Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a measured probing potential modulation current signal; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection functio

Abstract: The present invention allows for non-invasive monitoring of the blood sugar levels in diabetic patients. At least one heat and waterproof applicator is applied to the skin surface by a dosage pressure. Temporal dynamics of physiological parameters of the local tissue region are measured under the applicator. Temporal dynamics of climatic parameters of the environment are measured simultaneously or before the beginning of measurement of physiological parameters in the monitoring mode. Further, enthalpy of tissue is calculated with account for the influence of climatic parameters. Magnitude of thermal effect of metabolism of the local area of living tissue is calculated on the basic thermodynamics equation, connecting enthalpy of tissue with variables of thermodynamic state. Relative changes in the level of glucose are calculated in blood, proportional to the value of the thermal metabolism of the local area of living tissue.

Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.

Abstract: Medical devices configured for in vivo assays of one or more analytes can sometimes be problematic if left inserted in a tissue, such as skin, for an extended time. Certain medical device surface profiles may aid in alleviating this issue. Accordingly, medical devices may comprise a base surface having a tissue-facing surface profile defined thereon, and a sensor extending through the base surface and at least a portion of the tissue-facing surface profile. The tissue-facing surface profile deviates from the base surface, and the tissue-facing surface profile is also configured to undergo a change in shape, hardness, or a combination thereof after contacting a tissue for a length of time. A dynamic material may be present in at least a portion of the tissue-facing surface profile.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: A system using combined electrocardiography (EKG) and photoplethysmography (PPG) sensing, to determine venous oxygen saturation is described. The system uses averaging of similar pulses based on Prior (or n?1) R-to-R pulse wave duration, and current (or n) R-to-R pulse wave duration for evaluation of the metabolic reserve and/or stress of the patient.

Abstract: Technologies for a monitoring system for monitoring a user's movement include a sensor module and a monitoring device. The sensor module is attached to the user or wearable by the user. The monitoring device detects the sensor module positioned in proximity to the monitoring device, receives sensor data from the detected sensor module, analyzes the received sensor data to determine a position and an orientation of the detected sensor module relative to the monitoring device, compares the determined positions of the detected sensor module to predefined planned positions, and initiates an alert notification in response to a determination that a difference between the determined positions of the detected sensor module and the predefined positions is greater than a reference threshold.

Abstract: A biological fluid collection device (10) that receives a sample (12) and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications. Advantageously, a biological fluid collection device of the present disclosure includes an internal vacuum (28). In this manner, a biological fluid collection device of the present disclosure eliminates the need for additional vacuum creating components that must be connected to the biological fluid collection device during use.

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value.

Abstract: The present application relates to methods of using compounds of Formulae (I) and (II): for treatment of various cancers. The application further relates to pharmaceutical compositions and uses comprising the compounds of the application.

Abstract: The present intraoral sensing system which is configured to sense a biological information using a sensor module installed in an oral cavity, including a sensor module installed in an oral cavity of a patient and configured to store data acquired when the biological information is sensed, a storage configured to acquire the data and an identification information of the patient stored by the sensor module, associate the acquired data with the identification information of the patient, and store the association, a terminal apparatus for a dentist configured to analyze the data stored in the storage for each of the identification information of the patient, and a terminal apparatus for a doctor configured to acquire the data associated with a patient who has a developed disease among the data of patients stored in the storage, from the terminal apparatus for a dentist.

Abstract: An injector for transcutaneously introducing a sensor into a patient, including a cannula, a sensor arranged in the cannula, a base element, a sliding element arranged displaceably on the base element in an injection direction, for transcutaneously introducing the cannula having the sensor into the patient in an injection operation. The cannula has a slot in a longitudinal direction of the cannula. The injector has a holding element arranged displaceably on the base element that, in an ejection operation, prevents the sensor from being pulled out as the cannula is withdrawn, by engaging in a distal end region of the sensor through the slot into the cannula. The holding element and/or base element have at least one fixing arrangement to automatically lock the holding element on the base element when the cannula is introduced transcutaneously into the patient. A method for transcutaneously introducing a sensor into a patient is also provided.

Abstract: In some embodiments, a sensor assembly for a continuous glucose monitoring system is provided that includes (1) a sensor carrier having a sensor unit receiving area and an electronics receiving area, the electronics receiving area including a substrate; (2) a sensor unit having a sterilized region, the sterilized region including at least a portion of a sensor and an introducer; and (3) electronics for the continuous glucose monitoring system. The sensor unit is positioned within the sensor unit receiving area of the sensor carrier and the electronics are positioned on the substrate within the electronics receiving area of the sensor carrier so as to form a sensor assembly having the sensor electrically connected to the substrate of the electronics receiving area while maintaining sterilization of the sterilized region of the sensor unit. Numerous other aspects are provided.

Abstract: A biosensing device includes a sensor module and an electric signal transducer. The sensor module includes a biosensor adapted for measuring a biosignal of a host, and a fixed seat including a conducting member that is electrically connected to the biosensor. The electric signal transducer is for receiving and sending the biosignal measured by the biosensor, is coupled to the sensor module, and includes an electric signal unit electrically connected to the conducting member, and a battery connected to the electric signal unit. The electric signal unit has two electrical contacts that cooperatively define a switch. The battery provides power supply to the biosensor when the electric signal transducer is coupled to the sensor module.

Abstract: A system for detecting and treating an anastomotic leak includes a microcatheter implanted at an anastomosis site; a source of a perfusion fluid coupled to the microcatheter and configured to dispense the perfusion fluid to the microcatheter; and an analyzer coupled to the microcatheter configured to receive an extracellular fluid from the microcatheter and to analyze the extracellular fluid to determine status of the anastomosis site.

Abstract: The present disclosure relates to techniques for receiving glucose data from a continuous glucose sensor and controlling the use and redistribution of that data so it is used in an intended manner. In one aspect, a system includes a plurality of continuous glucose monitor (CGM) devices; a plurality of display devices to receive data from the CGM devices classified into a plurality of classifications based on data type; a cloud server architecture to receive the data from the display devices on an intermittent basis, in which the data routed to a particular server of the plurality of servers is determined by the data type, and in which the intermittent basis varies depending upon data type; a plurality of remote monitor display devices; and an analysis and report engine.

Abstract: A portable drain system having a subdermal drain and a container in fluid communication with the subdermal drain is disclosed. The subdermal drain is configured to drain fluid from a surgical site. The container provides a negative pressure to the subdermal drain. The container draws and receives the fluid. The container includes at least one sensor in which the at least one sensor is configured to detect at least one of fluid color, fluid volume in the container, and orientation of the container.

Abstract: In some embodiments, a sensor assembly for a continuous glucose monitoring system is provided that includes (1) a sensor carrier having a sensor unit receiving area and an electronics receiving area, the electronics receiving area including a substrate; (2) a sensor unit having a sterilized region, the sterilized region including at least a portion of a sensor and an introducer; and (3) electronics for the continuous glucose monitoring system. The sensor unit is positioned within the sensor unit receiving area of the sensor carrier and the electronics are positioned on the substrate within the electronics receiving area of the sensor carrier so as to form a sensor assembly having the sensor electrically connected to the substrate of the electronics receiving area while maintaining sterilization of the sterilized region of the sensor unit. Numerous other aspects are provided.

Abstract: A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.

Abstract: A disease prediction model construction apparatus is provided. The disease prediction model construction apparatus may include a spectral data acquisition unit that emits near-infrared rays toward a skin of a subject to acquire near-infrared spectral data and a prediction model construction unit that constructs a disease prediction model based on a time-blood glucose graph generated from the acquired near-infrared spectral data.

Abstract: A closed-loop wearable device or platform integrates sensors, actuators, and microcontroller on board. The device is applied directly to the skin using stretchable epidermal electronics. It can sense a variety of signals from the human body, thus collecting medically relevant information, and can activate delivery of a therapeutic upon detection of an abnormal condition. The therapeutic can be delivered at a personalized dosage and/or with a unique combination of drugs or other agents based on the individual's metabolism as tracked by various sensor modules integrated with the medical device.

Abstract: Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods and apparatuses for delivery of zolmitriptan for achieving a Tmax as quick as 2 minutes and not later than 30 minutes in the majority of subjects.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: Introduced here is a digital pill comprised of a capsule, an ingestible sensor, and a slot antenna. The ingestible sensor can be configured to generate a signal indicative of a characteristic of the living body in which the digital pill is located. Biometric data can be stored, at least temporarily, in a memory in the form of signal values. For example, the slot antenna may transmit biometric data to a computing device across a network on a periodic basis (e.g., every 5 minutes, 15 minutes, 60 minutes, etc.). Alternatively, the slot antenna may stream biometric data to a computing device across the network in real time.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: An apparatus for estimating a concentration of an analyte may include a spectrum acquisition device configured to acquire a first in vivo spectrum of an object, and a processor configured to estimate the concentration of the analyte using the first in vivo spectrum and a concentration estimation model that is generated based on a second in vivo spectrum measured during a timeframe in which the concentration of the analyte in the object is substantially constant, and update the concentration estimation model based on the first in vivo spectrum and the estimated concentration of the analyte.

Abstract: A digital system includes a non-volatile calculating register having a set of latches configured to perform a calculation. A set of non-volatile storage cells is coupled to the set of latches. Access detection logic is coupled to the calculating register and is operable to initiate a calculation of a next value by the calculating register each time the calculating register is accessed by an accessing module. The access detection logic is operable to cause the next value to be stored in the set of non-volatile storage cells at the completion of the calculation as an atomic transaction. After a power loss or other restore event, the contents of the calculating register may be restored from the non-volatile storage cells.

Abstract: Methods and apparatuses for monitoring either or both the performance of an orthodontic appliance for repositioning a patient's teeth and/or the user compliance in wearing the appliance using a biosensor. The apparatuses described herein may include one or more sensors, including biosensors, electrical sensors, or both, configured to generate sensor data related to user compliance and/or repositioning of the patient's teeth by an orthodontic appliance.

Abstract: Systems, devices, and methods are provided for changing the power state of a sensor control device in an in vivo analyte monitoring system in various manners, such as through the use of external stimuli (light, magnetics) and RF transmissions.

Abstract: An image processing apparatus according to a first aspect of the present invention acquires a first image and a second image in a first image acquisition mode, or a second image acquisition mode in which a second image acquisition ratio is higher than in the first image acquisition mode, on the basis of a detection result of a specific target (whether or not a specific target has been detected, what type of specific target). For example, in accordance with whether or not a specific target has been detected and the type of specific target, the first image and the second image can be acquired in the first image acquisition mode in a case where the necessity for acquiring the second image is low, whereas the first image and the second image can be acquired in the second image acquisition mode, in which the second image acquisition ratio is high, in a case where the necessity for acquiring the second image is high.

Abstract: A sensor includes: a needle member defining a hollow portion, wherein the needle member comprises a peripheral wall, and a through hole extends through the peripheral wall; an elongated detection member positioned in the hollow portion and extending along a longitudinal direction of the needle member; and at least one protruding portion that protrudes radially inward from the peripheral wall and restricts movement of the detection member in a radial direction.

Abstract: A medical device includes at least one memory device storing data; a communication interface defining a first communication path to allow communications between the medical device and an external device or network; and a hardware key interface defining a second communication path that is separate from the first communication path. A hardware key is configured to be coupled to the meter via the second communication path defined by the hardware key interface. The data on the at least one memory device cannot be modified unless the hardware key interface is physically coupled to the hardware key. The hardware key may include a key code component and conducting lines, where the hardware key interface receives the key code via the conducting lines and the data on the at least one memory device cannot be modified unless the key code provided by the hardware key is validated.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: There is provides a biological condition determining apparatus for determining a biological condition of a subject on a bed. A biological condition determining apparatus includes a plurality of load detectors which are placed in the bed or under feet of the bed and which detect a load of the subject, a biological information extracting unit which extracts biological information from an output of at least one of the load detectors, a determining unit which determines the biological condition of the subject by comparing the extracted biological information with a referential information prepared beforehand, and an output unit which outputs the biological condition of the subject determined by the determining unit.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A sensor module includes: a metal member having a recessed portion; a resin portion embedded within the recessed portion; a radiator provided within the resin portion and configured to emit radio waves; a wireless communication portion provided within the resin portion and connected to the radiator; and a sensor connected to the wireless communication portion, wherein the metal member is insulated from the radiator by the resin portion and functions as a parasitic element.

Abstract: Provided are an electronic device, a body-worn type device, a communication system, a communication controlling method and a storage medium which make it possible to appropriately perform necessary data communication while more reducing power consumption of the body-worn type device. The electronic device includes a transceiver which performs communication via short-range wireless communication, a memory which stores identification data on each electronic device which is communicable with the body-worn type device via the transceiver, and a processor which, in a case where communication connection is established between any one of the electronic devices which are contained in the identification data and the body-worn type device, operates to perform data transmission and reception between its own device and the body-worn type device via another electronic device that the communication connection with the body-worn type device is established.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: A medical capsule is equipped with a sensor device having light emitting and light receiving elements. The sensor device can detect blood on the basis of light absorption properties of the blood. The capsule has a casing forming a recess or gap at its outer surface. The recess has a pre-selected width which represents a fixed measuring track between the light emitting and light receiving elements being arranged at opposing sides of the recess or gap when seen in its width direction. The medical capsule also has a shielding plate/layer/membrane arranged at least at or near the bottom of the recess or gap and extending along the width direction of the recess or gap preferably to exceed the recess at both sides into its width direction to prohibit emitted light from bypassing the recess via the casing material of the capsule.

Abstract: A biosensing device for continuous monitoring of an analyte in a fluid matrix includes an electromagnetic excitation element [402], a biosensing surface [406], an opposing surface [410], a separation component [420,422], light collection optics [412], a light sensor [414], an image recording and analysis system [416], and an excitation control system [400]. The separation component is connected to the biosensing surface and to the opposing surface, forming a concave gap region [408] between the biosensing surface and the opposing surface. The biosensing surface comprises biosensing particles sensitive to electromagnetic signals from the electromagnetic excitation element, where an optical response of the biosensing particles to the electromagnetic signals is adapted to change in the presence of an analyte in the gap region. The light collection optics couple light emitted from the biosensing particles on the biosensing surface to the light sensor.

Abstract: A fluid dispensing catheter includes an inner member defining a first passage and an outer member defining a second passage. The inner member is disposed within the second passage. The fluid dispensing catheter also includes a plug having a proximal section positioned within the first passage and a distal section extending distally from the proximal section. The distal section is positioned outside of the first passage and within the second passage.

Abstract: Certain embodiments described herein pertain to optical sensors, systems and methods for continuous glucose monitoring. In some embodiments, methods of preparing a layered optical sensor are disclosed. The optical sensor can be formed by laminating a plurality of sheets together to form a final sensor. In some embodiments, the sensor tip comprises a oxygen conduit, an enzymatic layer, and an sensing layer. In some embodiments, the sensor includes a plurality of waveguides configured to direct light to and from a target material, such as an oxygen sensing polymer. Systems are also disclosed for an adhesive system for attaching an optical sensor-transmitter system. Methods and systems are also disclosed for a sensor inserter system. The inserter can include a lancet tip that includes a convex feature attached to a first surface of the lancet tip.

Abstract: A method for testing a sensor with a primary inductor which is galvanically isolated from first and second secondary inductors which are respectively coupled inductively to the primary inductor, including: calculating a sensor output signal, wherein the sensor output signal is dependent on the coupling between the primary inductor and the first secondary inductor as well as that between the primary inductor and the second secondary inductor; determining a first electrical variable, which is different from the sensor output signal; comparing the first electrical variable with a first limiting value in order to determine whether the sensor is in a faulty state, as well as to a corresponding device and to a sensor having the device.

Abstract: Provided is a smoking member cleaning device formed to clean a smoking member, the smoking member cleaning device including a main body unit; an accommodating unit formed in one region of the main body unit to accommodate one region of the smoking member when the smoking member is being cleaned; a cleaning unit formed in the accommodating unit and configured to clean the smoking member; a cleaning driving unit connected to the cleaning unit and configured to clean the smoking member by moving the cleaning unit; and a power supply unit configured to supply driving energy to the cleaning driving unit.

Abstract: One example system includes a biosensor applicator having a housing defining a cavity configured to receive and physically couple to a biosensor device, and to apply the biosensor device to a wearer; an applicator coil antenna oriented around a first axis; and a biosensor device including a biosensor coil antenna; a first wireless transceiver electrically coupled to the biosensor coil antenna; a Bluetooth antenna; and a second wireless transceiver coupled to the Bluetooth antenna; wherein the biosensor device is physically coupled to the biosensor applicator and positioned at least partially within the cavity; and wherein the applicator coil antenna is configured to wirelessly receive electromagnetic (“EM”) energy from a remote coil antenna and wirelessly provide at least a first portion of the received EM energy to the biosensor coil antenna.

Abstract: Methods, systems, apparatuses, and/or devices for taking optical measurements. The methods, systems, apparatuses, and/or devices may include: emitting a first wavelength of light into the body; receiving light from a depth below a surface of the body corresponding to blood or sub-epidermis tissue of the body; and determining a physiological condition of the body when a current amount of light reflected or backscattered the blood or the sub-epidermis tissue and by the received by the optical sensor is different than a previous amount of light reflected or backscattered the blood or the sub-epidermis tissue and by the received by the optical sensor.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: Glucose monitoring devices and related systems and methods, the glucose monitoring devices including a sensor electronics unit having a housing and a printed circuit board disposed within the housing, a transcutaneous glucose sensor assembly, and a conductive sensor connector. The printed circuit board includes a first electrical contact, the transcutaneous glucose sensor assembly includes a distal portion having a working electrode and proximal portion having a working-electrode contact in electrical communication with the working electrode, and the conductive sensor connector electrically connects the working-electrode contact with the first electrical contact. Further, the conductive sensor connector extends through a hole in the proximal portion of the transcutaneous glucose sensor assembly and through a hole in the printed circuit board.