Patents Represented by Attorney, Agent or Law Firm Celera
  • Isolated nucleic acid molecules encoding human synthase proteins, and uses thereof
    Patent number: 6825026
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human zinc metalloprotease, nucleic acid molecules encoding said enzymes, and uses thereof
    Patent number: 6825025
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Polymorphisms in known genes associated with osteoporosis, methods of detection and uses thereof
    Patent number: 6825336
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6821765
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: November 23, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M Beasley
  • Estrogen receptor beta variants and methods of detection thereof
    Patent number: 6818758
    Abstract: The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor beta genes and novel polymorphism in the estrogen receptor gene/protein. Such polymorphism can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism in the ESR-beta genes, methods of detecting these sequences/polymorphism in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: November 16, 2004
    Assignee: Applera Corporation
    Inventors: Francis Kalush, Michael J Cassel, Stuart Soo-In Hwang, Emily S Winn-Deen
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6818429
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: November 16, 2004
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Nucleic acid molecules encoding human secreted hemopexin-related proteins
    Patent number: 6815181
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 9, 2004
    Assignee: Applera Corporation
    Inventors: Toni Ceccardi, Emanuel Langit, Min Zhong, Istvan Ladunga
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6812014
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 2, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
    Patent number: 6812339
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 2, 2004
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Ishwar Chandramouliswaran, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6806072
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: October 19, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6800471
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: October 5, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Ming-Hui Wei, Karen Ketchum, Gennady Merkulov, Ellen M Beasley
  • Isolated human casein kinase proteins, nucleic acid molecules encoding human casein kinase proteins, and uses thereof
    Patent number: 6800283
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: October 5, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human dehydrogenases, nucleic acid molecules encoding these human dehydrogenases, and uses thereof
    Patent number: 6797499
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the dehydrogenase polypeptides, and methods of identifying modulators of the dehydrogenase polypeptides.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: September 28, 2004
    Assignee: Applera Corporation
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6787344
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: September 7, 2004
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Gennady V. Merkulov, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6780626
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: August 24, 2004
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
    Patent number: 6773904
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: August 10, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A. Ketchum, Ellen M. Beasley
  • Nucleic acid encoding retinoic acid receptor
    Patent number: 6756213
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the nuclear hormone receptor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the nuclear hormone receptor peptides, and methods of identifying modulators of the nuclear hormone receptor peptides.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: June 29, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human lactate dehydrogenase proteins
    Patent number: 6753174
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: June 22, 2004
    Assignee: Applera Corporation
    Inventors: Steven I. Ladunga, Eugene Spier, Maureen Higgins, Simon Greenberg, Yu Wang