Patents Represented by Attorney, Agent or Law Firm Celera
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6500656
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: December 31, 2002
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen Beasley
  • Isolated nucleic acid molecules encoding human carbonate transporter proteins, and uses thereof
    Patent number: 6498022
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: December 24, 2002
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jiayin Li, Fangcheng Gong, Andrei Gabrielian, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6492155
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: December 10, 2002
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6492156
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: December 10, 2002
    Assignee: PE Corporation (NY)
    Inventors: Chunhua Yan, Zhenya Li, Beena Neelam, Valentina DiFrancesco, Ellen M. Beasley
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Patent number: 6489456
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Steven I. Ladunga, Maureen E. Higgins
  • Isolated human NADPH oxidase, nucleic acid molecules encoding said proteins, and uses thereof
    Patent number: 6489149
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6489153
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Ellen M. Beasley, Valentina DiFrancesco
  • Isolated human transporter cofactor proteins, nucleic acid molecules encoding human transporter cofactor proteins, and uses thereof
    Patent number: 6485939
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: November 26, 2002
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human zinc metalloproteases, nucleic acids molecules encoding said enzymes, and uses thereof
    Patent number: 6482629
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: November 19, 2002
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6482935
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: November 19, 2002
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Patent number: 6482936
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: November 19, 2002
    Assignee: PE Corporation (NY)
    Inventors: Song Hu, Karen A. Ketchum, Fangcheng Gong, Istvan I. Ladunga, Maureen E. Higgins, Ralph Brandenberger
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6482630
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: November 19, 2002
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Jane Ye, Valentina DiFrancesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6482624
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: November 19, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6479269
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: November 12, 2002
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
    Patent number: 6479270
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphatase peptides, and methods of identifying modulators of the phosphatase peptides.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: November 12, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Methods and kits for obtaining DNA end sequence information for large cloned inserts and uses thereof
    Patent number: 6475731
    Abstract: The present invention provides a method of producing a cloned insert that is representative of the ends of a large segment of DNA from the genome of an organism. Specifically, the present invention provides a clone insert sequencing strategy that comprising the steps of isolating a nucleic acid molecule that is at least 20 kb, ligating the nucleic acid molecule into a plasmid vector molecule to produce a closed circle, cutting the ligated vector with a restriction endonuclease that cuts the ligated 20 kb nucleic acid molecule in at least two sites but does not cut the vector DNA, ligating the cut nucleic acid molecule to produce a deletion in the 20 kb nucleic acid molecule and determining the sequence of the ends of the nucleic acid insert and the sequence from the restriction endonuclease site.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: November 5, 2002
    Assignee: Applera Corporation
    Inventors: Robert Holt, Hamilton O. Smith, Cynthia Pfannkoch
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6461846
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: October 8, 2002
    Assignee: PE Corporation
    Inventors: Chunhua Yan, Ming-Hui Wei, Karen Ketchum, Gennady Merkulov, Ellen M Beasley
  • Isolated nucleic acid molecules encoding protease proteins, and uses thereof
    Patent number: 6461850
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: October 8, 2002
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Zhenya Li
  • Polynucleotides encoding human estrone sulfatases
    Patent number: 6461847
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: October 8, 2002
    Assignee: Applera Corporation
    Inventors: Jane Ye, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6455291
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: September 24, 2002
    Assignee: PE Corporation (NY)
    Inventors: Chunhua Yan, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley