Patents Represented by Attorney Edward McC. Roberts
  • Patent number: 5576028
    Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: November 19, 1996
    Assignee: Ciba Geigy Corporation
    Inventors: Stephen M. Martin, Fu-Pao Tsao
  • Patent number: 5573773
    Abstract: The present invention relates to stable highly concentrated formulations of specific fluorescein derivatives, to the preparation of said formulations and the use thereof, especially for the photodynamic therapy of secondary cataract.The invention principally relates to an aqueous solution comprising a fluorescein diester, preferably a fluorescein di-lower alkyl ester, most preferably fluorescein diacetate, and a partially etherified .beta.-cyclodextrin the ether substituents of which are hydroxyethyl, hydroxypropyl or dihydroxypropyl groups, some of which ether substituents may be methyl or ethyl groups, said .beta.-cyclodextrin ether having a water-solubility of more than 1.8 g in 100 ml of water, preferably hydroxy-.beta.-cyclodextrin.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: November 12, 1996
    Assignee: Ciba Geigy Corporation
    Inventors: Gyoergy L. Kis, Ernst D. Wachsmuth
  • Patent number: 5571882
    Abstract: Compounds of formulae I and IaR--Y--CO--R.sub.3 --CO--O--A (I),R--Y--CO--R.sub.3 --CO--O--CH.sub.2 --A.sub.1 (Ia),whereinR is a radically polymerizable hydrocarbon group,R.sub.3 is a direct bond, linear or branched C.sub.1 -C.sub.22 alkylene, C.sub.3 -C.sub.8 cycloalkylene or C.sub.6 C.sub.14 arylene,A is the radical, reduced by a hydroxy group in a 2- or 3-position, of a cyclic-oligomeric carbohydrate or of a derivative of such a carbohydrate,A.sub.1 is the radical, reduced by a hydroxymethyl group, of a monomeric or linear oligomeric carbohydrate or of a derivative of such a carbohydrate, andY is --O--, --NH-- or --N(C.sub.1 -C.sub.6 alkyl)-.Homo- and co-polymers having those monomers have, depending upon their composition, hydrophilic, amphiphilic or hydrophobic properties and are able to form hydrogels. The polymers can be used, for example, as surfactants, thickeners, carriers for biologically active ingredients or in the manufacture of contact lenses.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 5, 1996
    Assignee: Ciba-Geiby Corporation
    Inventor: Dirk Vetter
  • Patent number: 5567705
    Abstract: Mixtures of certain triazole fungicides (component I) and 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine (component II) have a synergistically increased activity against fungus infestation. Components I and II can also be applied to crops individually in immediate succession.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: October 22, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ludwig Mittermeier, Wilhelm Ruess
  • Patent number: 5558846
    Abstract: An ophthalmic lens disinfection apparatus, including a container and a mating cap, she apparatus having an improved seal and vent means for venting gas generated within the apparatus. The vent means is an integral part of the disinfection apparatus which allows venting of gas when internal pressure increases, while maintaining a seal which is substantially gas and liquid-impermeable at other times. The seal is defined by the interference mating of a flexible periphery on a container with a rigid mating rim on a cap. The apparatus is particularly useful in the disinfection of contact lenses with hydrogen peroxide in which the excess peroxide is decomposed into water and oxygen.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: September 24, 1996
    Assignee: Ciba Geigy Corporation
    Inventors: Larry A. Alvord, Robert F. McCoy
  • Patent number: 5554735
    Abstract: Azo oxime ethers of formula (I), in which X is CH or N, R.sub.1 is hydrogen, C.sub.1 -C.sub.3 alkyl, trifluoromethyl or cylclopopy and R.sub.2 is aryl or heteroaryl, have an activity against phytopathogenic fungi. They can be used in the form of formulaions as crop protection products, seed-dressing products and wood preservatives.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: September 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hugo Ziegler, Stephan Trah
  • Patent number: 5554619
    Abstract: Microbicidal composition for use in plants, having a synergistic action and comprising at least two active ingredient components, in which component I is a compound selected from the group of the compounds ##STR1## in which: X is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, trifluoromethyl, cyano, thiocarbamoyl or nitro, andY is hydrogen or fluorine; ##STR2## in which: Z radicals are identical or different and are halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl,C.sub.1 -C.sub.4 alkoxy, trifluoromethyl, phenyl, phenoxy or benzyl, these aromatic groups being unsubstituted or not more than trisubstituted by identical or different substituents from the series comprising halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, and n is 0 to 3; and ##STR3## in which: U is oxygen or the group --CH.sub.2 O--,A radicals are identical or different and are halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: September 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ronald Zeun, Ren e Zurfl uh
  • Patent number: 5552368
    Abstract: N-Phenylsulfonyl-N'-pyrimidinyl-,-N'-triazinyl-and-N'-triazolylureas and-thioureas of formula I ##STR1## in which X is oxygen, sulfur, SO or SO.sub.2 ; W is oxygen or sulfur; R.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen, fluorine, chlorine, bromine, iodine, (X).sub.n R.sub.3, NO.sub.2, NR.sub.4 R.sub.5,--C.tbd.CR.sub.6, ##STR2## or cyano; n is the number 0 or 1;R.sub.3, is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl which is substituted by 1-4 halogen atoms, C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 alkylthio; or C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkenyl which is substituted by 1-4 halogen atoms; R.sub.4 is hydrogen, CH.sub.3 O, CH.sub.3 CH.sub.2 O or C.sub.1 -C.sub.3 alkyl; R.sub.5 is hydrogen or C.sub.1 -C.sub.3 alkyl; R.sub.6 is hydrogen, methyl or ethyl; R.sub.7 is hydrogen or methyl; Z is ##STR3## E is methine or nitrogen; R.sub.8 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: September 3, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Willy Meyer
  • Patent number: 5538979
    Abstract: Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I and II can also be applied to plant crops individually, one immediately after the other.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: July 23, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Adolf Hubele, Ronald Zeun
  • Patent number: 5536900
    Abstract: According to the invention, there is provided an inbred corn line, designated CG00653. This invention thus relates to the plants and seeds of inbred corn line CG00653 and to methods for producing a corn plant produced by crossing the inbred line CG00653 with itself or with another corn line. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line CG00653 with another corn line.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: July 16, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Moez R. Meghji
  • Patent number: 5536726
    Abstract: A plant-microbicidal composition having synergistic action, comprising at least two active ingredient components, wherein component I is a compound selected from the groupIA) cis-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine (fenpropimorph"); and/or1-[3-(4-tert-butylphenyl)-2-methylpropyl]-piperidine ("fenpropidin"), or one of the salts or metal complexes thereof;IB) 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile ("fludioxonil");IC) N-(trichloromethylthio)cyclohex-4-ene-1,2-dicarboximide("captan");ID) a compound of formula ID ##STR1## wherein R.sub.1 is fluorine or chlorine andR.sub.2 is chlorine or trifluoromethyl, andIE) N-(trichloromethylthio)phthalimide ("folpet");and component II is the 2-anilinopyrimidine of formula II ##STR2## 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidineamine, or one of the salts or metal complexes thereof.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: July 16, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ronald Zeun, Gertrude Knauf-Beiter, Ruth B. Kung
  • Patent number: 5527760
    Abstract: An improved process for the phytoprotection of plant seeds, wherein there is simultaneously applied to the seeds, on the one hand, at least one first liquid composition containing at least one phytoprotection product, and on the other hand, a foam formed from a second composition, containing at least one nonphytotoxic foaming agent.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: June 18, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Cornelis W. Rensing, Hubert Sainsard
  • Patent number: 5527925
    Abstract: Compounds of formula I: ##STR1## are disclosed. The compounds are photoinitiators which can be functionalized by means of ethylenic groups or can be bonded to H-active substances, in order, for example, to modify surfaces by means of photopolymerizable substances. The compounds are especially useful in the manufacture of contact lenses.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: June 18, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Chabrecek, Dieter Lohmann
  • Patent number: 5527917
    Abstract: A process for the preparation of 1,2-benzisothiazoles of formula I ##STR1## wherein X is in any one of the 4 possible positions of the benzene ring and is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 alkoxy, halo-C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy or C.sub.2 -C.sub.4 alkynyloxy, in which process a compound of formula II ##STR2## wherein X is as defined for formula I and R.sub.1 is hydrogen or an unsubstituted or substituted C.sub.1 -C.sub.12 hydrocarbon radical, is reacted in the presence of a catalytic amount of a strong acid.Compounds of formula I are known as pesticides, especially as nematicides.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: June 18, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans-Ruedi Kanel, Arthur Wegmann, Denis Neff
  • Patent number: 5523311
    Abstract: A method and composition for the immunization of healthy useful plants against plant diseases containing as active ingredients compounds of formula ##STR1## in which: X is hydrogen, halogen, hydroxy, methyl, methoxy, HOOC or MOOC; Y is hydrogen, halogen, SO.sub.3 H, SO.sub.3 M, nitro, hydroxy or amino, M being the molar equivalent of an alkali metal or alkaline earth metal ion that is formed from a corresponding base or basic compound; and Z is cyano or --CO--A; A represents either --OH or --SH, the hydrogen atom of which may also be replaced by the molar equivalent of an inorganic or organic cationic residue, or wherein A represents any other organic residue which has a molecular weight of less than 900 and which may also contain one, or more than one, hetero atom, including the salts of the phytophysiologically tolerable 7-carboxylic acid or 7-thiocarboxylic acid with primary, secondary or tertiary amines or with inorganic bases.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: June 4, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Schurter, Walter Kunz, Robert Nyfeler
  • Patent number: 5520277
    Abstract: A contact lens holding device for use in a disinfecting system having a single-molded piece, the piece having a dividing portion having first and second surfaces, a first basket portion integrally attached to and capable of folding into closable engagement with the first surface of the dividing portion to form a first lens enclosure, and a second basket portion integrally attached to and capable of folding into closable engagement with the second surface of the dividing portion to form a second lens enclosure, the dividing portion, first basket portion and second basket portion lying on a substantially single plane when in unfolded configuration.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: May 28, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Larry A. Alvord
  • Patent number: 5521195
    Abstract: Plant fungicidal compositions based on two active ingredients a) and b) show a synergistically increased effect in the case where component a) is 2-(4-chlorophenyl)-3-cyclopropyl-1-[(1H-1,2,4-triazol-1-yl)butan-2-ol and component b) is either fenpropimorph or fenpropidin or a mixture of the two.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: May 28, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Ruth Kung
  • Patent number: 5519026
    Abstract: A plant-microbicidal composition having synergistic action, comprising at least two active ingredient components, wherein component I is a compound selected from the groupIA) cis-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine ("fenpropimorph"); and/or 1-[3-(4-tert-butylphenyl)-2-methylpropyl]-piperidine ("fenpropidin"), or one of the salts or metal complexes thereof;IB) 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile ("fludioxonil");IC) N-(trichloromethylthio)cyclohex-4-ene-1,2-dicarboximide ("captan");ID) a compound of formula ID ##STR1## wherein R.sub.1 is fluorine or chlorine andR.sub.2 is chlorine or trifluoromethyl, andIE) N-(trichloromethylthio)phthalimide ("folpet");and component II is the 2-anilinopyrimidine of formula II ##STR2## 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidineamine, or one of the salts or metal complexes thereof.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: May 21, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ronald Zeun, Gertrude Knauf-Beiter, Ruth B. Kung
  • Patent number: 5519148
    Abstract: Sulfonylcarbamates and sulfonylthiocarbamates which are useful as intermediates for the preparation of N-phenylsulfonyl-N'-pyrimidinyl (or triazinyl or triazolyl)-ureas (or thioureas), said intermediates being of the formula: ##STR1## whererin X is oxygen, sulfur, SO or SO.sub.2 ; W is oxygen or sulfur, R.sub.2 is hydron, fluorine, chlorine bromine, iodine, (X).sub.n R.sub.3, NO.sub.2, NR.sub.4 R.sub.5, --C.tbd.CR.sub.6, ##STR2## or cyano; n is the number 0 or 1; R.sub.3 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl which is substituted by 1-4 halogen atoms, C.sub.1 -C.sub.3 alkosy or C.sub.1 -C.sub.3 -alkylthio; or C.sub.2 -C.sub.4 alkenyl or C.sub.2 C.sub.4 alkenyl which is substituted by 1-4 halogen atoms; R.sub.4 is hydrogen, CH.sub.3 O, CH.sub.3 CH.sub.2 O or C.sub.1 -C.sub.3 alkyl; R.sub.5 is hydrogen of C.sub.1 -C.sub.3 alkyl; R.sub.6 is hydrogen, methyl or ethyl; R.sub.7 is hydrogen or methyl; and R.sub.15 is phenyl or phenyl which is substituted by C.sub.1 -C.sub.4 alkly or halogen.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: May 21, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Willy Meyer
  • Patent number: 5516529
    Abstract: An effervescent granulate consisting of a solid water-soluble acidic substance, potassium carbonate and/or potassium hydrogen carbonate and one or more water-insoluble substances that are capable of absorbing water, a pesticidal active ingredient concentrate that is in the form of effervescent tablets and contains the effervescent granulate, and the preparation of the effervescent granulate and of the pesticidal active ingredient concentrate are described.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: May 14, 1996
    Inventor: Jean-Michel Zellweger