Abstract: This invention relates to esters of 7 halo-substituted 8-hydroxy-3 methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, processes for the preparation thereof, and pharmaceutical compositions containing them. The novel compounds of this invention show neuroleptic, antidepressive and antiaggressive activity.
Abstract: The AR-5-3 Complex consisting of four macrolide antibiotics is elaborated by a mutant strain of Micromonospora polytrota. The antibiotics exhibit substantial activity against gram positive bacteria in vitro and in vivo.
Type:
Grant
Filed:
June 27, 1980
Date of Patent:
September 14, 1982
Assignee:
Schering Corporation
Inventors:
Bong K. Lee, Joseph A. Marquez, J. Allan Waitz
Abstract: Method and apparatus for safely destroying aerosol containers are disclosed. The movement of the container is restrained. Inert media is disposed about a point of puncture, and the container is punctured at the point of puncture.
Abstract: The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
Type:
Grant
Filed:
June 12, 1980
Date of Patent:
September 7, 1982
Assignee:
Schering Corporation
Inventors:
Bong K. Lee, Gerald H. Wagman, Dinanath F. Rane, Joseph A. Marquez, Peter J. L. Daniels
Abstract: Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.Also described are novel penems useful as antibacterials which are prepared by the described process.
Abstract: This invention relates to compositions of matter classified in the art of chemistry as substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles, various derivatives thereof, and to the processes for making and using such compositions as immunosuppressants.
Abstract: Alkoxyalkanoate esters of vidarabine of the formula ##STR1## wherein R.sub.x, R.sub.y and R.sub.z are ##STR2## or hydrogen and wherein R.sub.1 is lower alkyl and R.sub.2 is lower alkylene, which compounds are useful in treating susceptible viral infections, are disclosed.
Type:
Grant
Filed:
January 16, 1981
Date of Patent:
July 6, 1982
Assignee:
The Regents of the University of Minnesota
Abstract: Described are transition metal salt complexes of available neighboring amino and hydroxyl group pairs in polyamino organic compounds, their preparation, and use as intermediates in the preparation of selectively N-blocked polyamino organic compounds.
Type:
Grant
Filed:
December 26, 1979
Date of Patent:
June 29, 1982
Assignee:
Schering Corporation
Inventors:
Tattanahalli L. Nagabhushan, William N. Turner, Alan Cooper
Abstract: An injectable formulation for the pharmaceutically acceptable acid addition salts of labetalol, its isomers and mixtures thereof is provided which has enhanced stability properties.
Type:
Grant
Filed:
November 28, 1979
Date of Patent:
May 4, 1982
Assignee:
Schering Corporation
Inventors:
Varda Ecker, Yogendra M. Shah, Imtiaz A. Chaudry
Abstract: This invention relates to compositions of matter classified in the art of chemistry as substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles, various derivatives thereof, and to the processes for making and using such compositions as immunosuppressants.
Abstract: Apparatus is provided to facilitate viewing of one's facial image under controlled illumination patterns for purpose of either psychotherapy or merchandise selection.
Abstract: A highly pH- and color-stabilized parenteral formulation is provided comprising an aqueous solution of a salt of an aminoglycoside containing an allylic amine and having a pH between 5.0-7.0.
Abstract: A prefilled disposable syringe having a barrel, hub, and needle with a plunger rod/protector attached to the outer surface of the barrel near the hub by flexible protrusions from the inner surface of the plunger rod/protector. The flexible protrusions frictionally engage the outer surface.
Type:
Grant
Filed:
September 4, 1980
Date of Patent:
March 2, 1982
Assignee:
Schering Corporation
Inventors:
Thomas J. Ambrosio, Henry J. Buchman, Joseph J. Rogus, Henry R. Sochon
Abstract: This invention relates to contact lenses having an oxygen gas permeability constant of at least ##EQU1## comprising homopolymers and interpolymers formed by the polymerization of monomers comprising at least one alkyl styrene monomer having at least one C.sub.1 or higher alkyl group on the aromatic ring and improved surface wettability and to the method of making such contact lenses utilizing ultraviolet (UV) and chemical treatment.
Abstract: A sterilizer for use in sterilizing articles removably received therein, includes first thermal insulating means with a receiving cavity formed therein; cover means including a second thermal insulating means, the cover means being movable with respect to the first means for selectively covering said cavity; heating means received within the cavity and defining recess means for removably receiving therein an article to be sterilized, the heating means having a preselected volume for relatively slowly dissipating heat; and power control means for selectively applying electrical power to the heating means for heating the heating means, and for automatically cutting off the power to the heating means in response to a first predetermined temperature being reached by the heating means, the combination of the heating means and the first and second insulation means resulting in a relatively slow rate of heat loss from the heating means for enabling the temperature of the heating means not to fall below a second pred