Patents Represented by Attorney, Agent or Law Firm Arleen Palmberg
  • Transdermal formulation of xanomeline
    Patent number: 5980933
    Abstract: The present invention provides a method for treating Alzheimer's Disease using a xanomeline transdermal formulation. The invention provides desired transdermal xanomeline patch formulations.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Liily and Company
    Inventors: Franklin Porter Bymaster, Michael Horstmann, Harlan E. Shannon, Lisa A. Shipley, Kirti H. Valia
  • Pyrazoles as human non-pancreatic secretory phospholipase A.sub.2 inhibitors
    Patent number: 5972972
    Abstract: A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Edward D. Mihelich, Tulio Suarez, Gary A. Hite, Peter J. Doman, Stuart E. Willetts
  • Anesthetic method and composition
    Patent number: 5972932
    Abstract: The present invention provides a method for providing anesthesia using a composition comprising olanzapine and one or more opioids.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: October 26, 1999
    Assignee: Eli Lilly and Company
    Inventors: Mark J. Benvenga, Harlan E. Shannon
  • Method for treating depression with olanzapine
    Patent number: 5958921
    Abstract: This invention relates to the use of the antipsychotic drug olanzapine for the treatment of depression, including depressive signs and symptoms and Major Depression.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: September 28, 1999
    Assignee: Eli Lilly and Company
    Inventor: Gary D Tollefson
  • Method for treating neuropathic pain
    Patent number: 5952360
    Abstract: The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, Harlan Edgar Shannon
  • Method for treating pain
    Patent number: 5945416
    Abstract: The present invention provides a method for treating pain using a composition comprising olanzapine and Drug Useful in the Treatment of Pain.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Harlan E. Shannon, Daniel E. Womer
  • Method for treating pain
    Patent number: 5942530
    Abstract: The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: August 24, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, Harlan Edgar Shannon
  • Method for treating migraine pain with olanzapine
    Patent number: 5929070
    Abstract: The present invention provides a method for treating migraine pain comprising administering an analgesic dosage of olanzapine.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: July 27, 1999
    Assignee: Eli Lilly and Company
    Inventors: Harlan E. Shannon, Daniel E. Womer
  • Pyrroles as sPLA.sub.2 inhibitors
    Patent number: 5919774
    Abstract: A class of novel pyrroles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: July 6, 1999
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Robert D. Dillard, Susan E. Draheim
  • Oral 2-methyl-thieno-benzodiazepine formulation
    Patent number: 5919485
    Abstract: The invention provides a pharmaceutically acceptable solid oral formulation of olanzapine and a process for making such formulation.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: July 6, 1999
    Assignee: Eli Lilly and Company
    Inventors: George Randall Cochran, Tommy Clifford Morris
  • Phenyl glyoxamides as SPLA2 inhibitors
    Patent number: 5916922
    Abstract: A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: June 29, 1999
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., Richard Waltz Harper, David Kent Herron
  • Compounds having effects on serotonin-related systems
    Patent number: 5912256
    Abstract: A series of 1-(4-indolyloxy)-3-(4-hydroxy-4-naphthylpiperidin-1-yl)propanes are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor, yet lack mutagenic potential as measured by assays of chromosomal aberration. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: June 15, 1999
    Assignee: Eli Lilly and Company
    Inventors: Daniel James Koch, Vincent Patrick Rocco
  • Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
    Patent number: 5910505
    Abstract: This invention provides methods for the treatment or inhibitor of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B.sub.4 antagonist.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: June 8, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jerome H. Fleisch, William T. Jackson, Jason S. Sawyer
  • Heterocyclic compounds and their use
    Patent number: 5889019
    Abstract: The present invention relates to therapeutically active heterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: March 30, 1999
    Assignee: Eli Lilly and Company
    Inventor: Charles Howard Mitch
  • Method for treating anxiety with muscarinic cholinergic receptor agonists
    Patent number: 5888999
    Abstract: The present invention relates a method for treating anxiety using azacyclic and azabicyclic pyrazine compounds.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: March 30, 1999
    Assignee: Eli Lilly and Company
    Inventors: Neil C. Bodick, Franklin P. Bymaster, Walter W. Offen, Harlan E. Shannon
  • Tetrahydrobetacarboline compounds
    Patent number: 5886004
    Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: March 23, 1999
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, David L. G. Nelson
  • Methods of treating or ameliorating the symptoms of venomous bites and stings
    Patent number: 5886003
    Abstract: This invention provides a method for the treatment or amelioration of the symptoms of venomous bites or stings which comprises administering to a mammal in need thereof one or more 5-HT.sub.2 antagonists.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: March 23, 1999
    Assignee: Eli Lilly and Company
    Inventors: Marlene Lois Cohen, Kirk Willis Johnson
  • Aminoalkyl-indoles
    Patent number: 5869691
    Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: February 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Stephen Richard Baker, Jesus Ezquerra Carrera, Carlos Lamas Peteira, Concepcion Pedregal Tercero
  • Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
    Patent number: 5869497
    Abstract: This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a 5-HT.sub.2 antagonist.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: February 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Kirk Willis Johnson, David Lloyd Garver Nelson, Lee Alan Phebus
  • Indole-ethanamines
    Patent number: 5861425
    Abstract: The present invention provides 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central nervous system activity.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: January 19, 1999
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, James J. Droste, Gwyn L. Murdoch, David L. Nelson