Patents Represented by Attorney, Agent or Law Firm J. Michael Dixon
  • NMDA antagonism method
    Patent number: 5547991
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: August 20, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz
  • Antibiotic GE 2270 factors A.sub.1, A.sub.2, A.sub.3 and H
    Patent number: 5547666
    Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors A.sub.1, A.sub.2, A.sub.3 and H, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 20, 1996
    Assignee: Gruppo Lepetit SpA
    Inventors: Enrico Selva, Paolo Tavecchia
  • Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives
    Patent number: 5541201
    Abstract: The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.sub.1-4 alkyl; X is represented by CO or CHOH; R.sub.3 and R.sub.4 are each independently represented by methyl, ethyl, n-propyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they each are attached form a C.sub.5 or C.sub.6 cycloalkyl; and Alk is a C.sub.1-4 alkyl; or a pharmaceutically acceptable addition salt thereof.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 30, 1996
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Albert A. Carr, Richard C. Dage, David A. Hay, John E. Koerner, Tung Li
  • NMDA antagonists
    Patent number: 5538958
    Abstract: The present invention is directed to a new class of beta-ketone, beta oxime and beta hydrazine phosphonate NMDA antagonists.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 23, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventor: Jeffrey P. Whitten
  • Antibiotic A/16686 recovery process
    Patent number: 5539087
    Abstract: The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a process stream, which comprises extraction of the antibiotics by a non-ionic surfactant or a cationic surfactant miscible with or dispersable in water and capable of dissolving the antibiotics, formation of two phases in the first of which the antibiotic and the surfactant are present together, and separation of the antibiotic from the surfactant by addition of suitable organic solvents.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 23, 1996
    Assignee: Gruppo Lepetit SpA
    Inventors: Ermenegildo Restelli, Luigia Mainoli
  • Cyclic nitrones
    Patent number: 5532252
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 2, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • 7'-amino-naphthazarin antibiotic derivatives
    Patent number: 5530133
    Abstract: New naphthazarin derivatives obtained by introducing in the 7' position of Purpuromycin or .gamma.-Rubromycin an amino or a monosubstituted amino group.The compounds of the invention show antibiotic activity against Gram positive and Gram negative microorganisms, fungi and protozoa and are suitable for the treatment of vaginal infections.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: June 25, 1996
    Assignee: Gruppo Lepetit SpA
    Inventors: Aldo Trani, Clelia M. L. Dallanoce, Romeo Ciabatti
  • Cyclic nitrones
    Patent number: 5527812
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 18, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Cyclic nitrones
    Patent number: 5525615
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 11, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Ronald C. Bernotas, Craig E. Thomas
  • Amides of teicoplanin compounds
    Patent number: 5521155
    Abstract: The present invention is directed to an amide derivative of the glycopeptide, teicoplanin. This compound is an antibiotic that is active against gram positive bacteria. This compound is produced by subjecting teicoplanin to an amidation reaction.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: May 28, 1996
    Assignee: Gruppo Lepetit S.p.A
    Inventors: Adriano Malabarba, Giorgio Tarzia
  • Antibiotic GE 2270 factors C.sub.2a
    Patent number: 5514649
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Sergio Stella, Luigi Colombo, Maurizio Denaro
  • NMDA antagonists
    Patent number: 5500419
    Abstract: The present invention is directed to a new neuroprotective agent. The agent is R-4-oxo-5-phosphononorvaline. This agent is useful in the treatment of ischemic and hypoxic conditions such as stroke.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: March 19, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jeffrey P. Whitten, Bruce M. Baron
  • Substituted alkylamide derivatives of teicoplanin
    Patent number: 5500410
    Abstract: The present invention is directed to new C.sup.63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The derivatives are prepared by reacting a teicoplanin-like product with an active ester forming reagent such as chloroacetonitrile and then contacting said active ester with the appropriate di- or poly-alkylamine. The amide derivatives of the invention are active against gram positive and gram negative bacteria.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 19, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Pierfausto Seneci, Jurgen K. Kettenring, Romeo Ciabatti
  • Cyclic nitrone compounds useful in treating stroke
    Patent number: 5498778
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: March 12, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • Aglycons of A/16686 antibiotics
    Patent number: 5491128
    Abstract: The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the selective hydrolysis of antibiotic A/16686 factor A1, A2, A3, A'1, A'2 or A'3. The compounds have antibacterial activity against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: February 13, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Romeo Ciabatti, Bruno Cavalleri
  • Potentation of NMDA antagonists
    Patent number: 5489579
    Abstract: The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: February 6, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Bruce M. Baron
  • Teicoplanin recovery process
    Patent number: 5486465
    Abstract: The present invention relates to a method for extracting teicoplanin A.sub.2 from a whole culture fermentation broth by filtration of the mycelium in an alkaline medium and recovery by extraction of the filtered fermentation broth with organic solvents or mixtures thereof or by adsorption onto suitable matrixes.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: January 23, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Anacleto Giantonio, Gianbattista Panzone
  • NMDA antagonists
    Patent number: 5484814
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: January 16, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian Alexander McDonald, Francesco G. Salituro, Robert Schwarcz
  • 7'-amino-naphthazarin antibiotic derivatives
    Patent number: 5475010
    Abstract: The present invention concerns novel naphthazarin antibiotic derivatives having general formula I ##STR1## and the pharmaceutically acceptable addition salts thereof.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: December 12, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Aldo Trani, Clelia M. L. Dallanoce, Romeo Ciabatti
  • NMDA antagonists
    Patent number: 5470870
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: November 28, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz, Bruce M. Baron