Patents Represented by Attorney Heller Ehrman White & McAuliffe
  • Patent number: 7341719
    Abstract: Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically altered are cultured and transplanted into malfunctioning and/or degenerative tissues or organs to alleviate conditions that are hereditary, degenerative, debilitating, undesirable, and/or fatal. Treatment of these conditions is not limited to the usage of mechanical, electrical or physical properties of these myogenic cells, but includes the usage of biochemicals secreted/released by the latter. The present invention discloses the use of normal myoblasts to deliver the complete normal genome to effect genetic repair, or to augment the size, or the function of tissues or organs. Certain conditions may be better served with genetically altered myogenic cells derived from gene transduction, whereas others may be better served with cytoclimes converter cells.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: March 11, 2008
    Inventor: Peter K. Law
  • Patent number: 7098312
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 29, 2006
    Assignee: Genetech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood
  • Patent number: 6946145
    Abstract: Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: September 20, 2005
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Jorge Heller
  • Patent number: 6936697
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 30, 2005
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Patent number: 6936467
    Abstract: Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2?-O-Me base analogs.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: August 30, 2005
    Assignee: University of Delaware
    Inventors: Eric B. Kmiec, Howard B. Gamper, Michael C. Rice
  • Patent number: 6931037
    Abstract: A diode pumped, multi axial mode, intracavity doubled, intracavity tripled laser, includes at least two resonator mirrors defining a resonator cavity. A laser crystal and a doubling crystal are positioned in the resonator cavity. A tripling crystal is also positioned in the resonator cavity. A diode pump source supplies a pump beam to the laser crystal and produces a laser crystal beam with a plurality of axial modes that are incident on the doubling crystal. This produces a frequency doubled output beam. Further, a diode pumped, multi axial mode, intracavity nonlinearly-converted laser is provided and includes at least two resonator mirrors defining a resonator cavity, a laser crystal and a nonlinear conversion apparatus positioned in the resonator cavity. A nonlinear conversion apparatus is also positioned in the resonator cavity.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 16, 2005
    Assignee: Spectra Physics Lasers, Inc.
    Inventors: William L. Nighan, Jr., John Cole
  • Patent number: 6927204
    Abstract: Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: August 9, 2005
    Assignee: Genentech, Inc.
    Inventor: Wei-Qiang Gao
  • Patent number: 6924355
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 2, 2005
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Patent number: 6919311
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: July 19, 2005
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Petrus Johannes Lenting, Jan Aart Van Mourik, Koenraad Mertens, Hans Pannekoek, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger
  • Patent number: 6916648
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 12, 2005
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Patent number: 6905830
    Abstract: This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: June 14, 2005
    Assignees: Genentech, Inc., Esoterix, Inc.
    Inventors: Robert L. Cohen, Mary Beth Gardiner, Mark X. Sliwkowski, Gregory T. Stelzer
  • Patent number: 6901927
    Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: June 7, 2005
    Assignee: Emphasys Medical, Inc.
    Inventors: Mark E. Deem, Hanson S. Gifford, III, Ronald French, Douglas Sutton
  • Patent number: 6901084
    Abstract: The present invention relates to a stable solid-state Raman laser, the solid-state Raman laser including a resonator cavity defined by at least two reflectors, a laser material located in the resonator cavity and capable of generating a cavity laser beam which propagates within the resonator cavity, a solid Raman medium located in the resonator cavity for shifting the frequency of the cavity laser beam to produce a Raman laser beam which propagates within the resonator cavity; and an output coupler for coupling and outputting the Raman laser beam from the resonator cavity, wherein at least one parameter selected from the group consisting of the position of the laser material relative to the position of the Raman medium in the cavity, the length of the cavity and the curvature of at least one of the reflectors, is selected such that changes in the focal lengths of both the laser material and the Raman medium as a result of thermal effects in the laser material and the Raman medium during operation of the laser
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: May 31, 2005
    Assignee: Macquarie Research Ltd.
    Inventors: Helen M. Pask, James A. Piper
  • Patent number: 6900304
    Abstract: A chimeric phosphorylation indicator is provided. A chimeric phosphorylation indicator can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. A chimeric phosphorylation indicator also can contain a phosphorylatable polypeptide and a fluorescent protein, wherein the phosphorylatable polypeptide is contained within the sequence of the fluorescent protein, or wherein the fluorescent protein is contained within the sequence of the phosphorylatable polypeptide. Also provided are polynucleotides encoding such chimeric phosphorylation indicators, as well as kits containing the indicators or the polynucleotides. In addition, a method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: May 31, 2005
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Alice Y. Ting, Jin Zhang
  • Patent number: 6891876
    Abstract: An optical system has a diode pump source, and a gain media made of a material with an anisotropic absorption. The gain media is cut at an angle to produce substantially polarization-independent absorption of a pump beam. An optical coupler is positioned between the diode pump source and the gain media. The optical coupler produces a pump beam that has substantially equal amounts of pump power along any two orthogonal axis that are orthogonal to the pump beam in the gain medium. The wavelength range allowed for the pump source is extended.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: May 10, 2005
    Assignee: Spectra Physics, Inc.
    Inventors: Dirk Sutter, James D. Kafka
  • Patent number: 6890738
    Abstract: Recombinant nucleotide sequences encoding mutated prolactin are described. Expression of the sequences result in mimics of a phosphorylated prolactin corresponding to a selected species. A particularly preferred mimic is mutated at serine 179 (corresponding to human PRL) where serine is substituted by an aspartate residue. This aspartate mutant is a very effective antagonist and shows no ability to stimulate Nb2 to cell proliferation.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of California
    Inventor: Ameae Walker
  • Patent number: 6887705
    Abstract: This invention concerns new PSTPIP polypeptides which are bound by and dephosphorylated by the PEST family of protein tyrosine phosphatases. The invention specifically concerns native murine PSTPIP polypeptides and their homologues in other mammals, and their functional derivatives. The invention further relates to nucleic acids encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Methods for inducing the plymerization of actin monomers in eukaryotic cells and assays for identifying antagonists and agonists of the PSTPIP polypeptides of the present invention are also provided.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: May 3, 2005
    Assignee: Genentech, Inc.
    Inventors: Laurence A. Lasky, Donald J. Dowbenko
  • Patent number: 6882983
    Abstract: The present invention discloses a system and method for processing business transactions between trading partners using a central interactive platform. The processing may include comparing purchase order data and invoice data to identify matching information and non-matching information. If the information matches, the invoices are processed for payment. If the information does not match, the discrepancies are identified to the buying company or the selling company for resolution.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: April 19, 2005
    Assignee: Notiva Corporation
    Inventors: Thomas W. Furphy, David W. Bandych, John T. Marron, Jason A. Carreira
  • Patent number: D506253
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 14, 2005
    Assignee: Thermage, Inc.
    Inventor: Marlo Cinco
  • Patent number: D510247
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 4, 2005
    Assignee: B & Q PLC
    Inventor: Matthew White