Abstract: An aspiration apparatus includes handles with two members. Each of the handle members includes a proximal actuation end and an opposite distal connection end. The members of the handles are associated with one another (e.g., pivotally, etc.) in such a way that movement of the proximal actuation ends in first directions (e.g., toward one another, away from one another) causes the distal connection ends to move in opposite second directions (e.g., away from one another, toward one another). The distal connection end of the first member may configured for association with the barrel of a syringe, while the distal connection end of the second member may be configured for association with the plunger of the syringe. Association of one or both of the distal connection ends with its respective syringe element may be pivotal. Aspiration methods, including, but not limited to, methods of using such an aspiration apparatus, are also disclosed.

Abstract: The invention relates to an automatic injection device (1) for a product contained in a container (50), comprising: a housing (8, 19) receiving the container (50), the container being movable between an initial position and an insertion position, triggering means (23) for initiating the movement of said container (50) from its initial position to its insertion position, said triggering means (23) being in one of a passive state, in which application of a force on said triggering means does not initiate movement of said container (50), and an active state, in which application of said force on said triggering means does initiate said movement, and a safety shield (10) movable with respect to said housing (8, 19) between a first position and a second position, movement of said safety shield (10) from its first position to its second position placing said triggering means (23) in its active state, characterized in that said device comprises: an indicator (19c, 13) that provides an indication to a user of the

Abstract: A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

Abstract: Embodiments of the invention relate to a multi-syringe device where a coupling element causes a plurality of plungers to slide in unison within their respective barrels to simultaneously dispense fluids therefrom. At least one of the plungers is a variable-length plunger that is selectively engagable to the coupling element.

Abstract: A syringe has a dripless feature by using an O-ring located between a conical disc and a flat plunger disc in an annular groove on a moving plunger. The flat plunger disc has a series of projections that offset the o-ring off the flat plunger disc surface when the plunger is not actuated. When the plunger is actuated, the o-ring distorts to rest on the projections and also on the surface of the flat plunger disc. When the plunger is released, the o-ring's resiliency pulls the o-ring back to its original shape which sucks back the fluid being dispensed so that no or less drips occur.

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with said main body adjacent the closed front end. The core member includes a nose portion having a profile adapted to create a positive seal with an outlet opening of such syringe barrel.

Abstract: The invention relates to an auto-injector with an interlock mechanism for defining an operation sequence of the auto-injector (1) in a manner to allow a lateral trigger button (16) to be operated only when a proximal end (P) of the auto-injector (1) is pressed against an injection site, wherein a detector means (18) is arranged inside an elongate housing (2) of the auto-injector (1) at the proximal end (P), the detector means (18) slidable in longitudinal direction and biased by a detector spring (19) into a position with the detector means (18) protruding beyond the proximal end (P), wherein a dog (16.2) is arranged at the trigger button (16) and wherein at least one longitudinal bar (18.1, 21) is provided, at least one of the bars (21) slidable in longitudinal direction and coupled to the detector means (18) for joint movement at least in distal direction (D), wherein a recess (21.1) for the dog (16.

Abstract: A device for delivery of medicament, which device comprises an elongated housing; a container (4) mounted within said housing and adapted to contain liquid medicament; a stopper slidably arranged within said container; and actuating means comprising a resilient member (60), a driving means (50) having one end connected to the stopper and a second end being operably connected to the resilient member, retaining means (40) for releasably retaining said driving means in a first position where said resilient member has an accumulated energy, and activating means operably connected to said retaining means for releasing said driving means to a second position, upon actively operation by an user, such that said accumulated energy is transferred to the driving means for driving the stopper a predetermined distance within the container whereby the medicament within said container i delivered characterized in that the resilient member is a variable force spring adapted for generating a predetermined sequence of at least

Abstract: A medicine syringe has a syringe barrel, piston and plunger rod. The syringe barrel is provided with a cylindrical main body defining therein a chamber to be filled with a medical solution, and an injection nozzle portion formed at an end portion of the main body and defining therein a hollow bore in communication with the chamber. The chamber and hollow bore have a total capacity of not greater than 0.5 mL. The chamber and hollow bore are formed such that the piston is slidable in a range of from 20 to 100 mm and is allowed to slide liquid-tight into the hollow bore beyond the chamber.

Abstract: The invention relates to a gearbox for converting a first translation into a second translation, the gearbox comprising a drive collar connectable to a translative drive means and prevented from rotating with respect to a ground of the drive means, a drive sleeve rotatably arranged at least partially inside the drive collar, engaged to the drive collar by a first screw thread and prevented from translating, wherein a plunger is arranged at least partially inside the drive sleeve, engaged to the drive sleeve by a second screw thread and prevented from rotating.

Abstract: An ergonomic syringe includes a slide member, wherein force exerted on the slide member causes movement of a syringe plunger within a hollow or partially hollow syringe barrel, for withdrawing fluid from a source into the syringe, and also includes a reusable adaptor for use with existing conventional syringes, which has a ring that wholly or partially encircles the barrel and indirectly attaches to a plunger flange.

Abstract: A drive assembly for a drug delivery device, comprising a housing with a proximal end and a distal end, and a longitudinal axis (A) extending between the proximal end and the distal end, a rotation sleeve being rotatable relative to the housing, and a piston rod being axially moveable relative to the housing. The piston rod is in mechanical cooperation with the rotation sleeve to be rotatable and moveable in the distal direction relative to the housing when the rotation sleeve rotates in a first direction (D1) and to be stationary in axial direction relative to the housing when the rotation sleeve rotates in a second direction (D2) opposite to the first direction (D1).

Abstract: The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. A plunger and needle are slidable between a first position in which the plunger and needle are slidably disposed in the barrel and a second position in which the plunger and needle extend from an opening in the end of the barrel. A retaining member is disposed about the opening at the end of the barrel. A spring-biased actuation mechanism connects the trigger with the plunger and needle. A membranous cartridge containing bone morphogenic protein, antibiotics, and/or other medication is loaded into the retaining member. A surgeon can inject the cartridge into a bone fracture or degenerative bone tissue during surgery to deliver the medicament directly to the affected site.

Abstract: A medicament delivery device includes a housing with a circle-segment-shaped compartment for a drive unit that moves at least one stopper in a medicament container and that includes a support wheel and central hub on which first and second parallel disks are fixedly attached and interconnected by an abutment cross-wall; spherical members between the abutment wall and adjacent the stopper; a clock spring within the hub with an outer end connected to the hub and an inner end connected to a one-direction-rotatable tubular hub coaxially arranged around a shaft fixedly attached to a housing part; and an activation member connected to the first disk by a hold-and-release mechanism. When the activation member is not depressed, the wheel and spring are held in a tensioned static state, and when the activation member is depressed, the spring and wheel are released and the spherical members are forced against the stopper.

Abstract: A fluid injection system may include an injector, a syringe and an anti-rotation connection. The injector may have a drive piston having a plunger engaging end and the syringe may have a body and a plunger within the body. The plunger may have a proximal end with at least one coupling member adapted for engagement by the plunger engaging end. The anti-rotation connection may be formed by complementary anti-rotation elements associated between the proximal end of the plunger and the plunger engaging end of the drive piston to limit rotation of the plunger within the syringe body. The anti-rotation elements may include the at least one coupling member engaged in a radial groove defining at least one axial edge formed on the plunger engaging end to enable limited rotational movement of the plunger relative to the drive piston when the complementary anti-rotation elements are engaged.

Abstract: An applicator 270 includes a stem 174 having an axially-formed slot delivery passage 200. A slot 176 is formed transaxially through the stem 174 and is in communication with the slot delivery passage 200. An extended side wall 176b is formed on one side of the slot 176. A flat surface 276 is formed in the stem 174 and extends angularly away from an opposite side of the slot 176 and from the extended side wall 176b to provide a wide slot opening at an external surface 195 of the stem for dispensing a cream from the opening. A trough-like cleft 306 can be formed in the external surface 195 of a solid portion of the stem 174, distally of the slot 176, to provide an axially-extended path for the cream being dispensed through the slot.

Abstract: A syringe assembly includes a syringe barrel having a first end, a second end, and a sidewall extending between the first end and the second end. The syringe assembly further includes a stopper disposed within a chamber of the syringe barrel, a plunger adapter engaged with the stopper, and a plunger rod having first and second ends. The first end of the plunger rod is pivotally secured to the plunger adapter. The plunger rod has a pre-use position where the second end of the plunger rod is positioned adjacent to the syringe barrel, and a use position where the plunger rod is configured to displace the stopper relative to the syringe barrel. A recessed portion of the plunger adapter receives a portion of the first end of the plunger rod when the plunger rod is in the pre-use position and the use position.

Abstract: A syringe assembly includes a syringe barrel having a first end, a second end, and a sidewall extending between the first end and the second end. The syringe assembly further includes a stopper disposed within a chamber of the syringe barrel, a plunger adapter engaged with the stopper and defining a recessed portion therein, and first and second plunger arms each having a first end pivotally secured to the plunger adapter. The first and second plunger arms each have a pre-use position where the plunger arms are spaced from each other, and a use position where the plunger arms are positioned adjacent to each other and configured to displace the stopper relative to the syringe barrel. The recessed portion of the plunger adapter receives a portion of a first end of a plunger rod when the first and second plunger arms are in the pre-use position and the use position.

Abstract: A syringe assembly including a syringe barrel defining a chamber having a stopper therein is disclosed. The syringe assembly includes a plunger rod associated with the stopper, the plunger rod includes an outer sleeve having a distal end interconnected to the stopper and a sidewall portion defining an opening therein. The plunder rod also includes an inner sleeve disposed within the outer sleeve including a longitudinally extending track in alignment with the opening in the outer sleeve. The inner sleeve is adapted for telescopic movement with respect to the outer sleeve. The plunger rod also includes a spring mounted in association with the inner sleeve. The syringe assembly further includes a holding mechanism associated with the plunger rod and configured for cooperation with the inner and outer sleeves. Relative movement between the inner and outer sleeves causes the plunger rod to transition from a collapsed position to an extended position.

Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.

Abstract: An actuation mechanism for an automatic injector includes a first actuation spring, a first actuation pill, a second actuation spring, and a second actuation pill. In an initial configuration the first actuation spring resides in a compressed, energized state substantially within an upper portion of first actuation pill and the second actuation spring resides in a compressed, energized state between the first actuation pill and the second actuation pill. An automatic injector includes a housing, an activation mechanism, an actuation mechanism, and a syringe cartridge having a plunger and a needle assembly. A retractable syringe may be utilized as a syringe cartridge, such as a prefilled retractable syringe with integrated safety features which retract the needle after use. The automatic injector may be utilized to inject the needle, deliver a drug treatment, and activate retraction of the needle. Methods of assembly and operation are also provided.

Abstract: The present invention relates to an ergonomic drive mechanism for a drug delivery device comprising: a housing (36), an axially displaceable piston rod (12) to act on a piston (18) of a cartridge (16) containing a medicinal product to be dispensed, an actuating member (26) operably engageable with the piston rod (12) and being slidably disposed relative to the housing (36) between a distal and a proximal stop position along a displacement path, wherein the actuating member's displacement path is inclined with respect to the longitudinal extension of the piston rod (12).

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: The invention relates to an injection device (1) being in one of a passive and active state, triggering of injection being prevented when said device (1) is in its passive state and permitted when said device (1) is in its active state, having: a housing (30, 30a, 30b) receiving a container, the container being in one of a passive state and an active state, movement of the container out of its initial position being prevented when the container is in its passive state, and being permitted when the container is in its active state, and a safety shield (40) coupled with the housing (30) and being movable with respect to the housing along a movement path having a predetermined length, first retaining means (60, 61, 54a) for maintaining the container (20) in its passive state, second retaining means (34a, 81b) for maintaining said device (1) in its passive state, said device (1) being characterized in that it comprises: first deactivating means (50, 53) and second deactivating means (50, 50a) movable coinciden

Abstract: A new device and a method are provided which allow for making an electrical connection between an electrolyte and an electric wire. A new connector is provided which allows to be used by a single sterile operator. A new valved device is provided which allows for maintaining the integrity and the pressure of a saline column in the central venous line. A new device is provided which allows for automatically maintaining a continuous flush of a saline syringe in order to allow for keeping the valves of central venous lines open and capable of electric conduction. A new syringe is provided which allows for simultaneous electrical connection between the fluid in the syringe and an electrical wire. Several new methods are provided for making an electrical connection to a central venous line during and after the catheter placement procedure.

Abstract: A medical fluid injector, replaceable syringe, and coupling mechanism to engage the syringe plunger to the plunger drive ram of the injector are provided wherein coupling involves a cam cleat-like mechanism, thereby allowing for cooperative movement between the plunger drive ram and syringe plunger. The coupling mechanism of the plunger drive ram is provided with first and second movable members, each having toothed, arcuate surfaces, while the coupling mechanism of the syringe plunger is provided with a knurled cavity. Disengagement of the coupling mechanism is facilitated by translational movement of a face plate located on the forward end of the injector housing.

Abstract: A fluid dispensing device (10) for delivering a dose of fluid into a surgical site includes a tube (12) with a lumen (22) for receiving the dose of fluid, a housing (14) coupled to the tube, and a flexible plunger (24) at least partially disposed in the housing (14). The fluid dispensing device (10) also includes an actuation device (66, 140) engaging the flexible plunger (24) and a trigger (26) operable to cause the actuation device (66, 140) to move the flexible plunger (24). The actuation device (66, 140) may be toggled between a first operational mode in which movement of the trigger (26) advances the flexible plunger (24) into the lumen (22) and a second operational mode in which movement of the trigger (26) retracts the flexible plunger (24) from the lumen (22).

Abstract: A drug delivery device (100) includes a body (102, 116) having a reservoir (160) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (160) and the patient. The device (100) also includes a plunger (144) movable within the body (102, 116) for causing the medicament to be expelled from the reservoir (160), and a biasing means (140) for biasing the plunger (144) toward the reservoir (160), wherein in a pre-activated position, the biasing means (140) telescopes within itself, and upon activation, provides a force to the plunger (144) for expelling the medicament from the reservoir (160). The biasing means (140) is preferably provided in the form of a conical spring having a variable pitch.

Abstract: A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.

Abstract: An automatic injection apparatus including a delay mechanism for properly delivering medication prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (170) for the syringe, a follower (250), a locking member, a damping compound between the follower and a supporting surface (308) to dampen rotation of the follower relative to the shuttle, and a dual functioning biasing member (290) acting between the shuttle and the follower. When the locking member moves to a release position during an injection, the dual functioning biasing member first provides a torsional force to force the follower to rotate relative to the shuttle from a latching position to an unlatching position, and then the dual functioning biasing member provides an axial force to force the shuttle axially relative to the follower to move the shuttle for retracting the syringe needle into the housing of the apparatus after injection.

Abstract: A system to minimize fluid turbulence inside a tissue cavity during endoscopic procedures. A body tissue cavity of a subject is distended by continuous flow irrigation using a solenoid operated pump on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by the outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss into the subject's body system during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate.

Abstract: The present invention relates to a housing component of a drug delivery device (10) to accommodate a drive mechanism (11), wherein the drive mechanism (11) is operable to interact with a piston (20) of a cartridge(16) containing a medicinal product to be dispensed by the drug delivery device. The housing component comprises at least one radially inwardly extending flange portion (16) to be operably engaged with a piston rod (24) of the drive mechanism (11), characterized in that the flange portion (16) is at least partially structurally strengthened.

Abstract: A safety syringe with retractile rotation is disclosed. The plunger is capable of rapidly embedding with and positioning at the needle set, the next step of the retractile movement to retract the needle is easily processed by a user, and the needle set is firmly assembled and positioned at the open end of the barrel so as to not easily result an unpredictable phenomenon, such as deteriorating the suitability between the needle set and the barrel to result the needle set indentation and leakage when injecting from a sharp raise in temperatures, or overtightening the needle set and the barrel to result the needle and the needle set incapable of retracting in the barrel from the sharp fall of temperature. Furthermore, this invention is capable of achieving one hand operation with safety, improving environmental protection quantity, and easy use for retracting the needle.

Abstract: An autoinjector includes a housing (10) to receive a syringe (14), and a drive mechanism including first and second springs (30, 32) operating in tandem via an intermediate member (34), on a plunger (42). The plunger is retained in a locked position by a trigger. Release of the trigger causes the first spring to advance the syringe to an arrest point whereafter the second spring extends within the syringe to expel a dose.

Abstract: A medicament delivery device (1) comprises a housing (2) for holding a medicament cartridge (9), a piston rod (22, 24) and a drive (11, 20). The medicament cartridge (9) has a medicament outlet and a bung (13) moveable axially along the medicament cartridge for dispensing a medicament, the piston rod has a plunger (24) for moving the bung and a lead member (22) telescopically coupled to the plunger (24) that may be driven by the drive (11, 20) to extend or retract the piston rod (22, 24). Additionally, the device comprises a linkage (40) coupled between the plunger (24) and an anchorage (44) and a drive member (20) telescopically coupled to the lead member (22). The drive (11) is operative to rotate the drive member (20) to telescopically move the lead member relative to the drive member whereby the plunger is moved relative to the lead member by way of the linkage (40).

Abstract: A medicament delivery device (1) comprises a housing (2) for holding a medicament cartridge (9), a drive (18, 32) and a drive control means (46, 52). The medicament cartridge (9) has a medicament outlet and a bung (20) able to be driven via a piston rod (12, 14) driven by the drive force of the drive (18, 32) and controlled by the drive control means (46, 52). Additionally, the medicament delivery device (1) comprises a restraining means (38) for applying a restraining force to the piston rod (12, 14), in a direction opposite to the drive force. By varying the restraining force by the drive control means (46, 52) the movement of the bung (20) along the medicament cartridge can be controlled.

Abstract: Medical devices comprising a syringe barrel, a stopper and a two piece plunger rod are provided. According to one or more embodiments, the two piece plunger rod includes a first plunger rod piece slidably mounted to a second plunger rod piece. The first and second plunger rod pieces include locking elements which allow the length of the plunger rod to be extended during use or injection or compressed during storage or packaging. In one or more embodiments, the medical device is further packaged in a compressed position.

Abstract: A plunger (13) for a syringe (11), comprising a cylindrical hollow body having a closed base and an opening located at the opposite base of said hollow body, wherein a seat accessible through said opening is provided to receive the head of a rod or a pusher (15), said seat being equipped with engagement means for retaining said head inside the seat at the end of an axial translational or an axial translational and rotary coupling movement. The application further concerns the rod intended to be associated with said plunger and a syringe or a phial using the plunger.

Abstract: Disclosed are a piston for a micro-volume syringe and a plunger. The micro-volume syringe has a syringe barrel with a space defined in it. The piston is slidable on and along a wall of the space. A leading member to be arranged on a side where the piston comes into contact with a solution filled in the space and a trailing member to be arranged on a side where a plunger rod is to be connected, the latter side being opposite to a solution side of the leading member, have been integrated with each other. The trailing member has a higher hardness than the leading member. With the micro-volume syringe in which a drug solution can be filled in a very small quantity, the piston makes it possible to perform smooth drawing and ejection of the drug solution without leakage. Even if the small piston connected to a tip of the plunger rod is operated in a direction that the piston is to be pulled out of the syringe, the plunger rod does not slip off from the piston accidentally.

Abstract: An improved drug delivery device is provided having a piston rod that incorporates on its proximal end at least one guidepost that is configured for transmitting axial and rotational forces from a drive mechanism. The device comprises a drug delivery device housing and a medicament contained in the drug delivery device housing.

Abstract: The medical device comprises a wave spring or wave washer in a mechanism to engage or disengage a first element and a second element. The invention also discloses the use of a multiple wave spring or wave washer comprising at least two waved spring layers in a medical device.

Abstract: A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. The device is constructed in such a manner that a reset of the piston rod is facilitated.

Abstract: A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. The device is constructed in such a manner that a reset of the piston rod is facilitated by a stop element inhibiting a reversal of the movement of the piston rod when being reset.

Abstract: An apparatus and associated method are provided for controlling the plunging action of a syringe. A plunger control device includes an attachment member adapted to fixedly engage a syringe barrel. A translating member is slideably engaged with the attachment member. The translating member includes an elongate guide member slideably engaged with the attachment member such that the translating member is slideable with respect thereto between a proximal end and a distal end of the elongate guide member. The translating member further includes a plunger attachment portion disposed about the distal end of the elongate guide member and adapted to receive a portion of a syringe plunger for coupling thereto. The translating member further includes an engagement member extending from the proximal end of the elongate guide member so as to be spaced-apart from the syringe barrel when the attachment member is engaged with the syringe barrel.

Abstract: A medical injector is provided herein which includes first and second body portions rotatably coupled together; a displaceable plunger disposed in at least one of the first and second body portions; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first portion against force of the spring. The releasable retainer releases the plunger upon a predetermined extent of relative rotation between the first and second body portions, thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon rotation of injector body portions, thereby minimizing premature or failed activations.

Abstract: The present invention relates to a medicament delivery device comprising a housing (10) having opposite distal and proximal ends; a medicament container holder (15) with a medicament container (14), disposed within the housing, wherein the container has a front opening with or for a delivery member for delivering the medicament therethrough and at least a movable stopper (16); a drive unit comprising a power source (20) and a plunger rod (24), wherein said drive unit is arranged to be movable between a non-delivery state in which said power source is in a cocked state and a delivery state in which said power source acts on said plunger rod which in its turn acts on said stopper (16) for delivering a dose of medicament from said medicament container (14); retaining means operably connected to said drive unit, and capable of holding said drive unit in its non-delivery state; and activation means (36) operably connected to said retaining means, and capable of releasing said drive unit from its non-delivery state

Abstract: The present invention provides a coating system for an article including a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with a coating prepared from a composition including a first, curable organopolysiloxane comprising at least two alkenyl groups; and a second, curable organopolysiloxane comprising at least two polar groups, the second organopolysiloxane being different from the first organopolysiloxane, which can provide low breakloose force when used in syringe assemblies.

Abstract: A holding device for locking the head of a syringe piston on a pusher has arms connected to respective pinions pivotable and translationally displaceable so that the corresponding arm is involved in the same motion between a rest position, in which the arms are closed and pressed against the pusher, and an open position, in which the arms are opened and remote therefrom, the translation is carried out prior to rotation during the movement toward the open position or in reverse order toward the rest position. The holding device also has a control member and means for converting a part of the control member movement by transmitting it to at least one pinion as a translation movement, which are translationally locked, and means for converting a part of the control member movement by transmitting it to at least one pinion as a rotation movement.

Abstract: A medicine injection device comprises a cartridge having a cartridge barrel and a plunger having a plunger shaft slidable within the cartridge barrel. The cartridge may have, e.g., a pre-filled medicine. The medicine injection device farther comprises a body having a proximal end, a distal end, and a cavity in which the cartridge barrel is disposed. The proximal end of the body may optionally form a finger grip. The medicine injection device further comprises a plunger locking mechanism attached to the proximal end of the body. The plunger locking mechanism comprises a member with an aperture slidably engaged with the plunger shaft. The locking mechanism is configured for preventing the plunger from being removed from the cartridge barrel. For example, the plunger shaft may include a locking stop, e.g., a flange, that engages with the aperture in an interference arrangement.