Abstract: An immunoassay method and apparatus for diagnosing FeLV-induced, persistent viremia is provided comprising combining a feline saliva sample conveniently obtained with a specially designed probe, with anti-p27 antibodies and detecting complex formation as indicative of the viremia. Preferably, the antibodies are bound to the probe for complex formation.

Abstract: A method for enhancing the biodistribution of antibody for localization in lesions comprising initially exposing a mammalian subject containing lesion-associated marker substance to a first antibody specific for a given epitope of the marker substance, and after a period of time such that the marker substance has associated with the antibody, exposing the mammal to a further amount of the same antibody, or a second antibody specific either for an epitope of the marker substance different from the epitope for which the first antibody is specific, or for the same epitope of the marker substance as the first antibody but of a different binding affinity from the first antibody.

Abstract: Synthetic oligonucleotide for detection of the bcr-abl RNA from blood or bone marrow of patients with chronic myelogenous leukemia.

Abstract: A specific hybridoma cell line produces monoclonal antibodies which are effective in detecting carcinoembryonic antigens (CEA). The specific hydribome line and monoclonal antibodes are designated as T84.66-A3.1-H11. The monoclonal antibodies are preferably applied to tissues and fluids to detect the degree of binding of such monoclonal antibodies to such carcinoembryonic antigens.

Abstract: A catheter apparatus having a catheter tube with a length adjusting mechanism positioned on the catheter tube which can be used to change the length of the catheter tube from a bushing which is used to retain the catheter adjacent the patient's skin to the end of the catheter tube that is inserted in the patient.

Abstract: A method for promoting regeneration of damaged nerve tissue, comprising administering, either alone or in combination, an effective amount of an antimitotic agent or a proton-withdrawing buffer to the damage site. Antimitotic agents reduce the rate of growth of glial cells, and buffers facilitate the growth of nerve tissue and inhibit glial cell growth. Referred antimitotic agents are cytosine arabinoside, 5-fluorouracil, and hydroxyurea. Preferred buffers are TREA and HEPES. Compositions are disclosed which include antimitotic agent, buffer, and an oxygen-supplying compound, such as hydrogen peroxide.

Abstract: The invention replaces the natural joint structure with a porous globe structure, filled with bone graft, that is attached to a prosthetic shaft. The bone graft on the globe structure as it matures provides continuous bone structure which in combination with the globe structure provides a load sharing combination.

Abstract: An intracavitary hyperthermic applicator comprising outer and inner coaxial conductors, electrical insulation between the conductors, the outer conductor terminating in a distal end spaced proximally from the distal end of the inner conductor, the outer conductor being slotted at a location spaced from the distal end of the outer conductor, defining a junction, outer and inner tubular sleeves of conductive material disposed coaxially over a length of the outer conductor, electrical insulation between the sleeves and between the inner sleeve and the outer conductor, conductive attachments securing the proximal ends of the sleeves to the outer conductor, and the outer sleeve terminating in a distal end spaced proximally from the distal end of the inner sleeve.

Abstract: An apparatus is described for substantially automatically shaping the windings of coils in which the conductor is mainly directed longitudinally, parallel to the coil axis, with ends having different radius size, in any case relatively narrow, as it happens e.g. in the dipole or quadrupole magnets. The apparatus comprises a stationary bed to which a support bar for supporting a winding holder and form is mounted for an alternate rotation of about 180.degree.. Along a side of this bed and parallel to the support bar a carriage can run with a reciprocating motion, having a cantilevered bracket for mounting an arm rotatable around a vertical axis to support a supply reel of a superconductor to be wound onto the coil.

Abstract: A protective device and method for the removal and disposal of spinal needles. The protective device is comprised of a needle pulling assembly upon which is slidably mounted an external housing. In operation, a needle to be removed from a patient is engaged in the needle cradle portion of the needle pulling assembly. The external housing is moved into contact with the patient's skin and the needle is withdrawn by pulling on the pulling rod portion of the needle pulling assembly in a direction away from the patient. The needle is withdrawn into the interior of the external housing, thereby covering the entire length of the needle. The pulling assembly is then locked into place and the entire assembly including the withdrawn needle can be disposed of, thereby avoiding the possibility of needle pricks by contaminated spinal needles.

Abstract: A peptide is sequenced from its carboxyl terminal by coupling with an isothiocyanate having a chemical formula R(.sub.x)Si(NCS).sub.y where x=0-3 and y=1-4. R may be alkyl or aryl. The coupling reaction is preferably conducted at a temperature range of 50.degree.-90.degree. C. for a period to approximately sixty (60) minutes or less. A weak acid anhydride, preferably a carboxylic acid anhydride, or a weak acid chloride, preferably a carboxylic acid chloride, may be mixed with the isothiocyanate. An organic base catalyst selected from a group consisting of tertiary amines including aromatic amines such as pyridine may also be utilized.

Abstract: Dehydroepiandrosterone and acceptable salts thereof are utilized for sexual disfunction therapy.

Abstract: A method for preventing frost damage to plants, comprising applying a bactericide to the surfaces of the plants in an amount sufficient to effectively eliminate several species of ice-nucleation active (INA) bacteria, thereby reducing the temperature at which frost damage occurs.

Abstract: A procedure for the treatment of degenerative diseases of the central nervous system, including Alzheimer's disease, multiple sclerosis and the like, by the administration of amodiaquin and related compounds is disclosed.

Abstract: A method of preparing a multi-specimen tissue block, and sections thereof, comprising forming a plurality of different antigenically reactive tissue specimens into rods having a relatively small cross-sectional area and a relatively great length, disposing the rods in a substantially parallel relationship on a casing, wrapping the rods in the casing, embedding the wrapped rods in an embedding medium to form a tissue block in which the rods are perpendicular to the face of the block, and dividing the block into sections which each contain a cross-section of each of the rods.

Abstract: A sheath for use in removing hypodermic needles having butterfly-shaped gripping side strips from patients and retaining the point of the removed needle in the sheath even when the needle and sheath are disposed of so that all persons who handle the needle are protected from being pricked.

Abstract: Disclosed is a method for treating nervous system deterioration associated with aging and Alzheimer's disease by administering a therapeutically-effective amount of dehydroepiandrosterone or its sulfate. Also disclosed is the co-administration of dehydroepiandrosterone or its sulfate and a potassium channel antagonist. The disclosure is also directed to pharmaceutical compositions containing dehydroepiandrosterone, alone or in combination with a potassium channel antagonist. Dehydroepiandrosterone is also shown to facilitate the growth of nervous system tissue, particularly in culture.

Abstract: A procedure for the treatment of degenerative diseases of the central nervous system, including Alzeheimer's disease, multiple sclerosis and the like, by the administration of amodiaquin and related compounds is disclosed.

Abstract: A method and apparatus for digitally analyzing continuous visual images, particularly with reference to the detection of mammalian cell mitotic events is disclosed. The visual images are analyzed by first extracting high frequency picture components, threshold comparison of such components and probing for annular objects indicative of putative mitotic cells. The detection of annulae is performed by an algorithm for recognizing rings of differential radii and compensating for other variations. Thereafter, spatial and temporal relationships between such objects is stored and compared to determine whether cell division occurred.

Abstract: Pyrogens can be effectively removed from an aqueous solution by passing a stream of the solution through a device comprising at least two anisotropic ultrafiltration membranes positioned in series, said membranes having nominal molecular weight limits less than the molecular weight of the pyrogens, including aggregates or micelles thereof, to be removed, wherein at least one membrane is juxtaposed with at least one other membrane so that substantially all of the skin surface of one membrane is in intimate contact with substantially all of the skin surface of the other membrane and wherein the edges of one membrane are sealed to the corresponding edges of the other membrane.