Patents Represented by Attorney Bruce M. Eisen

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  • Method and nozzle for nasal vaccination of immature mammals
    Patent number: 4381773
    Abstract: Method and means for vaccinating a mammal using a convex nozzle with an elongated tip. The mammal's alar fold is pushed aside by the tip so that vaccine is deposited behind the alar fold. Vaccine is then dispensed through the nozzle.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: May 3, 1983
    Assignee: Schering Corporation
    Inventors: Robert A. Goodnow, Floyd J. Shade, Thomas A. Sloboth, Donald J. Kaye
  • Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
    Patent number: 4379166
    Abstract: This invention relates to 5-(2-alkylamino-1-hydroxyethyl)salicylamides and 4-(2-alkylamino-1-hydroxyethyl)-2-(methylsulfinyl)phenols wherein the alkyl group is substituted by arylmethoxy, arylmethylthio, heteroarylmethoxy, or heteroarylmethylthio, pharmaceutical compositions thereof, and their use as cardiovascular agents.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: April 5, 1983
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Turkey rhinotracheitis vaccine
    Patent number: 4379140
    Abstract: A live vaccine against Alcaligenes faecalis, for application to turkeys, containing a temperature-sensitive non-virulent genetically stable strain of Alcaligenes faecalis having good immunizing capabilities and the absence of adverse side-effects.
    Type: Grant
    Filed: January 12, 1981
    Date of Patent: April 5, 1983
    Assignee: Brigham Young University
    Inventor: Marcus M. Jensen
  • Substituted imidazo thiazoles thiazines, thiazepines and thiazocines
    Patent number: 4376769
    Abstract: Disclosed herein are novel tetrahydro imidazo thiazoles, tetrahydro imidazo thiazines, hexahydro imidazo thiazepines and hexahydro imidazo thiazocines, intermediates for the preparation thereof, methods of using the compounds as anti-inflammatory agents and methods of using an intermediate thereof as anti-secretory agents to relieve the symptoms of gastric distress.
    Type: Grant
    Filed: June 19, 1981
    Date of Patent: March 15, 1983
    Assignee: Schering Corporation
    Inventor: Sherlock Margaret H.
  • Kijanimicin antibiotics and derivatives thereof
    Patent number: 4375542
    Abstract: Actinomadura Kijaniata nov. sp produces a novel antibiotic which we have designated kijanimicin. The antibiotic or cationic salts thereof exhibit anti-acne, antitumor, antimalarial, antibacterial and anti-inflammatory activity.
    Type: Grant
    Filed: October 8, 1980
    Date of Patent: March 1, 1983
    Assignee: Schering Corporation
    Inventors: Jay A. Waitz, Mahesh G. Patel, Ann C. Horan
  • Stable derivatives of (5R,6S,8R)-6-hydroxyethyl-2-ethylthiopenem-3-carboxylic acids
    Patent number: 4374844
    Abstract: Sodium and Potassium (5R,6S,8R)-6-(1-hydroxyethyl)-2-ethylthiopenem-3-carboxylic acid exhibit potent, broad-spectrum antibacterial activity, are orally effective and chemically stable.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: February 22, 1983
    Assignee: Schering Corporation
    Inventor: Stuart W. Mc Combie
  • Process of producing antibiotic AR-5 complex
    Patent number: 4367287
    Abstract: The Antiboitic AR-5 complex is elaborated by a novel species of the Micromonospora; namely, Micromonospora polytrota. The microorganism also elaborates a number of minor components including the gentamicin complex and a complex of anthroquinone antibiotics.
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: January 4, 1983
    Assignee: Schering Corporation
    Inventors: J. Allan Waitz, Walter Reiblein, Imbi Truumees
  • Derivatives of antibiotic AR-5 components
    Patent number: 4366309
    Abstract: Novel macrolide antibacterial derivatives of the components of the Antibiotic AR-5-complex are disclosed herein. The invention specifically relates to compounds wherein the macrolide ring and/or the two attached sugars are derivatized. Also disclosed are methods for the preparation of the derivatives and methods for the use thereof.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: December 28, 1982
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Yi-Tsung Liu, Olga Sarre, Robert Jaret, Doris P. Schumacher
  • Injectable fluid container and method
    Patent number: 4364485
    Abstract: A pilfer-proof container for injectable fluid. An inner seal having an opening is fixedly secured to the neck of a bottle to hold a stopper. An outer seal covers the opening and is removably attached to the inner seal with non-flaking, non-rebondable adhesive.The sealing system allows inspection of the stopper after the inner seal has been attached.
    Type: Grant
    Filed: May 15, 1981
    Date of Patent: December 21, 1982
    Assignee: Schering Corporation
    Inventor: Julius Z. Knapp
  • Extraction of interferon from bacteria
    Patent number: 4364863
    Abstract: A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.
    Type: Grant
    Filed: February 2, 1982
    Date of Patent: December 21, 1982
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Marvin J. Weinstein
  • 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
    Patent number: 4361557
    Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: November 30, 1982
    Assignee: Schering Corporation
    Inventor: Tattanhalli L. Nagabhushan
  • Treatment of peptic ulcer disease
    Patent number: 4361567
    Abstract: Disclosed herein are certain imidazo[1,5-a]pyridines, and pharmaceutical compositions containing them as the active ingredient for treatment and promotion of healing of peptic ulcer disease by virtue of their antisecretory and cytoprotective properties.
    Type: Grant
    Filed: October 5, 1981
    Date of Patent: November 30, 1982
    Assignee: Schering Corporation
    Inventors: James A. Bristol, Raymond G. Lovey
  • 5 Phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles
    Patent number: 4360673
    Abstract: This invention relates to 5-phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles which are antidepressants useful in the treatment of mental depression.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: November 23, 1982
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Pirouz Tahbaz
  • Antibiotic 67-121, a new polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4359462
    Abstract: A microorganism of the genus Acetinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: May 14, 1980
    Date of Patent: November 16, 1982
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • 1,3,4-Triazolo[1,5-a]pyridines
    Patent number: 4358454
    Abstract: There are disclosed herein certain 1,3,4-triazolo[1,5-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
    Type: Grant
    Filed: January 8, 1982
    Date of Patent: November 9, 1982
    Assignee: Schering Corporation
    Inventors: James A. Bristol, Raymond G. Lovey
  • 1,2,4-Triazolo[4,3-a]pyridines
    Patent number: 4358453
    Abstract: There are disclosed herein certain 1,2,4-triazolo-[4,3-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
    Type: Grant
    Filed: January 8, 1982
    Date of Patent: November 9, 1982
    Assignee: Schering Corporation
    Inventors: James A. Bristol, Raymond G. Lovey
  • Tricyclic-substituted piperidine antihistamines
    Patent number: 4355036
    Abstract: Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optical double bond, R.sup.2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.
    Type: Grant
    Filed: March 16, 1981
    Date of Patent: October 19, 1982
    Assignee: Schering Corporation
    Inventor: Frank J. Villani
  • 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore
    Patent number: 4352808
    Abstract: 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl(benzo(b)thiophenes and related derivatives having antifungal, antibacterial, and antiprotozoal activity are prepared by the reaction of the corresponding 2,3-dihydro-3-hydroxy-2-(imidazolylmethyl)benzo(b)thiophene or related derivative and an aralkyl halide.Preferred compounds are those where the aralkyl function is a hetercyclic aromatic, particularly 2-chloro-3-thenyl, and where the benzene nucleus is substituted by chlorine or fluorine.Pharmaceutical formulations comprising compounds of this invention are described, as well as the method for their use in treating microbial infections.
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: October 5, 1982
    Assignee: Schering Corporation
    Inventors: Dinanath F. Rane, John J. Wright, Russell E. Pike
  • Plunger rod/needle protector for a hypodermic syringe
    Patent number: D267587
    Type: Grant
    Filed: September 4, 1980
    Date of Patent: January 11, 1983
    Assignee: Schering Corporation
    Inventors: Thomas J. Ambrosio, Henry J. Buchman, Joseph J. Rogus, Henry R. Sochon
  • Cosmetic container
    Patent number: D268647
    Type: Grant
    Filed: February 5, 1981
    Date of Patent: April 19, 1983
    Assignee: Plough, Inc.
    Inventor: Ted I. Kingsford