Patents Represented by Attorney, Agent or Law Firm Edward S. Irons
  • Patent number: 5144063
    Abstract: Novel cesium hydroxytriphenylborates are described. The addition of hydroxytriarylborate ions to aqueous media containing cesium ions to form such compounds as a precipitate is useful, for example, in the removal of radioactive cesium from nuclear fission plant waste streams and from cesium ion containing solutions resulting from the digestion of cesium ores.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 1, 1992
    Inventor: Jeffrey M. Sullivan
  • Patent number: 5144019
    Abstract: Stable, catalytic efficient ribozymes useful, inter alia, to cleave HIV-I RNA or any other viral or endogenous cellular RNA, in vitro and in vivo, cells transformed with such ribozymes and the use of such ribozymes and cells for anti-AIDs therapy are disclosed.
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: September 1, 1992
    Assignee: City of Hope
    Inventors: John J. Rossi, Edouard M. Cantin, John A. Zaia, Pairoj Chang
  • Patent number: 5137695
    Abstract: A compact apparatus having a gravity assisted, substantially linear, vertical fluid flow path through vertically aligned elements for the N-terminal and C-terminal sequencing of proteins and peptides is disclosed.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: August 11, 1992
    Assignee: City of Hope
    Inventors: Miro Rusnak, John E. Shively, Jimmy R. Calaycay
  • Patent number: 5137515
    Abstract: A sheath and method for the removal and disposal of removable needles used to guide insertion of catheters. The sheath having a one way entrance for allowing the removable needle to be taken into the sheath by pulling on a wire attached to the removable needle and passed through the sheath, but to prevent the removable needle from coming out of the sheath after the removable needle is in the sheath.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: August 11, 1992
    Assignee: City of Hope
    Inventor: J. Martin Hogan
  • Patent number: 5136056
    Abstract: A process for producing high purity .alpha.-zeranol from a zeralenone containing surface fermentation product is described. One feature of the process entails fractional crystallization from an aqueous acetonitrile solvent of high purity .alpha.-zeranol from a solution containing a mixture of 50 to 60 parts by weight .alpha.-zeranol and 40 to 50 parts by weight .beta.-zeranol.
    Type: Grant
    Filed: November 16, 1990
    Date of Patent: August 4, 1992
    Assignee: C.R.C. Compagnia di Ricerca Chimici S.p.A.
    Inventors: Flavio Moimas, Giuliano Clauti
  • Patent number: 5130436
    Abstract: A novel class of cross-linking agent, which comprises a monomeric organic compound having at least two hydroxyl groups each bonded to a different carbon atom, wherein said hydroxyl groups are activated by reaction with 2-fluoro-1-methylpyridinium toluene-4-sulfonate (FMP). Suitable monomeric organic compounds include diols and polyols. Such cross-linking agents may be conveniently prepared by reaction of the monomeric organic compound with FMP in a suitable solvent, followed by recovery of the resultant reaction products, e.g., via precipitation and filtration. The novel cross-linking agents have a wide variety of uses, including the interconnection of subunits of multimeric enzymes and the covalent immobilization of organic ligands to suitable carriers or supports.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: July 14, 1992
    Assignee: UniSyn Fibertec Corporation
    Inventors: That T. Ngo, Faizy Ahmed
  • Patent number: 5128802
    Abstract: A transparent plastic slide for microscopic examination of fluids with at least one grid defined on the floor portion of the slide. The grid consisting of lines rising symmetrically from the floor portion of the slide with a line width of from about 0.05 to 0.005 mm. The lines defining enclosed areas, in which particles suspended in sample fluids can be counted. The sizes of enclosed areas being selected to be within the field of view for microscopic examination.
    Type: Grant
    Filed: July 8, 1991
    Date of Patent: July 7, 1992
    Assignee: Hycor Biomedical
    Inventor: Vance C. Mitchell
  • Patent number: 5126238
    Abstract: A unique hollow fiber bioreactor system and method for the propagation of cells and the production of various cell propagation products is described. The system and method include the use of a flow block holder which allows a dissolved oxygen probe to be calibrated at the same pressure as the media in the bioreactor system.
    Type: Grant
    Filed: February 15, 1990
    Date of Patent: June 30, 1992
    Assignee: Unisyn Fibertec Corporation
    Inventors: Timothy C. Gebhard, Uday K. Veeramallu
  • Patent number: 5112123
    Abstract: A device for selectively masking portions of transparent visual material to be projected by an overhead projector onto a screen including an opaque flexible sheet attached at one side to the overhead projector and at the other to a rod portion of a spool. When not in use the opaque flexible sheet is wound onto the spool. A portion, or all, of the transparent material may be blocked from projection by rolling the spool over the transparent material so that the opaque flexible sheet covers the undesired material.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: May 12, 1992
    Inventors: Robert Fagan, deceased, by Ellen Fagan, personal administrator
  • Patent number: 5109875
    Abstract: An apparatus and method for treating skin lesions using an expansion chamber surgically implanted under the skin and progressively filled with fluid for growing new skin along the entire circumference surrounding the skin lesion so that upon removal of the expansion chamber the new skin radially contracts over the lesion.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: May 5, 1992
    Assignee: City of Hope
    Inventor: Marc E. Gottlieb
  • Patent number: 5110802
    Abstract: A method of inhibiting human immunodeficiency virus (HIV) comprising administering a therapeutically effective amount of an antiviral agent to attack the first splice acceptor site of the tat III gene of HIV.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: May 5, 1992
    Assignee: City of Hope
    Inventors: Edouard M. Cantin, John A. Zaia, R. Bruce Wallace, John J. Rossi
  • Patent number: 5108179
    Abstract: The use of continuous wave (CW) laser excitation to measure small differences in the fluorescence of bands of fluorophore stained nucleic acid fragments present in gels is described.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: April 28, 1992
    Inventor: Stephen A. Myers
  • Patent number: 5102412
    Abstract: A spinal rod system and method for instrumenting the spine in the treatment of spinal abnormalities, in which a plurality of vertebra engaging means are provided for engagement on spaced vertebra, and the vertebra engaging means are secured on at least one elongate rod in axially spaced relationship, to impose opposed axial forces on the spine. In a preferred arrangement, two rods are used, and cross bars extend laterally between the rods to form a quadrilateral construct. The vertebra engaging means may comprise hooks, screws, or a combination of hooks and bone screws. Couplers are used to secure the screws and the transverse cross bars to the rods.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: April 7, 1992
    Inventor: Chaim Rogozinski
  • Patent number: 5096676
    Abstract: An apparatus for growing diffraction quality, protein crystals by vapor diffusion techniques. The apparatus includes a plurality of equilibrating solution reservoirs each having a side wall terminating in a top wall disposed in a first plane; a column disposed within each of the equilibrating solution reservoirs, each column having a protein solution receptacle including a side wall terminating in a top wall disposed in a second plane spaced from the first plane; and a cover having a non-greasy adhesive on one surface therof for sealable engagement with the top walls of the equilibrating solution reservoirs for sealing the reservoirs relative to atmosphere.
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: March 17, 1992
    Inventors: Alexander McPherson, Daniel Morris
  • Patent number: 5085983
    Abstract: Changes in tumor cell RNA and DNA are utilized to detect the progression and the temporal changes in resistance to chemotherapy in human tumors.
    Type: Grant
    Filed: May 17, 1989
    Date of Patent: February 4, 1992
    Assignee: City of Hope
    Inventor: Kevin J. Scanlon
  • Patent number: 5085982
    Abstract: The invented method utilizes a signal amplification system comprising living cells which are specifically provided with the ability to survive, reproduce and be detected in the event that a target molecule is present. The method comprises first the step of binding a target molecule to a substratum. In the second step a phagemid is prepared which is capable of transfecting a cell enabling such transfected cell to produce a signal, such as color or light. The phagemid is then provided with a means for binding to a probe, thus forming a phagemid complex.The probe may also be provided with a means of binding to the phagemid complex. This modified probe is then hybridized with the target molecules bound to the substratum. Thereafter, the phagemid complex is hybridized with the modified probe and specific binding occurs between the phagemid complex and the modified probe thus forming a substrutum-target-probe phagemid complex.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: February 4, 1992
    Assignee: City of Hope
    Inventor: Douglas H. Keith
  • Patent number: 5083862
    Abstract: A device for detecting the flow of fluid through the lumen of a transparent or translucent tube and the presence or absence of bubbles in such flowing fluid is disclosed.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: January 28, 1992
    Assignee: City of Hope
    Inventor: Miro Rusnak
  • Patent number: 5081235
    Abstract: A chimeric anti CEA antibody comparable to ATCC Accession No. BH 8747 is described.
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: January 14, 1992
    Assignee: City of Hope
    Inventors: John E. Shively, Arthur D. Riggs, Michael Neumaier
  • Patent number: RE33810
    Abstract: A sealed portable isolation enclosure for use in removing asbestos material from ceiling or other elevated asbestos-containing structures including a booth and an adjustable ceiling-contacting plenum for accommodating ceiling of various heights. Disposed between the booth and the plenum is a flexible transparent film for enclosing and sealing the spaced formed therebetween regardless of the elevation of the plenum relative to the booth. The enclosure is equipped with EPA approved vacuum and ventilation systems for filtering and ventilating the contamainated air therein. A disposable bagtrap door system is provided for the disposal of the asbestos-containing materials. In addition, the enclosure may also include a shower system within the enclosure.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: February 4, 1992
    Inventor: Jerome F. Strieter
  • Patent number: RE33826
    Abstract: A microscope inspection slide including at least one examination chamber formed by bonding together a base plate and a cover plate. The base plate having a chamber floor surface raised above a deck surface on the base plate, and the cover plate having a roof surface with a depth control ridge positioned about a portion of the edge of the chamber roof surface. Bonding the cover plate to the base plate forms an examination chamber with the distance between the roof surface and floor surface maintained constant, and entrapped gases and excess fluid allowed to drain from the examination chamber through notches in the depth control ridge.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: February 18, 1992
    Assignee: Hycor Biomedical, Inc.
    Inventor: Vance C. Mitchell