Glucose Measurement Patents (Class 600/365)
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Patent number: 10980451Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.Type: GrantFiled: September 21, 2020Date of Patent: April 20, 2021Assignee: DexCom, Inc.Inventors: Jeffrey R. Wedekind, Douglas William Burnette, Aditya Mandapaka, Zebediah L. McDaniel, Peter C. Simpson, Arturo Garcia
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Patent number: 10985804Abstract: Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.Type: GrantFiled: July 9, 2020Date of Patent: April 20, 2021Assignee: DexCom, Inc.Inventors: Thomas Miller, Mark Dervaes, Phong Lieu, Peter C. Simpson, Shawn Larvenz, Jacob S. Leach, Sebastian Bohm
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Patent number: 10957438Abstract: A method includes obtaining blood glucose measurements and blood glucose times of a patient from a blood glucose meter and executing a patient management program configured to display on a screen a graphical user interface having a trend window of the blood glucose measurements on the time line. The patient management program is configured to receive, in the trend window magnifying inputs for a magnification window superimposed on a segment of the timeline to specify a date range for a magnified window. The patient management program is further configured to display the magnified window including the blood glucose measurements of the patient from the specified date range and display a first information window including quantitative information associated with the blood glucose measurements from the specified date range.Type: GrantFiled: September 6, 2018Date of Patent: March 23, 2021Assignee: Aseko, Inc.Inventors: Robert C. Booth, Robert Salitsky, Andrew Rhinehart
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Patent number: 10955423Abstract: A method includes estimating a value of a parameter indicative of an age or lifespan of a population of red blood cells of a subject, estimating a value of average glucose (AG) of the subject based on (i) the value of the parameter and (ii) a value indicative of an amount of glycated hemoglobin (HbA1c) of the subject, and providing information for treatment or diagnosis of a hyperglycemia condition of the subject based on the estimated value of AG.Type: GrantFiled: December 15, 2016Date of Patent: March 23, 2021Assignee: The General Hospital CorporationInventors: Roy Malka, John M. Higgins, David M. Nathan
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Patent number: 10945602Abstract: The embodiment of the present disclosure discloses a monitoring parameter threshold value setting method, comprising the following steps: selecting at least one threshold value indicator of the monitoring parameter that needs a threshold value setting; forming and displaying a corresponding threshold value setting graphic according to the said threshold value indicator, wherein, in the said threshold value setting graphic, said threshold value indicator corresponds to an indication icon; responding to the threshold value setting of the threshold value indicator by a user, and adjusting the indication icon corresponding to the threshold value indicator to the corresponding position of the said indicating graphic.Type: GrantFiled: March 23, 2018Date of Patent: March 16, 2021Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., SHENZHEN MINDRAY SCIENTIFIC CO., LTD.Inventor: Jianhui Zhang
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Patent number: 10943687Abstract: An apparatus including a controller can determine a rate of change of a blood glucose level of a patient and generate a pump setting based on the rate of change.Type: GrantFiled: July 10, 2019Date of Patent: March 9, 2021Assignee: Tandem Diabetes Care, Inc.Inventor: Michael L. Blomquist
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Patent number: 10935511Abstract: The present invention relates to systems that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first electrochemical sensor positioned within a conduit adjacent to a second electrochemical sensor and spaced apart from one another at a predetermined distance. The first electrochemical sensor includes an immobilized layer of antibodies. The second electrochemical sensor includes a magnetic field disposed locally around the second electrochemical sensor, and the magnetic field is configured to attract magnetic beads onto a surface of the second electrochemical sensor. The device further includes a scavenging electrode positioned between the first electrochemical sensor and the second electrochemical sensor. The scavenging electrode is configured to prevent crosstalk between the first electrochemical immunosensor and the second electrical immunosensor.Type: GrantFiled: December 8, 2017Date of Patent: March 2, 2021Assignee: Abbott Point of Care Inc.Inventors: Antti Leo Oskari Virtanen, Cary James Miller, Kenneth Harold Hardage
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Patent number: 10932672Abstract: Systems and methods for remote and host monitoring communication are disclosed. In some implementations, monitoring systems can comprise a host monitoring device associated with a Host communicatively coupled to one or more remote monitoring devices associated with Remote Monitors. The host monitoring device can send communications based at least in part on analyte measurements of a Host sensor and/or other contextual data giving such measurements context. Different remote monitoring devices can receive different communications based at least in part on the role of the respective Remote Monitors relative to the Host. These roles can be reflected in classifications of Remote Monitors.Type: GrantFiled: December 13, 2016Date of Patent: March 2, 2021Assignee: DexCom, Inc.Inventors: Aarthi Mahalingam, Esteban Cabrera, Jr., Basab Dattaray, Rian Draeger, Laura J. Dunn, Derek James Escobar, Thomas Hall, Hari Hampapuram, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Michael Robert Mensinger, Michael Levozier Moore, Andrew Attila Pal, Nicholas Polytaridis, Eli Reihman, Brian Christopher Smith
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Patent number: 10921257Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.Type: GrantFiled: October 25, 2017Date of Patent: February 16, 2021Assignee: University of MassachusettsInventor: Lili He
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Patent number: 10890569Abstract: A colorimetric array includes a substrate, a first spot on the substrate, and a second spot on the substrate. The first spot includes a first nanoporous pigment that includes a first nanoporous material and a first immobilized, chemoresponsive colorant. The second spot includes a second nanoporous pigment that includes a second nanoporous material and a second immobilized, chemoresponsive colorant. The first nanoporous pigment is different from the second nanoporous pigment.Type: GrantFiled: December 5, 2017Date of Patent: January 12, 2021Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Sung H. Lim, Christopher J. Musto, Liang Feng, Jonathan W. Kemling, Kenneth S. Suslick
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Patent number: 10881334Abstract: A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.Type: GrantFiled: August 14, 2015Date of Patent: January 5, 2021Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli, Boris Kovatchev
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Patent number: 10877022Abstract: An occult blood testing device is disclosed. The occult blood testing device includes a main body, a plurality of ribs, at least one light emitting unit, and at least one light sensing unit, wherein the ribs are disposed on an outer surface of the main body, and the light emitting unit and the light sensing unit are disposed in an accommodation space of the main body. The light emitting unit emits an incident light beam and aims the incident light beam towards a direction of an open end of the main body at a test solution, and the light sensing unit receives a detection light beam formed by the incident light beam that penetrated the test solution. When a filter unit is sleeved over the main body, a part of the filter unit is supported by the ribs and a gap is formed between the filter unit and the outer surface of the main body. Through the gap, gas in the accommodation space of the main body can be expelled to prevent the gas existence from affecting the accuracy of the occult blood test.Type: GrantFiled: February 14, 2020Date of Patent: December 29, 2020Assignee: Taiwan Redeye Biomedical Inc.Inventors: Shuo-Ting Yan, Tsung-Jui Lin, I-Hua Wang
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Patent number: 10863944Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.Type: GrantFiled: June 22, 2018Date of Patent: December 15, 2020Assignee: DexCom, Inc.Inventors: John Michael Gray, Jennifer Blackwell, Paul V. Neale, Justen Deering England, Andrew Joncich, Cameron Brock, Peter C. Simpson, Thomas Metzmaker, Neel Narayan Shah, Mark Douglas Kempkey, Patrick John Castagna, Warren Terry, Jason Halac, Christian Michael Andre George, Daniel E. Apacible, John Charles Barry, Maria Noel Brown Wells, Kenneth Pirondini, Andrew Michael Reinhardt, Jason C. Wong, Remy E. Gagnon, David DeRenzy, Randall Scott Koplin, Alan Baldwin, Young Woo Lee, David A. Keller, Louise Emma van den Heuvel, Carol Wood Sutherland
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Patent number: 10856783Abstract: An electronic device includes a sensor that acquires a pulse wave and a controller that calculates an index based on the acquired pulse wave. The controller estimates the subject's state of glucose metabolism or lipid metabolism using the calculated index.Type: GrantFiled: April 14, 2016Date of Patent: December 8, 2020Assignee: KYOCERA CorporationInventor: Hiromi Ajima
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Patent number: 10850033Abstract: Presented here are techniques for controlling glucose levels of a patient based on predicted time to a target glucose level. One methodology predicts a trajectory of the blood glucose level based on past observations of the blood glucose level, determines a cost expression based on the trajectory, and affects a future command to an infusion pump to affect a cost value according to the cost expression. Another methodology defines a target blood glucose concentration level for the patient, observes a current blood glucose concentration for the patient based on signals received from a blood-glucose sensor, and predicts a duration of time for the patient's blood glucose concentration to reach the target blood glucose concentration level based on the observed current blood glucose concentration.Type: GrantFiled: August 1, 2017Date of Patent: December 1, 2020Assignee: Medtronic MiniMed, Inc.Inventor: Paul H. Kovelman
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Patent number: 10820841Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.Type: GrantFiled: August 9, 2018Date of Patent: November 3, 2020Assignee: ABBOT DIABETES CARE INC.Inventors: Gary Alan Hayter, Geoffrey V. McGarraugh
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Patent number: 10825569Abstract: The present invention discloses a universal non-invasive blood glucose estimation method based on time series analysis, which comprises 5 steps, i.e., data input and preprocessing, features screening, establishment of single-feature model based on time series analysis, multi-feature fusion, and non-invasive blood glucose estimation. During non-invasive blood glucose estimation, new non-invasive test data is inputted, and the blood glucose estimation series is calculated using related feature information obtained through modeling, single-feature model, and multi-feature fusion model. The estimation method provided in the present invention is easy to execute, and can overcome the delay between changes of physiological parameters of human body and changes of blood glucose, and thereby can obtain more accurate non-invasive blood glucose test results. The estimation method is universal and is applicable to different non-invasive blood glucose monitoring methods.Type: GrantFiled: October 31, 2017Date of Patent: November 3, 2020Assignees: Global Health Ark Medical Technology (Beijing) Co. Ltd, Tsinghua UniversityInventors: Fei Tang, Zhanxiao Geng, Xiaohao Wang, Yadong Ding, Zhiwei Fan
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Patent number: 10813576Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: November 21, 2019Date of Patent: October 27, 2020Assignee: DexCom, Inc.Inventors: Mark C. Brister, Steve Masterson, John Nolting, James R. Petisce, Jack Pryor, Sean Saint, Peter C. Simpson, Vance Swanson, Matthew D. Wightlin
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Patent number: 10811133Abstract: A dosing controller for administering insulin. The dosing controller includes a data processing device and non-transitory memory in communication with the data processing device. The dosing controller receives blood glucose measurements of a patient from the glucometer, receives patient information, selects a subcutaneous insulin treatment from a collection of subcutaneous insulin treatments based on the blood glucose measurements and the patient information, and executes the selected subcutaneous insulin treatment. Each blood glucose measurement is separated by a time interval and includes a blood glucose time associated with a time of measuring the blood glucose measurement.Type: GrantFiled: August 22, 2018Date of Patent: October 20, 2020Assignee: Aseko, Inc.Inventors: Robert C. Booth, Harry Hebblewhite
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Patent number: 10806859Abstract: A method may include displaying to a user an interface at which the user inputs a fear of hypoglycemia index (FHI), the FHI corresponding to an acceptable probability of a blood glucose level being below a threshold blood glucose level. The method may also include receiving blood glucose data for a person with diabetes (PWD). The method may additionally include calculating a probability of the PWD having a blood glucose level below the threshold blood glucose level based on the variability of the received blood glucose data. The method may also include setting one or more target blood glucose levels to align the probability of the PWD having a blood glucose level below the threshold blood glucose level with the acceptable probability associated with the user input FHI. The method may additionally include delivering insulin, using the insulin delivery device, based on the target blood glucose level.Type: GrantFiled: January 13, 2017Date of Patent: October 20, 2020Assignee: Bigfoot Biomedical, Inc.Inventors: Lane Desborough, Bryan Mazlish
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Patent number: 10799184Abstract: The system and method described herein represent a totally new paradigm for assessing risk in critically ill patients by identifying physiologic patterns associated with a poor outcome. It then uses this information to detect these patterns on future patients, sending alerts to clinicians caring for patients with one or more of them. Moreover, the system and method can be extended to outcomes other than mortality, and can be adapted for use in a specific hospital system's EMR. The “code footprint” for embedding the patterns that indicate a trigger is small and thus favorably suited for embedding into an existing clinical decision support system.Type: GrantFiled: March 15, 2018Date of Patent: October 13, 2020Assignee: Prescient Healthcare Consulting, LLCInventor: Andrew Alan Kramer
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Patent number: 10792421Abstract: This invention relates to automatic insulin delivery systems and methods of administering insulin. Preferably the systems and methods comprise a predictive feedforward control.Type: GrantFiled: October 5, 2017Date of Patent: October 6, 2020Assignee: Iowa State University Research Foundation, Inc.Inventors: Derrick K. Rollins, Sr., Yong Mei
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Patent number: 10791969Abstract: The present disclosure refers to a method for determining a blood glucose level for a patient, the method comprising detecting a present sensor signal in a present continuous interstitial blood glucose measurement for a patient; providing measurement data representing the present sensor signal; providing sensor signal correction data representing a patient-specific signal correction, the sensor signal correction data being determined from a former interstitial blood glucose measurement for the patient and comprising at least one of time delay data representing a patient-specific time delay ?t between a blood glucose value measured in a continuous interstitial blood glucose measurement and a blood glucose reference value measured in a capillary blood glucose measurement, and sensor sensitivity data representing, for the patient, a patient-specific sensor sensitivity for the sensor, determining corrected measurement data representing a corrected present sensor signal by applying the sensor signal correction datType: GrantFiled: June 20, 2017Date of Patent: October 6, 2020Assignee: ROCHE DIABETES CARE, INCInventors: Guenther Schmelzeisen-Redeker, Nikolaus Schmitt, Christian Ringemann
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Patent number: 10780223Abstract: A method includes receiving up-to-date blood glucose data for a PWD, determining basal insulin dosages for the PWD based on a baseline basal rate, delivering the basal insulin dosages to the PWD, modifying a target blood glucose level based on variability of blood glucose data for the PWD, receiving a temporary override indicating a user preference to reduce the likelihood that the PWD has a hypoglycemic event or a user preference to reduce the likelihood that the PWD has a hyperglycemic event, determining a temporary target blood glucose level based on the input—greater than the modified blood glucose level if the preference is to reduce the likelihood of a hypoglycemic event—lower than the modified target blood glucose level if the preference is to reduce the likelihood that of a hyperglycemic event. The method includes delivering basal insulin for the temporary period of time based on the temporary target.Type: GrantFiled: January 13, 2017Date of Patent: September 22, 2020Assignee: Bigfoot Biomedical, Inc.Inventors: Lane Desborough, Bryan Mazlish
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Patent number: 10772552Abstract: A wearable device for the quantification of regulatory substances produced in the body, such as analytes and hormones, is disclosed. The wearable device includes contact sensors formed on an outer portion of a casing of the wearable device, and those contact sensors are positioned to contact skin of a wearer of the device and configured to measure galvanic skin response and temperature. The wearable device also includes a microprocessor in the casing of the wearable device adapted to control programs and execute algorithms, a system memory in the casing of the wearable device adapted to store data, an entry port in the casing of the wearable device adapted to receive a biological-assay cartridge containing a biological sample, and a biological-assay reader placed inside the casing of the device and configured to read the biological sample.Type: GrantFiled: February 2, 2018Date of Patent: September 15, 2020Inventor: Alfred H. Bedell, Jr.
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Patent number: 10761347Abstract: An ophthalmic device includes an enclosure that is compatible for wearing in or on an eye. An adjustable lens is disposed within the enclosure. Driver circuitry is disposed within the enclosure and coupled to drive the adjustable lens and change its optical power. Built-in-self-test (BIST) circuitry is disposed within the enclosure and coupled to the adjustable lens. The BIST circuitry includes an impedance measurement circuit coupled to selectively measure an impedance of the adjustable lens. A controller is disposed within the enclosure and includes BIST control logic that measures the impedance of the adjustable lens with the impedance measurement circuit to determine a health status of the adjustable lens.Type: GrantFiled: February 20, 2018Date of Patent: September 1, 2020Assignee: Verily Life Sciences LLCInventor: Shungneng Lee
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Patent number: 10746693Abstract: A device includes a biosensor, a sensing circuit electrically connected to the biosensor, a quantizer electrically connected to the sensing circuit, a digital filter electrically connected to the quantizer, a selective window electrically connected to the digital filter, and a decision unit electrically connected to the selective window.Type: GrantFiled: July 10, 2017Date of Patent: August 18, 2020Assignee: Taiwan Semiconductor Manufacturing CompanyInventors: Jui-Cheng Huang, Yi-Shao Liu, Chun-Wen Cheng, Tung-Tsun Chen, Chin-Hua Wen
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Patent number: 10736549Abstract: An example continuous glucose monitor includes a printed circuit board (“PCB”) having first and second outer layers and an inner layer; a semiconductor package having a plurality of pins coupled to the first outer layer of the PCB; an electrical contact formed on the second outer layer of the PCB; a trace having a first portion disposed on the first outer layer, a second portion disposed on the inner layer, and a third portion disposed on the second outer layer, the trace having a first end coupled to a first pin of the plurality of pins and a second end coupled to the electrical contact; and an encapsulant disposed around a perimeter of the semiconductor package, the encapsulant covering the plurality of pins, the first portion of the sensor trace, the third portion of the sensor trace, wherein an upper surface of the semiconductor package remains exposed.Type: GrantFiled: December 19, 2018Date of Patent: August 11, 2020Assignee: Verily Life Sciences LLCInventors: Mandy Philippine, Scott Matula, Johan Vanderhaegen, Louis Jung, Nivi Arumugam
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Patent number: 10724066Abstract: Devices and methods capable of detecting glucose in saliva (FIG. 12). The devices feature a sensor having a substrate containing electrodes and one or more reagents on the electrodes. A detection device is operably coupled with the sensor to detect glucose based on measurement of an electrical parameter when electricity is applied to the electrode.Type: GrantFiled: January 27, 2017Date of Patent: July 28, 2020Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Jeffrey LaBelle, Chi Lin, Jonus Reyna, Amnah Alkhan, Cael Muggeridge, Susan Sheffield
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Patent number: 10714212Abstract: A portable data-management system based on an analyte testing device which communicates wirelessly with a mobile device. The mobile device runs an application to manage and analyze data obtained by the analyte testing device. The mobile device may assist the user in displaying testing data, identifying patterns to assist healthy behavior or issue warnings based on the collected data. The mobile device may be connected to a network to store user health data for use by other parties.Type: GrantFiled: November 13, 2015Date of Patent: July 14, 2020Assignee: Ascensia Diabetes Care Holding AGInventors: Jun Chen, Harris Lieber, Erik Nelson, Jeffery S. Reynolds, Kevin Curran, Aseem Mehta, Dawn Rountree
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Patent number: 10709978Abstract: An example system includes a physiological sensor for generating physiological data associated with a user bearing the physiological sensor. The physiological sensor is configured to wirelessly communicate the physiological data. A portable device includes a touch input device; an accelerometer for generating accelerometer data indicative of activity of the user; wireless communication circuitry for receiving the physiological data; memory for storing the accelerometer data and the physiological sensor data; and a vibrator for providing tactile output to the user. The wireless communication circuitry transmits the physiological data and the accelerometer data to a computer device for use in a presentation application.Type: GrantFiled: September 3, 2015Date of Patent: July 14, 2020Assignees: NINTENDO CO., LTD., TOHOKU UNIVERSITYInventors: Makoto Yoshizawa, Tomoyuki Yambe, Norihiro Sugita, Norikatsu Furuta
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Patent number: 10702165Abstract: The invention in at least one embodiment includes a method for determining the core body temperature of a person by setting an initial core body temperature with a processor; receiving a heart rate of the person with the processor; calculating a predicted core body temperature with the processor using an extended Kalman filter based on the heart rate and the initial core body temperature; and providing the predicted core body temperature. In another embodiment, a system for performing the method.Type: GrantFiled: March 4, 2017Date of Patent: July 7, 2020Assignee: The Government of the United States, as Represented by the Secretary of the ArmyInventor: Mark J. Buller
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Patent number: 10702198Abstract: In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.Type: GrantFiled: November 29, 2016Date of Patent: July 7, 2020Assignee: DexCom, Inc.Inventors: Ohseung Kwon, Xianyan Wang, Timothy Stowe
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Patent number: 10653344Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.Type: GrantFiled: November 19, 2018Date of Patent: May 19, 2020Assignee: Abbott Diabetes Care Inc.Inventor: Gary Alan Hayter
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Patent number: 10642960Abstract: A system and method for controlling medication-dispensing patches by a wearable device is provided. The method comprises receiving a transmission at a wearable device, wherein the transmission identifies a medication-dispensing patch; transmitting information corresponding to the identified medication-dispensing patch to an external computing device; receiving information at the wearable device from the external computing device, wherein the received information corresponds to a dosage of a medication that should be dispensed by the medication-dispensing patch; and transmitting information from the wearable device, wherein the transmission is configured for controlling a medication dosage that is dispensed by the medication-dispensing patch.Type: GrantFiled: December 17, 2015Date of Patent: May 5, 2020Assignee: KONINKLIJKE PHILIPS N.V.Inventor: Jonathan T. Goguen
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Patent number: 10638979Abstract: Apparatus and methods for error modeling and correction in a blood analyte sensor or system. In one exemplary embodiment, the apparatus employs: (i) a training mode of operation, whereby the apparatus conducts “machine learning” to model one or more errors (e.g., unmodeled variable system errors) associated with the blood analyte measurement process, and (ii) generation of an operational model (based at least in part on data collected/received in the training mode), which is applied to correct or compensate for the errors during normal operation and collection of blood analyte data. This enhances device signal stability and accuracy over extended periods, thereby enabling among other things extended periods of blood analyte sensor implantation, and “personalization” of the sensor apparatus to each user receiving an implant. In one variant, the blood analyte is glucose, and the implanted sensor utilizes an oxygen-based molecular measurement principle.Type: GrantFiled: July 10, 2017Date of Patent: May 5, 2020Assignee: GlySens IncorporatedInventors: Piyush Gupta, Joseph Lucisano
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Patent number: 10624221Abstract: Introduced here is an attachable unit that connects to a base unit through a snap-fitting mechanism. The attachable unit can include a top housing structure and a bottom housing structure that are ultrasonically welded together. The top housing structure can include the toe portion that is integral with remaining portions of the top housing structure, where the toe portion is configured to provide the snap-fit with the base unit.Type: GrantFiled: July 30, 2018Date of Patent: April 14, 2020Assignee: Verily Life Sciences LLCInventors: Arthur Lin, Sean Frick
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Patent number: 10617822Abstract: Methods, devices, algorithms, and systems controlling insulin delivery employ velocity-weighting. Predicted glucose outcomes are penalized with a cost modulated by a factor that is a function of the glucose velocity, wherein glucose outcomes are penalized increasingly less for increasingly negative glucose velocities, when glucose level is high, and/or wherein a hyperglycemic glucose value that is already converging to the euglycemic zone results in less corrective action by the controller than were the hyperglycemic state steady.Type: GrantFiled: June 29, 2016Date of Patent: April 14, 2020Assignee: The Regents of the University of CaliforniaInventors: Ravi L. Gondhalekar, Eyal Dassau, Francis J. Doyle, III
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Patent number: 10610154Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.Type: GrantFiled: June 23, 2012Date of Patent: April 7, 2020Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Boris P. Kovatchev, Patrick T. Keith-Hynes, Marc D. Breton, Stephen D. Patek
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Patent number: 10596295Abstract: An adhesive patch arrangement for a sensor includes a flexible patch, a sensor-affixing feature located in a sensor mounting region of the component-facing side of the flexible patch, the sensor-affixing feature securing the sensor to the flexible patch, and a device-affixing feature located in a device mounting region of the component-facing side of the flexible patch. The device-affixing feature secures a device to the flexible patch. The sensor mounting and device mounting regions are distinct and separate regions. The arrangement also includes a removable reinforcement liner adhered to, and covering, the device-affixing feature, and shaped to define a cutout area that partially surrounds the sensor-affixing feature. The arrangement also includes a removable backing liner adhered to, and covering, the adhesive skin-facing side of the flexible adhesive patch.Type: GrantFiled: August 28, 2017Date of Patent: March 24, 2020Assignee: Medtronic MiniMed, Inc.Inventors: Eric Allan Larson, Voltaire Isaac Lebron
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Patent number: 10595754Abstract: A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.Type: GrantFiled: May 22, 2017Date of Patent: March 24, 2020Assignee: Sano Intelligence, Inc.Inventors: Ashwin Pushpala, Dominic Pitera, Matthew Chapman, Michael Gifford
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Patent number: 10589019Abstract: An IV line identification system to enable ready identification of an IV line and its associated fluid source and output and to enable distinguishing the IV line from other IV lines and their fluid sources and outputs. The IV line identification system includes a first light source and a second light source communicatively coupled to one another via a wireless connection. The light sources are configured such that when one is activated so as to generate a light signal, the other is automatically activated to generate a corresponding light signal. Each light source may be placed on opposite ends of an IV line to enable ready identification of each end of the same IV line.Type: GrantFiled: August 2, 2018Date of Patent: March 17, 2020Assignee: MJ Stewart InvestmentsInventors: Wayne A. Provost, Jeffrey D. Stewart
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Patent number: 10575790Abstract: A patient diabetes monitoring system with an efficient unsupervised daily monitoring profile clustering algorithm, a method, and a computer product thereof are disclosed. The system may include a physiological data input device or sensor which receives a plurality of physiological measurements to generate a dataset, a memory which stores a clustering algorithm, and a processor. The clustering algorithm when executed by the processor, causes the processor to automatically pre-process the dataset to control an amount of bias/aggressiveness from the collected unsupervised daily monitoring profiles, thereby generating a pre-processed dataset, build a similarity matrix from the pre-processed dataset, and output an optimum number of similarity clusters found by the processor from the similarity matrix.Type: GrantFiled: March 2, 2016Date of Patent: March 3, 2020Assignee: Roche Diabetes Care, Inc.Inventors: David L. Duke, Bernd Steiger, Chinmay Uday Manohar
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Patent number: 10568511Abstract: A handheld diabetes management device for managing blood glucose test data and continuous glucose monitoring data includes a port configured to receive a test strip, a wireless transceiver, a communications processor, and a user interface processor. The communications processor communicates with the wireless transceiver to periodically collect glucose measurement data from a continuous glucose monitoring device and to store the glucose measurement data in a first data storage module. The communications processor is operable to consume electrical power at a first rate. The user interface processor communicates with the communication processor to receive the glucose measurement data and operable to display the glucose measurement data on the device. The communications processor operates asynchronously from operation of the user interface processor to collect the glucose measurement data and the user interface processor operates to consume electrical power at a second rate that is higher than the first rate.Type: GrantFiled: August 31, 2016Date of Patent: February 25, 2020Assignee: Roche Diabetes Care, Inc.Inventors: Timothy P. Engelhardt, Gerhard Frisch, Robert E. Reinke, Wilfried Schmidt, Michael Schoemaker, Uwe Wittmann
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Patent number: 10528701Abstract: Systems and methods are disclosed for sepsis care management. First data regarding a patient and second data regarding a clinician's treatment of a patient are received by at least one processor. The first data regarding the patient is processed to assess a likelihood that the patient would benefit from administration of each of one or more critical actions for treatment of sepsis, wherein at least one of the one or more critical actions relates to a request for at least one additional diagnostic action. A target treatment protocol, comprising a decision for each of the one or more critical actions, is determined based on the assessed likelihoods. The second data regarding a clinician's treatment of the patient is compared to the target treatment protocol and a notification is provided to the clinician if the second data is incompatible with the target treatment protocol.Type: GrantFiled: February 16, 2016Date of Patent: January 7, 2020Assignees: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Thomas Heldt, Andrew Tomas Reisner, Michael Filbin
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Patent number: 10478100Abstract: A medical device and a method for configuring a process for determining a dose of insulin to be administered for glycemic control is provided, wherein the dose is stepwise adapted, comprising defining different dose adjustment profiles for stepwise adapting the dose, wherein each of the different dose adjustment profiles is based at least on a specific initial dose value, a specific time interval for increasing the dose, a specific dose increase step and a specific low blood glucose threshold value, storing the different dose adjustment profiles, selecting one of the stored different dose adjustment profiles based on specific requirements for stepwise adapting the dose, and personalizing the selected dose adjustment profile by defining at least a specific target blood glucose value for a specific user.Type: GrantFiled: February 3, 2010Date of Patent: November 19, 2019Assignee: Sanofi-Aventis Deutschland GmbHInventor: Andrew Tubb
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Patent number: 10463786Abstract: A device for infusing liquid medicaments such as insulin includes an infusion pump. The device can modify an insulin delivery protocol stored in memory to delivery an alternative insulin delivery protocol with the pump.Type: GrantFiled: November 1, 2016Date of Patent: November 5, 2019Assignee: Tandem Diabetes Care, Inc.Inventor: Sean Saint
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Patent number: 10463789Abstract: A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.Type: GrantFiled: September 2, 2016Date of Patent: November 5, 2019Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Marc D. Breton, Boyi Jiang, Chiara Fabris
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Patent number: 10456090Abstract: This invention relates to a method and a device for predicting the glucose concentration of a subject and recommending therapeutic action. The responses of the user's glucose to administered doses of insulin, dietary carbohydrates, and other factors influencing glucose concentration are measured individually for a given user. Once these responses are learned as a function of time, the method and device can receive information about the factors which that have been recently or will soon be administered and can recommend which other factors should also be administered.Type: GrantFiled: November 20, 2015Date of Patent: October 29, 2019Assignee: Bigfoot Biomedical, Inc.Inventors: Dayton Gray Thorpe, Jonathan S. Landy
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Patent number: 10462277Abstract: A mobile terminal includes a communicator configured to communicate with wearable devices; a memory configured to store capability information indicating capabilities of the wearable devices; and a processor configured to determine a first wearable device and a second wearable device among the wearable devices capable of executing a function of the mobile terminal, based on the capability information, the first wearable device being configured to perform a first sub-function for executing the function of the mobile terminal, the second wearable device being configured to perform a second sub-function to be executed together with the first sub-function to execute the function of the mobile terminal, the processor being configured to control the first wearable device to perform the first sub-function and to control the second wearable device to perform the second sub-function.Type: GrantFiled: October 20, 2017Date of Patent: October 29, 2019Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventors: Dae-ho Lee, Jung-hye Min, Kyung-ho Jeong