Abstract: The present invention provides modified Cdc14 phosphatase proteins, and novel constructs for expression thereof, in which the sequence C-terminal to the catalytic domain has been deleted. This modification results in the expression of a single form of the enzyme, enabling purification of a homogeneous preparation of active enzyme at a high yield.
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
Type:
Grant
Filed:
November 18, 2002
Date of Patent:
January 31, 2006
Assignee:
Applera Corporation
Inventors:
Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
September 30, 2002
Date of Patent:
January 31, 2006
Assignee:
Applera Corporation
Inventors:
Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
Type:
Grant
Filed:
February 16, 2001
Date of Patent:
January 17, 2006
Assignee:
Applera Corporation
Inventors:
Ming-Hui Wei, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
December 9, 2003
Date of Patent:
January 10, 2006
Assignee:
Applera Corporation
Inventors:
Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen Beasley
Abstract: The present invention provides hepsin/46 protein, a soluble form of hepsin lacking the transmembrane region. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying molecules that interacting with the protease peptides, and methods of identifying modulators of the protease peptides.
Type:
Grant
Filed:
September 6, 2002
Date of Patent:
December 20, 2005
Assignee:
Applera Corporation
Inventors:
Hedy Chan, Kirsta Bowman, Erik Gjerstad
Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
Type:
Grant
Filed:
February 8, 2001
Date of Patent:
November 29, 2005
Assignee:
Applera Corporation
Inventors:
Beena Neelam, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
Type:
Grant
Filed:
July 22, 2002
Date of Patent:
November 22, 2005
Assignee:
Applera Corporation
Inventors:
Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
July 3, 2002
Date of Patent:
October 18, 2005
Assignee:
Applera Corporation
Inventors:
Ellen M. Beasley, Wei Shao, Karen A. Ketchum, Valentina Di Francesco
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
Type:
Grant
Filed:
July 22, 2002
Date of Patent:
October 11, 2005
Assignee:
Applera Corporation
Inventors:
Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
Type:
Grant
Filed:
January 9, 2003
Date of Patent:
September 27, 2005
Assignee:
Applera Corporation
Inventors:
Gennady V. Merkulov, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
April 8, 2004
Date of Patent:
September 20, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
December 2, 2003
Date of Patent:
September 20, 2005
Assignee:
Applera Corporation
Inventors:
Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides a method of producing a cloned insert that is representative of the ends of a large segment of DNA from the genome of an organism. Specifically, the present invention provides a clone insert strategy that comprising the steps of: a) isolating a nucleic acid molecule, or portion thereof, wherein said nucleic acid molecule is at least 20 kb; b) ligating said nucleic acid molecule into a vector molecule; c) cutting said nucleic acid molecule with a restriction endonuclease, wherein said restriction endonuclease cuts said isolated nucleic acid molecule of step (a) in at least two sites but does not cut said vector DNA, d) ligating said cut nucleic acid molecule; e) transforming a host cell with said ligated nucleic acid molecule to propagate said molecule; f) determining the sequence of the ends of the nucleic acid insert and the sequence from the restriction endonculease site.
Type:
Grant
Filed:
September 16, 2002
Date of Patent:
September 13, 2005
Assignee:
Applera Corporation
Inventors:
Robert Holt, Hamilton O. Smith, Cynthia Pfannkoch
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
Type:
Grant
Filed:
January 30, 2004
Date of Patent:
September 13, 2005
Assignee:
Applera Corporation
Inventors:
Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
July 8, 2004
Date of Patent:
September 13, 2005
Assignee:
Applera Corporation
Inventors:
Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
Type:
Grant
Filed:
February 8, 2001
Date of Patent:
September 13, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
Type:
Grant
Filed:
April 1, 2002
Date of Patent:
September 6, 2005
Assignee:
Applera Corporation
Inventors:
Wei Shao, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
May 20, 2003
Date of Patent:
August 30, 2005
Assignee:
Applera Corporation
Inventors:
Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
Type:
Grant
Filed:
August 8, 2003
Date of Patent:
August 30, 2005
Assignee:
Applera Corporation
Inventors:
Ellen M Beasley, Chunhua Yan, Valentina Di Francesco