Abstract: Novel BRAFV600E mutant peptides or a pharmaceutically acceptable salt thereof, that induce MHC Class I-dependent cytotoxic T cell responses in mammals are useful in prophylactic, diagnostic and therapeutic treatments for melanoma. Such compounds are also useful in drug development for non-peptide mimics of the compounds described herein and in the development of therapeutic or diagnostic antibodies.

Abstract: A mortar and debris collection device for use within a cavity wall to prevent the blockage of weep holes at the base of the wall. The cavity wall assembly includes a masonry wall, an adjacent inner wall, a wall cavity therebetween, and a free-standing elongate strip of openwork material located within the cavity forming a debris collection surface a spaced distance above a base surface of the cavity. Preferably, the openwork material is inserted and positioned within the cavity after the inner wall and only a base portion of the outer masonry wall is constructed. Thereafter, the upper portion of the outer masonry wall is constructed and any mortar or debris falling into the cavity is caught and supported on the debris collection surface.

Abstract: A child-resistant and senior-friendly unit dose package has a hollow container body, an internal divider, and at least first and second separate trays each carrying a plurality of tablets or like items for being dispensed from the container body. The container body has an end with an opening, and each tray can be slid to a retracted position in which the tray is located within the container body and a dispensing position in which the tray extends at least partially through the opening of the container body. The package includes a separate cap removably securable to the container body to seal the opening and prevent access to the trays. Multiple simultaneous manipulations are required to remove the cap from the container body thereby providing a child-resistant connection. A method of assembling a package with at least two separate blister cards and a divider is also disclosed.

Abstract: Provided is an Sb—Te alloy sintered compact sputtering target having at least Sb or Te as its primary component, wherein surface roughness Ra is 0.4 ?m or less, purity excluding gas components is 4N or more, content of gas components as impurities is 1500 ppm or less, and average crystal grain size is 50 ?m or less. With this Sb—Te alloy sintered compact sputtering target, the density of defects having a maximum length of 10 ?m or greater arising in a surface finish by machining is 80 or less in an 800 ?m square. Thus, the Sb—Te alloy sputtering target structure can be uniformalized and refined, generation of cracks in the sintered target can be inhibited, and generation of arcing during sputtering can be inhibited. Further, surface ruggedness caused by sputter erosion can be reduced in order to obtain a high quality Sb—Te alloy sputtering target.

Abstract: Provided is a cathode material for a lithium secondary battery composed of an aggregate of Li-A-O composite oxide particles (wherein A represents one or more metal elements selected from Mn, Fe, Co and Ni), wherein the lithium composite oxide contains 20 to 100 ppm (by mass) of P, and the total content of impurity elements excluding essential components is 2000 ppm or less. Also provided is a manufacturing method of such a cathode material for a lithium secondary battery including the steps of suspending lithium carbonate in water and thereafter introducing a metallic salt solution of one or more metal elements selected from Mn, Fe, Co and Ni in the lithium carbonate suspension, adding a small amount of phosphoric acid so that the P content in the Li-A-O composite oxide particles will be 20 to 100 ppm (by mass), and forming an aggregate of Li-A-O composite oxide particles containing 20 to 100 ppm (by mass) of P by filtering, cleansing, drying and thereafter oxidizing the obtained carbonate.

Abstract: The present invention pertains to an electrolytic copper plating method characterized in employing pure copper as the anode upon performing electrolytic copper plating, and performing electrolytic copper plating with the pure copper anode having a crystal grain diameter of 10 ?m or less or 60 ?m or more. Provided are an electrolytic copper plating method and a pure copper anode for electrolytic copper plating used in such electrolytic copper plating method capable of suppressing the generation of particles such as sludge produced on the anode side within the plating bath upon performing electrolytic copper plating, and capable of preventing the adhesion of particles to a semiconductor wafer, as well as a semiconductor wafer plated with the foregoing method and anode having low particle adhesion.

Abstract: Nucleic acid and amino acid sequences of the Omp85 proteins of N. gonorrhoeae and N. meningitidis, and fragments thereof are useful in vaccine compositions, therapeutic compositions and diagnostic compositions for use in the prevention, treatment and diagnosis of non-symptomatic gonococcal infection or symptomatic disease and non-symptomatic meningococcal infection and symptomatic disease. Antibodies are developed to these proteins and also useful in the compositions and methods described herein.

Abstract: Provided is a hydrogen separation membrane characterized by comprising a structure obtained by sintering atomized powder having a composition of NixMyZr100-x-y (wherein M is Nb and/or Ta, 25?x?40, 25?y?40) and an average grain size of 50 ?m or less. The prepared hydrogen separation membrane does not require the use of costly Pd metal, and can be used as a substitute for conventional high-cost bulk metallic glass obtained by quenching of molten metal. This hydrogen separation membrane is free from problems such as defects in the hydrogen separation membrane and unevenness of composition, has a uniform structure, and is capable of separating hydrogen at low cost. Further provided are a sputtering target for forming such as hydrogen separation membrane and its manufacturing method.

Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.

Abstract: Provided are a packaging device and packaging method of a hollow cathode sputtering target which installs, in the hollow cathode sputtering target, a cover of a size capable of covering a void of the target; provides one or more through-holes to the cover; places a resin bag over them, and performs vacuum suction to the inside of the bag. This packaging device and packaging method of a hollow cathode sputtering target is capable of performing vacuum suction even to the inside of the hollow portion covered with the resin bag.

Abstract: In a silent chain comprising interleaved and relatively pivotable rows of link plates, protrusions formed in the link plates contact relatively pivotable link plates in adjacent rows so that the area of contact is reduced. The protrusions can be annular, or they can be in the form of arcs that are of a size and position such that the arcuate protrusions of each plate do not interfere with the arcuate protrusions of an adjacent plate as the chain bends during use. The plates can have rectangular protrusions, or arcuate protrusions each consisting of an arc-shaped collection of dot-shaped protrusions.

Abstract: Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.

Abstract: In a coating film transfer tool having a supply reel a transfer head, a take-up reel mounted in a main casing, and a ratchet gear on one of the reels, a sliding body, which is slidable relative to the main casing, has a cover with an opening through which the transfer head can protrude for spot transfer, and a pawl arranged to drive the ratchet gear in a direction to feed tape past the transfer head when the main casing moves relative to the sliding body in a direction such that the transfer head is withdrawn to a protected position within the cover. The cover is movable to an open position for continuous transfer.

Abstract: This invention provides the use of CCI-779 in the treatment of neoplasms.

Abstract: An oil-free chain has bushings which protrude from the outer surfaces of the inner link plates into which they are press-fit, and extend into bushing supporting bores formed in the inner surfaces of the outer link plates of the chain. These bushing supporting bores are formed by a pressing operation which produces offsets in portions of the outer plate, so that, as the bushing supporting bores are formed in the inner surfaces of the outer plates, bosses are simultaneously formed on the outer surfaces. The connecting pins of the chain are press-fit into pin holes in these bosses. The bushing supporting bores are formed without removal of material by machining, and therefore the strength of the outer plates is not compromised.

Abstract: The present nanofiltration method is applicable on solutions of plasma-derived and recombinantly produced MBL. The MBL containing solution is subjected to a pre-treatment prior to the nanofiltration step. The nanofiltration is used for removal of viruses in general and other infectious agents to obtain an MBL product free from infectious viruses and agents. The nanofiltered MBL product is ready for preparing a pharmaceutical composition for therapeutic or prophylactic treatment of infections and other diseases in individuals with MBL deficiency and insufficiency.

Abstract: A microutrophin containing a utrophin having internal deletions (relative to a native utrophin) in the hinge regions and a C-terminal deletion is provided. Also provided are vectors and compositions useful for delivering the microutrophin for the treatment of muscular disorders, including Duchenne Muscular Dystrophy.

Abstract: Provided is a manufacturing method of a crystallized rare-earth thin films on a glass or a silicon substrate. This manufacturing method of a crystallized metal oxide thin film includes a step of retaining an metal organic thin film or a metal oxide film containing at least one type of rare-earth metal element selected from a group comprised of Y, Dy, Sm, Gd, Ho, Eu, Tm, Tb, Er, Ce, Pr, Yb, La, Nd and Lu formed on a substrate at a temperature of 250 to 600° C., and a step of crystallizing the organic metal thin film or the metal oxide film while irradiating ultraviolet radiation having a wavelength of 200 nm or less.

Abstract: In a double-sided engagement silent chain having inner link plates with inwardly protruding teeth, outermost link plates with outwardly protruding teeth, and outer link plates with outwardly protruding teeth, adjacent the outermost link plates, the plates are composed of a bainite and martensite mixed plate material. The bainite mixing ratio in the outermost link plates is higher than the bainite mixing ratio of the inner link plates and the adjacent outer link plates. The martensite mixing ratio of the inner link plates and of the adjacent outer link plates is higher than the martensite mixing ratio in the outermost link plates. The heights of the backs of the outermost link plates, measured from the tooth gap bottoms, are greater than the corresponding heights of the backs of the inner link plates, and may be equal to or greater than the heights of the backs of the adjacent outer tooth plates.