Patents Represented by Attorney Celera Genomics

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  • Modified Cdc14 phosphatase proteins and constructs for improved expression and purification
    Patent number: 6991915
    Abstract: The present invention provides modified Cdc14 phosphatase proteins, and novel constructs for expression thereof, in which the sequence C-terminal to the catalytic domain has been deleted. This modification results in the expression of a single form of the enzyme, enabling purification of a homogeneous preparation of active enzyme at a high yield.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Craig Hill, Joseph Buggy
  • Isolated human transporter proteins, nucleic acid molecules, encoding human transporter proteins, and uses thereof
    Patent number: 6991920
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6991928
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human drug metabolizing proteins
    Patent number: 6987014
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: January 17, 2006
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6984511
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: January 10, 2006
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen Beasley
  • Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
    Patent number: 6977170
    Abstract: The present invention provides hepsin/46 protein, a soluble form of hepsin lacking the transmembrane region. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying molecules that interacting with the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: December 20, 2005
    Assignee: Applera Corporation
    Inventors: Hedy Chan, Kirsta Bowman, Erik Gjerstad
  • Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof
    Patent number: 6969588
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: November 29, 2005
    Assignee: Applera Corporation
    Inventors: Beena Neelam, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6967094
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: November 22, 2005
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6955625
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 18, 2005
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Wei Shao, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6953681
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: October 11, 2005
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6949371
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: September 27, 2005
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6946545
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: September 20, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6946276
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: September 20, 2005
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Methods and kits for obtaining DNA end sequence information for large cloned inserts and uses thereof
    Patent number: 6942975
    Abstract: The present invention provides a method of producing a cloned insert that is representative of the ends of a large segment of DNA from the genome of an organism. Specifically, the present invention provides a clone insert strategy that comprising the steps of: a) isolating a nucleic acid molecule, or portion thereof, wherein said nucleic acid molecule is at least 20 kb; b) ligating said nucleic acid molecule into a vector molecule; c) cutting said nucleic acid molecule with a restriction endonuclease, wherein said restriction endonuclease cuts said isolated nucleic acid molecule of step (a) in at least two sites but does not cut said vector DNA, d) ligating said cut nucleic acid molecule; e) transforming a host cell with said ligated nucleic acid molecule to propagate said molecule; f) determining the sequence of the ends of the nucleic acid insert and the sequence from the restriction endonculease site.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Robert Holt, Hamilton O. Smith, Cynthia Pfannkoch
  • Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6942999
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6942983
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6943003
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
  • Isolated human aminoacylase, nucleic acid molecules encoding human aminoacylase, and uses thereof
    Patent number: 6939700
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: September 6, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6936451
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: August 30, 2005
    Assignee: Applera Corporation
    Inventors: Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6936453
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: August 30, 2005
    Assignee: Applera Corporation
    Inventors: Ellen M Beasley, Chunhua Yan, Valentina Di Francesco