Abstract: Plunger sub-assemblies for automatic injectors include a plunger outer having one or more engagement prongs, a plunger inner having one or more engagement slots which correspond with the engagement prongs of the plunger outer, and a retraction biasing member. The retraction biasing member is retained in a first energized state between the plunger outer and plunger inner when the engagement prongs of the plunger outer are releasably engaged with the engagement slots of the plunger inner. The one or more engagement prongs are capable of flexing substantially radially to release from engagement with the engagement slots of the plunger inner to permit the retraction biasing member to expand from the first energized state to a second expanded state. An automatic injector having a plunger sub-assembly includes a housing, an activation mechanism, and a plunger sub-assembly at least partially mounted within a syringe cartridge having a needle assembly.

Abstract: Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.

Abstract: A method of delivering graft material to a surgical site includes positioning graft material in a tube of a delivery device. The tube defines an open end and a bend along its length. A plunger within the tube is advanced to dispense the graft material through the open end.

Abstract: An injector includes a trigger mechanism including: a trigger member disposed about an axis having an aperture and a protrusion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to engage the aperture of the trigger member when the trigger member is in a pre-firing condition; an energy source associated with the ram for powering the ram to expel the medicament; and a user-operable firing-initiation member having an aperture engaged with the protrusion of the trigger member and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

Abstract: Embodiments are described for engaging a pumping cartridge with a pump drive. In certain embodiments, the cartridge, including a cylinder and a movable piston assembly, is initially assembled or subsequently positioned so that the distance between the attachment point on the piston assembly for coupling to a drive assembly, and a reference point on the cylinder, is greater than the maximal distance that will be encountered during normal oscillation of the piston during use. The cartridge, in certain embodiments, may be pressed into a drive assembly that immobilizes the cartridge and couples the piston assembly to the driveshaft. In certain embodiments, when the cartridge is fully inserted into the drive assembly, the piston is pressed into the cylinder sufficiently to establish a selected distance so that the piston shaft is in the proper position to engage with a coupling mechanism carried on the driveshaft.

Abstract: A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.

Abstract: The present invention relates to a medicament delivery device (10) comprising a front housing (12) and a rear housing (14) connected to each other; a medicament container (18) disposed within the front housing (12), wherein the container (18) has a front opening with or for a delivery member for delivering the medicament therethrough and at least one movable stopper (25); and a compression spring (26) having a predetermined compressed length and a predetermined outer diameter, wherein the compressed length is the length of the spring when it is in a pre-tensioned state; wherein the device further comprises a first guide means comprising a front part (28) having a predetermined first length (61), a middle part (42) having a predetermined second length (62), and a rear part (34) having a predetermined third length (63), wherein said predetermined third length corresponds to the predetermined compressed length of the compression spring, wherein the front part (28) is arranged to be in contact with the movable st

Abstract: A system and method for resetting a locking mechanism of a medicament delivery or training device is provided herein. The system and method include a central shaft comprising a slotted ring, a pronged ring, a spring, a spring clamp, an actuator button, and a lock ring. Following the firing of the medicament device, wherein the actuation member has been activated and the lock ring in the unlocked position, the system and method can be initiated to reset the locking mechanism such that the components of the system and the lock ring are reset to the locked position before the actuation member can be actuated for a subsequent injection or training.

Abstract: Described is an autoinjector comprising a spring holder, a guide cylinder releasably coupled to the spring holder, a drive assembly releasably coupled to the spring holder, a drive spring adapted to apply a force on the drive assembly, and a penetration spring adapted to apply a force on the guide cylinder. The guide cylinder is adapted to accommodate a syringe having a plunger. The drive assembly is coupled to the guide cylinder and adapted to engage the plunger.

Abstract: A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.

Abstract: Syringe systems and flow control systems configured to detect information associated with a liquid material are described. The syringe systems may include a syringe body for housing the liquid material and an injector piston for expelling the liquid material out of the syringe through a discharge outlet at a distal end of the syringe body. Components of the syringe, such as an injector piston, may include sensors configured to measure and/or detect a property of the liquid material, such as concentration, pH, or radioactivity. The flow control system may include a pinch valve and a platen arranged about a fluid delivery channel. Flow within the fluid delivery channel may be controlled by increasing (squeezing the fluid delivery channel) or decreasing the distance between the pinch valve and the platen. Components of the flow control system may include detectors configured to detect properties of fluid in the fluid control channel.

Abstract: A syringe includes a barrel and a rotatable element on the barrel; for example at a proximal location along the length of the barrel. The rotatable element rotates at least partially around the barrel. When a handle is associated with the rotatable element, the barrel may rotate as the handle is held substantially stationary or the handle may be rotated while the barrel and any peripheral device secured thereto remain substantially stationary. When handles are associated with a rotatable element that may be removed from a barrel, a barrel that is disassembled from the rotatable element may be replaced with another barrel of the same or a different configuration. The barrel and plunger may be configured to cause the barrel to rotate as the plunger moves along the length of the barrel. Methods of using a syringe with a rotatable element on a barrel thereof are also disclosed.

Abstract: Medicament delivery device comprising: a first housing part (12) having a container holder (14) into which a medicament container (16) can be placed and wherein the container has a front opening with or for a delivery member for delivering the medicament therethrough and a movable stopper (17); a second housing part (38) arranged to be moved between a closed position and an open position in relation to said first housing part (12); a plunger rod (48) having a front end and a rear end, and wherein said plunger rod is arranged parallel beside said container holder when the second housing part is in its closed position; wherein the second housing part comprises resiliently displacement means (50, 52) wherein one of the resiliently displacement means (50) is fixedly connected to said plunger rod, such that when said second housing part (38) is moved from its closed position to its open position, the plunger rod (48) is moved by said resiliently displacement means into a position where the front end of the plunger

Abstract: A medicament delivery device includes a housing having a proximal housing part and a distal housing part movable relative each other, a drive force mechanism accommodated in the distal housing part, a container filled with medicament arranged within the proximal housing part, a holding member for holding the drive force mechanism in a loaded state, and an actuation member arranged to interact with the holding member for releasing the drive force mechanism from its loaded state. The holding member is arranged to be moved from a disengaged position, in which the holding member is disengaged from the actuation member, to an engaged position, in which the holding member is engaged to the actuation member by moving the housing parts in relation to each other.

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.

Abstract: An automatic injection apparatus including a delay mechanism for properly delivering medication prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (170) for the syringe, a follower (250), a locking member, a damping compound between the follower and a supporting surface (308) to dampen rotation of the follower relative to the shuttle, and a dual functioning biasing member (290) acting between the shuttle and the follower. When the locking member moves to a release position during an injection, the dual functioning biasing member first provides a torsional force to force the follower to rotate relative to the shuttle from a latching position to an unlatching position, and then the dual functioning biasing member provides an axial force to force the shuttle axially relative to the follower to move the shuttle for retracting the syringe needle into the housing of the apparatus after injection.

Abstract: An applicator comprises a transmission member, a housing guiding a reciprocation of the transmission member, and a cap covering the housing. The transmission member is provided with a stopper extending in a direction orthogonal to an axial direction thereof. An upper end of the housing is formed with a projection sliding the stopper. The inside of the cap is formed with a lead part. The stopper is slid by the lead part to an end part of the projection when the cap is pushed and thereafter disengages from the projection when the cap is further pushed, so that the transmission member transmits the biasing force of an elastic member to a microneedle. This enables the microneedle to be applied to a skin.

Abstract: The present invention relates to a medicament delivery device comprising a distal housing part (12), and a proximal housing part (10) adapted to receive a medicament container (14) comprising a movable stopper (15), wherein said housing parts are configured to be attached to each other; a threaded plunger rod (22) arranged within said medicament delivery device and being movable in the longitudinal direction of the device; wherein the medicament delivery device further comprises plunger force means (98) operably associated with said threaded plunger rod (22) and configured to exert both a torsion force and a tension force on said threaded plunger rod (22) for positioning the plunger rod in relation to the stopper and for avoiding drooling respectively.

Abstract: A modular administration appliance including a reusable base unit and a replaceable cartridge detachably connected to the base unit and including a container for a substance and a rotatable transmission element, the base unit including a drive device by which a rotary movement is transmitted between the base unit and the cartridge, and a driving element displaceable in a rotary movement about a rotational axis by the drive device, wherein a rotation of the transmission element causes the ejection of at least a portion of the substance from the container. In some embodiments, the transmission element at least partially surrounds the drive device, and/or the drive element and the transmission element are detachably connectable to each other for transmitting the rotational movement.

Abstract: A hand-held syringe includes a handle configured for suspending and using the syringe with a single hand. The handle includes pivotally connected first and second members. The members of the handle may be pivotally connected at intermediate positions along the lengths thereof or at or near ends thereof. The first member is associated with, and may be pivotally connected to, a syringe barrel, while the second member is associated with, and may be pivotally connected to, a syringe plunger. The syringe may be configured for a single-use (i.e., it may be disposable). Applications of use and methods of using a hand-held syringe are also disclosed.

Abstract: A cartridge holder for retaining a cartridge comprising a distal end and a proximal end being spaced apart from one another in the direction of an axis, an interior which is suitable to receive and retain a cartridge in a cartridge retaining section of the interior, and a main part and at least one protrusion which is moveably connected to the main part. The protrusion is arranged to define the radial extension of a subsection of the interior, wherein the subsection is arranged at an axial position which is further away from the distal end than the cartridge retaining section. Furthermore, the protrusion is arranged to vary the radial extension of the subsection when the protrusion is moved with respect to the main part. Moreover, a method for securing a cartridge in a cartridge holder is proposed.

Abstract: A medical syringe with an extendible plunger rod is provided which facilitates injection of a large volume of material, for example, a dermal filler. The rod may include an outer plunger rod, an inner plunger rod, a compression spring configured to exert force tending to push the inner plunger rod in a direction distal to the outer plunger rod, and a locking mechanism. The locking mechanism prevents movement of the inner plunger rod relative to the outer plunger rod while both the inner and outer plunger rods are depressed, until the outer plunger rod has been depressed a first predetermined distance.

Abstract: An autoinjector device includes an elongate housing containing a syringe or cartridge having an internal piston for expressing a dose from the syringe or cartridge. A drive mechanism includes a drive member engaging the piston and a drive spring acting on the drive member. A side-operated trigger arrangement includes a retention element movably mounted in the housing from a retaining position in which the drive member is kept in a cocked condition, and a release position in which the drive member may more forwardly under spring pressure. An outer sleeve is mounted on the housing movable between a position in which the retention element is prevented from moving to release the plunger, and a position in which the retention member moves freely. The outer sleeve includes a trigger wall portion which may be depressed to move the retention element once the retention element is free to move, releasing the plunger.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: A syringe assembly having a collapsible or pivotable plunger rod with magnification properties is provided. In a pre-use or packaged state, the plunger rod is positioned substantially parallel to a barrel of the syringe assembly resulting in the syringe assembly having a reduced length and a smaller packaging footprint. The smaller packaging footprint allows for reduced storage space of the syringe assembly. Upon removal from a packaging and/or a storage space, the plunger rod can be slid or pivoted toward a proximal end of the syringe barrel and locked into place such that the syringe assembly is ready for use. The plunger rod can be shaped to provide magnification to indicia of the syringe barrel and/or contents. Alternatively, a separate magnification member can be associated with the plunger rod and/or secured about the syringe barrel.

Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.

Abstract: A syringe assembly includes a syringe barrel having an exterior surface, an inside surface defining a chamber, an open proximal end, a distal end, and an outlet disposed adjacent the distal end in fluid communication with the chamber; and a plunger assembly disposed at least partially within the syringe barrel. The plunger assembly includes an elongated plunger rod and a plunger head. The elongated plunger rod is associated with the plunger head to move the plunger head within the chamber of the syringe barrel through an injection cycle. The plunger rod is adapted to move from a collapsed position extending alongside the exterior surface of the syringe barrel to an extended position engaging the plunger head to move the plunger head through the injection cycle.

Abstract: A power injector syringe assembly (110) is disclosed. The power injector syringe assembly (110) includes a power injector syringe (112) and coupling (130) that are permanently joined. The coupling (130) includes a wedge-shaped mounting flange (144) to facilitate installation of the assembly (110) on a syringe mount (200) of a power injector. The coupling (130) also includes at least one coupling member (150) to facilitate removal of the assembly (110) from the syringe mount (200).

Abstract: A safety syringe that effectively prevents the administration of an injection in excess of a maximum injection pressure, and that provides a clear, immediate tactile feedback to the practitioner each time a maximum injection pressure is exceeded. The practitioner is provided a predetermined number of attempts to inject fluid without exceeding the maximum injection pressure, each time receiving a direct tactile feedback in the form of a ratcheting click within the plunger assembly of the syringe. After a final attempt, the next over-pressure event causes a disconnect between the thumb plate of the syringe and the piston that engages the fluid within the syringe barrel, positively prevent a potentially harmful injection. In an illustrative embodiment, the plunger assembly includes a distal portion connected to the piston and a proximal portion, connected to the thumb plate.

Abstract: A disposable injector with a cylinder/piston unit that can be filled at least temporarily with active substance, with a housing in which a pretensioned and releasable mechanical spring energy reservoir is arranged, and with at least one piston-actuating ram positioned between the spring energy reservoir and the piston of the cylinder/piston unit. The piston-actuating ram has two draw hooks that engage around the housing in some areas. In addition, the piston-actuating ram is separable from the housing by means of the relaxing spring energy reservoir.

Abstract: An injection system includes a syringe, which preferably includes larger and smaller inner diameters, and a plunger. A wiper sidewall of the plunger defines a cavity, into which a plunger shaft of the system is inserted, for moving the plunger, within the syringe, for fluid injection. The plunger includes a feature for engaging the shaft, and the sidewall preferably includes a expandable-contractible portion, in which the feature is formed. When the plunger is initially mounted within the larger inner diameter of the syringe, the portion of the sidewall is expanded and the feature of the plunger does not operably engage the inserted shaft. When the shaft moves the plunger into the smaller inner diameter of the syringe, the portion of the sidewall contracts and the feature operably engages the shaft. An optional deformable end wall of the plunger may be spaced apart from a distal terminal end of the inserted shaft.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

Abstract: The invention refers to a shuttering mechanism (1) for controlling translation of a longitudinally moveable component (2) within a housing (4), the shuttering mechanism (1) comprising at least one fixed shutter (3) attached to or integrated with the housing (4) and at least one moving shutter arm (7) moveable between at least one locking position and at least one unlocking position, wherein at least one resilient arm (5) is associated with the longitudinally moveable component (2), the resilient arm (5) having a dog (6) resiliently biased towards the fixed shutter (3), wherein the moving shutter arm (7) is arranged alongside the fixed shutter (3), wherein at least one fixed protrusion (3.1 to 3.n) is arranged on the fixed shutter (3) at least one of them arranged for engaging the dog (6) so as to prevent translation of the longitudinally moveable component in a proximal direction (P), wherein at least one moving protrusion (7.1 to 7.

Abstract: The invention provides a drive mechanism for an autoinjector, configured to be coupled to a drug containing portion to form a complete autoinjector, the drive mechanism comprising: a housing (20); a drive means coupled to the housing, the drive means comprising a resilient member (22); a retaining means coupled to the housing, the retaining means (60) engaging the drive means in a first position to retain the resilient member in a deformed condition, and releasing the drive means in a second position; and a coupling means (24) for coupling with a drug containing portion (10). The drug containing portion retains the drive means in a second deformed condition when the retaining means is in the second position, the drive means storing enough energy in the second deformed condition to drive needle insertion and/or drug delivery.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having a tubular chassis telescopable in an elongate chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis and inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier.

Abstract: The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction (P, D), the detent mechanism comprising at least one clip on one of the components arranged to be in a ramped engagement with a recess in the other one of the components in an initial state in such a manner that translation between the components is constrained and that application of a translative force between the components in one longitudinal direction (P, D) with the clip engaged with the recess deflects the clip out of the recess when a predetermined value of the translative force, at least depending on the resilience of the clip, is overcome so as to allow translation between the components.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: A minimal pain microneedle based transdermal drug delivery device and method. The device has a clamshell configuration, where the top part of the clamshell holds one or more chambers configured to store liquid drugs, and also configured to store one or more spring operated plungers, and at least one microneedle. The top portion of the device is attached to the bottom portion of the device by a combination hinge and a moveable shutter mechanism. In its shut position, the shutter mechanism prevents the plungers from moving, and the open shutter position releases the plunger. When the user applies the bottom of the device to the user's skin and presses on the top portion with enough force to overcome a detent mechanism, the top portion pivots against the bottom portion forcing the microneedle through an aperture and into the skin painlessly. Pressing on the shutter mechanism then results in drug self-administration.

Abstract: A safety syringe with retractile rotation is disclosed. The plunger is capable of rapidly embedding with and positioning at the needle set, the next step of the retractile movement to retract the needle is easily processed by a user, and the needle set is firmly assembled and positioned at the open end of the barrel so as to not easily result an unpredictable phenomenon, such as deteriorating the suitability between the needle set and the barrel to result the needle set indentation and leakage when injecting from a sharp raise in temperatures, or overtightening the needle set and the barrel to result the needle and the needle set incapable of retracting in the barrel from the sharp fall of temperature. Furthermore, this invention is capable of achieving one hand operation with safety, improving environmental protection quantity, and easy use for retracting the needle.

Abstract: A syringe device and injector system including a vent for relieving a vacuum within a syringe is provided. Embodiments provide a syringe device including a reservoir having a sidewall. The reservoir includes a dispensing distal end a proximal end. The syringe device also includes a piston in movable sealing engagement with the sidewall. Furthermore, the sidewall defines a vent extending from the proximal end of the reservoir. The vent is configured to interrupt the sealing engagement between the piston and the sidewall so as to allow a gas to enter the reservoir through the proximal aperture and past the piston member as the piston member is moved from the distal end to the proximal end of the tubular aperture.

Abstract: The present invention relates to an injection device comprises a generally elongated tubular housing having opposite proximal and distal ends; a needle shield sleeve slidably and coaxially arranged inside the housing and protruding a distance outside the proximal end of the housing; a syringe carrier mechanism comprising a syringe carrier slidably and coaxially arranged to the needle shield sleeve, wherein said syringe carrier comprises a syringe having a medicament and a needle; a first activator member slidably and coaxially arranged to the housing and connected to said needle shield sleeve; an actuating member slidably and coaxially arranged to the first activator member; a drive mechanism slidably and coaxially arranged to the actuating member and to the syringe carrier mechanism, said drive mechanism being controlled by the actuating member; a second activator member slidably and coaxially arranged to the distal end of the housing and fixedly connected to the actuating member; wherein the first and the s

Abstract: A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of the pistol housing, the needle direction control mechanism, the boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

Abstract: An applicator 10 for applying a microneedle to a skin includes a tubular housing 11, a piston 20 which transmits a biasing force of a spring 40 to the microneedle, fixation means (a claw receiving portion 16 and claw portions 22a) for fixing the piston 20 against the biasing force of the spring 40 in the housing 11, and a cap 30 provided near a first end of the housing 11. A projecting portion 31 for releasing the piston 20 fixed by the fixation means is provided at a surface of the cap 30 facing the piston 20. The cap 30 is provided to be freely movable in an extending direction of the housing 11 such that the projecting portion 31 can contact the fixation means when the piston 20 is fixed by the fixation means.

Abstract: A medicament delivery device includes a housing; a drive force mechanism slidable in the housing's distal part; a member connected to the drive force mechanism for holding it in a loaded state and axially movable in relation to the distal part a predetermined distance by the housing's proximal part when the parts are moved toward each other; and an actuation member to be biased in relation to the distal part from a non-operating position partially protruding from the distal part to an operating position confined within the distal part. The actuation member can release the drive force mechanism from its loaded state, and is resiliently connected to the distal part such that it is always recoiled after being biased regardless of whether the actuation mechanism is released. The drive force mechanism is released only after the holding member moves and the actuation member is biased from non-operating to operating position.

Abstract: An I.V. flush syringe assembly includes a barrel having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end with a passageway therethrough in fluid communication with the chamber. An elongate plunger having a proximal end, a distal end and a stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for drawing fluid into and out of the chamber by movement of the stopper relative to the barrel. The plunger includes anti-reflux structure for minimizing stopper deflection when fluid has been delivered from the chamber and the stopper is being forced against the distal end of the chamber.

Abstract: A syringe device having a syringe barrel and a syringe piston having a container housing. At least a portion of the container housing is insertable within an internal chamber of the syringe barrel. A fluid passageway extends from the container housing through a piston stem. A method of protecting a syringe handler including providing the components of a syringe device and encasing the components in a protective film. The protective film is loose to allow manipulation of the syringe components relative to one another without opening or puncturing the film. Protective syringe device packaging that includes a laminate film of material sealed to encase the components of a syringe device containing a potentially harmful agent.

Abstract: A reservoir may be filled with fluidic media in a first type of environment, a plunger head may be placed within the reservoir in the first type of environment, and a casing that may be configured to envelop at least a portion of a plunger arm operatively connected to the plunger head may be attached adjacent to at least a portion of the reservoir in a second type of environment. A reservoir may be provided having a first and second portion for respectively containing fluidic media, the second portion may be adapted to be removable, the reservoir may be selectively filled with a first volume or a second volume of fluidic media, a seal member may be placed in the reservoir, and the second portion may be removed in a case where the reservoir contains the first volume of fluidic media.

Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.

Abstract: A device for delivery of medicament, which device comprises an elongated housing; a container (4) mounted within said housing and adapted to contain liquid medicament; a stopper slidably arranged within said container; and actuating means comprising a resilient member (60), a driving means (50) having one end connected to the stopper and a second end being operably connected to the resilient member, retaining means (40) for releasably retaining said driving means in a first position where said resilient member has an accumulated energy, and activating means operably connected to said retaining means for releasing said driving means to a second position, upon actively operation by an user, such that said accumulated energy is transferred to the driving means for driving the stopper a predetermined distance within the container whereby the medicament within said container i delivered characterized in that the resilient member is a variable force spring adapted for generating a predetermined sequence of at least