Patents Represented by Attorney James L. Rowe

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  • Treating immediate hypersensitivity conditions with 3,5-disubstituted hydantoin derivatives
    Patent number: 4230716
    Abstract: Hydantoin compounds are described of the formula (I) : ##STR1## wherein R.sup.1 is phenyl, C.sub.1-4 hydroxyalkyl or carboxy C.sub.1-4 alkyl and wherein R.sub.2 is C.sub.1-6 alkyl. The compounds are useful in the prophylactic treatment of immediate hypersensitivity diseases including asthma.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: October 28, 1980
    Assignee: Eli Lilly Industries Limited
    Inventors: William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
  • Crystalline forms of N-2-(6-methoxy)benzothiazolyl N'-phenyl urea
    Patent number: 4223153
    Abstract: Crystalline monohydrate (Form III) and anhydrate (Form IV) of N-2-(6-methoxy)benzothiazolyl-N'-phenylurea (frentizole) are stable, have a greater bulk density, are less electrostatic and more freely flowing than previous crystalline forms.
    Type: Grant
    Filed: February 9, 1979
    Date of Patent: September 16, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lewis C. Lappas, Leslie J. Lorenz, James H. Wikel
  • N-Methyl and N-phenethyl-cis-decahydroisoquinolines
    Patent number: 4219652
    Abstract: 1-Methyl and 1-phenethyl-3a-hydroxy or alkoxy phenyl-cis-decahydroisoquinolines, useful as analgetics.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: August 26, 1980
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • Process for preparing cis-bicyclooctylamines
    Patent number: 4215074
    Abstract: A process for preparing antidepresssant 2-phenylbicyclooctylamines of formula (I): ##STR1## where R.sup.1 and R.sup.2 represent C.sub.1-3 alkyl and Ar represents a phenyl group optionally substituted by up to two halogen atoms, by reduction of a novel enamine intermediate of formula: ##STR2## where R.sup.3 and R.sup.4 are hydrogen or taken together represent a single bond and where X is hydrogen, bromine or chlorine.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: July 29, 1980
    Assignee: Lilly Industries Limited
    Inventors: David C. Horwell, Graham H. Timms
  • Antiviral combinations
    Patent number: 4210647
    Abstract: Antiviral combinations containing a 2-ester-substituted-3,4-dihydro-3-oxoquinoxaline and a hindered amine.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: July 1, 1980
    Assignee: Eli Lilly and Company
    Inventor: Donald C. DeLong
  • Vindesine synthesis
    Patent number: 4210584
    Abstract: Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: July 1, 1980
    Assignee: Eli Lilly and Company
    Inventors: Gloria C. Paschal, Gerald L. Thompson
  • Flurandrenolide film formulation
    Patent number: 4210633
    Abstract: Film-forming formulation containing fluroandrenolide. The film can be removed by peeling or washing.
    Type: Grant
    Filed: October 20, 1978
    Date of Patent: July 1, 1980
    Assignee: Eli Lilly and Company
    Inventors: Harun Takruri, Jane E. Chavers
  • N-Alkenyl decahydroisoquinolines
    Patent number: 4208524
    Abstract: 1-Alkenyl-3a-substituted-phenyl decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.
    Type: Grant
    Filed: May 7, 1974
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • Vinblastine in rheumatoid arthritis
    Patent number: 4208414
    Abstract: Vinblastine (vincaleucoblastine, VLB) and other anti-mitotic vinca alkaloid is useful in the treatment of rheumatoid arthritis and related diseases, alone or in combination with an anti-inflammatory agent.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventor: Michael R. Schinitsky
  • N-Heterocyclic ureas as immune regulants
    Patent number: 4208419
    Abstract: Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, John L. Sands
  • 1-Phenyl-3-(substituted phenoxy)propylamines
    Patent number: 4207343
    Abstract: 1-Phenyl-3-(optionally substituted phenoxy)-propylamines, inhibitors of norepinephrine uptake.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: June 10, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edward R. Lavagnino, Lawrence J. McShane, Bryan B. Molloy
  • Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
    Patent number: 4203898
    Abstract: Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids are useful as anti viral and anti-neoplastic agents or as intermediates in the preparation of such agents.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: May 20, 1980
    Assignee: Eli Lilly and Company
    Inventors: George J. Cullinan, Koert Gerzon
  • 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
    Patent number: 4202979
    Abstract: 6-n-Propyl (ethyl or allyl)-8.beta.-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.
    Type: Grant
    Filed: January 11, 1979
    Date of Patent: May 13, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • 2-Azaergolines and 2-aza-8(or 9)-ergolenes
    Patent number: 4201862
    Abstract: 2-Azaergolines, 2-aza-8(or 9)-ergolenes, neuroleptic agents.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: May 6, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • Bridged cathranthus alkaloid dimers
    Patent number: 4199504
    Abstract: Bridged vinca dimers in which two indole-dihydro-indole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group, useful as oncolytic agents.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: April 22, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Conrad, Koert Gerzon
  • Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
    Patent number: 4198415
    Abstract: Octahydropyrazolo[3,4-g]quinolines, dopamine agonists, useful in treatment of Parkinsonism and in inhibiting secretion of prolactin.
    Type: Grant
    Filed: April 19, 1979
    Date of Patent: April 15, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • 4-Desacetoxy-4.alpha.-hydroxyvinblastine and related compounds
    Patent number: 4195022
    Abstract: 4-Desacetoxy-4.alpha.-hydroxyvinblastine, prepared by reduction of 4-desacetoxy-4-oxovinblastine, and derivatives thereof, useful as antimitotic agents.
    Type: Grant
    Filed: March 27, 1978
    Date of Patent: March 25, 1980
    Assignee: Eli Lilly and Company
    Inventor: Gerald L. Thompson
  • Nabilone granulation
    Patent number: 4195078
    Abstract: A solution of nabilone and PVP in anhydrous ethanol is used to granulate ethanol-insoluble pharmaceutically-acceptable excipients such as starch.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: March 25, 1980
    Assignee: Eli Lilly and Company
    Inventor: James W. Conine
  • Substituted pyrroloquinoxalinones and diones
    Patent number: RE30314
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: June 24, 1980
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Substituted pyrroloquinoxalinones and diones
    Patent number: RE30415
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: October 7, 1980
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes