Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
January 21, 2004
Date of Patent:
August 16, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Zhenya Li, Beena Neelam, Valentina DiFrancesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
Type:
Grant
Filed:
February 1, 2002
Date of Patent:
August 9, 2005
Assignee:
Applera Corporation
Inventors:
Marion Webster, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
May 6, 2003
Date of Patent:
July 26, 2005
Assignee:
Applera Corporation
Inventors:
Jane Abu-Threideh, Beena Neelam, Chunhua Yan
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
October 30, 2002
Date of Patent:
July 19, 2005
Assignee:
Applera Corporation
Inventors:
Beena Neelam, Natalia Milshina, Chunhua Yan, Valentina DiFrancesco, Ellen M. Beasley, Karen A. Ketchum
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the lipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the lipase peptides, and methods of identifying modulators of the lipase peptides.
Type:
Grant
Filed:
September 2, 2003
Date of Patent:
July 12, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
October 9, 2003
Date of Patent:
July 12, 2005
Assignee:
Applera Corporation
Inventors:
Ming-Hui Wei, Karen A. Ketchum, Ellen M. Beasley, Valentina DiFrancesco
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
Type:
Grant
Filed:
March 27, 2001
Date of Patent:
July 5, 2005
Assignee:
Applera Corporation
Inventors:
Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
Type:
Grant
Filed:
March 29, 2001
Date of Patent:
June 21, 2005
Assignee:
Applera Corporation
Inventors:
Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
Type:
Grant
Filed:
July 22, 2002
Date of Patent:
June 14, 2005
Assignee:
Applera Corporation
Inventors:
Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the dehydrogenase polypeptides, and methods of identifying modulators of the dehydrogenase polypeptides.
Type:
Grant
Filed:
February 6, 2003
Date of Patent:
May 31, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Zhenya Li, Gennady V Merkulov, Valentina Di Francesco, Ellen Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Type:
Grant
Filed:
February 26, 2004
Date of Patent:
May 31, 2005
Assignee:
Applera Corporation
Inventors:
Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
Type:
Grant
Filed:
September 10, 2001
Date of Patent:
May 31, 2005
Assignee:
Applera Corporation
Inventors:
J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.
Type:
Grant
Filed:
August 4, 2000
Date of Patent:
May 10, 2005
Assignee:
Applera Corporation
Inventors:
Chinnappa Kodira, Anibal Cravchik, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
Type:
Grant
Filed:
January 30, 2003
Date of Patent:
April 26, 2005
Assignee:
Applera Corporation
Inventors:
Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
Type:
Grant
Filed:
October 22, 2002
Date of Patent:
April 12, 2005
Assignee:
Applera Corporation
Inventors:
Ming-Hui Wei, Jiayin Li, Fangcheng Gong, Andrei Gabrielian, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
Type:
Grant
Filed:
March 12, 2004
Date of Patent:
April 5, 2005
Assignee:
Applera Corporation
Inventors:
Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromating structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides.
Type:
Grant
Filed:
October 22, 2002
Date of Patent:
March 22, 2005
Assignee:
Applera Corporation
Inventors:
Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.
Type:
Grant
Filed:
March 12, 2002
Date of Patent:
March 15, 2005
Assignee:
Applera Corporation
Inventors:
Ming-Hui Wei, Xin Wang, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley