Patents Represented by Attorney Celera Genomics

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  • Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof
    Patent number: 6867030
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the lipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the lipase peptides, and methods of identifying modulators of the lipase peptides.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof
    Patent number: 6867019
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6858420
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 22, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6852519
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 8, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human UDP-glycosyltransferase, nucleic acid molecules encoding human UDP-glycosyltransferase, and uses thereof
    Patent number: 6846661
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: January 25, 2005
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6835562
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: December 28, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6830911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventor: Zhaoxi Ke
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6830912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventors: Douglas Rusch, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human glutamate receptor DNA
    Patent number: 6830900
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human synthase proteins, and uses thereof
    Patent number: 6825026
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human zinc metalloprotease, nucleic acid molecules encoding said enzymes, and uses thereof
    Patent number: 6825025
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Polymorphisms in known genes associated with osteoporosis, methods of detection and uses thereof
    Patent number: 6825336
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6825022
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Jane Ye, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6821765
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: November 23, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M Beasley
  • Estrogen receptor beta variants and methods of detection thereof
    Patent number: 6818758
    Abstract: The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor beta genes and novel polymorphism in the estrogen receptor gene/protein. Such polymorphism can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism in the ESR-beta genes, methods of detecting these sequences/polymorphism in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: November 16, 2004
    Assignee: Applera Corporation
    Inventors: Francis Kalush, Michael J Cassel, Stuart Soo-In Hwang, Emily S Winn-Deen
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6818429
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: November 16, 2004
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Nucleic acid molecules encoding human secreted hemopexin-related proteins
    Patent number: 6815181
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 9, 2004
    Assignee: Applera Corporation
    Inventors: Toni Ceccardi, Emanuel Langit, Min Zhong, Istvan Ladunga
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6812014
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 2, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Ishwar Chandramouliswaran, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley