Abstract: A radiographic marker containing a sensing medium that initially includes a gas and liquid mixture for producing increased signal intensity in a first imaging modality. The radiographic marker can have a permeable portion allowing the exchange of the gases or liquids of the sensing medium to be changed or exchanged for at least a second fluid in the surrounding tissue to reduce the bubbles or air pockets created by the gas portion of the sensing medium. The change or exchange of gas for the second liquid in the radiographic marker produces a detectable signal intensity of the radiographic marker in a second imaging modality different from the first imaging modality.

Abstract: An assembly for magnetic resonance imaging (MRI) of a patient and a method of magnetic resonance imaging (MRI) of a patient using different MRI scanners is disclosed. In one example, the assembly includes a plurality of RF coils, wherein the RF coils are configured to be positioned adjacent to an anatomy of interest, a patient support structure configured to support of the patient, a base removably coupled to the patient support structure, the base and the patient support being configured for receipt in the bore of an MRI scanner, and an interface coupled to the plurality of RF coils and to the MRI scanner and configured to connect the plurality of RF coils and the MRI scanner and to selectively control a first RF coil and a second RF coil included in the plurality of RF coils.

Abstract: An intracorporeal marker for marking a site within living tissue of a host having a body of porous hydroxyapatite whose physical properties permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities.

Abstract: A phantom for co-registering a magnetic resonance image and a nuclear medical image is disclosed. The phantom includes a longitudinal member having a first end cap and a second end cap and a chamber contained within the longitudinal member. The chamber contains a fluid for producing a first image using a first imaging modality. The phantom further includes a first rod disposed within the chamber of the longitudinal member. The first rod contains a radioactive substance for producing a second image using a second imaging modality.

Abstract: A biopsy grid is provided that is useful in medical imaging. The biopsy grid comprises a hydrogel layer containing a mixture of contrast agents that are visible in images from X-ray, CT scans, MRI, and/or positron emission tomographs. The hydrogel mixture is attached to a frame having a silicone coated release liner and an adhesive layer. The hydrogel layer is cut into strips that serve as markers in an image. The biopsy grid can be used to locate the position of the marker relative to a tissue of interest in a medical image.

Abstract: Described is an approach to enabling gesture interactions for the viewport widget in a graphical user interface (GUI) library. The gesture interactions may include continuous operations such as panning, zooming and rotating of the viewport's content with fingers (or styluses). The approach is based on using a camera to detect occlusion patterns in a sensor grid rendered over the viewport. The sensor grid consists of sensor blobs, which are small blobs of pixels with a distinct color. A sensor blob is aware of its location in both the viewport's coordinate system and the camera's coordinate system, and triggers an occlusion event at the location when it is occluded by a finger (or stylus). Robust techniques are devised to eliminate unintentional gestures, provide visual guidance and feedback for interactions, and minimize the visual interference of the sensor grid with the viewport's content.

Abstract: A multimodal fiducial marker (10) for registration of data is disclosed. The multimodal fiducial marker (10) generally comprises a first portion (12) made from at least one radiopaque material and a second portion (14) made from a porous material capable of absorbing at least one radioactive material. The second portion (14) at least partially surrounds the first portion (12).

Abstract: According to one embodiment, a medical image processing apparatus includes an X-ray image obtaining unit, a marker detection unit, a contrast image generation unit and a display image generation unit. The X-ray image obtaining unit obtains X-ray contrast image data and X-ray fluoroscopic image data. The marker detection unit detects positions of a marker from the X-ray contrast image data, or the X-ray contrast image data and the X-ray fluoroscopic image data. The marker is attached to a device. The contrast image generation unit generates X-ray contrast image data for a combination with a movement correction making the positions of the marker be positions which can be regarded as a same position. The display image generation unit generates X-ray image data for a display by combining the X-ray contrast image data for the combination with the X-ray fluoroscopic image data.

Abstract: The present invention is directed to the use of isotopically labeled citrulline for gnosing the presence or absence of a bacterial infection in the lungs of a patient.

Abstract: A method for an image data acquisition with a magnetic resonance device that has a display unit includes acquisition of at least one overview measurement with at least one image data set, evaluation of the at least one image data set, generation of information of a slice geometry, graphical presentation of the information of the slice geometry along at least one slice plane, and acquisition of image data regarding a medical and/or diagnostic question and/or examination.

Abstract: Systems and methods for registering objects with a surgical navigation system are described herein. In one embodiment, a method for registering objects with a surgical navigation system can include detecting identification information associated with an object using a sensing device coupled to a digital data processor and detecting a position-tracking array using the sensing device. The method can also include searching a digital data store coupled to the digital data processor that contains a listing of objects and associated identification information to identify an object having identification information that matches the identification information detected by the sensing device, and registering with the surgical navigation system an association between the position-tracking array and the identified object.

Abstract: A position monitoring system comprises a single composite fiducial reference comprised of a fiducial key and a fiducial extension rigidly and removably attached to the fiducial key, a tracker for obtaining image information of the surgical site, and a computer system with processor, memory, a software program, and access to a database. The computer has scan data of an area of a surgical patient with the fiducial reference fixed to the area by a multipodal surgical screw fixture. A uniquely identifiable first marker is attached to the fiducial key in a predetermined fixed relative position and orientation. The computer determines the relative position and orientation of the marker based on live image information from the tracker, relates and displays the current position and orientation of the composite fiducial reference to the scan data during a surgical procedure. Further implements at the surgical site may bear further markers that may be tracked.

Abstract: An intracorporeal marker, for marking a site within living tissue of a host, includes an outer body portion of biodegradable material. An inner body portion is located in the outer body portion. The inner body portion includes biological material that becomes calcified in the living tissue of the host over time. An agent interacts with the biological material to promote calcification of the biological material of the inner body portion in the living tissue of the host.

Abstract: The present invention involves a surgical hardware and software monitoring system and method which allows for surgical planning while the patient is available for surgery, for example while the patient is being prepared for surgery so that the system may model the surgical site. In one embodiment, the model may be used to track contemplated surgical procedures and warn the physician regarding possible boundary violations that would indicate an inappropriate location in a surgical procedure. In another embodiment, the hardware may track the movement of instruments during the procedure and in reference to the model to enhance observation of the procedure.

Abstract: An inventive medical imaging marker includes a base (2) composed of a non-imageable material, three spherical members (10, 11, 12) provided in a predetermined positional relationship in the base (2) and each composed of an imageable material, and auxiliary marker members (20, 21, 22) provided in the base (2) and composed of the imageable material. The auxiliary marker members (20, 21, 22) respectively have linear portions (20L, 21L, 22L) which are disposed parallel to straight lines extending through center points of the three spherical members (10, 11, 12) and each have a predetermined length sufficient to serve as a mark. The center points of the three spherical members (10, 11, 12) can be correctly identified in a captured image with reference to the linear portions (20L, 21L, 22L) of the auxiliary marker members (20, 21, 22) of the inventive medical imaging marker. Thus, reference axes can be correctly defined in the image.

Abstract: A system and method for automatic registration of medical images includes accessing image data of a subject and plurality of elongated fiducial markers arranged in an asymmetrical orientation and analyzing the image data to detect the elongated fiducial markers by applying a line filter to treat the elongated fiducial markers as lines within the image data. The system and method also includes matching the elongated fiducial markers within the image data to a model of the elongated fiducial markers, registering the image data with a coordinate system based on the matching, and generating a report indicating at least the registered image data.

Abstract: In part, the invention relates to fiduciary markers suitable for affixing to a patient that are detectable with respect an imaging modality such as MRI and methods of making the same. The markers include a paramagnetic material disposed therein that generates a distinguishable signal relative to a patient or other biological sample of interest during an imaging data collection session. Further, the markers demonstrate desirable signal to noise ratios across two or more MRI data collection procedures in one embodiment. The length of the markers is also adjustable by, for example, cutting or tearing a substrate upon which a substantially fluid-free region straddles a specified separation position on the substrate.

Abstract: The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

Abstract: The present application provides an apparatus and method for determining a position of a joint prosthesis using a computer assisted orthopedic surgery system in support of an arthroplasty surgery. The apparatus and method includes attaching a first locatable element to a first bone on one side of a joint, providing a sensor having a second locatable element and moving the sensor in proximity of the joint to locate a plurality of positions of the sensor relative to the first locatable element using a tracking device. The apparatus and method further includes selecting a generic model of a joint, determining the generic model in response to the plurality of positions located using the tracking device to generate a deformed model, determining a position for a joint prosthesis on the deformed model, and outputting on a display the determined position upon the deformed model.

Abstract: An MR marker for magnetic resonance imaging includes: (1) a closed volume containing a marker medium, (2) a first marker coil surrounding the volume for detecting an MR signal from the marker medium, (3) an RF shield which surrounds at least the volume and the first marker coil and screens against external RF fields, (4) a second marker coil, arranged outside the RF shield, for inductive and/or capacitive coupling to a magnetic field, and/or for emitting the MR signal detected by the first marker coil, (5) a first electrical interface for controllable electrical connection of the first marker coil to the magnetic resonance imaging scanner, (6) a second electrical interface for controllable coupling of the second marker coil and first marker coil, and (7) an electrical controller with which the first interface and/or the second interface may be controlled.

Abstract: A magnetic resonant imaging (MRI) review workstation includes a control processor, and a display integrated or otherwise operatively coupled with the control processor, wherein the control processor is configured to receive and analyze magnetic resonant imaging information pertaining to an imaged volume of tissue, and to cause to be displayed on the display output information that reflects or is otherwise indicative of an absorption rate of a contrast agent in the volume of tissue.

Abstract: The present disclosure relates generally to an MRI-compatible fiducial marker assembly and methods of use in planning and conducting brain surgery. This invention relates to the field of anatomic orientation and positioning, particularly in relation to an implement for effectively and efficiently defining an anatomic orientation and position for conducting surgical resection of a patient's brain.

Abstract: Devices and methods for identifying and destroying cancer cells are disclosed. Devices and methods may relate to techniques of imaging and/or irradiating cells bearing a plurality of surface-modified superparamagnetic iron oxide nanoparticles (SPIONs) therein. Imaging can be realized with a magnetic imaging device that generates an imaging magnetic field. A magnetic field associated with the SPION-bearing cancer cells and resulting from imaging, can be detected with a detection device. Irradiation can be realized with a magnetic field emission device that generates an irradiation magnetic field such that the SPIONs in the SPION-bearing cells are heated as a result of said magnetic field, thereby killing the SPION-bearing cells. The magnetic imaging device may be used as the magnetic field emission device. The magnetic fields produced for imaging and/or irradiating, as well as the associated magnetic field, can be focused using one or more magnetic metalens devices.

Abstract: Multimodal optical and magnetic resonance imaging methods based on the use of persistent luminescence nanoparticles. Use of mesoporous persistent luminescence <<core-shell>> complexes for theranostic applications.

Abstract: A medical method includes: obtaining marker positions at a plurality of time points; determining a first subset of the marker positions that belongs to a first phase bin; using the marker positions in the first subset to determine a first variance information, wherein the first variance information is determined using a processor; and storing the first variance information in a non-transitory medium.

Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.

Abstract: A substrate configured for placement on an internal organ or internal tissue is provided. In certain embodiments, the substrate conforms to and moves with the internal organ or internal tissue. Three or more sensor elements are integrated on the substrate. In one implementation, the substrate and associated sensor elements provide dynamic referencing of the internal organ or internal tissue after registration of the sensor data with images and/or volumetric representations of the internal organ or internal tissue.

Abstract: The device enables the detection of positions of the navigation marking elements on a reference star by way of at least two projection images taken by an X-ray system at different pivoting angles of a C-arm. The positions of the navigation marking elements on the reference star are also calculated by a navigation system tracking camera. The transformation from the coordinate system of the navigation system into the coordinate system of the X-ray system is calculated from the position of the reference star detected by the X-ray system and the position of the reference star detected by the tracking camera. The navigation marking elements are located outside of the volume which is reconstructed by way of the imaging process in order to prepare tomographic images. The positions of the navigation marking elements are determined from two-dimensional projections. All the navigation marking elements need only be detected by at least two projection images.

Abstract: An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.

Abstract: The present disclosure provides a surgical planning and navigation system imports multiple medical imaging sources of the same body part for integrated display in the same coordinate. Images are converted into 3D volumes, spatially co-registering each image volume to a base anatomical image.

Abstract: Embodiments include a fiducial deployment system including a needle and at least two adjacent and releasably-engaged fiducials retained within a lumen of the needle by engagement with each other and/or by engagement with a pusher element. A fiducial may include one or more mechanical engagement structures that interengage with and/or are rupturably attached to one or more adjacent fiducials. The needle, which may include echogenic enhancements, may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. A variety of releasably-engaged fiducials are disclosed, as are methods for use.

Abstract: Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance imaging (MRI) of the liver. Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a liver. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the liver from a signal intensity in the data based, at least in part, on a compartment model of the liver. The quantized value describes a perfusion parameter for the liver. Greater precision is achieved for estimates of the perfusion parameter as a result of the quantization performed on data acquired with greater spatial resolution and temporal resolution.

Abstract: A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter.

Abstract: A system for automatically identifying a needle insertion location from a medical diagnostic image, such as an MRI image, and providing a visual indication of the needle insertion location is disclosed. A grid plate is located proximate to an anatomical region and is preferably incorporated in an MRI support structure utilized to immobilize the anatomical region. An MRI scanner obtains an MRI image of the anatomical region, and an MRI technician places a marker on the MRI image, identifying the needle insertion location. The MRI image and the marker are transferred from the MRI scanner to another device, such as a tablet computer, which is configured to convert the MRI image and the marker to coordinates and an insertion depth. A visual indicator is located proximate to or integrated with the grid plate that provides the needle insertion coordinates and insertion depth to the MRI technician.

Abstract: An imaging marker including a body portion having a cavity in the shape of a letter is described. The cavity can be filled with a liquid containing a substance that illuminates during an imaging process. The imaging marker can also include a first end cap and a second end cap. The first end cap can be configured to be placed on a first end of the body portion, and the second end cap can be configured to be placed on a second end of the body portion.

Abstract: In part, the invention relates to fiduciary markers suitable for affixing to a patient that are detectable with respect an imaging modality such as MRI and methods of making the same. The markers include a paramagnetic material disposed therein that generates a distinguishable signal relative to a patient or other biological sample of interest during an imaging data collection session. Further, the markers demonstrate desirable signal to noise ratios across two or more MRI data collection procedures in one embodiment. The length of the markers is also adjustable by, for example, cutting or tearing a substrate upon which a substantially fluid-free region straddles a specified separation position on the substrate.

Abstract: CEST imaging technique and MR scanning are used as an MRI method for measuring glutaminase mediated tumors. The method takes advantage of the fact that glutamine does not exhibit a significant Chemical Exchange Saturation Transfer (CEST) effect while glutamate does. In accordance with this method, one first obtains a glutamate CEST MRI map of the area of a tumor. L-glutamine (nontoxic up to several millimolar level) or glutaminase blocker is then injected and a post injection Glutamate CEST map is obtained. The difference in the spatial maps indicates the level of expression of glutaminase in the tumor.

Abstract: Wireless markers having predetermined relative positions with respect to each other are employed for motion tracking and/or correction in magnetic resonance (MR) imaging. The markers are inductively coupled to the MR receive coil(s). The correspondence between marker signals and markers can be determined by using knowledge of the marker relative positions in various ways. The marker relative positions can be known a priori, or can be obtained from a preliminary scan. This approach is applicable for imaging (both prospective and retrospective motion correction), spectroscopy, and/or intervention.

Abstract: Methods, devices, and systems for use in accomplishing registration of a patient to a robot to facilitate image guided surgical procedures, such as stereotactic procedures.

Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100.mu. or better.

Abstract: Methods, devices (such as computer readable media), and systems (such as computer systems) for defining and executing automated movements using robotic arms (such as robotic arms configured for use in performing surgical procedures), so that a remotely-located surgeon is relieved from causing the robotic arm to perform the automated movement through movement of an input device such as a hand controller.

Abstract: An implantable applicator (10) has at least one guide channel (12) for guiding a radioactive seed or source (66) to a target region. A plurality of imageable fiducials (40) are configured for attachment to the patient adjacent the target region. Electromagnetic sensors (18, 20, 22, 20?, 42) are mounted to the applicator and the imageable fiducials. An electromagnetic tracking system determines the relative position of the applicator mounted sensors (18, 20, 22, 20?) and the fiducial mounted sensors (42). A localizing processor (52) generates a map of the sensors which is combined (56) with a high resolution image (46). A comparing processor (70) monitors for changes in sensor positions, generates a movement correction transform (72) which transforms (74) the planning image into a transformed planning image (76).

Abstract: A magnetic resonance tomography device has a local coil that is fashioned to receive a magnetic resonance signal. This device has a detector system that is fashioned to detect a position of the local coil on the basis of electromagnetic waves that are affected by the position of the local coil and can be differentiated from the magnetic resonance signal. A method to detect a position of a local coil in a magnetic resonance tomography device Is implemented in this manner as well.

Abstract: Systems and methods for aiding users in viewing, assessing and analyzing images, especially images of lumens and medical devices contained within the lumens. Systems and methods for interacting with images of lumens and medical devices, for example through a graphical user interface.

Abstract: Methods and systems are described for determining, in a patient that suffers from a mood disorder (e.g., depression), a propensity of the patient to manifest reduced symptoms or levels of indicators of the mood disorder in response to a psychiatric treatment. This can involve determining levels of a marker (e.g., a metabolite) indicative of a brain bioenergetic state of the patient that is predictive of whether the patient will response favorably to an antidepression treatment. Such bioenergetic state markers, tending to normalize in response to antidepression therapy, can include, e.g., a pH, a magnesium level, and a phosphorus level. Brain levels of such markers can be determined by, e.g., 31P MRS.

Abstract: A method for determining arrangement data which represents an arrangement of measurement points on an anatomical structure of a patient, wherein the arrangement data is individually determined for different regions of the anatomical structure.

Abstract: A tracking device configured to be coupled to an interventional instrument and tracked by a magnetic resonance imaging system is provided. The tracking device includes, for example, paramagnetic and diamagnetic components that form first and second tracking members. When the tracking device is adjusted into a first arrangement, the tracking device will produce a local magnetic field in the presence of the magnetic field of an MRI system that is measurable by the MRI system. However, when the tracking device is adjusted into a second arrangement, the local magnetic field produced by the tracking device is reduced relative to the first arrangement, wherein the reduced local magnetic field produces substantially no magnetic field disturbances detectable by the MRI system. Images may be acquired of a patient in which the tracking device has been introduced and, using a numerical fitting method, an accurate location of the tracking device can be determined.

Abstract: A system and method combines information from a plurality of medical imaging modalities, such as PET, CT, MRI, MRSI, Ultrasound, Echo Cardiograms, Photoacoustic Imaging and Elastography for a medical image guided procedure, such that a pre-procedure image using one of these imaging modalities, is fused with an intra-procedure imaging modality used for real time image guidance for a medical procedure for any soft tissue organ or gland such as prostate, skin, heart, lung, kidney, liver, bladder, ovaries, and thyroid, wherein the soft tissue deformation and changes between the two imaging instances are modeled and accounted for automatically.

Abstract: A tissue manipulation system includes Programmable Markers configured to be implanted on opposite sides of one or more portions of tissue within a patient's body, Markers communicating with one another to enable a determination of their relative positions and External Device receiving and transmitting signals to Markers containing information as to Marker's positions. Device is configured to: capture an image of the tissue portions with Markers; manipulate the image of the tissue portions in a virtual environment or a simulated environment to a desired restored orientation; determine desired positions Markers will have when the tissue portions are in the desired restored orientation; program implanted Markers with the desired orientations.

Abstract: The invention relates to a method of performing contrast enhanced first pass magnetic resonance angiography, the method comprising: acquiring (302) magnetic resonance datasets of a region of interest using a single- or multi-echo data acquisition technique, wherein the echo times of the one or multiple echoes are flexible, wherein at the time of the data acquisition the region of interest comprises fat, water and a contrast agent, processing (304) the datasets using a generalized Dixon water-fat separation technique to eliminate the signal originating from the fat from the background for reconstruction of an image data set.