Patents Represented by Attorney Heller Ehrman White & McAuliffe
  • Patent number: 6828422
    Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: December 7, 2004
    Assignee: Morphosys AG
    Inventors: Knappik Achim, Peter Pack, Ge Liming, Moroney Simon, Plückthun Andreas
  • Patent number: 6826097
    Abstract: A nonvolatile memory device including a write protected region, comprising a program command processor, a write protected region setting unit and a write controller. The program command processor outputs a program command signal by decoding an external signal. The write protected region setting unit stores a region address corresponding to an inputted address when the program command signal is activated, and outputs a write protect signal when the program command signal is inactivated. The write controller controls a cell corresponding to the region address not to perform a write mode when the write protect signal is activated.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: November 30, 2004
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6826164
    Abstract: A network includes a plurality of antennas coupled to a plurality of base stations. The network can be optical or constructed with RF microwave links. The antennas and base stations are configured to transmit and receive digital signals representing cellular signals and the digital signals are exchanged over the network. A plurality of links couple the plurality of antennas and the plurality of base stations. At least one link of the plurality of links provides multiple transmission paths between at least a portion of the base stations and at least a portion of the antennas.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: November 30, 2004
    Assignee: NEXTG Networks
    Inventors: Sanjay Mani, David Cutrer
  • Patent number: 6825002
    Abstract: The present invention provides a method for changing production ratios of carotenoid compounds in a process of microbiological production of a plurality of carotenoid compounds. By controlling the concentration of dissolved oxygen in the culture during cultivation, production ratios of carotenoid compounds such as astaxanthin, adonixanthin, &bgr;-carotene, echinenone, canthaxanthin, zeaxanthin, &bgr;-cryptoxanthin, 3-hydroxyechinenone, asteroidenone and adonirubin, are changed.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: November 30, 2004
    Assignee: Nippon Mitsubishi Oil Corporation
    Inventors: Akira Tsubokura, Haruyoshi Mizuta
  • Patent number: 6822978
    Abstract: A laser apparatus includes a modelocked laser system with a high reflector and an output coupler that define an oscillator cavity. An output beam is produced from the oscillator cavity. A gain medium and a modelocking device are positioned in the oscillator cavity. A diode pump source produces a pump beam that is incident on the gain medium. A second harmonic generator is coupled to the oscillator cavity. A third harmonic generator that produces a UV output beam, is coupled to the second harmonic generator. A photonic crystal fiber is provided with a proximal end coupled to the laser system. A delivery device is coupled to a distal portion of the photonic crystal fiber.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: November 23, 2004
    Assignee: Spectra Physics, Inc.
    Inventors: James D. Kafka, David E. Spence
  • Patent number: 6822000
    Abstract: Bioerodible poly(orthoesters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain hydrogen bonding groups and &agr;-hydroxy acid-containing groups.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: November 23, 2004
    Assignee: AP Pharma, Inc.
    Inventors: Steven Y. Ng, Jorge Heller
  • Patent number: 6821956
    Abstract: The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes involved in cell growth, differentiation and signalling or to viral genes. By inhibiting endogenous trans-activating factors from binding transcription regulatory regions, the decoys modulate gene expression and thereby regulating pathological processes including inflammation, intimal hyperplasia, angiogenesis, neoplasia, immune responses and viral infection. The decoys are administered in amounts and under conditions whereby binding of the endogenous transcription factor to the endogenous gene is effectively competitively inhibited without significant host toxicity. The subject compositions comprise the decoy molecules in a context which provides for pharmacokinetics sufficient for effective therapeutic use.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 23, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Victor J. Dzau, Gary H. Gibbons, Ryuichi Morishita
  • Patent number: 6818446
    Abstract: The invention relates to compositions and methods for the assessment of mucin gene expression. The invention also relates to compositions and methods for the identification of compounds useful in the treatment of various disorders caused by mucin overproduction. The invention provides novel MUC5B promoter sequences and reporter constructs comprising these MUC5B promoter sequences. The invention further provides methods for drug screening to identify compounds have the ability to inhibit MUC5B gene expression. Compounds having the ability to inhibit MUC5B gene expression find use in the treatment of diseases characterized by mucin hyperproduction.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: November 16, 2004
    Assignee: The Regents of the University of California
    Inventors: Reen Wu, Yin Chen
  • Patent number: 6818394
    Abstract: Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: November 16, 2004
    Assignee: Sequenom, Inc.
    Inventors: Maryanne J. O'Donnell-Maloney, Charles R. Cantor, Hubert Köster
  • Patent number: 6816536
    Abstract: A method and apparatus are provided for in situ protection of sensitive optical materials from alternation or damage due to exposure to trace atmospheric components, during shipping, storage or operation. The sensitive optical material is disposed within an enclosure adaptable to be substantially sealed against the external atmosphere. A container, enclosing a sink material absorbing trace atmospheric components, is coupled to the enclosure by a gas permeable surface, which allows fast diffusion of the trace atmospheric component inside the enclosure to the sink material.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: November 9, 2004
    Assignee: Spectra Physics, Inc.
    Inventors: Karin Julliard, Steve Utter, Alan B. Petersen
  • Patent number: 6815540
    Abstract: The present invention relates to the modification of immunoglobulin superfamily (IgSF) domains, IgSF fragments and fusion proteins thereof, especially to the modification of antibody derivatives, so as to improve their solubility, and hence the yield, and ease of handling. The inventors have found that this can be achieved by making the region which comprised the interface with domains adjoined to said IgSF domain in a larger fragment or a full IgSF protein, and which becomes exposed in the IgSF domain, more hydrophilic by modification. The present invention describes DNA sequences encoding modified IgSF domains or fragments and fusion proteins thereof, vectors and hosts containing these DNA sequences, IgSF domains or fragments or fusion proteins obtainable by expressing said DNA sequences in suitable expression systems, and a method for modifying IgSF domains, so as to improve their solubility, expressibility and ease of handling.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: November 9, 2004
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Lars Nieba, Annemarie Honegger
  • Patent number: 6814303
    Abstract: A fluid-cooled mount for an injector; suitable, for example, for mounting an automotive fuel injector on a combustion exhaust system to inject an NOx reducing fluid into the exhaust system.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: November 9, 2004
    Assignee: Cleaire Advanced Emission Controls
    Inventors: Bradley L. Edgar, Richard G. Lemke, Marc D. Rumminger, Michael Streichsbier, Dean B. Wehrley
  • Patent number: 6815424
    Abstract: Pharmaceutical compositions of biologically active polypeptides in powder form suitable for nasal administration, comprising a therapeutically effective amount of a biologically active polypeptide and a water-soluble polysaccharide.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: November 9, 2004
    Assignee: Pfizer Corporation
    Inventors: Brian H. Vickery, Eric J. Benjamin, Cherng-Chyi Fu, Lynda M. Sanders
  • Patent number: 6812152
    Abstract: A method to obtain contamination free surfaces of a material chosen from the group comprising GaAs, GaAlAs, InGaAs, InGaAsP and InGaAs at crystal mirror facets for GaAs based laser cavities. The crystal mirrors facets are cleaved out exposed to an ambient atmosphere containing a material from the group comprising air, dry air, or dry nitrogen ambients. Any oxides and other foreign contaminants obtained during the ambient atmosphere exposure of the mirror facets are removed by dry etching in vacuum. Thereafter, a native nitride layer is grown on the mirror facets by treating them with nitrogen.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: November 2, 2004
    Assignee: Comlase AB
    Inventors: L. Karsten V. Lindström, N. Peter Blixt, Svante H. Söderholm, Anand Srinivasan, Carl-Fredrik Carlström
  • Patent number: 6812330
    Abstract: Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable misprocessed, misfolded, size, glycosylated, or charge forms. Compositions of neurotrophins, including mature NGF, substantially free of these variants are also provided.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 2, 2004
    Assignee: Genentech, Inc.
    Inventors: Louis E. Burton, Charles H. Schmelzer, Joanne T. Beck
  • Patent number: 6812256
    Abstract: Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for the prophylaxis or treatment of obesity are also disclosed herein.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Patent number: 6812335
    Abstract: Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: November 2, 2004
    Assignee: The Regents of the University of California
    Inventors: Edward Goetzl, Songzhu An
  • Patent number: 6811966
    Abstract: The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: November 2, 2004
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Jim Wells, Dan Erlanson, Andrew C. Braisted
  • Patent number: 6802081
    Abstract: The moisture-absorbent/releasable heat-generating intermediate material of the present invention is inserted between an outer material and a lining, both having a moisture-permeable/waterproof property, a windproof property and other desired properties, thereby constituting a heat-retaining article. It comprises a blend of a heat-retaining fiber including an air layer of not less than 50 ml per 1 gram and a moisture-absorbent/releasable heat-generating fiber. The moisture-absorbent/releasable heat-generating fiber generates heat by absorbing moisture in a vapor phase or in a liquid phase discharged from a human body and an immobile air layer formed by the heat-retaining fiber retains the heat.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: October 12, 2004
    Assignee: Mizuno Corporation
    Inventors: Takeshi Ogino, Shigeru Aoyama
  • Patent number: D497246
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: October 19, 2004
    Assignee: Apex Medical Corporation
    Inventor: Daniel Darst