least one event sequence and a leaf node in the probability process model.

Abstract: A method for calibrating a blood pressure measurement device includes obtaining first blood pressure measurement information and a current confidence coefficient corresponding to the first blood pressure measurement information, determining the first blood pressure measurement information as blood pressure calibration information in response to the blood pressure measurement device comprising the historical calibration parameter list, and the current confidence coefficient being greater than or equal to a preset confidence coefficient or the historical confidence coefficient, and updating the historical calibration parameter list based on the first blood pressure measurement information and the current confidence coefficient.

Abstract: The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Abstract: Provided are a physiological signal analysis device and method to detect and analyze physiological information of a subject. The physiological signal analysis device includes a memory device configure to store a wrinkle pattern at a measurement position of a subject as a reference position; a sensor configured to sense the reference position and a physiological signal of the subject at the reference position in response to the stored reference position being within a range of the sensor; and a signal processor configured to process the physiological signal sensed the sensor.

Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.

Abstract: There is provided a method of calibrating a sensor comprising a luminescent compound having a luminescence that depends on the concentration of an analyte, and a detector configured to detect light emitted by the luminescent compound, the method comprising providing a component comprising the luminescent compound in a package that maintains exposure of the luminescent compound to the analyte at a known first concentration, assembling the component into the sensor and measuring a first value of a characteristic of the luminescence of the luminescent compound while exposed to the analyte at the first concentration, measuring a second value of the characteristic of the luminescence of the luminescent compound while exposed to the analyte at a known second concentration different from the first concentration, and determining parameters representing the dependence of the characteristic of the luminescence on concentration of the analyte using the first value and the second value.

Abstract: A transmitter comprises a main body case, a controller that is provided inside the main body case, a communication unit that is connected to the controller, and an elongated antenna unit that is connected to the communication unit. The antenna unit is disposed along an inner wall surface of the main body case.

Abstract: The disclosed technology includes a system and method for providing pairing information to assist in pairing devices for wireless communication. For example, the disclosed technology includes a method for visually displaying time remaining in pairing time windows for hearing aid devices. A hearing aid professional can view the displayed information on a computer, fitting station, or mobile device and then use this information to determine which devices can be paired or how much time is remaining to pair the device.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: A system, method and non-transient computer readable medium for tracking hypoglycemia risk in patients with diabetes exercise. A system may include a digital processor configured to execute instructions to receive an input from each available data source of a plurality of intermittently available data sources; determine a plurality of probability signals for impending hypoglycemia, wherein each probability signal is based on one or more of the inputs from the available data sources or a lack of input from an unavailable data source; wherein a probability signal for each unavailable data source is assigned a value corresponding to a zone of uncertainty; and determine an aggregate risk of hypoglycemia based on the plurality of intermittently data sources by aggregating the plurality of probability signals.

Abstract: Apparatus for recording information concerning the use of an injection device, the apparatus comprising: one or more sensors for providing information indicative of how the injection device is used; a processor configured to analyse said information detected by the one or more sensors to determine use information, said use information corresponding to how the injection device is used; and a memory for storing said use information in an image format such that said use information can be retrieved from the memory and displayed in an image.

Abstract: Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Abstract: A method is provided. The method includes selecting a neural network model, wherein the neural network model includes a plurality of layers, and wherein each of the plurality of layers includes weights and activations; modifying the neural network model by inserting a plurality of quantization layers within the neural network model; associating a cost function with the modified neural network model, wherein the cost function includes a first coefficient corresponding to a first regularization term, and wherein an initial value of the first coefficient is pre-defined; and training the modified neural network model to generate quantized weights for a layer by increasing the first coefficient until all weights are quantized and the first coefficient satisfies a pre-defined threshold, further including optimizing a weight scaling factor for the quantized weights and an activation scaling factor for quantized activations, and wherein the quantized weights are quantized using the optimized weight scaling factor.

Abstract: A system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

Abstract: An infusion device includes a pump for pumping a medical fluid from a fluid container through a delivery line towards a patient at a flow rate, a sensor for measuring a force on the pump or the delivery line, and a processor device configured to derive, from the force measured by the sensor, a pressure value indicative of the pressure in the delivery line and to compare the pressure value to a threshold value for determining whether an occlusion in the delivery line is present. A storage device stores a compliance value associated with the pump and/or the delivery line, and the processor device is configured to compute, from the stored compliance value, the flow rate and the threshold value, an estimate of a duration between the time of an occurrence of an occlusion and the time at which the pressure value exceeds the threshold value.

Abstract: A computer system for recursive calibration of a sensor network receives a first data communication from a first sensor node that is a neighbor to a calibrated sensor node. The computer system then updates a set of linear regressions between the first sensor node and a set of neighboring sensor nodes, which include the neighboring, calibrated sensor node. The computer system calibrates the first sensor node using an average of the set of linear regressions weighted by a correlation. When the first sensor node is calibrated, the computer system uses the calibrated first sensor node in calibration of a neighboring, uncalibrated sensor node. The computer system then gathers, at the first sensor node, a calibrated sensor reading.

Abstract: A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance contained in a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance contained in a second sample; a calculation unit to calculate a concentration value of the specified substance contained in the first sample, based on the signal value and the reference value; a determination unit to determine whether a variation in the concentration value of the specified substance contained in the first sample is equal to or less than a threshold value; and an output unit to output, to a display unit, recommendation information representing recommendation for acquiring the reference value when the variation in the concentration value of the specified substance contained in the first sample is equal to or less than the threshold value.

Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves storing alert configuration information for the user, identifying an alert condition while operating the infusion device to deliver the fluid based at least in part on the alert configuration information for the user, and in response to identifying the alert condition, providing a user notification in accordance with the user's stored alert configuration information.

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed.

Abstract: The device measures glucose concentration in blood without any extraction of blood. The device is a non-invasive method for measuring glucose Radio Frequency and Antenna Circuits and Systems. The device is a wearable device that can non-invasively measure blood glucose levels in an instantaneous manner and continuous manner.

Abstract: A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance of a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance of a second sample; a calculating unit to calculate a concentration value of the specified substance of the first sample, based on the signal value and the reference value; a timing determination unit to determine timing for calibrating the reference value when satisfying at least one of a first condition that an activity status of a user is a predetermined status and a second condition that a variation in the concentration value of the specified substance of the first sample is equal to or smaller than a threshold value; and an input request unit to request the user to input the reference value at the determined timing.

Abstract: Embodiments provide a mutable CRTM schema for ensuring the integrity of a client workload on a single system as updates are made to the firmware used to initialize and run that system by booting a computing system in a secure mode; when successfully validating a boot image for the computing system via a secure verification code that is blocked from write access when the system is booted in a unsecure mode, allowing write access to the secure verification code; and continuing to boot the computing system in the secure mode according to the boot image. When booting the system and unseccessfully validating the boot image at the third time, the system boot is failed.

Abstract: Embodiments of the invention provide multilayer analyte sensors having material layers (e.g. high-density amine layers) and/or configurations of material layers that function to enhance sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: A presentation method for presenting a time period to measure a blood glucose level, the presentation method includes: acquiring first information, the first information including a measurement result in which a glucose level of a user is measured with a time interval using a first measurement device and a measurement time at which the measurement result was acquired; determining, based on a comparison result obtained by comparing the first information with a predetermined threshold of the glucose level and a preset period, the time period for the user to measure the blood glucose level by using a second measurement device; and presenting the time period at a display.

Abstract: Provided is a non-invasive system and method for determining a fuel value for a target muscle and potentially at least one indicator muscle. The method includes receiving an ultrasound scan of a target muscle; evaluating at least a portion of the ultrasound scan to determine fuel value within the target muscle; recording the determined fuel value for the muscle as an element of a data set for the muscle; evaluating the fuel data set to determine a value range; and in response to the range being at least above a pre-determined threshold, establishing a target score for the muscle as based on an upper portion of the value range. The method may be repeated to identify ranges for a plurality of muscles, the muscle with the greatest range being identified as an indicator muscle. Based on these findings the muscles estimated fuel level, fuel rating and energy status may be determined. An associated system is also disclosed.

Abstract: The present disclosure relates to a sensor including an elongated member including at least a portion that is electrically conductive. The elongated member includes a sensing layer adapted to react with a material desired to be sensed. An insulating layer surrounds the elongated member. The insulating layer defines at least one access opening for allowing the material desired to be sensed to enter an interior region defined between the elongated member and the insulating layer. The insulating layer has an inner transverse cross-sectional profile that is different from an outer transverse cross-sectional profile of the elongated member. The difference in transverse cross-sectional profiles between the elongated member and the insulating layer provides channels at the interior region defined between the insulating layer and the elongated member. The channels extend generally along the length of the elongated member and are sized to allow the material desired to be sensed to move along the length of the sensor.

Abstract: A method for obtaining blood glucose concentration using near infrared spectroscopy (NIR) data is provided. The method includes obtaining, by an independent component analysis (ICA) temporal module, orthogonal pure spectra from human NIR spectra; performing, by a processing module, one or more preprocessings and drift removal on the human NIR spectra and the orthogonal pure spectra to obtain preprocessed spectra; and obtaining, by a regression block, the blood glucose concentration from the preprocessed spectra.

Abstract: Systems, methods, and computer-readable media are disclosed for network node communication using dynamically configurable interaction modes. Example methods may include identify a first triggering event associated with an agent, the agent comprising a vehicle or a user; determine a first mode for the agent based on the first triggering event; exchange a first communication with other agents over a network, wherein the first communication is based on the first mode and comprises a first action to be taken by the other agents; determine a second mode for the agent based on a second triggering event; and exchange a second communication with the other agents over the network, wherein the second communication is based on the second mode and comprises a second action to be taken by the other agents, and wherein the second mode and the first mode are of different types.

Abstract: A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.

Abstract: According to an aspect of the invention, a data transmitting apparatus includes a transmitting unit that transmits a first packet through a unidirectional communication based on an instruction to transmit the first packet, and that transmits a second packet through a unidirectional communication based on an instruction to transmit the second packet.

Abstract: An electronic insulin delivery device receives glucose data from a glucose monitor and sets a bolus dose amount. The device may take the form of an insulin pen with automatic priming and accurate dosing provided by a motor in connection with an encoder. The device may communicate with and be controlled by a smart phone device. The smart phone device provides a user interface to receive user data including patient weight, insulin to carbohydrate ratio and exercise factor, and to send instructions to the device, including dose amount. The dose amount is determined taking into account glucose level and trend, and other factors. The delivery device may be in continuous communication with the glucose monitor and smart phone to provide for near real-time adjustments in glucose treatment. Glucose data, insulin injection data, and other relevant data may be stored and accessible to interested parties.

Abstract: An insulin device configured to control insulin dispensing based on insulin sensitivity. The insulin device includes a processor configured to receive insulin dosing schedule information, psychological stress level data, and body mass index (BMI) data; a sensor configured to generate a blood glucose level measurement. The sensor is calibrated as a function of the psychological stress level data and the BMI data and the processor is configured to monitor and detect changes of the blood glucose level measurement that are determined to have occurred as a function of changes of the psychological stress level data, and identify a time when the BMI data counteracts a detected change in the blood glucose level measurement. The insulin device also includes an insulin dispensing valve controlled by the processor to change the insulin dosing schedule information in accordance with the counteracting BMI data.

Abstract: An apparatus for providing corrected bio-information by using a bio-information sensor includes a communicator configured to receive bio-information from the bio-information sensor; a processor configured to extract metabolic information based on food intake information of a user and correct the received bio-information based on the extracted metabolic information; and an outputter configured to provide a result of correcting the bio-information.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to determine, in response to a port receiving a test strip, whether an auto-send feature is enabled on the handheld medical device, determine whether the handheld medical device is paired with a mobile computing device, and selectively instruct a wireless transceiver to establish a wireless connection and communicate a glucose measurement and identifying information to the mobile computing device. The mobile computing device is configured to execute the diabetes management application. The diabetes management application is configured to process a plurality of glucose measurements and identifying information associated with each of a plurality of glucose measurements.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: Introduced here is an attachable unit that connects to a base unit through a snap-fitting mechanism. The attachable unit can include a top housing structure and a bottom housing structure that are ultrasonically welded together. The top housing structure can include the toe portion that is integral with remaining portions of the top housing structure, where the toe portion is configured to provide the snap-fit with the base unit.

Abstract: A method includes capturing continuously vital signs and motion data from one or more sensors adapted to be coupled to a user; capturing food consumption of the user; predicting a predetermined health condition of the user based on the vital signs; generating a plan for the predetermined health condition; and prompting the user to execute the plan with a closed-loop feedback based on sensor data.

Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.