Patents Represented by Attorney, Agent or Law Firm Arleen Palmberg
  • Process for preparing indane-like compounds
    Patent number: 6211364
    Abstract: The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: April 3, 2001
    Assignee: Eli Lilly and Company
    Inventors: Bret E Huff, Michael A Staszak, John S Ward
  • Oral 2-methyl-thieno-benzodiazepine formulation
    Patent number: 6190698
    Abstract: The invention provides a pharmaceutically acceptable solid oral formulation of olanzapine and a process for making such formulation.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: February 20, 2001
    Assignee: Eli Lilly and Company
    Inventors: George Randall Cochran, Tommy Clifford Morris
  • Heterocyclic compounds
    Patent number: 6187798
    Abstract: The present invention provides aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: February 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S. Ward
  • Substituted tricyclics
    Patent number: 6177440
    Abstract: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: January 23, 2001
    Assignee: Eli Lilly and Company
    Inventors: Nicholas James Bach, Susan Elizabeth Draheim, Robert Delane Dillard, Edward David Mihelich, Jason Scott Sawyer, Douglas Wade Beight, Michael LeRoy Phillips, Tulio Suarez, Daniel Jon Sall, Jolie Anne Bastian, Michael Lyle Denney, Gary Alan Hite, Michael Dean Kinnick, Robert Theodore Vasileff, John Michael Morin, Jr., Ho-Shen Lin, Michael Enrico Richett, Richard Waltz Harper, John McNeill McGill, III, Benjamin Alan Anderson, Nancy Kay Harn, Richard James Loncharich, Richard Walter Schevitz
  • 2-methyl-thieno-benzodiazepine formulation
    Patent number: 6169084
    Abstract: The invention provides a pharmaceutically acceptable oleaginous or cholesterol microsphere formulation of olanzapine or olanzapine pamoate or solvates thereof. The invention further provides novel olanzapine pamoate salts or solvates thereof.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: January 2, 2001
    Assignee: Eli Lilly and Company
    Inventors: Charles Arthur Bunnell, Thomas Harry Ferguson, Barry Arnold Hendriksen, Manuel Vicente Sanchez-Felix, David Edward Tupper
  • Compounds useful as neuro-protective agents
    Patent number: 6166216
    Abstract: This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: December 26, 2000
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, John Kevin Shadle, Lawrence Joseph Heinz, Michael LeRoy Phillips, John Robert Rizzo, Benjamin Alan Anderson, John Allan Rieck, III, David Lee Varie
  • Method for treating substance abuse
    Patent number: 6159963
    Abstract: The invention provides a method for treating substance abuse comprising administering an effective amount of olanzapine or pharmaceutically acceptable salt thereof to a patient in need thereof.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: December 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Charles M Beasley, Kurt Rasmussen, Gary D Tollefson
  • Naphthyl acetamides as sPLA.sub.2 inhibitors
    Patent number: 6160175
    Abstract: A class of novel naphthyl acetamide compounds is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: December 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., Richard W. Harper, David K. Herron
  • Compounds useful as neuro-protective agents
    Patent number: 6156748
    Abstract: This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: December 5, 2000
    Assignee: Eli Lilly and Company
    Inventors: Jill Ann Panetta, John Kevin Shadle, Lawrence Joseph Heinz, Michael LeRoy Phillips, John Robert Rizzo, Benjamin Alan Anderson, John Allan Rieck, III, David Lee Varie
  • Heterocyclic compounds
    Patent number: 6117883
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: September 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Jon K Reel, Celia A Whitesitt, Richard L Simon
  • Naphthyl glyoxamides as SPLA.sub.2 inhibitors
    Patent number: 6090850
    Abstract: A class of novel naphthyl glyoxamide compounds of formula (I) is disclosed together with a process for making the novel naphthyl glyoxamide compounds and the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., David K. Herron
  • Tetrahydro-beta-carbolines
    Patent number: 6090945
    Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, David L. Nelson
  • Method for treating excessive aggression
    Patent number: 6071902
    Abstract: The invention provides a method for treating extreme aggression in a mammal comprising administering an effective amount of olanzapine, or a pharmaceutically acceptable salt or solvate thereof, to the mammal.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 6, 2000
    Assignee: Eli Lilly and Company
    Inventors: Charles M Beasley Jr., Pierre V Tran
  • Heterocyclic compounds
    Patent number: 6069159
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: May 30, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S Ward
  • Thienobenzodiazepine compounds
    Patent number: 6034078
    Abstract: Pharmaceutical compounds of the formula ##STR1## in which R.sup.1 is hydrogen or halo, and R.sup.2 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.3-6 cycloalkyl optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl in which the cycloalkyl group is optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, or optionally substituted phenyl-C.sub.1-4 alkyl; or a salt thereof. Such compounds are useful for treating a disorder of the central nervous system which is associated with the modulation of a 5-HT.sub.3 receptor.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: March 7, 2000
    Assignees: Eli Lilly and Company Limited, Eli Lilly and Company
    Inventors: John Fairhurst, Terrence Michael Hotten, David Edward Tupper, David Taiwai Wong
  • Intermediates and process for preparing olanzapine
    Patent number: 6020487
    Abstract: The present invention provides a process for preparing olanzapine and intermediates therefor.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: February 1, 2000
    Assignee: Eli Lilly and Company
    Inventors: Charles Arthur Bunnell, Samuel Dean Larsen, John Richard Nichols, Susan Marie Reutzel, Gregory Alan Stephenson
  • Process for preparing 2-methyl-thieno-benzodiazepine
    Patent number: 6008216
    Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: December 28, 1999
    Assignee: Eli Lilly And Company and Limited
    Inventors: Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
  • Composition for treating pain
    Patent number: 5998434
    Abstract: The present invention provides a composition and method for treating pain using Selected Muscarinic Compounds and one or more compounds selected from the group consisting of Nonsteroidal Anti-inflammatory drugs, acetaminophen, opioids, and alpha-adrenergic compounds.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: December 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Charles H. Mitch, Harlan E. Shannon
  • Process for preparing 4-substituted-1H-indole-3-glyoxamides
    Patent number: 5986106
    Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA.sub.2 and novel intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: November 16, 1999
    Assignee: Eli Lilly and Company
    Inventors: Vien Van Khau, Michael John Martinelli, Joseph Matthew Pawlak
  • Compounds and methods for treating multiple sclerosis
    Patent number: 5981523
    Abstract: This invention provides thiomorpholinone compounds useful for treating multiple sclerosis of formula I wherein:R.sup.1 and R.sup.2 are each independently selected from C.sub.1 -C.sub.8 alkyl; C.sub.2 -C.sub.8 alkenyl; C.sub.2 -C.sub.8 alkynyl; C.sub.1 -C.sub.8 alkyloxy; C.sub.1 -C.sub.8 alkylthio; trifluoromethyl; C.sub.1 -C.sub.4 alkyl substituted with phenyl; phenyl; F; Cl; NO.sub.2 ; phenoxy; C.sub.1 -C.sub.4 alkyl substituted with phenoxy; thiophenyl; C.sub.1 -C.sub.4 alkylthiophenyl; --COOR.sup.7 ; --N(R.sup.7).sub.2 or --N(R.sup.7)SO.sub.2 R.sup.7 where each R.sup.7 is independently hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.3 is H or C.sub.1 -C.sub.4 alkyl;R.sup.4 and R.sup.5 are each individually H, or when taken together form a bond;R.sup.6 is H; C.sub.1 -C.sub.8 alkyl; C.sub.2 -C.sub.8 alkenyl; C.sub.2 -C.sub.8 alkynyl; --SO.sub.2 CH.sub.3 ; --(CH.sub.2).sub.n NR.sup.8 R.sup.9 ; --(CH.sub.2).sub.n CO.sub.2 R.sup.8 ; --(CH.sub.2).sub.n OR.sup.8 where n is an integer from 1 to 6, both inclusive, and R.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jill A Panetta, Michael L Phillips