Patents Represented by Attorney, Agent or Law Firm Arleen Palmberg
  • Oral 2-methyl-thieno-benzodiazepine formulation
    Patent number: 6780433
    Abstract: The invention provides a pharmaceutically elegant solid oral formulation of olanzapine and a process for making such formulation.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: August 24, 2004
    Assignee: Eli Lilly and Company
    Inventors: George Randall Cochran, Tommy Clifford Morris
  • Substituted tricyclics
    Patent number: 6713645
    Abstract: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 30, 2004
    Assignee: Eli Lilly and Company
    Inventors: Nicholas James Bach, Susan Elizabeth Draheim, Robert Delane Dillard, Edward David Mihelich, Jason Scott Sawyer, Douglas Wade Beight, Michael LeRoy Phillips, Tulio Suarez, Daniel Jon Sall, Jolie Anne Bastian, Michael Lyle Denney, Gary Alan Hite, Michael Dean Kinnick, Robert Theodore Vasileff, John Michael Morin, Jr., Ho-Shen Lin, Michael Enrico Richett, Richard Waltz Harper, John McNeill McGill, III, Benjamin Alan Anderson, Nancy Kay Harn, Richard James Loncharich, Richard Walter Schevitz
  • Palladium-catalyzed cross-coupling chemistry on 3-chloro-4-halo-1,2,5-thiadiazole
    Patent number: 6620940
    Abstract: The present invention relates to 3-chloro-4-halo-1,2,5-thiadiazole compounds, a method of producing novel mono- and di-substituted-1,2,5-thiadiazoles therefrom, as well as mono- and di-substituted -1,2,5-thiadiazoles.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: September 16, 2003
    Assignee: Eli Lilly and Company
    Inventor: Roger Lewis Robey
  • 2-methyl-thieno-benzodiazepine formulation
    Patent number: 6617321
    Abstract: The invention provides a pharmaceutically acceptable oleaginous or cholesterol microsphere formulation or olanzapine or olanzapine pamoate or solvates thereof. The invention further provides novel olanzapine pamoate salts or solvates thereof.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: September 9, 2003
    Assignee: Eli Lilly and Company
    Inventors: Douglas J. Allen, Kurt D. Dekemper, Thomas H. Ferguson, Stuart J. Garvin, Linda C. Murray, Norman D. Brooks, Charles A. Bunnell, Snehlata S. Mascarenhas, Sharon L. Shinkle, Barry A. Hendriksen, David E. Tupper, Manuel V. Sanchez-Felix
  • Methods of using novel compounds as neuro-protective agents
    Patent number: 6579871
    Abstract: This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
    Type: Grant
    Filed: September 3, 2002
    Date of Patent: June 17, 2003
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, John Kevin Shadle, Lawrence Joseph Heinz, Michael LeRoy Phillips, John Robert Rizzo, Benjamin Alan Anderson, John Allan Rieck, III, David Lee Varie
  • Process for preparing toluenesulfinates
    Patent number: 6570023
    Abstract: A process for preparing novel compounds useful in the preparation of 1H-indole-3-glyoxamides.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: May 27, 2003
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
  • Method for treating cognitive dysfunction
    Patent number: 6506746
    Abstract: The invention provides a method of treating a cognitive dysfunction comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b][1,5]benzodiazepine.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: January 14, 2003
    Assignee: Eli Lilly and Company
    Inventor: Charles M Beasley, Jr.
  • Substituted tricyclics
    Patent number: 6448284
    Abstract: A class of tricycles is disclosed together with the use of such for inhibiting Spla2 mediated release of fatty acids for the treatment of conditions such as septic shock.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: September 10, 2002
    Assignee: Eli Lilly and Company
    Inventors: Nicholas James Bach, Daniel Jon Sall
  • Method for treating pain
    Patent number: 6444665
    Abstract: The present invention provides a method for treating pain using an atypical antipsychotic compound.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: September 3, 2002
    Assignee: Eli Lilly and Company
    Inventors: David R. Helton, Harlan E. Shannon, Daniel E. Womer, Mary Jeanne Kallman
  • Method for treating sexual dysfunction
    Patent number: 6432943
    Abstract: The invention provides a method for treating a sexual dysfunction comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: August 13, 2002
    Assignee: Eli Lilly and Company
    Inventor: Pierre Van Tran
  • Indane derivatives for antipsychotic compositions
    Patent number: 6429317
    Abstract: The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: August 6, 2002
    Assignee: Eli Lilly and Company
    Inventors: Sean P. Hollinshead, Michael A. Staszak, John S. Ward, Joseph W. Wilson, Bret E. Huff, Philip F. Hughes, Jose S. Mendoza, Charles H. Mitch
  • Process for preparing 4-hdyroxy indole, indazole and carbazole compounds
    Patent number: 6407261
    Abstract: A process for preparing 4-hydroxy carbazoles useful as intermediates for preparing compounds that are useful for inhibiting sPLA2 and novel intermediates.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: June 18, 2002
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn
  • Process for preparing 4-substituted-1H-indole-3-glyoxamides
    Patent number: 6380397
    Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: April 30, 2002
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
  • Phenyl acetamides as sPLA2 inhibitors
    Patent number: 6353128
    Abstract: A class of novel phenyl acetamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: March 5, 2002
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., Richard Waltz Harper, David Kent Herron
  • Method for treating schizophrenia
    Patent number: 6284771
    Abstract: The present invention provides a method for treating a condition selected from the group consisting of schizophrenia, schizoaffective disorder, and schizophreniform disorder in a patient using a Compound (I).
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: September 4, 2001
    Assignee: Eli Lilly and Company
    Inventors: Charles H. Mitch, Per Sauerberg, Harlan E. Shannon
  • Method for treating a tic disorder
    Patent number: 6274636
    Abstract: The invention provides a method for treating a tic disorder comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 14, 2001
    Assignee: Eli Lilly and Company
    Inventor: Charles M. Beasley, Jr.
  • Process for preparing 4-substituted-1h-indole-3-glyoxamides
    Patent number: 6265591
    Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: July 24, 2001
    Assignee: Eli Lilly and Company
    Inventors: Benjamin Alan Anderson, Nancy Kay Harn
  • Method for treating pain
    Patent number: 6258807
    Abstract: The present invention provides a method for treating pain comprising administering an analgesic dosage of olanzapine to an animal in need of such treatment.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: July 10, 2001
    Assignee: Eli Lilly and Company
    Inventors: David R. Helton, Harlan E. Shannon, Daniel E. Womer, Mary J. Kallman
  • Olanzapine dihydrate D
    Patent number: 6251895
    Abstract: The present invention provides the novel Dihydrate D 2-methyl-thieno-benzodiazepine and a formulation therefor.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: June 26, 2001
    Assignee: Eli Lilly and Company
    Inventors: Samuel Dean Larsen, John Richard Nichols, Susan Marie Reutzel, Gregory Alan Stephenson
  • Arylpiperazines having activity at the serotonin 1A receptor
    Patent number: 6239135
    Abstract: A series of aryl piperazine compounds of the formula: or the pharmaceutically acceptable salts thereof, are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: May 29, 2001
    Assignee: Eli Lilly and Company
    Inventors: Daniel Timothy Kohlman, Yao-Chang Xu