Patents Represented by Attorney, Agent or Law Firm Arleen Palmberg
  • Method for treating insomnia
    Patent number: 5744470
    Abstract: The invention provides a method for treating insomnia comprising administering an effective amount of olanzapine to a patient in need thereof.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: April 28, 1998
    Assignee: Eli Lilly and Company
    Inventor: Pierre Van Tran
  • Compounds having effects on serotonin-related systems
    Patent number: 5741789
    Abstract: A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 21, 1998
    Assignee: Eli Lilly and Company
    Inventors: David J. Hibschman, Joseph H. Krushinski, Jr., Kurt Rasmussen, Vincent P. Rocco, John M. Schaus, Dennis C. Thompson
  • 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz?CD ! indoles
    Patent number: 5736562
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz?cd!indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 7, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • Naphthylpiperazinyl compounds useful for treating 5HT.sub.2B receptor mediated conditions
    Patent number: 5736544
    Abstract: The present invention provides methods for binding a 5-HT.sub.2B receptor in mammals using both known and novel compounds. Further, the invention provides a method for treating or preventing 5-HT.sub.2B related conditions. Finally, the invention provides an article of manufacture.
    Type: Grant
    Filed: March 25, 1996
    Date of Patent: April 7, 1998
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Marlene L. Cohen, Jaswant S. Gidda, David L. G. Nelson
  • Method for treating multiple sclerosis
    Patent number: 5731336
    Abstract: Provided is a method of treating multiple sclerosis employing certain aryl-substituted rhodanines.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: March 24, 1998
    Assignee: Eli Lilly and Company
    Inventors: Ann E. Kingston, Jill A. Panetta
  • Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
    Patent number: 5726167
    Abstract: Viridin, viridiol, demethoxyviridin, demethoxyviridiol, virone, and wortmannolone, and analogs thereof, are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in vertebrates and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, restenosis and atherosclerosis, and bone disorders in vertebrates.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: March 10, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey A. Dodge, Masahiko Sato, Chris J. Vlahos
  • Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
    Patent number: 5716975
    Abstract: Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds and pharmaceutical formulations thereof are also provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 1998
    Assignee: Eli Lilly and Company
    Inventors: Juliana M. Bue-Valleskey, David C. Hunden, Charles D. Jones, Jill A. Panetta, Walter N. Shaw
  • Method of preventing emesis using tetrahydrobenz ?CD!indole-6-carbonxamides
    Patent number: 5703112
    Abstract: The present invention provides methods of preventing emesis and treating sexual dysfunction in mammals utilizing certain tetrahydrobenz?cd!indoles. The invention further provides pharmaceutical formulations suitable for use in such methods.
    Type: Grant
    Filed: November 17, 1995
    Date of Patent: December 30, 1997
    Assignee: Eli Lilly and Company
    Inventors: Mark M. Foreman, J. David Leander
  • Aryl-substituted rhodanine derivatives
    Patent number: 5691367
    Abstract: Provided are certain aryl-substituted rhodanine derivatives, treatment methods and pharmaceutical formulations thereof.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: November 25, 1997
    Assignee: Eli Lilly and Company
    Inventor: Jill A. Panetta
  • 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz ?cd! indoles
    Patent number: 5674884
    Abstract: 6-thiazolyl-4-amino-1,3,4,5-tetrahydrobenz?cd!indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 7, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • Method of blocking human 5-hydroxytryptamine-2 receptors
    Patent number: 5674875
    Abstract: N-unsubstituted ergolines specifically bind to human 5-HT.sub.2 receptors, and are thus useful in treating diseases such as depression, hypertension and migraine.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: October 7, 1997
    Assignee: Eli Lilly and Company
    Inventors: Marlene L. Cohen, David L. G. Nelson
  • 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD] indoles
    Patent number: 5665758
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD] indoles
    Patent number: 5665743
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenzn [cd] indoles
    Patent number: 5665744
    Abstract: 6-Thiadiazole-4-1-amino-1,2,2a,3,4,5-hexahydrobenz[c-d]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Hypoglycemic agents
    Patent number: 5661168
    Abstract: Provided is a method for treating hyperglycemia utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant method are novel and, accordingly, such compounds and pharmaceutical formulations thereof, are also provided.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: August 26, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jill A. Panetta, Juliana Bue-Valleskey, David C. Hunden, Charles D. Jones, Walter N. Shaw
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5656653
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 12, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5654324
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 5, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles
    Patent number: 5648356
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
    Patent number: 5643934
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,3,4,5,-tetrahydrobenz [cd]indoles
    Patent number: 5643930
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus