Patents Represented by Attorney Heller Ehrman White & McAuliffe
  • Patent number: 7341719
    Abstract: Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically altered are cultured and transplanted into malfunctioning and/or degenerative tissues or organs to alleviate conditions that are hereditary, degenerative, debilitating, undesirable, and/or fatal. Treatment of these conditions is not limited to the usage of mechanical, electrical or physical properties of these myogenic cells, but includes the usage of biochemicals secreted/released by the latter. The present invention discloses the use of normal myoblasts to deliver the complete normal genome to effect genetic repair, or to augment the size, or the function of tissues or organs. Certain conditions may be better served with genetically altered myogenic cells derived from gene transduction, whereas others may be better served with cytoclimes converter cells.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: March 11, 2008
    Inventor: Peter K. Law
  • Patent number: 7264963
    Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: September 4, 2007
    Assignee: Morphosys AG
    Inventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Pl├╝ckthun
  • Patent number: 7098312
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 29, 2006
    Assignee: Genetech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood
  • Patent number: 6964258
    Abstract: An engine revolution limiter system is utilized to limit engine speed during a break-in period. The system provides for programming a variable break-in period and a variable selectable engine revolution limit. During the break-in period, if the revolution limit is exceeded by the engine speed, firing of the ignition is limited. In addition, the system provides for an over revolution limit wherein the ignition stops firing if the over revolution limit is exceeded. In addition, multiple break-in periods may be programmed with different associated revolution limits and over revolution limits. This provides for gradually increasing the allowable engine speed as the engine has been operating for greater periods of time.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 15, 2005
    Assignee: S & S Cycle, Incorporated
    Inventors: Joseph A. Gudgeon, Nevin R. Hillegass, Brian S. Lindell
  • Patent number: 6946145
    Abstract: Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: September 20, 2005
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Jorge Heller
  • Patent number: 6944050
    Abstract: The present invention relates to a nonvolatile memory device, and more specifically, to a programmable nonvolatile logic switch memory (register) device using a resistive memory device. The programmable nonvolatile register uses a logic switch or a nonvolatile resistive memory device whose resistive state can be set by flowing a controlled current through it.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: September 13, 2005
    Assignee: Hynix Semiconductor, Inc.
    Inventors: Hee Bok Kang, Young Jin Park
  • Patent number: 6936467
    Abstract: Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2?-O-Me base analogs.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: August 30, 2005
    Assignee: University of Delaware
    Inventors: Eric B. Kmiec, Howard B. Gamper, Michael C. Rice
  • Patent number: 6936697
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 30, 2005
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Patent number: 6931037
    Abstract: A diode pumped, multi axial mode, intracavity doubled, intracavity tripled laser, includes at least two resonator mirrors defining a resonator cavity. A laser crystal and a doubling crystal are positioned in the resonator cavity. A tripling crystal is also positioned in the resonator cavity. A diode pump source supplies a pump beam to the laser crystal and produces a laser crystal beam with a plurality of axial modes that are incident on the doubling crystal. This produces a frequency doubled output beam. Further, a diode pumped, multi axial mode, intracavity nonlinearly-converted laser is provided and includes at least two resonator mirrors defining a resonator cavity, a laser crystal and a nonlinear conversion apparatus positioned in the resonator cavity. A nonlinear conversion apparatus is also positioned in the resonator cavity.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 16, 2005
    Assignee: Spectra Physics Lasers, Inc.
    Inventors: William L. Nighan, Jr., John Cole
  • Patent number: 6927204
    Abstract: Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: August 9, 2005
    Assignee: Genentech, Inc.
    Inventor: Wei-Qiang Gao
  • Patent number: 6924685
    Abstract: The device for controlling a setup/hold time of an input signal can change a setup/hold time of various control signals applied from an input buffer without physically changing the control device. The device for controlling a setup/hold time of an input signal has transmission gates for performing selectively switching operations according to a decoded test mode control signal, thereby selectively using a signal delay device in driving of drivers to appropriately control the setup/hold time of various control signals applied from a global bus line. Accordingly, the device for controlling a setup/hold time of an input signal can provide a technique which can optimize the setup/hold time at a small cost in comparison with a physical metal option control system.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: August 2, 2005
    Assignee: Hynix Semiconductor, Inc.
    Inventor: Seung Cheol Bae
  • Patent number: 6924355
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 2, 2005
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Patent number: 6919311
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: July 19, 2005
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Petrus Johannes Lenting, Jan Aart Van Mourik, Koenraad Mertens, Hans Pannekoek, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger
  • Patent number: 6916648
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 12, 2005
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Patent number: 6906968
    Abstract: An input buffer of a semiconductor memory device includes a first buffer block for buffering an input data through a delay path selected from a plurality of delay paths, and a second buffer block for buffering an input data strobe signal through a delay path selected from a plurality of delay paths, wherein the plurality of delay paths of the first buffer block and the plurality of delay paths of the second buffer block are identically formed by the same devices, and the corresponding delay paths are selected from the plurality of delay paths according to the same selecting signals. Although the input buffer fails to obtain a margin of a data setup and hold time in an input/output sense amplifier due to variations of the data setup and hold time by maximum and minimum values of tDQSS in a write operation mode, the input buffer can easily obtain the margin of the data setup and hold time in response to a special test mode signal.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: June 14, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Kwang Hyun Kim, Sun Suk Yang
  • Patent number: 6905830
    Abstract: This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: June 14, 2005
    Assignees: Genentech, Inc., Esoterix, Inc.
    Inventors: Robert L. Cohen, Mary Beth Gardiner, Mark X. Sliwkowski, Gregory T. Stelzer
  • Patent number: 6901927
    Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: June 7, 2005
    Assignee: Emphasys Medical, Inc.
    Inventors: Mark E. Deem, Hanson S. Gifford, III, Ronald French, Douglas Sutton
  • Patent number: 6901084
    Abstract: The present invention relates to a stable solid-state Raman laser, the solid-state Raman laser including a resonator cavity defined by at least two reflectors, a laser material located in the resonator cavity and capable of generating a cavity laser beam which propagates within the resonator cavity, a solid Raman medium located in the resonator cavity for shifting the frequency of the cavity laser beam to produce a Raman laser beam which propagates within the resonator cavity; and an output coupler for coupling and outputting the Raman laser beam from the resonator cavity, wherein at least one parameter selected from the group consisting of the position of the laser material relative to the position of the Raman medium in the cavity, the length of the cavity and the curvature of at least one of the reflectors, is selected such that changes in the focal lengths of both the laser material and the Raman medium as a result of thermal effects in the laser material and the Raman medium during operation of the laser
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: May 31, 2005
    Assignee: Macquarie Research Ltd.
    Inventors: Helen M. Pask, James A. Piper
  • Patent number: D506253
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 14, 2005
    Assignee: Thermage, Inc.
    Inventor: Marlo Cinco
  • Patent number: D510247
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 4, 2005
    Assignee: B & Q PLC
    Inventor: Matthew White