Patents Represented by Attorney, Agent or Law Firm J. Michael Dixon
  • Heterocyclic-NMDA antagonists
    Patent number: 5470844
    Abstract: The present invention is directed to a class of 3-phosphono-pyrrolidine derivatives as described by Formula I and their use as NMDA antagonists.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: November 28, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Jeffrey P. Whitten
  • Potentiation of NMDA antagonists
    Patent number: 5441963
    Abstract: The present invention is directed to a composition and method for poteniating the therapeutic effects of a class of known NMDA antagonists.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: August 15, 1995
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Ian A. McDonald, Bruce M. Baron
  • Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
    Patent number: 5438117
    Abstract: Hexapeptides of formula (I) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts wherein R is hydrogen or a protecting ##STR1## group of the amino function. The products of formula (I), wherein R is hydrogen, possess antimicrobial activity in particular against coagulase-negative strains and some S. aureus and S. epidermidis strains which have low sensitivity toward teicoplanin. The hexapeptides are produced by reductive cleavage of aglucoteicoplanin with alkali metal borohydrides in the presence of a hydroalcoholic mixture as solvent.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: August 1, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Romeo Ciabatti
  • Cyclic nitrones
    Patent number: 5397789
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: March 14, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • 1,4 benzodioxin derivatives and their use as serotonin 5HT.sub.1A agonists
    Patent number: 5387604
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: February 7, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse
  • Antiallergic compounds
    Patent number: 5380731
    Abstract: The present invention is directed to a new class of piperidinyl benzimidazoles that are useful in the treatment of allergic disorders.
    Type: Grant
    Filed: August 17, 1993
    Date of Patent: January 10, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, Hsien C. Cheng
  • Process for preparing 2'-(diethylamino)rifamycin P (P/DEA)
    Patent number: 5378837
    Abstract: The present invention relates to a new one-pot process for preparing 2'-(diethylamino)rifamycin P and its 25-desacetyl derivative which consists in cyclizing 3-bromorifamycin S or its 25-desacetyl derivative, dissolved in dimethylformamide, with 1,1-diethylthiourea and reducing, without isolation, the obtained 1,2-quinonimine intermediate with a mild reducing agent.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: January 3, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Gianbattista Panzone, Anacleto Gianantonio
  • NMDA antagonists
    Patent number: 5360814
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: November 1, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz, Bruce M. Baron
  • Method for producing an orexigenic effect
    Patent number: 5352686
    Abstract: The present invention is directed to the use of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines in the manufacture of a medicament for producing an orexigenic effect.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 4, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: John T. Burke
  • R-4-oxo-5 phosphononorvaline used as NMDA antagonists
    Patent number: 5326756
    Abstract: The present invention is directed to a new class of beta-ketone, beta oxime and beta hydrazine phosphonate NMDA antagonists.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: July 5, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jeffrey P. Whitten, Bruce M. Baron
  • Antibiotic GE 2270
    Patent number: 5322777
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: June 21, 1994
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Potentiation of NMDA antagonists
    Patent number: 5318985
    Abstract: The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: June 7, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Bruce M. Baron
  • Rifapentine hydrohalides
    Patent number: 5306715
    Abstract: A solid rifapentine hydrohalide useful for anti-bacterial purposes.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: April 26, 1994
    Assignee: Gruppo Lepetit SpA
    Inventors: Emilio Occelli, Marino Nebuloni, Bruno Cavalleri
  • Antithrombotic compounds
    Patent number: 5292752
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak
  • Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
    Patent number: 5292746
    Abstract: The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
  • N-(2,3-epoxycyclopentyl) carbamate derivatives
    Patent number: 5214169
    Abstract: The present invention as directed to a new class of N-(2,3-epoxycyclopentyl) carbamate derivatives as described by Formula V below, that are useful as chemical intermediates in the production of a new class of anti-hypertensives: ##STR1##
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: May 25, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Theophilus F. Leapheart
  • Process for the production of (S)-vinyl and allenyl gaba
    Patent number: 5208345
    Abstract: The present invention is directed to a new class of pyrrolidinone derivatives that are useful as chemical intermediates in the synthesis of S-allenyl and S-vinyl GABA, both of which are antiepileptic agents.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: May 4, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Jonathan C. Evans
  • Antibiotic GE 2270
    Patent number: 5202241
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 13, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Substituted alkylamides of teicoplanin compounds
    Patent number: 5198418
    Abstract: The present invention is directed to teicoplanin derivatives in which position 63 of the glycopeptide core is substituted with a substituted alkylamide.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: March 30, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Giorgio Tarzia
  • Heterocyclic-NMDA antagonists
    Patent number: 5194430
    Abstract: The present invention is directed to a class of 3-phosphono-piperidine and pyrrolidine derivatives and their use as NMDA antagonists.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: March 16, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Jeffrey P. Whitten